DE10109898A1 - Lipide mit veränderlicher Ladung - Google Patents
Lipide mit veränderlicher LadungInfo
- Publication number
- DE10109898A1 DE10109898A1 DE10109898A DE10109898A DE10109898A1 DE 10109898 A1 DE10109898 A1 DE 10109898A1 DE 10109898 A DE10109898 A DE 10109898A DE 10109898 A DE10109898 A DE 10109898A DE 10109898 A1 DE10109898 A1 DE 10109898A1
- Authority
- DE
- Germany
- Prior art keywords
- liposomes
- acid
- compound according
- linker
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 239000002502 liposome Substances 0.000 claims abstract description 73
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- 150000001875 compounds Chemical class 0.000 claims description 16
- -1 gluthation Chemical compound 0.000 claims description 12
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 11
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- 102000004169 proteins and genes Human genes 0.000 claims description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 8
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 229910021645 metal ion Inorganic materials 0.000 claims description 8
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- 125000000217 alkyl group Chemical group 0.000 claims description 5
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- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
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- 239000011668 ascorbic acid Substances 0.000 claims description 4
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- BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 claims description 3
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- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 claims description 3
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 claims description 3
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- 125000003118 aryl group Chemical group 0.000 claims description 2
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- RWIVICVCHVMHMU-UHFFFAOYSA-N n-aminoethylmorpholine Chemical compound NCCN1CCOCC1 RWIVICVCHVMHMU-UHFFFAOYSA-N 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940067605 phosphatidylethanolamines Drugs 0.000 description 1
- 229920001977 poly(N,N-diethylacrylamides) Polymers 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000002328 sterol group Chemical group 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10109898A DE10109898A1 (de) | 2001-02-21 | 2001-02-21 | Lipide mit veränderlicher Ladung |
| BR0207776-0A BR0207776A (pt) | 2001-02-21 | 2002-02-21 | Derivado de esterol, lipossomos compreendendo o mesmo, método de carga dos referidos lipossomos e uso dos mesmos |
| US10/468,654 US7407947B2 (en) | 2001-02-21 | 2002-02-21 | Amphoteric sterols and the use thereof |
| DE50213524T DE50213524D1 (de) | 2001-02-21 | 2002-02-21 | Kationische sterolderivate, ph-sensitive liposomen diese umfassend und verfahren zur wirkstoffbeladung von liposomen |
| CNB028053206A CN1231493C (zh) | 2001-02-21 | 2002-02-21 | 两性固醇及其应用 |
| CA002438910A CA2438910C (en) | 2001-02-21 | 2002-02-21 | Amphoteric sterols and the use thereof in the production of ph-sensitive liposomes |
| US10/468,652 US7312206B2 (en) | 2001-02-21 | 2002-02-21 | Sterol derivatives, liposomes comprising sterol derivatives and method for loading liposomes with active substances |
| AU2002302364A AU2002302364B2 (en) | 2001-02-21 | 2002-02-21 | Amphoteric sterols and the use thereof in the production of pH-sensitive liposomes |
| AT02729931T ATE364620T1 (de) | 2001-02-21 | 2002-02-21 | Amphotere sterole und deren verwendung |
| EP02712923A EP1363933B1 (de) | 2001-02-21 | 2002-02-21 | Kationische sterolderivate, ph-sensitive liposomen diese umfassend und verfahren zur wirkstoffbeladung von liposomen |
| PCT/EP2002/001878 WO2002066489A2 (de) | 2001-02-21 | 2002-02-21 | Amphotere sterole und deren verwendung zur herstellung von ph- sensitiven liposemen |
| DE50210313T DE50210313D1 (de) | 2001-02-21 | 2002-02-21 | Amphotere sterole und deren verwendung |
| PCT/EP2002/001879 WO2002066490A2 (de) | 2001-02-21 | 2002-02-21 | Kationische sterolderivate, ph-sensitive liposomen umfassend diese und verfahren zur wirkstoffbeladung von liposomen |
| AT02712923T ATE430759T1 (de) | 2001-02-21 | 2002-02-21 | Kationische sterolderivate, ph-sensitive liposomen diese umfassend und verfahren zur wirkstoffbeladung von liposomen |
| JP2002566202A JP2004521917A (ja) | 2001-02-21 | 2002-02-21 | 両性ステロール類およびその使用 |
| EP07106269A EP1806354A2 (de) | 2001-02-21 | 2002-02-21 | Amphotere Sterole und deren Verwendung |
| JP2002566203A JP4470197B2 (ja) | 2001-02-21 | 2002-02-21 | ステロール誘導体、ステロール誘導体含有リポソーム及びリポソームに活性物質を装填する方法 |
| EP02729931A EP1363932B1 (de) | 2001-02-21 | 2002-02-21 | Amphotere sterole und deren verwendung |
| AU2002244726A AU2002244726A1 (en) | 2001-02-21 | 2002-02-21 | Cationic sterol derivatives, ph-sensitive liposomes comprising cationic sterol derivatives and method for loading liposomes with active substances |
| US11/934,147 US20080113017A1 (en) | 2001-02-21 | 2007-11-02 | Sterol derivatives, liposomes comprising sterol derivatives and method of loading liposomes with active substances |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10109898A DE10109898A1 (de) | 2001-02-21 | 2001-02-21 | Lipide mit veränderlicher Ladung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10109898A1 true DE10109898A1 (de) | 2002-09-05 |
Family
ID=7675951
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10109898A Withdrawn DE10109898A1 (de) | 2001-02-21 | 2001-02-21 | Lipide mit veränderlicher Ladung |
| DE50210313T Expired - Lifetime DE50210313D1 (de) | 2001-02-21 | 2002-02-21 | Amphotere sterole und deren verwendung |
| DE50213524T Expired - Lifetime DE50213524D1 (de) | 2001-02-21 | 2002-02-21 | Kationische sterolderivate, ph-sensitive liposomen diese umfassend und verfahren zur wirkstoffbeladung von liposomen |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50210313T Expired - Lifetime DE50210313D1 (de) | 2001-02-21 | 2002-02-21 | Amphotere sterole und deren verwendung |
| DE50213524T Expired - Lifetime DE50213524D1 (de) | 2001-02-21 | 2002-02-21 | Kationische sterolderivate, ph-sensitive liposomen diese umfassend und verfahren zur wirkstoffbeladung von liposomen |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7312206B2 (https=) |
| EP (3) | EP1363933B1 (https=) |
| JP (2) | JP2004521917A (https=) |
| CN (1) | CN1231493C (https=) |
| AT (2) | ATE430759T1 (https=) |
| AU (2) | AU2002244726A1 (https=) |
| BR (1) | BR0207776A (https=) |
| CA (1) | CA2438910C (https=) |
| DE (3) | DE10109898A1 (https=) |
| WO (2) | WO2002066490A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10207177A1 (de) * | 2002-02-19 | 2003-09-04 | Novosom Ag | Fakultativ kationische Lipide |
| DE10207178A1 (de) * | 2002-02-19 | 2003-09-04 | Novosom Ag | Komponenten für die Herstellung amphoterer Liposomen |
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| EP1393719A1 (en) * | 2002-08-23 | 2004-03-03 | Munich Biotech AG | Camptothecin-carboxylate formulations |
| AU2004238076A1 (en) * | 2003-05-09 | 2004-11-25 | Novosom Ag | Injectable liposomal depots for delivering active ingredients |
| CN1849112B (zh) * | 2003-09-09 | 2012-06-13 | 吉里德科学公司 | 治疗性脂质体 |
| EP1547580A1 (en) * | 2003-12-23 | 2005-06-29 | MediGene Oncology GmbH | Loading of a camptothecin drug into colloidal nanoparticles |
| WO2005063212A1 (en) * | 2003-12-31 | 2005-07-14 | Amorepacific Corporation | Cholesteryl hemisuccinate incorporated lipid-based nano-carriers and skin-care compositions for external application containing the same |
| US20050191344A1 (en) * | 2004-01-15 | 2005-09-01 | Samuel Zalipsky | Liposome composition for delivery of therapeutic agents |
| US8815599B2 (en) * | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| WO2006048329A1 (en) * | 2004-11-05 | 2006-05-11 | Novosom Ag | Improvements in or relating to pharmaceutical compositions comprising an oligonucleotide as an active agent |
| JP2008520600A (ja) * | 2004-11-19 | 2008-06-19 | ノヴォソム アクチェンゲゼルシャフト | 局所投与のための医薬組成物におけるまたはそれに関する改善 |
| EP1764090A1 (en) * | 2005-09-15 | 2007-03-21 | Novosom AG | Amphoteric liposomes for local drug applications |
| EP1911443A1 (en) * | 2006-10-13 | 2008-04-16 | Novosom AG | Amphoteric liposomes, method of formulating an amphoteric liposome and a method of loading an amphoteric liposome |
| AU2006291429B2 (en) | 2005-09-15 | 2013-04-04 | Biontech Delivery Technologies Gmbh | Improvements in or relating to amphoteric liposomes |
| PL1957044T3 (pl) * | 2005-12-01 | 2013-11-29 | Pronai Therapeutics Inc | Amfoteryczny preparat liposomowy |
| ES2548240T3 (es) | 2005-12-01 | 2015-10-15 | Pronai Therapeutics, Inc. | Terapias para el cáncer y composiciones farmacéuticas usadas en las mismas |
| CA2665783C (en) | 2006-10-13 | 2015-12-15 | Novosom Ag | Improvements in or relating to amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome |
| WO2008074487A2 (en) * | 2006-12-19 | 2008-06-26 | Novosom Ag | Lipids and lipid assemblies comprising transfection enhancer elements |
| HUE040417T2 (hu) | 2007-05-04 | 2019-03-28 | Marina Biotech Inc | Aminosavlipidek és alkalmazásuk |
| US8822409B2 (en) | 2007-06-20 | 2014-09-02 | Phylogica Limited | Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith |
| JP2009203228A (ja) * | 2008-01-29 | 2009-09-10 | Kochi Univ | キレーター化合物含有薬物輸送剤 |
| US8765171B2 (en) | 2009-03-09 | 2014-07-01 | The Regents Of The University Of California | Methods and compositions for liposomal formulation of antigens and uses thereof |
| WO2010135714A2 (en) | 2009-05-22 | 2010-11-25 | The Methodist Hospital Research Institute | Methods for modulating adipocyte expression using microrna compositions |
| EP3318248B1 (en) * | 2009-12-01 | 2019-04-10 | Translate Bio, Inc. | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| WO2012109495A1 (en) | 2011-02-09 | 2012-08-16 | Metabolic Solutions Development Company, Llc | Cellular targets of thiazolidinediones |
| CZ201181A3 (cs) * | 2011-02-15 | 2012-09-12 | Ústav organické chemie a biochemie Akademie ved CR, v.v.i. | Deriváty pregnanolonu substituované v poloze 3alfa kationickou skupinou, zpusob jejich výroby, jejich použití a prostredek je obsahující |
| WO2012159164A1 (en) | 2011-05-23 | 2012-11-29 | Phylogica Limited | Method of determining, identifying or isolating cell-penetrating peptides |
| GB201116248D0 (en) * | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| US20150297725A1 (en) | 2012-07-30 | 2015-10-22 | Rutgers, The State University Of New Jersey | Cochleates made with soy phosphatidylserine |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| EP4170031A1 (en) | 2012-10-23 | 2023-04-26 | Caris Science, Inc. | Aptamers and uses thereof |
| CA2890725A1 (en) | 2012-11-05 | 2014-05-08 | Pronai Therapeutics, Inc. | Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression |
| AU2013361323B2 (en) | 2012-12-19 | 2018-09-06 | Caris Science, Inc. | Compositions and methods for aptamer screening |
| US20170000715A1 (en) * | 2014-01-29 | 2017-01-05 | Humedix Co., Ltd. | Pegylated 7-dehydrocholesterol derivatives |
| JP6399530B1 (ja) * | 2017-09-04 | 2018-10-03 | 一丸ファルコス株式会社 | ｐＨ感受性リポソーム |
| US20200208152A1 (en) | 2017-09-08 | 2020-07-02 | Mina Therapeutics Limited | Stabilized sarna compositions and methods of use |
| EP3775211B1 (en) | 2018-04-12 | 2023-04-05 | MiNA Therapeutics Limited | Sirt1-sarna compositions and methods of use |
| US12240824B2 (en) * | 2018-05-30 | 2025-03-04 | Translate Bio, Inc. | Vitamin cationic lipids |
| EP3953473A1 (en) | 2019-04-12 | 2022-02-16 | MiNA Therapeutics Limited | Sirt1-sarna compositions and methods of use |
| GB2603454A (en) | 2020-12-09 | 2022-08-10 | Ucl Business Ltd | Novel therapeutics for the treatment of neurodegenerative disorders |
| TW202305133A (zh) | 2021-03-26 | 2023-02-01 | 英商米納治療有限公司 | Tmem173 sarna組合物及其使用方法 |
| WO2023099884A1 (en) | 2021-12-01 | 2023-06-08 | Mina Therapeutics Limited | Pax6 sarna compositions and methods of use |
| GB202117758D0 (en) | 2021-12-09 | 2022-01-26 | Ucl Business Ltd | Therapeutics for the treatment of neurodegenerative disorders |
| WO2023170435A1 (en) | 2022-03-07 | 2023-09-14 | Mina Therapeutics Limited | Il10 sarna compositions and methods of use |
| WO2024125597A1 (en) | 2022-12-14 | 2024-06-20 | Providence Therapeutics Holdings Inc. | Compositions and methods for infectious diseases |
| WO2024134199A1 (en) | 2022-12-22 | 2024-06-27 | Mina Therapeutics Limited | Chemically modified sarna compositions and methods of use |
| WO2026027887A2 (en) | 2024-08-02 | 2026-02-05 | Mina Therapeutics Limited | Hbg1/2-sarna compositions and methods of use |
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| US4891208A (en) | 1985-04-10 | 1990-01-02 | The Liposome Company, Inc. | Steroidal liposomes |
| ATE45744T1 (de) | 1984-07-25 | 1989-09-15 | Ciba Geigy Ag | Phosphatidylverbindungen, verfahren zu ihrer herstellung und ihre verwendung. |
| US4788162A (en) * | 1985-12-23 | 1988-11-29 | General Electric Company | Composite by compression |
| US5993823A (en) * | 1990-12-18 | 1999-11-30 | Institut Pasteur De Lille | Cytotoxic T lymphocyte-inducing lipopeptides and methods of use |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US5365487A (en) * | 1992-03-24 | 1994-11-15 | Texas Instruments Incorporated | DRAM power management with self-refresh |
| JP2579730B2 (ja) * | 1993-01-22 | 1997-02-12 | 株式会社ディ・ディ・エス研究所 | ペプチド−脂質誘導体及びリポソーム |
| GB9420390D0 (en) | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
| DE59507224D1 (de) * | 1994-12-28 | 1999-12-16 | Max Delbrueck Centrum | Neues cholesterolderivat für den liposomalen gentransfer |
| PT888379E (pt) | 1996-03-01 | 2001-05-31 | Centre Nat Rech Scient | Compostos analogos a familia dos amidinios composicoes farmaceuticas que os contem e suas aplicacoes |
| WO1997039019A1 (en) | 1996-04-12 | 1997-10-23 | University Of Pittsburgh | Novel cationic cholesteryl derivatives containing cyclic polar groups |
| DE69727384T2 (de) | 1996-05-24 | 2004-11-04 | IC-VEC Ltd. | Polykatonische sterin-derivate zur transfektion |
| US5925628A (en) * | 1997-03-31 | 1999-07-20 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
| US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
| DE19852928C1 (de) | 1998-11-17 | 2000-08-03 | Steffen Panzner | Strukturen in Form von Hohlkugeln |
| US6342598B1 (en) * | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
| GB2345868A (en) | 1999-01-23 | 2000-07-26 | Martin Hodgson | Self adhesive magnetic or electromagnetic tapes |
| US6379698B1 (en) * | 1999-04-06 | 2002-04-30 | Isis Pharmaceuticals, Inc. | Fusogenic lipids and vesicles |
| DE10010264A1 (de) * | 2000-03-02 | 2001-09-13 | Novosom Gmbh | Stabilisierte Liposomen und Hüllstrukturen |
| GB0015624D0 (en) | 2000-06-26 | 2000-08-16 | Nat Cancer Centre | Materials and methods relating to improved gene delivery |
-
2001
- 2001-02-21 DE DE10109898A patent/DE10109898A1/de not_active Withdrawn
-
2002
- 2002-02-21 US US10/468,652 patent/US7312206B2/en not_active Expired - Lifetime
- 2002-02-21 JP JP2002566202A patent/JP2004521917A/ja active Pending
- 2002-02-21 CA CA002438910A patent/CA2438910C/en not_active Expired - Fee Related
- 2002-02-21 EP EP02712923A patent/EP1363933B1/de not_active Expired - Lifetime
- 2002-02-21 CN CNB028053206A patent/CN1231493C/zh not_active Expired - Fee Related
- 2002-02-21 DE DE50210313T patent/DE50210313D1/de not_active Expired - Lifetime
- 2002-02-21 WO PCT/EP2002/001879 patent/WO2002066490A2/de not_active Ceased
- 2002-02-21 EP EP07106269A patent/EP1806354A2/de not_active Withdrawn
- 2002-02-21 WO PCT/EP2002/001878 patent/WO2002066489A2/de not_active Ceased
- 2002-02-21 US US10/468,654 patent/US7407947B2/en not_active Expired - Lifetime
- 2002-02-21 JP JP2002566203A patent/JP4470197B2/ja not_active Expired - Fee Related
- 2002-02-21 EP EP02729931A patent/EP1363932B1/de not_active Expired - Lifetime
- 2002-02-21 BR BR0207776-0A patent/BR0207776A/pt not_active IP Right Cessation
- 2002-02-21 AT AT02712923T patent/ATE430759T1/de active
- 2002-02-21 DE DE50213524T patent/DE50213524D1/de not_active Expired - Lifetime
- 2002-02-21 AT AT02729931T patent/ATE364620T1/de active
- 2002-02-21 AU AU2002244726A patent/AU2002244726A1/en not_active Abandoned
- 2002-02-21 AU AU2002302364A patent/AU2002302364B2/en not_active Ceased
-
2007
- 2007-11-02 US US11/934,147 patent/US20080113017A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10207177A1 (de) * | 2002-02-19 | 2003-09-04 | Novosom Ag | Fakultativ kationische Lipide |
| DE10207178A1 (de) * | 2002-02-19 | 2003-09-04 | Novosom Ag | Komponenten für die Herstellung amphoterer Liposomen |
Also Published As
| Publication number | Publication date |
|---|---|
| DE50210313D1 (de) | 2007-07-26 |
| EP1806354A2 (de) | 2007-07-11 |
| EP1363932B1 (de) | 2007-06-13 |
| CA2438910A1 (en) | 2002-08-29 |
| JP4470197B2 (ja) | 2010-06-02 |
| WO2002066489A2 (de) | 2002-08-29 |
| AU2002302364B2 (en) | 2008-01-03 |
| WO2002066490A3 (de) | 2003-04-24 |
| BR0207776A (pt) | 2004-03-23 |
| US20040131666A1 (en) | 2004-07-08 |
| JP2004521917A (ja) | 2004-07-22 |
| EP1363932A2 (de) | 2003-11-26 |
| US7407947B2 (en) | 2008-08-05 |
| DE50213524D1 (de) | 2009-06-18 |
| EP1363933A2 (de) | 2003-11-26 |
| CN1492876A (zh) | 2004-04-28 |
| JP2004525902A (ja) | 2004-08-26 |
| CA2438910C (en) | 2009-10-13 |
| US7312206B2 (en) | 2007-12-25 |
| EP1363933B1 (de) | 2009-05-06 |
| AU2002244726A1 (en) | 2002-09-04 |
| ATE364620T1 (de) | 2007-07-15 |
| WO2002066490A2 (de) | 2002-08-29 |
| ATE430759T1 (de) | 2009-05-15 |
| US20040120997A1 (en) | 2004-06-24 |
| US20080113017A1 (en) | 2008-05-15 |
| CN1231493C (zh) | 2005-12-14 |
| WO2002066489A3 (de) | 2003-01-03 |
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