CN1177825C - 取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖辛因及其作为药物的用途 - Google Patents
取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖辛因及其作为药物的用途 Download PDFInfo
- Publication number
- CN1177825C CN1177825C CNB008162530A CN00816253A CN1177825C CN 1177825 C CN1177825 C CN 1177825C CN B008162530 A CNB008162530 A CN B008162530A CN 00816253 A CN00816253 A CN 00816253A CN 1177825 C CN1177825 C CN 1177825C
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- CN
- China
- Prior art keywords
- compound
- methyl
- hydrogen
- general formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19957156A DE19957156A1 (de) | 1999-11-27 | 1999-11-27 | Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel |
DE19957156.2 | 1999-11-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1399630A CN1399630A (zh) | 2003-02-26 |
CN1177825C true CN1177825C (zh) | 2004-12-01 |
Family
ID=7930562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008162530A Expired - Fee Related CN1177825C (zh) | 1999-11-27 | 2000-11-21 | 取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖辛因及其作为药物的用途 |
Country Status (33)
Country | Link |
---|---|
EP (1) | EP1235809B1 (es) |
JP (1) | JP2003519687A (es) |
KR (1) | KR20020058042A (es) |
CN (1) | CN1177825C (es) |
AR (1) | AR026586A1 (es) |
AT (1) | ATE254108T1 (es) |
AU (1) | AU5789701A (es) |
BG (1) | BG106682A (es) |
BR (1) | BR0015786A (es) |
CA (1) | CA2383114C (es) |
CO (1) | CO5251469A1 (es) |
CZ (1) | CZ20022120A3 (es) |
DE (2) | DE19957156A1 (es) |
DK (1) | DK1235809T3 (es) |
EA (1) | EA005681B1 (es) |
EE (1) | EE200200267A (es) |
ES (1) | ES2210036T3 (es) |
HK (1) | HK1052176A1 (es) |
HR (1) | HRP20020460A2 (es) |
HU (1) | HUP0204169A3 (es) |
IL (1) | IL149607A0 (es) |
MX (1) | MXPA02003822A (es) |
NO (1) | NO20022457D0 (es) |
NZ (1) | NZ519758A (es) |
PL (1) | PL355493A1 (es) |
PT (1) | PT1235809E (es) |
SK (1) | SK9302002A3 (es) |
TR (1) | TR200302031T4 (es) |
UA (1) | UA72566C2 (es) |
UY (1) | UY26448A1 (es) |
WO (1) | WO2001051471A1 (es) |
YU (1) | YU37902A (es) |
ZA (1) | ZA200204056B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6683089B2 (en) | 2002-02-02 | 2004-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols |
DE10204276A1 (de) * | 2002-02-02 | 2003-08-07 | Boehringer Ingelheim Pharma | N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel |
CA2890655A1 (en) * | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4121821A1 (de) * | 1991-07-02 | 1993-01-14 | Boehringer Ingelheim Kg | Neue benzomorphane und ihre verwendung als arzneimittel |
US5354758A (en) * | 1992-12-16 | 1994-10-11 | Japan Tobacco Inc. | Benzomorphans useful as NMDA receptor antagonists |
DE19740110A1 (de) * | 1997-09-12 | 1999-03-18 | Boehringer Ingelheim Pharma | Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE19907874A1 (de) * | 1999-02-23 | 2000-08-24 | Boehringer Ingelheim Pharma | N-(5-Phenyl-tetrahydrofuranyl)methyl- und N-(6-Phenyl-tetrahydropyranyl)methyl substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
-
1999
- 1999-11-27 DE DE19957156A patent/DE19957156A1/de not_active Withdrawn
-
2000
- 2000-11-21 BR BR0015786-4A patent/BR0015786A/pt not_active Expired - Fee Related
- 2000-11-21 DE DE50004455T patent/DE50004455D1/de not_active Expired - Fee Related
- 2000-11-21 TR TR2003/02031T patent/TR200302031T4/xx unknown
- 2000-11-21 YU YU37902A patent/YU37902A/sh unknown
- 2000-11-21 WO PCT/EP2000/011585 patent/WO2001051471A1/de not_active Application Discontinuation
- 2000-11-21 EP EP00993781A patent/EP1235809B1/de not_active Expired - Lifetime
- 2000-11-21 DK DK00993781T patent/DK1235809T3/da active
- 2000-11-21 AT AT00993781T patent/ATE254108T1/de not_active IP Right Cessation
- 2000-11-21 PL PL00355493A patent/PL355493A1/xx not_active Application Discontinuation
- 2000-11-21 HU HU0204169A patent/HUP0204169A3/hu unknown
- 2000-11-21 KR KR1020027006752A patent/KR20020058042A/ko not_active Application Discontinuation
- 2000-11-21 NZ NZ519758A patent/NZ519758A/en unknown
- 2000-11-21 EA EA200200491A patent/EA005681B1/ru not_active IP Right Cessation
- 2000-11-21 CN CNB008162530A patent/CN1177825C/zh not_active Expired - Fee Related
- 2000-11-21 EE EEP200200267A patent/EE200200267A/xx unknown
- 2000-11-21 IL IL14960700A patent/IL149607A0/xx unknown
- 2000-11-21 CZ CZ20022120A patent/CZ20022120A3/cs unknown
- 2000-11-21 SK SK930-2002A patent/SK9302002A3/sk unknown
- 2000-11-21 CA CA002383114A patent/CA2383114C/en not_active Expired - Fee Related
- 2000-11-21 ES ES00993781T patent/ES2210036T3/es not_active Expired - Lifetime
- 2000-11-21 MX MXPA02003822A patent/MXPA02003822A/es unknown
- 2000-11-21 UA UA2002065301A patent/UA72566C2/uk unknown
- 2000-11-21 PT PT00993781T patent/PT1235809E/pt unknown
- 2000-11-21 AU AU57897/01A patent/AU5789701A/en not_active Abandoned
- 2000-11-21 JP JP2001551853A patent/JP2003519687A/ja active Pending
- 2000-11-23 AR ARP000106183A patent/AR026586A1/es not_active Suspension/Interruption
- 2000-11-24 CO CO00090163A patent/CO5251469A1/es not_active Application Discontinuation
- 2000-11-24 UY UY26448A patent/UY26448A1/es not_active Application Discontinuation
-
2002
- 2002-05-09 BG BG106682A patent/BG106682A/bg active Pending
- 2002-05-22 ZA ZA200204056A patent/ZA200204056B/en unknown
- 2002-05-24 HR HR20020460A patent/HRP20020460A2/hr not_active Application Discontinuation
- 2002-05-24 NO NO20022457A patent/NO20022457D0/no not_active Application Discontinuation
-
2003
- 2003-06-11 HK HK03104095A patent/HK1052176A1/xx not_active IP Right Cessation
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