BR9815059A - triagem de alta produtividade em formato contìnuo - Google Patents
triagem de alta produtividade em formato contìnuoInfo
- Publication number
- BR9815059A BR9815059A BRPI9815059-6A BR9815059A BR9815059A BR 9815059 A BR9815059 A BR 9815059A BR 9815059 A BR9815059 A BR 9815059A BR 9815059 A BR9815059 A BR 9815059A
- Authority
- BR
- Brazil
- Prior art keywords
- high productivity
- continuous format
- sorting
- hts
- continuous
- Prior art date
Links
- 238000012216 screening Methods 0.000 abstract 2
- 150000005829 chemical entities Chemical class 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Paper (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Image Processing (AREA)
- Geophysics And Detection Of Objects (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/990,168 US5976813A (en) | 1997-12-12 | 1997-12-12 | Continuous format high throughput screening |
| PCT/US1998/026465 WO1999030154A2 (en) | 1997-12-12 | 1998-12-11 | Continuous format high throughput screening |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9815059A true BR9815059A (pt) | 2007-05-22 |
Family
ID=25535858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9815059-6A BR9815059A (pt) | 1997-12-12 | 1998-12-11 | triagem de alta produtividade em formato contìnuo |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5976813A (enExample) |
| EP (1) | EP1038179B1 (enExample) |
| JP (1) | JP4558197B2 (enExample) |
| KR (1) | KR100657777B1 (enExample) |
| CN (2) | CN101256187A (enExample) |
| AT (1) | ATE336001T1 (enExample) |
| AU (1) | AU759538B2 (enExample) |
| BG (1) | BG65264B1 (enExample) |
| BR (1) | BR9815059A (enExample) |
| CA (1) | CA2310684C (enExample) |
| CY (1) | CY1106220T1 (enExample) |
| CZ (1) | CZ299740B6 (enExample) |
| DE (1) | DE69835537T2 (enExample) |
| DK (1) | DK1038179T3 (enExample) |
| ES (1) | ES2270539T3 (enExample) |
| HU (1) | HU228578B1 (enExample) |
| IL (1) | IL135793A (enExample) |
| NO (1) | NO326662B1 (enExample) |
| NZ (1) | NZ504112A (enExample) |
| PL (1) | PL194813B1 (enExample) |
| PT (1) | PT1038179E (enExample) |
| SK (1) | SK286095B6 (enExample) |
| TR (1) | TR200001647T2 (enExample) |
| TW (1) | TW555967B (enExample) |
| WO (1) | WO1999030154A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL186473B1 (pl) | 1996-01-26 | 2004-01-30 | Virco Nv | Sposób oceny in vitro chemioterapii HIV u pacjentów HIV dodatnich oraz sposób oznaczania fenotypowej wrażliwości lekowej poszczególnych szczepów HIV u pacjenta na inhibitory co najmniej dwóch enzymówkodowanych przez gen pol HIV |
| US6790652B1 (en) * | 1998-01-08 | 2004-09-14 | Bioimage A/S | Method and apparatus for high density format screening for bioactive molecules |
| US6410332B1 (en) | 1998-09-08 | 2002-06-25 | Symyx Technologies, Inc. | Sampling and analysis of reactions by trapping reaction components on a sorbent |
| CN1315001A (zh) * | 1998-09-08 | 2001-09-26 | 泰博特克有限公司 | 快速筛选分析物的方法 |
| AU2368900A (en) * | 1998-12-18 | 2000-07-03 | Symyx Technologies, Inc. | Apparatus and method for characterizing libraries of different materials using x-ray scattering |
| US20040185432A1 (en) * | 1999-01-08 | 2004-09-23 | Bioimage A/S | Method and apparatus for high density format screening for bioactive molecules |
| US6690399B1 (en) * | 1999-05-07 | 2004-02-10 | Tropix, Inc. | Data display software for displaying assay results |
| US6800437B1 (en) | 1999-08-06 | 2004-10-05 | Tibotec Bvba | Method of monitoring a biological system by labeling with an apo metal binding protein |
| US6544480B1 (en) | 1999-10-26 | 2003-04-08 | Tibotec Bvba | Device and related method for dispensing small volumes of liquid |
| US20010044112A1 (en) * | 2000-03-24 | 2001-11-22 | Lyles Mark B. | High throughput screening array containing porous material |
| US20030031675A1 (en) | 2000-06-06 | 2003-02-13 | Mikesell Glen E. | B7-related nucleic acids and polypeptides useful for immunomodulation |
| WO2001096597A2 (en) * | 2000-06-13 | 2001-12-20 | Glaxo Group Limited | High throughput screening of compounds for biological activity |
| US7087375B1 (en) | 2000-06-23 | 2006-08-08 | Johan Lennerstrand | Method for determining the mechanism of HIV RT inhibitors |
| US7052659B1 (en) | 2000-07-18 | 2006-05-30 | General Electric Company | Sequential high throughput screening method and system |
| US6653124B1 (en) | 2000-11-10 | 2003-11-25 | Cytoplex Biosciences Inc. | Array-based microenvironment for cell culturing, cell monitoring and drug-target validation |
| AUPR224600A0 (en) * | 2000-12-21 | 2001-01-25 | Polymerat Pty Ltd | Novel polymers |
| US20030060695A1 (en) * | 2001-03-07 | 2003-03-27 | Connelly Patrick R. | Implantable artificial organ devices |
| US7244232B2 (en) * | 2001-03-07 | 2007-07-17 | Biomed Solutions, Llc | Process for identifying cancerous and/or metastatic cells of a living organism |
| US20020142304A1 (en) * | 2001-03-09 | 2002-10-03 | Anderson Daniel G. | Uses and methods of making microarrays of polymeric biomaterials |
| US20080009019A1 (en) * | 2001-06-13 | 2008-01-10 | Smithkline Beecham Corporation | High throughput method for screening candidate compounds for biological activity |
| DE10138766A1 (de) * | 2001-08-07 | 2003-02-20 | Bayer Cropscience Ag | Verfahren zum Identifizieren von makrocyclischen Polyketiden |
| US20030032198A1 (en) * | 2001-08-13 | 2003-02-13 | Symyx Technologies, Inc. | High throughput dispensing of fluids |
| EP1298433A1 (en) * | 2001-09-28 | 2003-04-02 | EMC microcollections GmbH | Device and method for the generation of arrays of substance mixtures by diffusion |
| JP2005511066A (ja) * | 2001-12-07 | 2005-04-28 | ダイアックス、コープ | 磁気応答性粒子を洗浄する方法及び装置 |
| EP1463807A4 (en) * | 2001-12-19 | 2006-04-12 | Bristol Myers Squibb Co | FORMATHYDROGENASE FROM PICHIA PASTORIS AND USES THEREOF |
| US20050054118A1 (en) * | 2002-02-27 | 2005-03-10 | Lebrun Stewart J. | High throughput screening method |
| AU2003212471A1 (en) * | 2002-02-27 | 2003-09-09 | Miragene, Inc. | Improved substrate chemistry for protein immobilization on a rigid support |
| US20040072274A1 (en) * | 2002-05-09 | 2004-04-15 | Lebrun Stewart J. | System and method for visualization and digital analysis of protein and other macromolecule microarrays |
| EP1534755B1 (en) | 2002-05-10 | 2011-10-12 | Bio-Layer Pty Limited | Generation of surface coating diversity |
| EP1900827A3 (en) | 2002-05-21 | 2008-04-16 | Bayer HealthCare AG | Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia |
| US20040028804A1 (en) * | 2002-08-07 | 2004-02-12 | Anderson Daniel G. | Production of polymeric microarrays |
| USD480815S1 (en) | 2002-08-13 | 2003-10-14 | Discovery Partners International | Card carrying an array of compounds |
| AU2003255253A1 (en) * | 2002-08-13 | 2004-02-25 | Discovery Partners International | Spotting pattern for placement of compounds in an array |
| US20040032058A1 (en) * | 2002-08-13 | 2004-02-19 | Neeper Robert K. | Systems and methods for casting and handling assay matrices |
| US8557743B2 (en) * | 2002-09-05 | 2013-10-15 | Dyax Corp. | Display library process |
| US20040058327A1 (en) * | 2002-09-20 | 2004-03-25 | Pan Jeffrey Y | Method for using a blank matrix in a continuous format high throughput screening process |
| US20050008212A1 (en) * | 2003-04-09 | 2005-01-13 | Ewing William R. | Spot finding algorithm using image recognition software |
| US7025935B2 (en) * | 2003-04-11 | 2006-04-11 | Illumina, Inc. | Apparatus and methods for reformatting liquid samples |
| WO2004106934A2 (en) * | 2003-05-28 | 2004-12-09 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine (serotonin) receptor 7 (5-ht7) |
| JP2005046121A (ja) * | 2003-07-31 | 2005-02-24 | Japan Science & Technology Agency | オンチップバイオアッセイ方法及びキット |
| US20050136536A1 (en) * | 2003-09-15 | 2005-06-23 | Anderson Daniel G. | Embryonic epithelial cells |
| US20050069462A1 (en) * | 2003-09-30 | 2005-03-31 | International Business Machines Corporation | Microfluidics Packaging |
| US20050069949A1 (en) * | 2003-09-30 | 2005-03-31 | International Business Machines Corporation | Microfabricated Fluidic Structures |
| EP1892306A3 (en) | 2003-10-06 | 2008-06-11 | Bayer HealthCare AG | Methods and kits for investigating cancer |
| US20060127963A1 (en) * | 2003-11-21 | 2006-06-15 | Lebrun Stewart J | Microarray-based analysis of rheumatoid arthritis markers |
| JP2007516704A (ja) | 2003-12-02 | 2007-06-28 | ビーエーエスエフ アクチェンゲゼルシャフト | 除草剤の標的としての2−メチル−6−ソラニルベンゾキノン・メチルトランスフェラーゼ |
| US20050124017A1 (en) * | 2003-12-05 | 2005-06-09 | Stewart Lebrun | Quantitative alkaline-phosphatase precipitation reagent and methods for visualization of protein microarrays |
| AU2004296412B2 (en) * | 2003-12-12 | 2011-03-10 | Anteo Technologies Pty Ltd | A method for designing surfaces |
| CA2553468A1 (en) * | 2004-01-21 | 2005-08-04 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Inhibitors of mammalian hdac 11 useful for treating hdac 11 mediated disorders |
| EP1564556A1 (de) * | 2004-02-17 | 2005-08-17 | DST Diagnostic Science & Technology GmbH | Verfahren und Vorrichtung zur Bestimmung mehrerer Analyten mit simultaner interner Kontrolle |
| US8101431B2 (en) | 2004-02-27 | 2012-01-24 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems |
| US8105849B2 (en) | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
| EP1773866B1 (en) | 2004-07-02 | 2013-06-19 | Bio-Layer Pty Limited | Use of metal complexes |
| US20080206855A1 (en) * | 2005-05-06 | 2008-08-28 | Kalypsys, Inc. | Automated Compound Screening Using Gel-Permeation Matrix and Pin-Based Sample Transfer |
| US7629115B2 (en) * | 2005-05-13 | 2009-12-08 | Honeywell International Inc. | Cell-based platform for high throughput screening |
| AU2006309284B2 (en) | 2005-05-31 | 2012-08-02 | Board Of Regents, The University Of Texas System | Methods and compositions related to determination and use of white blood cell counts |
| ES2389111T3 (es) | 2005-12-02 | 2012-10-23 | Sirtris Pharmaceuticals, Inc. | Ensayos de espectrometría de masas para la actividad acetiltransferasa/desacetilasa |
| WO2007076580A1 (en) * | 2005-12-30 | 2007-07-12 | Bio-Layer Pty Limited | Binding of molecules |
| US8715665B2 (en) | 2007-04-13 | 2014-05-06 | The General Hospital Corporation | Methods for treating cancer resistant to ErbB therapeutics |
| US20090118135A1 (en) * | 2007-06-08 | 2009-05-07 | The Burnham Institute | Methods and compounds for regulating apoptosis |
| US20090272657A1 (en) * | 2008-05-01 | 2009-11-05 | Massachusetts Institute Of Technology | Devices and processes for analyzing nucleic acid damage and repair using electrophoresis |
| US9594054B2 (en) * | 2012-07-25 | 2017-03-14 | Bio-Rad Laboratories, Inc. | Targeted delivery of reagents to spots on a planar support through patterned transfer sheets |
| US9447135B2 (en) | 2012-12-14 | 2016-09-20 | University Of Kentucky Research Foundation | Semi-synthetic mithramycin derivatives with anti-cancer activity |
| GB201318814D0 (en) | 2013-10-24 | 2013-12-11 | Petroleum & Chemical Corp | Microfluidic devices and arrangements for supplying such devices with reagents and biological samples |
| EP3087391B1 (en) | 2013-12-23 | 2021-05-19 | Basf Se | Methods for determining modulators of insect transient receptor potential v (trpv) channel |
| WO2019023559A1 (en) | 2017-07-27 | 2019-01-31 | University Of Southern California | OTOPETRIN PROTON CHANNELS AS TARGETS FOR PHARMACEUTICAL DISCOVERY |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447526A (en) * | 1981-04-20 | 1984-05-08 | Miles Laboratories, Inc. | Homogeneous specific binding assay with carrier matrix incorporating specific binding partner |
| EP0063810B1 (en) * | 1981-04-29 | 1986-03-05 | Ciba-Geigy Ag | New devices and kits for immunological analysis |
| US4591570A (en) * | 1983-02-02 | 1986-05-27 | Centocor, Inc. | Matrix of antibody-coated spots for determination of antigens |
| JP2564181B2 (ja) * | 1988-11-24 | 1996-12-18 | コニカ株式会社 | 特定成分の分析方法 |
| DE4208645A1 (de) * | 1992-03-18 | 1993-09-23 | Bayer Ag | Optischer festphasenbiosensor auf basis fluoreszenzfarbstoffmarkierter polyionischer schichten |
| WO1994002515A1 (en) * | 1992-07-21 | 1994-02-03 | Bunsen Rush Laboratories Inc. | Oligomer library formats and methods relating thereto |
| CA2130947C (en) * | 1993-11-12 | 2001-02-06 | Robert E. Emmons | Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents |
| EP0758313A4 (en) * | 1994-05-06 | 1999-09-15 | Pharmacopeia Inc | COMBINATORIAL LIBRARY OF DIHYDROBENZOPYRANES |
| US5856083A (en) * | 1994-05-06 | 1999-01-05 | Pharmacopeia, Inc. | Lawn assay for compounds that affect enzyme activity or bind to target molecules |
| AU2986395A (en) * | 1994-07-22 | 1996-02-22 | Zeneca Limited | Method for screening compound libraries |
-
1997
- 1997-12-12 US US08/990,168 patent/US5976813A/en not_active Expired - Lifetime
-
1998
- 1998-12-10 TW TW087120533A patent/TW555967B/zh not_active IP Right Cessation
- 1998-12-11 SK SK836-2000A patent/SK286095B6/sk not_active IP Right Cessation
- 1998-12-11 IL IL13579398A patent/IL135793A/xx not_active IP Right Cessation
- 1998-12-11 BR BRPI9815059-6A patent/BR9815059A/pt not_active Application Discontinuation
- 1998-12-11 AT AT98963130T patent/ATE336001T1/de active
- 1998-12-11 PT PT98963130T patent/PT1038179E/pt unknown
- 1998-12-11 ES ES98963130T patent/ES2270539T3/es not_active Expired - Lifetime
- 1998-12-11 WO PCT/US1998/026465 patent/WO1999030154A2/en not_active Ceased
- 1998-12-11 DE DE69835537T patent/DE69835537T2/de not_active Expired - Lifetime
- 1998-12-11 DK DK98963130T patent/DK1038179T3/da active
- 1998-12-11 KR KR1020007006322A patent/KR100657777B1/ko not_active Expired - Fee Related
- 1998-12-11 EP EP98963130A patent/EP1038179B1/en not_active Expired - Lifetime
- 1998-12-11 NZ NZ504112A patent/NZ504112A/xx not_active IP Right Cessation
- 1998-12-11 CA CA2310684A patent/CA2310684C/en not_active Expired - Fee Related
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- 1998-12-11 AU AU18216/99A patent/AU759538B2/en not_active Ceased
- 1998-12-11 CN CNA2008100817676A patent/CN101256187A/zh active Pending
- 1998-12-11 PL PL341655A patent/PL194813B1/pl unknown
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2000
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