CN116751298A - 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途 - Google Patents

抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途 Download PDF

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Publication number
CN116751298A
CN116751298A CN202310475405.XA CN202310475405A CN116751298A CN 116751298 A CN116751298 A CN 116751298A CN 202310475405 A CN202310475405 A CN 202310475405A CN 116751298 A CN116751298 A CN 116751298A
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antibody
binding
antigen
antibody fragment
sequence
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CN202310475405.XA
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Chinese (zh)
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杰·M·肖特
怀文·张
格哈德·弗雷
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Bioatla Inc
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Bioatla Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
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  • Food Science & Technology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202310475405.XA 2016-05-13 2017-05-12 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途 Pending CN116751298A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662335719P 2016-05-13 2016-05-13
US62/335,719 2016-05-13
US201762447218P 2017-01-17 2017-01-17
US62/447,218 2017-01-17
PCT/US2017/032357 WO2017197234A1 (en) 2016-05-13 2017-05-12 Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
CN201780029427.6A CN109311987A (zh) 2016-05-13 2017-05-12 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途

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CN201780029427.6A Division CN109311987A (zh) 2016-05-13 2017-05-12 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途

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CN116751298A true CN116751298A (zh) 2023-09-15

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CN202310475405.XA Pending CN116751298A (zh) 2016-05-13 2017-05-12 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途
CN202310475379.0A Pending CN116731174A (zh) 2016-05-13 2017-05-12 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途
CN201780029427.6A Pending CN109311987A (zh) 2016-05-13 2017-05-12 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途

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CN201780029427.6A Pending CN109311987A (zh) 2016-05-13 2017-05-12 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途

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US (4) US11254742B2 (https=)
EP (2) EP3455261B1 (https=)
JP (4) JP7051715B2 (https=)
KR (3) KR102713679B1 (https=)
CN (3) CN116751298A (https=)
AU (2) AU2017263568B2 (https=)
CA (1) CA3023979A1 (https=)
DK (1) DK3455261T3 (https=)
ES (1) ES2930255T3 (https=)
HR (1) HRP20221298T1 (https=)
HU (1) HUE060072T2 (https=)
IL (2) IL308504A (https=)
LT (1) LT3455261T (https=)
MX (2) MX394735B (https=)
PL (1) PL3455261T3 (https=)
PT (1) PT3455261T (https=)
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SG (1) SG11201808882QA (https=)
SI (1) SI3455261T1 (https=)
SM (1) SMT202200432T1 (https=)
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US11542332B2 (en) * 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
CN116751298A (zh) * 2016-05-13 2023-09-15 生物蛋白有限公司 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途
KR102873209B1 (ko) 2016-08-31 2025-10-17 바이오아트라, 인코퍼레이티드 조건부 활성 폴리펩티드 및 이를 제조하는 방법
CN111378040B (zh) * 2018-12-29 2021-08-10 深圳大学 检测多种恶性肿瘤细胞的抗体及其应用
CN111378039B (zh) * 2018-12-29 2021-08-24 深圳大学 治疗恶性肿瘤的抗体及其应用
WO2020143506A1 (zh) * 2019-01-08 2020-07-16 深圳大学 检测多种恶性肿瘤细胞的抗体及其应用
BR112022009611A2 (pt) * 2019-11-18 2022-08-09 Univ California Anticorpos anti-ror-2 e métodos de uso
WO2023164618A1 (en) * 2022-02-25 2023-08-31 Bioatla, Inc. Cancer treatment with a conditionally active anti-ror2 antibody-drug conjugate
CN121181696A (zh) * 2024-06-21 2025-12-23 深圳大学 一种治疗肿瘤的抗体及其应用
WO2026011121A1 (en) * 2024-07-03 2026-01-08 Solve Therapeutics, Inc. Anti-ror2 antibody-drug conjugates

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