CN1231493C - 两性固醇及其应用 - Google Patents

两性固醇及其应用 Download PDF

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Publication number
CN1231493C
CN1231493C CNB028053206A CN02805320A CN1231493C CN 1231493 C CN1231493 C CN 1231493C CN B028053206 A CNB028053206 A CN B028053206A CN 02805320 A CN02805320 A CN 02805320A CN 1231493 C CN1231493 C CN 1231493C
Authority
CN
China
Prior art keywords
liposome
liposomes
acid
sterol
charge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028053206A
Other languages
English (en)
Chinese (zh)
Other versions
CN1492876A (zh
Inventor
斯特芬·潘茨纳
格罗尔德－恩德特
斯特凡·范克豪尼尔
纳斯尔－埃尔穆克达德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marina Biotech Inc
Original Assignee
Novosom AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novosom AG filed Critical Novosom AG
Publication of CN1492876A publication Critical patent/CN1492876A/zh
Application granted granted Critical
Publication of CN1231493C publication Critical patent/CN1231493C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB028053206A 2001-02-21 2002-02-21 两性固醇及其应用 Expired - Fee Related CN1231493C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10109898.7 2001-02-21
DE10109898A DE10109898A1 (de) 2001-02-21 2001-02-21 Lipide mit veränderlicher Ladung

Publications (2)

Publication Number Publication Date
CN1492876A CN1492876A (zh) 2004-04-28
CN1231493C true CN1231493C (zh) 2005-12-14

Family

ID=7675951

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028053206A Expired - Fee Related CN1231493C (zh) 2001-02-21 2002-02-21 两性固醇及其应用

Country Status (10)

Country Link
US (3) US7312206B2 (https=)
EP (3) EP1363933B1 (https=)
JP (2) JP2004521917A (https=)
CN (1) CN1231493C (https=)
AT (2) ATE430759T1 (https=)
AU (2) AU2002244726A1 (https=)
BR (1) BR0207776A (https=)
CA (1) CA2438910C (https=)
DE (3) DE10109898A1 (https=)
WO (2) WO2002066490A2 (https=)

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EP1911443A1 (en) * 2006-10-13 2008-04-16 Novosom AG Amphoteric liposomes, method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
AU2006291429B2 (en) 2005-09-15 2013-04-04 Biontech Delivery Technologies Gmbh Improvements in or relating to amphoteric liposomes
PL1957044T3 (pl) * 2005-12-01 2013-11-29 Pronai Therapeutics Inc Amfoteryczny preparat liposomowy
ES2548240T3 (es) 2005-12-01 2015-10-15 Pronai Therapeutics, Inc. Terapias para el cáncer y composiciones farmacéuticas usadas en las mismas
CA2665783C (en) 2006-10-13 2015-12-15 Novosom Ag Improvements in or relating to amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
WO2008074487A2 (en) * 2006-12-19 2008-06-26 Novosom Ag Lipids and lipid assemblies comprising transfection enhancer elements
HUE040417T2 (hu) 2007-05-04 2019-03-28 Marina Biotech Inc Aminosavlipidek és alkalmazásuk
US8822409B2 (en) 2007-06-20 2014-09-02 Phylogica Limited Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith
JP2009203228A (ja) * 2008-01-29 2009-09-10 Kochi Univ キレーター化合物含有薬物輸送剤
US8765171B2 (en) 2009-03-09 2014-07-01 The Regents Of The University Of California Methods and compositions for liposomal formulation of antigens and uses thereof
WO2010135714A2 (en) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Methods for modulating adipocyte expression using microrna compositions
EP3318248B1 (en) * 2009-12-01 2019-04-10 Translate Bio, Inc. Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
WO2012109495A1 (en) 2011-02-09 2012-08-16 Metabolic Solutions Development Company, Llc Cellular targets of thiazolidinediones
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WO2012159164A1 (en) 2011-05-23 2012-11-29 Phylogica Limited Method of determining, identifying or isolating cell-penetrating peptides
GB201116248D0 (en) * 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
US20150297725A1 (en) 2012-07-30 2015-10-22 Rutgers, The State University Of New Jersey Cochleates made with soy phosphatidylserine
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
EP4170031A1 (en) 2012-10-23 2023-04-26 Caris Science, Inc. Aptamers and uses thereof
CA2890725A1 (en) 2012-11-05 2014-05-08 Pronai Therapeutics, Inc. Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression
AU2013361323B2 (en) 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
US20170000715A1 (en) * 2014-01-29 2017-01-05 Humedix Co., Ltd. Pegylated 7-dehydrocholesterol derivatives
JP6399530B1 (ja) * 2017-09-04 2018-10-03 一丸ファルコス株式会社 ｐＨ感受性リポソーム
US20200208152A1 (en) 2017-09-08 2020-07-02 Mina Therapeutics Limited Stabilized sarna compositions and methods of use
EP3775211B1 (en) 2018-04-12 2023-04-05 MiNA Therapeutics Limited Sirt1-sarna compositions and methods of use
US12240824B2 (en) * 2018-05-30 2025-03-04 Translate Bio, Inc. Vitamin cationic lipids
EP3953473A1 (en) 2019-04-12 2022-02-16 MiNA Therapeutics Limited Sirt1-sarna compositions and methods of use
GB2603454A (en) 2020-12-09 2022-08-10 Ucl Business Ltd Novel therapeutics for the treatment of neurodegenerative disorders
TW202305133A (zh) 2021-03-26 2023-02-01 英商米納治療有限公司 Tmem173 sarna組合物及其使用方法
WO2023099884A1 (en) 2021-12-01 2023-06-08 Mina Therapeutics Limited Pax6 sarna compositions and methods of use
GB202117758D0 (en) 2021-12-09 2022-01-26 Ucl Business Ltd Therapeutics for the treatment of neurodegenerative disorders
WO2023170435A1 (en) 2022-03-07 2023-09-14 Mina Therapeutics Limited Il10 sarna compositions and methods of use
WO2024125597A1 (en) 2022-12-14 2024-06-20 Providence Therapeutics Holdings Inc. Compositions and methods for infectious diseases
WO2024134199A1 (en) 2022-12-22 2024-06-27 Mina Therapeutics Limited Chemically modified sarna compositions and methods of use
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US5993823A (en) * 1990-12-18 1999-11-30 Institut Pasteur De Lille Cytotoxic T lymphocyte-inducing lipopeptides and methods of use
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JP2579730B2 (ja) * 1993-01-22 1997-02-12 株式会社ディ・ディ・エス研究所 ペプチド−脂質誘導体及びリポソーム
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DE59507224D1 (de) * 1994-12-28 1999-12-16 Max Delbrueck Centrum Neues cholesterolderivat für den liposomalen gentransfer
PT888379E (pt) 1996-03-01 2001-05-31 Centre Nat Rech Scient Compostos analogos a familia dos amidinios composicoes farmaceuticas que os contem e suas aplicacoes
WO1997039019A1 (en) 1996-04-12 1997-10-23 University Of Pittsburgh Novel cationic cholesteryl derivatives containing cyclic polar groups
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Also Published As

Publication number Publication date
DE50210313D1 (de) 2007-07-26
EP1806354A2 (de) 2007-07-11
EP1363932B1 (de) 2007-06-13
CA2438910A1 (en) 2002-08-29
JP4470197B2 (ja) 2010-06-02
WO2002066489A2 (de) 2002-08-29
AU2002302364B2 (en) 2008-01-03
WO2002066490A3 (de) 2003-04-24
BR0207776A (pt) 2004-03-23
US20040131666A1 (en) 2004-07-08
JP2004521917A (ja) 2004-07-22
EP1363932A2 (de) 2003-11-26
US7407947B2 (en) 2008-08-05
DE50213524D1 (de) 2009-06-18
EP1363933A2 (de) 2003-11-26
CN1492876A (zh) 2004-04-28
JP2004525902A (ja) 2004-08-26
CA2438910C (en) 2009-10-13
US7312206B2 (en) 2007-12-25
EP1363933B1 (de) 2009-05-06
AU2002244726A1 (en) 2002-09-04
ATE364620T1 (de) 2007-07-15
WO2002066490A2 (de) 2002-08-29
ATE430759T1 (de) 2009-05-15
US20040120997A1 (en) 2004-06-24
DE10109898A1 (de) 2002-09-05
US20080113017A1 (en) 2008-05-15
WO2002066489A3 (de) 2003-01-03

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: MARINA BIOLOGICAL TECHNOLOGY CO., LTD.

Effective date: 20110824

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20110824

Address after: Washington, USA

Patentee after: Mdrna Inc.

Address before: Harley

Patentee before: Novosom AG

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20051214

Termination date: 20170221

CF01 Termination of patent right due to non-payment of annual fee