CN116133673A - 用于修复黏膜损伤或皮肤创伤的多肽及其应用 - Google Patents

用于修复黏膜损伤或皮肤创伤的多肽及其应用 Download PDF

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CN116133673A
CN116133673A CN202180044414.2A CN202180044414A CN116133673A CN 116133673 A CN116133673 A CN 116133673A CN 202180044414 A CN202180044414 A CN 202180044414A CN 116133673 A CN116133673 A CN 116133673A
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耿福能
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Sichuan Gooddoctor Panxi Pharmaceutical Co ltd
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Sichuan Gooddoctor Panxi Pharmaceutical Co ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Gastroenterology & Hepatology (AREA)
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Abstract

一种用于修复黏膜损伤或皮肤创伤的新型多肽及其应用，所述多肽与已知多肽无同源性，而且能够在体内和体外均稳定存在，具有调控干细胞增殖和分化修复黏膜损伤或皮肤创伤的效果；以及涉及所述新型多肽通过调控干细胞增殖和分化修复黏膜损伤或皮肤创伤的用途，以及用于预防、减轻或治疗胃肠疾病的用途。

Description

PCT国内申请，说明书已公开。

Claims (24)

  1. PCT国内申请，权利要求书已公开。
CN202180044414.2A 2020-07-01 2021-07-01 用于修复黏膜损伤或皮肤创伤的多肽及其应用 Pending CN116133673A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010619687 2020-07-01
CN2020106196872 2020-07-01
PCT/CN2021/103943 WO2022002186A1 (zh) 2020-07-01 2021-07-01 用于修复黏膜损伤或皮肤创伤的多肽及其应用

Publications (1)

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CN116133673A true CN116133673A (zh) 2023-05-16

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CN202110747197.5A Active CN113880915B (zh) 2020-07-01 2021-07-01 用于修复黏膜损伤或皮肤创伤的多肽及其应用

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US (1) US20230295233A1 (zh)
EP (1) EP4177259A1 (zh)
JP (1) JP2023531282A (zh)
KR (1) KR20230031898A (zh)
CN (2) CN116133673A (zh)
AU (1) AU2021302188A1 (zh)
CA (1) CA3184710A1 (zh)
IL (1) IL299498A (zh)
TW (1) TW202202515A (zh)
WO (1) WO2022002186A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117045534A (zh) * 2023-10-12 2023-11-14 深圳市维琪科技股份有限公司 六肽的新用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202207967A (zh) * 2020-08-26 2022-03-01 大陸商四川好醫生攀西藥業有限責任公司 用於修復皮膚創傷或黏膜損傷的多肽及其應用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214795B1 (en) * 1996-11-12 2001-04-10 Praecis Pharmaceuticals, Inc. Peptide compounds useful for modulating FGF receptor activity
US20060293228A1 (en) * 2005-06-24 2006-12-28 Bhatnagar Rajendra S Therapeutic compositions and methods using transforming growth factor-beta mimics
CN108503690B (zh) * 2017-02-28 2020-07-03 暨南大学 一种促进创伤后组织修复与再生的修复肽及其应用
CN107973838B (zh) * 2017-12-06 2021-02-26 广州恒宁生物科技有限公司 一种促进皮肤损伤修复的小分子多肽及其应用
CN108715600B (zh) * 2018-04-12 2021-07-13 中国科学院南海海洋研究所 一种促进肠黏膜上皮细胞增殖和迁移的寡肽及其制备方法和应用
CN110903348B (zh) * 2019-12-10 2022-04-29 南京财经大学 一种促进伤口愈合的小肽及其应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117045534A (zh) * 2023-10-12 2023-11-14 深圳市维琪科技股份有限公司 六肽的新用途
CN117045534B (zh) * 2023-10-12 2024-01-23 深圳市维琪科技股份有限公司 六肽的新用途

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AU2021302188A1 (en) 2023-02-02
US20230295233A1 (en) 2023-09-21
JP2023531282A (ja) 2023-07-21
IL299498A (en) 2023-02-01
WO2022002186A1 (zh) 2022-01-06
CN113880915A (zh) 2022-01-04
CA3184710A1 (en) 2022-01-06
TW202202515A (zh) 2022-01-16
KR20230031898A (ko) 2023-03-07
EP4177259A1 (en) 2023-05-10
CN113880915B (zh) 2024-02-13

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