CN1255680C - 液相色谱仪 - Google Patents
液相色谱仪 Download PDFInfo
- Publication number
- CN1255680C CN1255680C CN200310120153.1A CN200310120153A CN1255680C CN 1255680 C CN1255680 C CN 1255680C CN 200310120153 A CN200310120153 A CN 200310120153A CN 1255680 C CN1255680 C CN 1255680C
- Authority
- CN
- China
- Prior art keywords
- dilution
- stream
- post
- moving phase
- mentioned
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007791 liquid phase Substances 0.000 title description 3
- 238000010790 dilution Methods 0.000 claims description 50
- 239000012895 dilution Substances 0.000 claims description 50
- 238000012546 transfer Methods 0.000 claims description 37
- 238000001802 infusion Methods 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 14
- 239000003480 eluent Substances 0.000 claims description 13
- 230000008676 import Effects 0.000 claims description 13
- 239000012141 concentrate Substances 0.000 claims description 8
- 238000006073 displacement reaction Methods 0.000 claims description 4
- 239000011903 deuterated solvents Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 abstract description 7
- 239000003085 diluting agent Substances 0.000 abstract 3
- 238000007865 diluting Methods 0.000 abstract 1
- 239000012071 phase Substances 0.000 description 35
- 238000004458 analytical method Methods 0.000 description 19
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 14
- 239000000470 constituent Substances 0.000 description 10
- 239000003960 organic solvent Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 4
- 238000005481 NMR spectroscopy Methods 0.000 description 4
- 229910052805 deuterium Inorganic materials 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000004451 qualitative analysis Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000013396 workstream Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/462—Flow patterns using more than one column with serial coupling of separation columns with different eluents or with eluents in different states
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8411—Intermediate storage of effluent, including condensation on surface
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
Claims (3)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002375103A JP3868899B2 (ja) | 2002-12-25 | 2002-12-25 | 液体クロマトグラフ |
JP2002375103 | 2002-12-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1510418A CN1510418A (zh) | 2004-07-07 |
CN1255680C true CN1255680C (zh) | 2006-05-10 |
Family
ID=32652694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200310120153.1A Expired - Lifetime CN1255680C (zh) | 2002-12-25 | 2003-12-08 | 液相色谱仪 |
Country Status (3)
Country | Link |
---|---|
US (1) | US6955760B2 (zh) |
JP (1) | JP3868899B2 (zh) |
CN (1) | CN1255680C (zh) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005099015A (ja) * | 2003-09-05 | 2005-04-14 | Sumitomo Chemical Co Ltd | 液体クロマトグラフィー装置 |
JP4093201B2 (ja) * | 2004-03-30 | 2008-06-04 | 株式会社島津製作所 | 液体クロマトグラフ |
JP2006125856A (ja) * | 2004-10-26 | 2006-05-18 | Sumitomo Chemical Co Ltd | 液体クロマトグラフィー装置 |
US8123949B2 (en) | 2005-01-20 | 2012-02-28 | Waters Technologies Corporation | Methods for separating compounds |
JP2006275873A (ja) * | 2005-03-30 | 2006-10-12 | Sumitomo Chemical Co Ltd | 液体クロマトグラフィー装置 |
US8992778B2 (en) * | 2006-02-08 | 2015-03-31 | Waters Technologies Corporation | Methods and apparatus for generating solvent gradients in liquid chromatography |
US8104330B2 (en) * | 2006-02-09 | 2012-01-31 | Shimadzu Corporation | Method and apparatus for analysis by liquid chromatography |
JP4728879B2 (ja) * | 2006-06-07 | 2011-07-20 | 株式会社島津製作所 | 味解析装置 |
EP1879026A1 (en) * | 2006-06-24 | 2008-01-16 | Agilent Technologies, Inc. | Focussing a sample on an analytical column |
US8642351B2 (en) * | 2006-09-20 | 2014-02-04 | Waters Technologies Corporation | Apparatus and methods of fluid chromatography |
CN101169391B (zh) * | 2006-10-25 | 2011-01-19 | 中国科学院大连化学物理研究所 | 一种二维高效液相色谱系统及其应用 |
JP5012148B2 (ja) * | 2007-04-03 | 2012-08-29 | 株式会社島津製作所 | 液体クロマトグラフ |
JP2010014429A (ja) * | 2008-07-01 | 2010-01-21 | Shimadzu Corp | 液体クロマトグラフ |
SG172033A1 (en) * | 2008-12-10 | 2011-07-28 | Alltech Associates Inc | Solvent feed systems for chromatography systems and methods of making and using the same |
US20100206920A1 (en) * | 2009-02-17 | 2010-08-19 | Stanley Rex Byrns | Wine glass holster and method of manufacture thereof |
FI20115785A0 (fi) * | 2011-08-08 | 2011-08-08 | Thermo Fisher Scientific Oy | Menetelmä ja laite automaattiseen analyysiin |
WO2013021101A1 (en) | 2011-08-08 | 2013-02-14 | Thermo Fisher Scientific Oy | Method and apparatus for automated analysis |
US9316216B1 (en) | 2012-03-28 | 2016-04-19 | Pumptec, Inc. | Proportioning pump, control systems and applicator apparatus |
JP6002610B2 (ja) * | 2013-03-19 | 2016-10-05 | 株式会社日立ハイテクノロジーズ | 送液デバイスおよびそれを用いた化学分析装置 |
JP2015052592A (ja) * | 2013-08-07 | 2015-03-19 | アークレイ株式会社 | 液体クロマトグラフィ装置、液体クロマトグラフィ分析方法、及び液体クロマトグラフィ分析プログラム |
EP3236256A4 (en) * | 2014-12-15 | 2017-11-29 | Shimadzu Corporation | Liquid chromatograph |
US10732153B2 (en) * | 2015-08-24 | 2020-08-04 | Shimadzu Corporation | Separation/purification apparatus |
US10799813B2 (en) * | 2016-01-25 | 2020-10-13 | Waters Technologies Corporation | Multi-dimensional chromatographic system for analyzing multiple sample components |
US10760557B1 (en) | 2016-05-06 | 2020-09-01 | Pumptec, Inc. | High efficiency, high pressure pump suitable for remote installations and solar power sources |
CN106198150A (zh) * | 2016-08-30 | 2016-12-07 | 中国科学院寒区旱区环境与工程研究所 | 一种化学分析样品综合前处理仪 |
JP6733733B2 (ja) * | 2016-09-16 | 2020-08-05 | 株式会社島津製作所 | 液体クロマトグラフ |
WO2018059639A1 (en) * | 2016-09-28 | 2018-04-05 | Evosep Aps | Chromatographic analysis with low pressure dual gradient refocusing |
US10823160B1 (en) | 2017-01-12 | 2020-11-03 | Pumptec Inc. | Compact pump with reduced vibration and reduced thermal degradation |
WO2018189871A1 (ja) * | 2017-04-13 | 2018-10-18 | 株式会社島津製作所 | 液体クロマトグラフ質量分析による試料分析方法 |
CN109541051B (zh) * | 2018-11-12 | 2021-08-17 | 复旦大学 | 二维液相色谱接口在线浓缩溶剂交换装置 |
GB2594006B (en) * | 2018-11-27 | 2023-03-08 | Agilent Technologies Inc | Removing portions of undefined composition from the mobile phase |
EP3760292B1 (en) * | 2019-07-01 | 2023-04-12 | F. Hoffmann-La Roche AG | Liquid chromatography systems |
US11835496B2 (en) | 2019-12-23 | 2023-12-05 | Waters Technologies Corporation | Sample metering and injection for liquid chromatography |
US20230003631A1 (en) * | 2019-12-25 | 2023-01-05 | Shimadzu Corporation | Analysis system |
CN113533540A (zh) * | 2020-04-13 | 2021-10-22 | 株式会社岛津制作所 | 使用超临界流体的分析系统以及分析方法 |
CN112505171A (zh) * | 2020-11-12 | 2021-03-16 | 南通药明康德医药科技有限公司 | 一种适用于制备型液相色谱仪器的在线稀释器与稀释方法 |
EP4089401A1 (de) * | 2021-05-10 | 2022-11-16 | Siemens Aktiengesellschaft | Messeinrichtung und verfahren zur messung von mindestens zwei verschiedenen komponenten eines fluids mittels ramanstreuung und chemilumineszenz |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4837157A (en) * | 1982-07-20 | 1989-06-06 | Coventry Health Authority | Sample preparation method for liquid chromatography |
US4950397A (en) * | 1987-12-09 | 1990-08-21 | Atlantic Richfield Company | Apparatus for analyzing diluted and undiluted fluid samples |
US4872992A (en) * | 1987-12-09 | 1989-10-10 | Atlantic Richfield Company | Method and apparatus for analyzing diluted and undiluted fluid samples |
JP2892795B2 (ja) * | 1989-09-12 | 1999-05-17 | エーザイ株式会社 | 高速液体クロマトグラフィー質量分析における移動相の変換方法と装置 |
US5183486A (en) * | 1990-12-04 | 1993-02-02 | Spectra-Physics, Inc. | Apparatus for degassing a liquid |
EP0610297A1 (en) * | 1991-09-30 | 1994-08-17 | Perseptive Biosystems, Inc. | Protein chromatography system |
AU720420B2 (en) * | 1996-02-09 | 2000-06-01 | Kalibrant Limited | Assay apparatus |
US6406632B1 (en) * | 1998-04-03 | 2002-06-18 | Symyx Technologies, Inc. | Rapid characterization of polymers |
AU2002243220A1 (en) * | 2000-11-21 | 2002-07-01 | Waters Investments Limited | Mobile phase dilution scheme for enhanced chromatography |
-
2002
- 2002-12-25 JP JP2002375103A patent/JP3868899B2/ja not_active Expired - Lifetime
-
2003
- 2003-12-03 US US10/725,387 patent/US6955760B2/en not_active Expired - Lifetime
- 2003-12-08 CN CN200310120153.1A patent/CN1255680C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2004205358A (ja) | 2004-07-22 |
CN1510418A (zh) | 2004-07-07 |
JP3868899B2 (ja) | 2007-01-17 |
US6955760B2 (en) | 2005-10-18 |
US20040124128A1 (en) | 2004-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHIMADZU SCISAKUSHO LTD.; WEI CAI & D MANAGEMENT Free format text: FORMER OWNER: SHIMADZU SCISAKUSHO LTD.; EISAI CO., LTD. Effective date: 20070112 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20070112 Address after: Kyoto Japan Co-patentee after: R& D Management Co., Ltd. Patentee after: SHIMADZU Corp. Address before: Kyoto Japan Co-patentee before: Eisai Co.,Ltd. Patentee before: Shimadzu Corp. |
|
ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: EISAI R + D MANAGEMENT CO., LTD. Effective date: 20150624 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150624 Address after: Kyoto Japan Patentee after: SHIMADZU Corp. Address before: Kyoto Japan Patentee before: Shimadzu Corp. Patentee before: Eisai Co.,Ltd. |
|
CX01 | Expiry of patent term |
Granted publication date: 20060510 |
|
CX01 | Expiry of patent term |