JP2004521917A - 両性ステロール類およびその使用 - Google Patents
両性ステロール類およびその使用 Download PDFInfo
- Publication number
- JP2004521917A JP2004521917A JP2002566202A JP2002566202A JP2004521917A JP 2004521917 A JP2004521917 A JP 2004521917A JP 2002566202 A JP2002566202 A JP 2002566202A JP 2002566202 A JP2002566202 A JP 2002566202A JP 2004521917 A JP2004521917 A JP 2004521917A
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- JP
- Japan
- Prior art keywords
- liposome
- liposomes
- sterol
- sterol derivative
- active substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 235000003702 sterols Nutrition 0.000 title claims description 34
- 150000003432 sterols Chemical class 0.000 title claims description 33
- 239000002502 liposome Substances 0.000 claims abstract description 121
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 6
- 239000013543 active substance Substances 0.000 claims description 41
- 239000000126 substance Substances 0.000 claims description 28
- 150000002632 lipids Chemical class 0.000 claims description 25
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- 102000004169 proteins and genes Human genes 0.000 claims description 15
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- 239000013598 vector Substances 0.000 claims description 11
- 125000006850 spacer group Chemical group 0.000 claims description 10
- 125000000129 anionic group Chemical group 0.000 claims description 9
- 125000002091 cationic group Chemical group 0.000 claims description 9
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- 235000001014 amino acid Nutrition 0.000 claims description 7
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10109898A DE10109898A1 (de) | 2001-02-21 | 2001-02-21 | Lipide mit veränderlicher Ladung |
| PCT/EP2002/001878 WO2002066489A2 (de) | 2001-02-21 | 2002-02-21 | Amphotere sterole und deren verwendung zur herstellung von ph- sensitiven liposemen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521917A true JP2004521917A (ja) | 2004-07-22 |
| JP2004521917A5 JP2004521917A5 (https=) | 2005-12-22 |
Family
ID=7675951
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002566202A Pending JP2004521917A (ja) | 2001-02-21 | 2002-02-21 | 両性ステロール類およびその使用 |
| JP2002566203A Expired - Fee Related JP4470197B2 (ja) | 2001-02-21 | 2002-02-21 | ステロール誘導体、ステロール誘導体含有リポソーム及びリポソームに活性物質を装填する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2002566203A Expired - Fee Related JP4470197B2 (ja) | 2001-02-21 | 2002-02-21 | ステロール誘導体、ステロール誘導体含有リポソーム及びリポソームに活性物質を装填する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7312206B2 (https=) |
| EP (3) | EP1363933B1 (https=) |
| JP (2) | JP2004521917A (https=) |
| CN (1) | CN1231493C (https=) |
| AT (2) | ATE430759T1 (https=) |
| AU (2) | AU2002244726A1 (https=) |
| BR (1) | BR0207776A (https=) |
| CA (1) | CA2438910C (https=) |
| DE (3) | DE10109898A1 (https=) |
| WO (2) | WO2002066490A2 (https=) |
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| EP1393719A1 (en) * | 2002-08-23 | 2004-03-03 | Munich Biotech AG | Camptothecin-carboxylate formulations |
| AU2004238076A1 (en) * | 2003-05-09 | 2004-11-25 | Novosom Ag | Injectable liposomal depots for delivering active ingredients |
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| WO2005063212A1 (en) * | 2003-12-31 | 2005-07-14 | Amorepacific Corporation | Cholesteryl hemisuccinate incorporated lipid-based nano-carriers and skin-care compositions for external application containing the same |
| US20050191344A1 (en) * | 2004-01-15 | 2005-09-01 | Samuel Zalipsky | Liposome composition for delivery of therapeutic agents |
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| JP2008520600A (ja) * | 2004-11-19 | 2008-06-19 | ノヴォソム アクチェンゲゼルシャフト | 局所投与のための医薬組成物におけるまたはそれに関する改善 |
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| EP1911443A1 (en) * | 2006-10-13 | 2008-04-16 | Novosom AG | Amphoteric liposomes, method of formulating an amphoteric liposome and a method of loading an amphoteric liposome |
| AU2006291429B2 (en) | 2005-09-15 | 2013-04-04 | Biontech Delivery Technologies Gmbh | Improvements in or relating to amphoteric liposomes |
| PL1957044T3 (pl) * | 2005-12-01 | 2013-11-29 | Pronai Therapeutics Inc | Amfoteryczny preparat liposomowy |
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| CA2665783C (en) | 2006-10-13 | 2015-12-15 | Novosom Ag | Improvements in or relating to amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome |
| WO2008074487A2 (en) * | 2006-12-19 | 2008-06-26 | Novosom Ag | Lipids and lipid assemblies comprising transfection enhancer elements |
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| JP2009203228A (ja) * | 2008-01-29 | 2009-09-10 | Kochi Univ | キレーター化合物含有薬物輸送剤 |
| US8765171B2 (en) | 2009-03-09 | 2014-07-01 | The Regents Of The University Of California | Methods and compositions for liposomal formulation of antigens and uses thereof |
| WO2010135714A2 (en) | 2009-05-22 | 2010-11-25 | The Methodist Hospital Research Institute | Methods for modulating adipocyte expression using microrna compositions |
| EP3318248B1 (en) * | 2009-12-01 | 2019-04-10 | Translate Bio, Inc. | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| WO2012109495A1 (en) | 2011-02-09 | 2012-08-16 | Metabolic Solutions Development Company, Llc | Cellular targets of thiazolidinediones |
| CZ201181A3 (cs) * | 2011-02-15 | 2012-09-12 | Ústav organické chemie a biochemie Akademie ved CR, v.v.i. | Deriváty pregnanolonu substituované v poloze 3alfa kationickou skupinou, zpusob jejich výroby, jejich použití a prostredek je obsahující |
| WO2012159164A1 (en) | 2011-05-23 | 2012-11-29 | Phylogica Limited | Method of determining, identifying or isolating cell-penetrating peptides |
| GB201116248D0 (en) * | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| US20150297725A1 (en) | 2012-07-30 | 2015-10-22 | Rutgers, The State University Of New Jersey | Cochleates made with soy phosphatidylserine |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| EP4170031A1 (en) | 2012-10-23 | 2023-04-26 | Caris Science, Inc. | Aptamers and uses thereof |
| CA2890725A1 (en) | 2012-11-05 | 2014-05-08 | Pronai Therapeutics, Inc. | Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression |
| AU2013361323B2 (en) | 2012-12-19 | 2018-09-06 | Caris Science, Inc. | Compositions and methods for aptamer screening |
| US20170000715A1 (en) * | 2014-01-29 | 2017-01-05 | Humedix Co., Ltd. | Pegylated 7-dehydrocholesterol derivatives |
| JP6399530B1 (ja) * | 2017-09-04 | 2018-10-03 | 一丸ファルコス株式会社 | ｐＨ感受性リポソーム |
| US20200208152A1 (en) | 2017-09-08 | 2020-07-02 | Mina Therapeutics Limited | Stabilized sarna compositions and methods of use |
| EP3775211B1 (en) | 2018-04-12 | 2023-04-05 | MiNA Therapeutics Limited | Sirt1-sarna compositions and methods of use |
| US12240824B2 (en) * | 2018-05-30 | 2025-03-04 | Translate Bio, Inc. | Vitamin cationic lipids |
| EP3953473A1 (en) | 2019-04-12 | 2022-02-16 | MiNA Therapeutics Limited | Sirt1-sarna compositions and methods of use |
| GB2603454A (en) | 2020-12-09 | 2022-08-10 | Ucl Business Ltd | Novel therapeutics for the treatment of neurodegenerative disorders |
| TW202305133A (zh) | 2021-03-26 | 2023-02-01 | 英商米納治療有限公司 | Tmem173 sarna組合物及其使用方法 |
| WO2023099884A1 (en) | 2021-12-01 | 2023-06-08 | Mina Therapeutics Limited | Pax6 sarna compositions and methods of use |
| GB202117758D0 (en) | 2021-12-09 | 2022-01-26 | Ucl Business Ltd | Therapeutics for the treatment of neurodegenerative disorders |
| WO2023170435A1 (en) | 2022-03-07 | 2023-09-14 | Mina Therapeutics Limited | Il10 sarna compositions and methods of use |
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| WO2024134199A1 (en) | 2022-12-22 | 2024-06-27 | Mina Therapeutics Limited | Chemically modified sarna compositions and methods of use |
| WO2026027887A2 (en) | 2024-08-02 | 2026-02-05 | Mina Therapeutics Limited | Hbg1/2-sarna compositions and methods of use |
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-
2001
- 2001-02-21 DE DE10109898A patent/DE10109898A1/de not_active Withdrawn
-
2002
- 2002-02-21 US US10/468,652 patent/US7312206B2/en not_active Expired - Lifetime
- 2002-02-21 JP JP2002566202A patent/JP2004521917A/ja active Pending
- 2002-02-21 CA CA002438910A patent/CA2438910C/en not_active Expired - Fee Related
- 2002-02-21 EP EP02712923A patent/EP1363933B1/de not_active Expired - Lifetime
- 2002-02-21 CN CNB028053206A patent/CN1231493C/zh not_active Expired - Fee Related
- 2002-02-21 DE DE50210313T patent/DE50210313D1/de not_active Expired - Lifetime
- 2002-02-21 WO PCT/EP2002/001879 patent/WO2002066490A2/de not_active Ceased
- 2002-02-21 EP EP07106269A patent/EP1806354A2/de not_active Withdrawn
- 2002-02-21 WO PCT/EP2002/001878 patent/WO2002066489A2/de not_active Ceased
- 2002-02-21 US US10/468,654 patent/US7407947B2/en not_active Expired - Lifetime
- 2002-02-21 JP JP2002566203A patent/JP4470197B2/ja not_active Expired - Fee Related
- 2002-02-21 EP EP02729931A patent/EP1363932B1/de not_active Expired - Lifetime
- 2002-02-21 BR BR0207776-0A patent/BR0207776A/pt not_active IP Right Cessation
- 2002-02-21 AT AT02712923T patent/ATE430759T1/de active
- 2002-02-21 DE DE50213524T patent/DE50213524D1/de not_active Expired - Lifetime
- 2002-02-21 AT AT02729931T patent/ATE364620T1/de active
- 2002-02-21 AU AU2002244726A patent/AU2002244726A1/en not_active Abandoned
- 2002-02-21 AU AU2002302364A patent/AU2002302364B2/en not_active Ceased
-
2007
- 2007-11-02 US US11/934,147 patent/US20080113017A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE50210313D1 (de) | 2007-07-26 |
| EP1806354A2 (de) | 2007-07-11 |
| EP1363932B1 (de) | 2007-06-13 |
| CA2438910A1 (en) | 2002-08-29 |
| JP4470197B2 (ja) | 2010-06-02 |
| WO2002066489A2 (de) | 2002-08-29 |
| AU2002302364B2 (en) | 2008-01-03 |
| WO2002066490A3 (de) | 2003-04-24 |
| BR0207776A (pt) | 2004-03-23 |
| US20040131666A1 (en) | 2004-07-08 |
| EP1363932A2 (de) | 2003-11-26 |
| US7407947B2 (en) | 2008-08-05 |
| DE50213524D1 (de) | 2009-06-18 |
| EP1363933A2 (de) | 2003-11-26 |
| CN1492876A (zh) | 2004-04-28 |
| JP2004525902A (ja) | 2004-08-26 |
| CA2438910C (en) | 2009-10-13 |
| US7312206B2 (en) | 2007-12-25 |
| EP1363933B1 (de) | 2009-05-06 |
| AU2002244726A1 (en) | 2002-09-04 |
| ATE364620T1 (de) | 2007-07-15 |
| WO2002066490A2 (de) | 2002-08-29 |
| ATE430759T1 (de) | 2009-05-15 |
| US20040120997A1 (en) | 2004-06-24 |
| DE10109898A1 (de) | 2002-09-05 |
| US20080113017A1 (en) | 2008-05-15 |
| CN1231493C (zh) | 2005-12-14 |
| WO2002066489A3 (de) | 2003-01-03 |
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