CN1227363C - 具有脯氨酰二肽氨肽酶活性的多肽和编码该多肽的核酸 - Google Patents

具有脯氨酰二肽氨肽酶活性的多肽和编码该多肽的核酸 Download PDF

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Publication number
CN1227363C
CN1227363C CNB988051753A CN98805175A CN1227363C CN 1227363 C CN1227363 C CN 1227363C CN B988051753 A CNB988051753 A CN B988051753A CN 98805175 A CN98805175 A CN 98805175A CN 1227363 C CN1227363 C CN 1227363C
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China
Prior art keywords
polypeptide
ala
leu
pro
asp
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Expired - Fee Related
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CNB988051753A
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English (en)
Chinese (zh)
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CN1268976A (zh
Inventor
A·布林克沃斯凯
K·布朗
M·W·雷伊
A·科洛茨
T·博恩
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Novozymes AS
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Novozymes Biotech Inc
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Publication of CN1268976A publication Critical patent/CN1268976A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/24—Organic nitrogen compounds
    • A21D2/26—Proteins
    • A21D2/267—Microbial proteins
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
    • A21D8/00—Methods for preparing or baking dough
    • A21D8/02—Methods for preparing dough; Treating dough prior to baking
    • A21D8/04—Methods for preparing dough; Treating dough prior to baking treating dough with microorganisms or enzymes
    • A21D8/042—Methods for preparing dough; Treating dough prior to baking treating dough with microorganisms or enzymes with enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/21—Synthetic spices, flavouring agents or condiments containing amino acids

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB988051753A 1997-05-16 1998-05-12 具有脯氨酰二肽氨肽酶活性的多肽和编码该多肽的核酸 Expired - Fee Related CN1227363C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85788497A 1997-05-16 1997-05-16
US08/857,884 1997-05-16
US6289297P 1997-10-20 1997-10-20
US06/062,892 1997-10-20

Publications (2)

Publication Number Publication Date
CN1268976A CN1268976A (zh) 2000-10-04
CN1227363C true CN1227363C (zh) 2005-11-16

Family

ID=26742833

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988051753A Expired - Fee Related CN1227363C (zh) 1997-05-16 1998-05-12 具有脯氨酰二肽氨肽酶活性的多肽和编码该多肽的核酸

Country Status (9)

Country Link
US (2) US6664092B1 (https=)
EP (1) EP0981630B1 (https=)
JP (1) JP4050329B2 (https=)
CN (1) CN1227363C (https=)
AT (1) ATE414775T1 (https=)
AU (1) AU7381098A (https=)
DE (1) DE69840230D1 (https=)
DK (1) DK0981630T3 (https=)
WO (1) WO1998051803A1 (https=)

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WO2002077223A1 (fr) 2001-03-19 2002-10-03 Ajinomoto Co.,Inc. Nouvelle aminopeptidase et son gene
US7186540B2 (en) * 2001-12-27 2007-03-06 National Institute of Advanced Indusrtial Science and Technology Thermostable glutaminase and thermostable glutaminase gene
ES2540926T3 (es) * 2002-06-04 2015-07-14 Dsm Ip Assets B.V. Hidrolizado de proteínas rico en tripéptidos
JP4300289B2 (ja) * 2002-08-27 2009-07-22 国立大学法人 岡山大学 加水分解又は脱水縮合酵素、及び当該酵素の生産方法、並びに当該酵素を用いたアミドの合成方法
US7550590B2 (en) 2003-03-25 2009-06-23 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2004103993A1 (en) 2003-05-14 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
JP5341300B2 (ja) 2003-08-01 2013-11-13 カルピス株式会社 アンジオテンシン変換酵素阻害活性又は血圧降下作用を有する剤
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
KR20060041309A (ko) 2003-08-13 2006-05-11 다케다 야쿠힌 고교 가부시키가이샤 ４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7790734B2 (en) 2003-09-08 2010-09-07 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN102127057A (zh) 2004-03-15 2011-07-20 武田药品工业株式会社 二肽基肽酶抑制剂
JP2008501714A (ja) 2004-06-04 2008-01-24 武田薬品工業株式会社 ジペプチジルペプチダーゼインヒビター
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
WO2006068978A2 (en) 2004-12-21 2006-06-29 Takeda Pharmaceutial Company Limited Dipeptidyl peptidase inhibitors
GEP20135838B (en) 2005-09-14 2013-06-10 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors usage at diabetes treatment
CN101360723A (zh) 2005-09-16 2009-02-04 武田药品工业株式会社 制备嘧啶二酮衍生物的方法
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US9493759B2 (en) 2008-12-12 2016-11-15 Novozymes, Inc. Polypeptides having aspartic endopeptidase activity and polynucleotides encoding same
EP2398822B1 (en) * 2009-02-19 2013-01-02 Novo Nordisk A/S Modification of factor viii
JP5759132B2 (ja) * 2010-09-21 2015-08-05 月桂冠株式会社 糸状菌ペプチダーゼの生産方法
WO2013092731A1 (en) * 2011-12-21 2013-06-27 Dsm Ip Assets B.V. Method for making a dough with a glutamyl endopeptidase
CN103695361B (zh) * 2013-12-06 2015-11-11 江南大学 一种生产脯氨酸氨肽酶的基因工程菌及其构建方法
GB201705750D0 (en) * 2017-04-10 2017-05-24 Univ Oxford Innovation Ltd Peptide ligase and use therof
EP4273249A3 (en) * 2023-07-07 2024-05-22 Novozymes A/S Improved expression of recombinant proteins

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US4288627A (en) 1980-02-12 1981-09-08 Phillips Petroleum Company Oxidation of thiols employing cobalt molybdate/triethylamine catalyst
JPS61279528A (ja) 1985-06-05 1986-12-10 Hokkai Can Co Ltd 容器の製造方法
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JPH0665280B2 (ja) 1987-03-04 1994-08-24 味の素株式会社 タンパクゲル化剤及びそれを用いるタンパクのゲル化方法
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JP3153237B2 (ja) 1990-03-09 2001-04-03 ノボ ノルディスク アクティーゼルスカブ タンパク質加水分解物
CA2082279C (en) 1990-05-09 2007-09-04 Grethe Rasmussen Cellulase preparation comprising an endoglucanase enzyme
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
EP0555649B1 (en) 1992-01-14 2004-12-08 Ajinomoto Co., Inc. Gene encoding transglutaminase derived from fish
AU665805B2 (en) 1992-01-22 1996-01-18 Novo Nordisk A/S Activated factor XIII
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JPH07115969A (ja) * 1993-10-25 1995-05-09 Asahi Chem Ind Co Ltd 加水分解蛋白質の製造方法
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ATE294871T1 (de) 1994-06-30 2005-05-15 Novozymes Biotech Inc Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren
DE69535037T2 (de) 1994-08-26 2006-12-07 Novozymes A/S Mikrobielle transglutaminasen, ihre herstellung und ihre verwendung
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Also Published As

Publication number Publication date
JP4050329B2 (ja) 2008-02-20
DE69840230D1 (de) 2009-01-02
CN1268976A (zh) 2000-10-04
US7098001B2 (en) 2006-08-29
AU7381098A (en) 1998-12-08
JP2002511746A (ja) 2002-04-16
US6664092B1 (en) 2003-12-16
US20040171104A1 (en) 2004-09-02
WO1998051803A1 (en) 1998-11-19
EP0981630B1 (en) 2008-11-19
ATE414775T1 (de) 2008-12-15
EP0981630A1 (en) 2000-03-01
DK0981630T3 (da) 2009-03-09

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C56 Change in the name or address of the patentee

Owner name: NUOWOQIMEIZI CO.,LTD.

Free format text: FORMER NAME OR ADDRESS: NOVO NORDISK BIOTECH INC.

CP01 Change in the name or title of a patent holder

Address after: American California

Patentee after: NOVOZYMES A/S

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Patentee before: NOVOZYMES BIOTECH, Inc.

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20051116

Termination date: 20130512