BR0207776A - Derivado de esterol, lipossomos compreendendo o mesmo, método de carga dos referidos lipossomos e uso dos mesmos - Google Patents

Derivado de esterol, lipossomos compreendendo o mesmo, método de carga dos referidos lipossomos e uso dos mesmos

Info

Publication number
BR0207776A
BR0207776A BR0207776-0A BR0207776A BR0207776A BR 0207776 A BR0207776 A BR 0207776A BR 0207776 A BR0207776 A BR 0207776A BR 0207776 A BR0207776 A BR 0207776A
Authority
BR
Brazil
Prior art keywords
liposomes
loading
same
sterol
sterol derivative
Prior art date
Application number
BR0207776-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Steffen Panzner
Gerold Endert
Stefan Fankhonel
Nasr El-Mokdad
Original Assignee
Novosom Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novosom Ag filed Critical Novosom Ag
Publication of BR0207776A publication Critical patent/BR0207776A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR0207776-0A 2001-02-21 2002-02-21 Derivado de esterol, lipossomos compreendendo o mesmo, método de carga dos referidos lipossomos e uso dos mesmos BR0207776A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10109898A DE10109898A1 (de) 2001-02-21 2001-02-21 Lipide mit veränderlicher Ladung
PCT/EP2002/001878 WO2002066489A2 (de) 2001-02-21 2002-02-21 Amphotere sterole und deren verwendung zur herstellung von ph- sensitiven liposemen

Publications (1)

Publication Number Publication Date
BR0207776A true BR0207776A (pt) 2004-03-23

Family

ID=7675951

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207776-0A BR0207776A (pt) 2001-02-21 2002-02-21 Derivado de esterol, lipossomos compreendendo o mesmo, método de carga dos referidos lipossomos e uso dos mesmos

Country Status (10)

Country Link
US (3) US7312206B2 (https=)
EP (3) EP1363933B1 (https=)
JP (2) JP2004521917A (https=)
CN (1) CN1231493C (https=)
AT (2) ATE430759T1 (https=)
AU (2) AU2002244726A1 (https=)
BR (1) BR0207776A (https=)
CA (1) CA2438910C (https=)
DE (3) DE10109898A1 (https=)
WO (2) WO2002066490A2 (https=)

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WO2006048329A1 (en) * 2004-11-05 2006-05-11 Novosom Ag Improvements in or relating to pharmaceutical compositions comprising an oligonucleotide as an active agent
JP2008520600A (ja) * 2004-11-19 2008-06-19 ノヴォソム アクチェンゲゼルシャフト 局所投与のための医薬組成物におけるまたはそれに関する改善
EP1764090A1 (en) * 2005-09-15 2007-03-21 Novosom AG Amphoteric liposomes for local drug applications
EP1911443A1 (en) * 2006-10-13 2008-04-16 Novosom AG Amphoteric liposomes, method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
AU2006291429B2 (en) 2005-09-15 2013-04-04 Biontech Delivery Technologies Gmbh Improvements in or relating to amphoteric liposomes
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ES2548240T3 (es) 2005-12-01 2015-10-15 Pronai Therapeutics, Inc. Terapias para el cáncer y composiciones farmacéuticas usadas en las mismas
CA2665783C (en) 2006-10-13 2015-12-15 Novosom Ag Improvements in or relating to amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
WO2008074487A2 (en) * 2006-12-19 2008-06-26 Novosom Ag Lipids and lipid assemblies comprising transfection enhancer elements
HUE040417T2 (hu) 2007-05-04 2019-03-28 Marina Biotech Inc Aminosavlipidek és alkalmazásuk
US8822409B2 (en) 2007-06-20 2014-09-02 Phylogica Limited Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith
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US8765171B2 (en) 2009-03-09 2014-07-01 The Regents Of The University Of California Methods and compositions for liposomal formulation of antigens and uses thereof
WO2010135714A2 (en) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Methods for modulating adipocyte expression using microrna compositions
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WO2012159164A1 (en) 2011-05-23 2012-11-29 Phylogica Limited Method of determining, identifying or isolating cell-penetrating peptides
GB201116248D0 (en) * 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
US20150297725A1 (en) 2012-07-30 2015-10-22 Rutgers, The State University Of New Jersey Cochleates made with soy phosphatidylserine
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
EP4170031A1 (en) 2012-10-23 2023-04-26 Caris Science, Inc. Aptamers and uses thereof
CA2890725A1 (en) 2012-11-05 2014-05-08 Pronai Therapeutics, Inc. Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression
AU2013361323B2 (en) 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
US20170000715A1 (en) * 2014-01-29 2017-01-05 Humedix Co., Ltd. Pegylated 7-dehydrocholesterol derivatives
JP6399530B1 (ja) * 2017-09-04 2018-10-03 一丸ファルコス株式会社 ｐＨ感受性リポソーム
US20200208152A1 (en) 2017-09-08 2020-07-02 Mina Therapeutics Limited Stabilized sarna compositions and methods of use
EP3775211B1 (en) 2018-04-12 2023-04-05 MiNA Therapeutics Limited Sirt1-sarna compositions and methods of use
US12240824B2 (en) * 2018-05-30 2025-03-04 Translate Bio, Inc. Vitamin cationic lipids
EP3953473A1 (en) 2019-04-12 2022-02-16 MiNA Therapeutics Limited Sirt1-sarna compositions and methods of use
GB2603454A (en) 2020-12-09 2022-08-10 Ucl Business Ltd Novel therapeutics for the treatment of neurodegenerative disorders
TW202305133A (zh) 2021-03-26 2023-02-01 英商米納治療有限公司 Tmem173 sarna組合物及其使用方法
WO2023099884A1 (en) 2021-12-01 2023-06-08 Mina Therapeutics Limited Pax6 sarna compositions and methods of use
GB202117758D0 (en) 2021-12-09 2022-01-26 Ucl Business Ltd Therapeutics for the treatment of neurodegenerative disorders
WO2023170435A1 (en) 2022-03-07 2023-09-14 Mina Therapeutics Limited Il10 sarna compositions and methods of use
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Also Published As

Publication number Publication date
DE50210313D1 (de) 2007-07-26
EP1806354A2 (de) 2007-07-11
EP1363932B1 (de) 2007-06-13
CA2438910A1 (en) 2002-08-29
JP4470197B2 (ja) 2010-06-02
WO2002066489A2 (de) 2002-08-29
AU2002302364B2 (en) 2008-01-03
WO2002066490A3 (de) 2003-04-24
US20040131666A1 (en) 2004-07-08
JP2004521917A (ja) 2004-07-22
EP1363932A2 (de) 2003-11-26
US7407947B2 (en) 2008-08-05
DE50213524D1 (de) 2009-06-18
EP1363933A2 (de) 2003-11-26
CN1492876A (zh) 2004-04-28
JP2004525902A (ja) 2004-08-26
CA2438910C (en) 2009-10-13
US7312206B2 (en) 2007-12-25
EP1363933B1 (de) 2009-05-06
AU2002244726A1 (en) 2002-09-04
ATE364620T1 (de) 2007-07-15
WO2002066490A2 (de) 2002-08-29
ATE430759T1 (de) 2009-05-15
US20040120997A1 (en) 2004-06-24
DE10109898A1 (de) 2002-09-05
US20080113017A1 (en) 2008-05-15
CN1231493C (zh) 2005-12-14
WO2002066489A3 (de) 2003-01-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011.