CN1218936C - 甲酰胺取代的苯基脲衍生物以及用于将其作为药物的制备方法 - Google Patents
甲酰胺取代的苯基脲衍生物以及用于将其作为药物的制备方法 Download PDFInfo
- Publication number
- CN1218936C CN1218936C CNB028105974A CN02810597A CN1218936C CN 1218936 C CN1218936 C CN 1218936C CN B028105974 A CNB028105974 A CN B028105974A CN 02810597 A CN02810597 A CN 02810597A CN 1218936 C CN1218936 C CN 1218936C
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- Prior art keywords
- alkyl
- phenyl
- coo
- alkenyl
- cooh
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10125567.5 | 2001-05-25 | ||
| DE10125567A DE10125567B4 (de) | 2001-05-25 | 2001-05-25 | Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10207369A DE10207369A1 (de) | 2002-02-21 | 2002-02-21 | Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10207369.4 | 2002-02-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1525955A CN1525955A (zh) | 2004-09-01 |
| CN1218936C true CN1218936C (zh) | 2005-09-14 |
Family
ID=26009397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028105974A Expired - Fee Related CN1218936C (zh) | 2001-05-25 | 2002-05-11 | 甲酰胺取代的苯基脲衍生物以及用于将其作为药物的制备方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6812250B2 (enExample) |
| EP (1) | EP1404650B1 (enExample) |
| JP (1) | JP4167592B2 (enExample) |
| KR (1) | KR20040003007A (enExample) |
| CN (1) | CN1218936C (enExample) |
| AR (1) | AR036029A1 (enExample) |
| AT (1) | ATE386017T1 (enExample) |
| AU (1) | AU2002344151B2 (enExample) |
| BG (1) | BG108318A (enExample) |
| BR (1) | BR0210008A (enExample) |
| CA (1) | CA2448023A1 (enExample) |
| CZ (1) | CZ20033200A3 (enExample) |
| DE (1) | DE50211685D1 (enExample) |
| EE (1) | EE200300581A (enExample) |
| HR (1) | HRP20030971A2 (enExample) |
| HU (1) | HUP0400052A3 (enExample) |
| IL (1) | IL159031A0 (enExample) |
| MX (1) | MXPA03009840A (enExample) |
| NO (1) | NO20035220D0 (enExample) |
| NZ (1) | NZ529697A (enExample) |
| PE (1) | PE20021091A1 (enExample) |
| PL (1) | PL363871A1 (enExample) |
| RU (1) | RU2291858C2 (enExample) |
| SK (1) | SK14442003A3 (enExample) |
| WO (1) | WO2002096864A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205162D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205176D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| DE10215908B4 (de) * | 2002-04-11 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel |
| US7223796B2 (en) | 2002-04-11 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use |
| DE10215907A1 (de) * | 2002-04-11 | 2003-11-06 | Aventis Pharma Gmbh | Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US7262220B2 (en) | 2002-07-11 | 2007-08-28 | Sanofi-Aventis Deutschland Gmbh | Urea- and urethane-substituted acylureas, process for their preparation and their use |
| WO2004007437A1 (de) * | 2002-07-11 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Harnstoff- und urethan-substituierte acylharnstoffe, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| KR20050025345A (ko) * | 2002-07-12 | 2005-03-14 | 아벤티스 파마 도이칠란트 게엠베하 | 헤테로사이클릭으로 치환된 벤조일우레아, 이들의제조방법 및 약제로서 이의 용도 |
| DE10302452B4 (de) * | 2003-01-23 | 2005-02-24 | Aventis Pharma Deutschland Gmbh | Carbonylamino-substituierte Acyl-phenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung |
| DE10306502B4 (de) * | 2003-02-17 | 2005-03-17 | Aventis Pharma Deutschland Gmbh | Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel |
| US7148246B2 (en) | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
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| ZA793186B (en) * | 1978-07-06 | 1981-02-25 | Duphar Int Res | New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds |
| ATE43788T1 (de) | 1983-09-01 | 1989-06-15 | Duphar Int Res | Benzoylharnstoffe mit antitumoraler wirkung. |
| DE3567642D1 (en) | 1984-07-05 | 1989-02-23 | Duphar Int Res | Benzoylurea compounds, and insecticidal and acaricidal compositions comprising same |
| TW255880B (enExample) * | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| CZ220498A3 (cs) | 1996-01-17 | 1998-11-11 | Novo Nordisk A/S | Deriváty 1,2,4-thiadiazinu a 1,4-thiazinu, příprava a použití |
| ES2283025T3 (es) | 1996-08-30 | 2007-10-16 | Novo Nordisk A/S | Derivados de glp-1.1. |
| HUP0301101A3 (en) | 1996-12-31 | 2009-03-30 | Reddy S Res Foundation | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| BR9810592A (pt) | 1997-07-16 | 2000-09-12 | Novo Nordisk As | Composto, processos para preparar um composto, para tratar ou prevenir doenças do sistema endócrino e para a fabricação de um medicamento, composição farmacêutica, e, uso de um composto |
| TWI234557B (en) * | 1999-05-26 | 2005-06-21 | Telik Inc | Novel naphthalene ureas as glucose uptake enhancers |
| HRP20020968A2 (en) * | 2000-06-09 | 2005-02-28 | Aventis Pharma Deutschland Gmbh | Acylphenyl urea derivatives, methods for the production therof and use thereof as a medicament |
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2002
- 2002-05-03 PE PE2002000376A patent/PE20021091A1/es not_active Application Discontinuation
- 2002-05-11 BR BR0210008-8A patent/BR0210008A/pt not_active IP Right Cessation
- 2002-05-11 AU AU2002344151A patent/AU2002344151B2/en not_active Ceased
- 2002-05-11 WO PCT/EP2002/005205 patent/WO2002096864A1/de not_active Ceased
- 2002-05-11 CA CA002448023A patent/CA2448023A1/en not_active Abandoned
- 2002-05-11 CZ CZ20033200A patent/CZ20033200A3/cs unknown
- 2002-05-11 KR KR10-2003-7015334A patent/KR20040003007A/ko not_active Ceased
- 2002-05-11 JP JP2003500044A patent/JP4167592B2/ja not_active Expired - Fee Related
- 2002-05-11 HR HR20030971A patent/HRP20030971A2/xx not_active Application Discontinuation
- 2002-05-11 NZ NZ529697A patent/NZ529697A/en unknown
- 2002-05-11 PL PL02363871A patent/PL363871A1/xx not_active Application Discontinuation
- 2002-05-11 EE EEP200300581A patent/EE200300581A/xx unknown
- 2002-05-11 IL IL15903102A patent/IL159031A0/xx unknown
- 2002-05-11 HU HU0400052A patent/HUP0400052A3/hu unknown
- 2002-05-11 RU RU2003137222/04A patent/RU2291858C2/ru not_active IP Right Cessation
- 2002-05-11 MX MXPA03009840A patent/MXPA03009840A/es active IP Right Grant
- 2002-05-11 SK SK1444-2003A patent/SK14442003A3/sk unknown
- 2002-05-11 CN CNB028105974A patent/CN1218936C/zh not_active Expired - Fee Related
- 2002-05-11 AT AT02774016T patent/ATE386017T1/de not_active IP Right Cessation
- 2002-05-11 EP EP02774016A patent/EP1404650B1/de not_active Expired - Lifetime
- 2002-05-11 DE DE50211685T patent/DE50211685D1/de not_active Expired - Lifetime
- 2002-05-23 AR ARP020101919A patent/AR036029A1/es unknown
- 2002-05-24 US US10/153,597 patent/US6812250B2/en not_active Expired - Lifetime
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2003
- 2003-11-05 BG BG108318A patent/BG108318A/xx unknown
- 2003-11-24 NO NO20035220A patent/NO20035220D0/no not_active Application Discontinuation
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2004
- 2004-11-01 US US10/978,674 patent/US20050143456A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1525955A (zh) | 2004-09-01 |
| EE200300581A (et) | 2004-02-16 |
| JP4167592B2 (ja) | 2008-10-15 |
| MXPA03009840A (es) | 2004-04-02 |
| HUP0400052A2 (hu) | 2004-04-28 |
| RU2003137222A (ru) | 2005-05-20 |
| ATE386017T1 (de) | 2008-03-15 |
| KR20040003007A (ko) | 2004-01-07 |
| AR036029A1 (es) | 2004-08-04 |
| US20030176497A1 (en) | 2003-09-18 |
| AU2002344151B2 (en) | 2007-01-18 |
| RU2291858C2 (ru) | 2007-01-20 |
| HK1065027A1 (en) | 2005-02-08 |
| PL363871A1 (en) | 2004-11-29 |
| CA2448023A1 (en) | 2002-12-05 |
| EP1404650B1 (de) | 2008-02-13 |
| BR0210008A (pt) | 2004-08-10 |
| DE50211685D1 (de) | 2008-03-27 |
| US6812250B2 (en) | 2004-11-02 |
| BG108318A (en) | 2005-01-31 |
| NO20035220D0 (no) | 2003-11-24 |
| NZ529697A (en) | 2005-12-23 |
| PE20021091A1 (es) | 2003-02-04 |
| HUP0400052A3 (en) | 2008-12-29 |
| JP2004529194A (ja) | 2004-09-24 |
| CZ20033200A3 (cs) | 2004-02-18 |
| IL159031A0 (en) | 2004-05-12 |
| EP1404650A1 (de) | 2004-04-07 |
| US20050143456A1 (en) | 2005-06-30 |
| WO2002096864A1 (de) | 2002-12-05 |
| SK14442003A3 (sk) | 2004-05-04 |
| HRP20030971A2 (en) | 2005-08-31 |
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