CN115916777A - 一种atx抑制剂及其制备方法和应用 - Google Patents

一种atx抑制剂及其制备方法和应用 Download PDF

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Publication number
CN115916777A
CN115916777A CN202180046308.8A CN202180046308A CN115916777A CN 115916777 A CN115916777 A CN 115916777A CN 202180046308 A CN202180046308 A CN 202180046308A CN 115916777 A CN115916777 A CN 115916777A
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compound
amino
ethyl
pyridin
methyl
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CN202180046308.8A
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CN115916777B (zh
Inventor
彭程
钱梦飞
吕遐师
武进
尹伟
刘奉友
金羿
邹罡
袁海卿
邬征
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Suzhou Ark Biopharmaceutical Co Ltd
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Suzhou Ark Biopharmaceutical Co Ltd
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Priority claimed from CN202010658085.8A external-priority patent/CN113912600A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

一种ATX抑制剂及其制备方法和应用，属于药物化学技术领域。具体而言，所述ATX抑制剂为具备式I’结构的化合物或其药学上可接受的盐、酯、异构体、溶剂化物、前药或同位素标记物。相对于现有的ATX抑制剂GLPG‑1690，所述的ATX抑制剂具有更高的抑制活性，同时具有优异的药效、体外/体内药代动力学性质和安全性，临床应用前景高。

Description

PCT国内申请，说明书已公开。

Claims (25)

  1. PCT国内申请，权利要求书已公开。
CN202180046308.8A 2020-07-09 2021-07-08 一种atx抑制剂及其制备方法和应用 Active CN115916777B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN202010658085.8A CN113912600A (zh) 2020-07-09 2020-07-09 一种atx抑制剂及其制备方法和应用
CN2020106580858 2020-07-09
CN202110308656 2021-03-23
CN202110308656X 2021-03-23
PCT/CN2021/105180 WO2022007882A1 (zh) 2020-07-09 2021-07-08 一种atx抑制剂及其制备方法和应用

Publications (2)

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CN115916777A true CN115916777A (zh) 2023-04-04
CN115916777B CN115916777B (zh) 2024-07-12

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US (1) US20230295159A1 (zh)
EP (1) EP4180430A4 (zh)
JP (1) JP2023533294A (zh)
CN (1) CN115916777B (zh)
TW (1) TW202202499A (zh)
WO (1) WO2022007882A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4225756A2 (en) 2020-10-06 2023-08-16 Ildong Pharmaceutical Co., Ltd. Autotaxin inhibitor compounds
TW202342138A (zh) * 2022-03-31 2023-11-01 大陸商蘇州愛科百發生物醫藥技術有限公司 Ａｔｘ抑制劑或其鹽的結晶形式及其制備方法與應用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019228403A1 (en) * 2018-05-29 2019-12-05 Fronthera U.S. Pharmaceuticals Llc Autotaxin inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3269716T (pt) * 2013-03-14 2020-10-09 Galapagos Nv Novos compostos e suas composições farmacêuticas para o tratamento de doenças inflamatórias
JP6435323B2 (ja) * 2013-06-19 2018-12-05 ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． 炎症性障害の治療のための新規化合物及びその医薬組成物
TW201534597A (zh) * 2013-06-20 2015-09-16 Ab Science 作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物
CN109384803B (zh) * 2017-08-09 2021-08-31 广州市恒诺康医药科技有限公司 Atx抑制剂及其制备方法和应用
CA3091049A1 (en) * 2018-02-14 2019-08-22 Suzhou Sinovent Pharmaceuticals Co., Ltd. Heterocyclic compound, application thereof and pharmaceutical composition comprising same
CN112955432B (zh) * 2019-03-06 2022-11-22 江苏恒瑞医药股份有限公司 稠合芳香环类衍生物、其制备方法及其在医药上的应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019228403A1 (en) * 2018-05-29 2019-12-05 Fronthera U.S. Pharmaceuticals Llc Autotaxin inhibitors and uses thereof

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Publication number Publication date
EP4180430A1 (en) 2023-05-17
EP4180430A4 (en) 2023-12-20
TW202202499A (zh) 2022-01-16
WO2022007882A1 (zh) 2022-01-13
JP2023533294A (ja) 2023-08-02
CN115916777B (zh) 2024-07-12
US20230295159A1 (en) 2023-09-21

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