CN115671017A - Liquid containing saccharide and distiller's grains - Google Patents
Liquid containing saccharide and distiller's grains Download PDFInfo
- Publication number
- CN115671017A CN115671017A CN202211434699.3A CN202211434699A CN115671017A CN 115671017 A CN115671017 A CN 115671017A CN 202211434699 A CN202211434699 A CN 202211434699A CN 115671017 A CN115671017 A CN 115671017A
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- Prior art keywords
- molasses
- hair
- test
- present
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The present invention provides a liquid containing a saccharide and lees. Further, there is provided a use of a liquid for producing an external preparation, the liquid containing molasses or an extract thereof, and distiller's grains or an extract thereof.
Description
The application is a divisional application with the application date of 2019, 4 and 26 months, the application number of 201910344024.1 and the name of the invention being 'liquid containing saccharides and vinasse'.
Technical Field
The present invention relates to a liquid containing 1 or more useful saccharides (glucose, fructose, galactose, sucrose, granulated sugar, brown sugar, molasses, brown sugar paste, brown sugar, lactose, maltose) or saccharide extracts and 1 or more useful distiller's grains (sake, sake blend, sake powder (Japanese: sake powder), sake (Japanese: sake), cooking wine, shochu, cooking wine, liqueur, sake, whiskey, spirits, liqueur, beer, brewer's grains of sparkling liquors) or distiller's grain extracts, and an external preparation or oral composition containing the liquid.
Background
Sugars and saccharides have been used for various purposes since ancient times, and for example, there are known: a sugar infusion solution prepared by mixing maltose and a small amount of sorbitol (patent document 1); alternatively, a nutritional food composition containing a medium-chain fatty acid, a sugar, an animal or vegetable oil and fat, a milk casein, a whole milk powder, an amino acid, and the like (patent document 2), and a deodorizing/deodorizing agent using a crushed material of a grain stillage as an active ingredient (patent document 3), and a fermentation liquid obtained by subjecting a mixture of a rice bran saccharification liquid and a grain stillage to alcoholic fermentation as a nutritional liquid (patent document 4) are used for various food materials or bath agents.
Patent document 1: japanese patent laid-open No. Sho 56-30910
Patent document 2: japanese patent laid-open No. 57-110176
Patent document 3: japanese patent laid-open No. Sho 60-126161
Patent document 4: japanese laid-open patent publication No. Sho 61-187777
Disclosure of Invention
Technical problem to be solved by the invention
Accordingly, an object of the present invention is to provide a substance having various effects on the skin or hair when administered externally or orally, and specifically, a substance that provides a cosmetic composition or a food or beverage composition with a very good feel and use feeling for the skin or hair.
Means for solving the problems
As a result of intensive studies to solve the above problems, the present inventors have found that natural substances using a combination of a saccharide or a saccharide extract and distiller's grains or a distiller's grain extract can impart various excellent effects on skin and hair when added to an external preparation or an oral composition, and that a novel cosmetic composition or a novel food or beverage composition can be provided by using these natural substances, and have completed the present invention.
That is, the present invention includes the following embodiments.
(1) A liquid contains molasses or its extract and distiller's grains or its extract, and has a sugar degree of 60-85.
(2) The liquid according to (1), which contains 1% by mass or less of a preservative with respect to the total mass.
(3) The liquid according to (1) or (2), which has a viscosity of 2000 mPas or less as measured at 20 ℃ with a B-type viscometer.
(4) An external preparation comprising the liquid according to any one of (1) to (3).
(5) An oral composition comprising the liquid according to any one of (1) to (3).
(6) The liquid according to any one of (1) to (3), which is used for imparting a skin moisturizing effect, a skin texture improving effect, a hair moisture content increasing effect, a hair cuticle protecting effect, a foam quality improving effect, a deodorizing effect, a cell activating effect, an antioxidant effect and/or a melanin production inhibiting effect to an external preparation or an oral composition.
(7) Use of the liquid according to any one of (1) to (3) for producing an external preparation or an oral composition having skin moisturizing, skin texture improving, hair moisture content increasing, hair cuticle protecting, foam quality improving, deodorizing, cell activating, antioxidant and/or melanin production inhibiting effects.
Effects of the invention
The present invention can provide an external preparation, an oral composition, or a liquid as a raw material thereof, which has various excellent effects on the skin or hair when administered externally or internally, and which, for example, provides a very excellent feeling to the skin or hair or a very excellent feeling in use.
Drawings
FIG. 1 is a graph showing the moisturizing effect of a cosmetic water containing 1% of the molasses lees mixed extract of the present invention and a comparative purified water.
Fig. 2 is a graph showing the skin texture improving effect of a cosmetic water containing 1% of the molasses-vinasse mixed extract of the present invention and a comparative purified water.
FIG. 3 is a graph showing the secondary moisture content (%) of healthy hair or damaged hair and hair treated with the product of the present invention.
Fig. 4 is an electron microscopic observation photograph of healthy hair.
Fig. 5 is an electron microscopic observation photograph of damaged hair.
FIG. 6 is an electron microscopic photograph of treated hair of the present invention.
FIG. 7 is a graph showing the foamability of the foam quality improving effect of the mixed solution of the present invention and a 1% glycerin solution and a control solution.
FIG. 8 is a graph showing foam viscosities of the foam quality improving effects of the mixed solution of the present invention and the 1% glycerin solution and the control solution.
Detailed Description
In one embodiment of the present invention, a liquid containing a saccharide or an extract thereof and brewer's grains of alcoholic beverages or an extract thereof is provided. Examples of the saccharide include glucose, fructose, galactose, sucrose, granulated sugar, brown sugar, molasses, brown sugar paste, brown sugar, lactose, maltose, and the like. Brown sugar is a substance containing honey, also called brown sugar, and is a crude black-lumpy granulated sugar rich in iron, calcium, and other inorganic substances.
Molasses is, for example, a by-product produced when sugar is extracted from a raw material (sugar cane or sugar beet), and is a blackish brown liquid having high viscosity and containing sugars, minerals, and the like, and is also called brown sugar paste or molasses. Raw sugar (raw sugar) is one of granulated sugars in the processing stage. The molasses is prepared, for example, as follows: the procedure can be the same as the procedure for producing brown sugar, but sugar cane or sugar beet is pretreated by squeezing and crystallized, and molasses (= brown sugar paste) is separated to some extent by using a centrifugal separator or the like, and the remaining crystals become crude sugar. This separated molasses may be used in the present invention. Examples of the source of the molasses include white granulated sugar (Japanese: white sugar), and three pots.
Among the above sugars, molasses or an extract thereof is also preferably used. In the present specification, "molasses" is a broad concept indicating a liquid containing the above-mentioned sugars, and includes molasses, brown sugar paste, and molasses, which are byproducts generated when sugars are extracted from raw materials, but is not limited to these, and examples thereof include three pots of molasses. The molasses extract means: the molasses extract is obtained by alcohol fermentation or cold extraction or hot extraction of molasses with water, methanol, ethanol, etc., filtering, and concentrating.
The "lees" in the present embodiment means brewery lees of sake, sake blend, sake powder, miscellaneous liquor, distilled liquor, cooking liquor, fruit liquor, whisky, spirit, liqueur, beer and sparkling liquor. The lees refers to a brewery lees of sake, i.e., sake, blended sake, shochu, wirshan, beer, fruit-based alcohol, whisky, spirit, liqueur and miscellaneous alcoholic beverages prescribed by the liquor tax Law, and refers to a filtered residue of a substance obtained by fermenting various edible raw materials including saccharides and starchy materials with a microorganism. In addition, any residues obtained by saccharifying various raw materials (rice, wheat, sweet potato, potatoes, corn, sorghum, potato, malt, hop, grapes, various fruits, various grains, and the like) with a microorganism and the like and then subjecting the saccharified materials to alcoholic fermentation can be used. The brewer's grain extract is obtained by cold or hot leaching the brewer's grain with a solvent such as water, methanol, or ethanol, filtering, and concentrating.
In a preferred embodiment of the present invention, the liquid contains molasses or an extract thereof and distiller's grains or an extract thereof, and has a sugar degree of 60 to 85. The liquid is rich in nutrients such as sugars, amino acids, and vitamins, and therefore, from the viewpoint of preventing microbial contamination, for example, the sugar degree is preferably 60 or more, more preferably 65 or more, and still more preferably 70 or more. On the other hand, when the sugar degree is too high, for example, the viscosity of the liquid increases, and the handling is difficult when the liquid is mixed into an external preparation or various compositions, and therefore, the sugar degree is preferably 85 or less. The sugar degree is more preferably 80 or less, and still more preferably 75 or less.
In the present specification, the Brix means a Brix value. The Brix value is a unit for measuring the number of grams of soluble solid components (sugars, etc.) contained in 100g of the solution. The Brix value can be measured using a commercially available refractometer or a saccharimeter. The specific definition is as follows: when 1 gram of sucrose was dissolved in 100 grams of an aqueous solution at 20 ℃, the Brix (Brix) value of the solution was set to 1 degree, and the Brix value of a solution showing the same value of the Brix refractometer as that of the sucrose solution was defined as 1 degree. By this definition, the Brix value does not necessarily refer to the mass percent of sucrose in the sample solution.
Further, the liquid of the present embodiment preferably contains a preservative in an amount of 1 mass% or less based on the total mass of the liquid. Here, the preservative is not particularly limited as long as it is added to a cosmetic composition described later, but there are problems such as skin irritation and stickiness when added to an external preparation for skin, and it is desirable to reduce the amount to be used as much as possible. The liquid of the present embodiment has a high sugar content, and therefore, the growth of microorganisms is suppressed, and a preservative may not be added in the case of low-temperature storage. Therefore, it is possible to produce an external preparation composition that can be used by people with sensitive skin, who feel skin irritation at a conventional antiseptic dose, without having a feeling of irritation. Therefore, the lower limit concentration in the case of adding the preservative is not particularly limited, and may be more than 0 mass%. The upper limit concentration is 1 mass%, preferably 0.5 mass%, and more preferably 0.1 mass%. As the preservative having a preservative effect at a low concentration, parabens, benzoic acid and a salt thereof are preferable, and sodium benzoate is more preferable.
The liquid in the present embodiment is a substance having fluidity at normal temperature, and includes a paste-like or slurry-like substance. The viscosity of the liquid in the present embodiment at 20 ℃ is preferably adjusted to 10000 mPas or less, preferably 7000 mPas or less, preferably 5000 mPas or less, preferably 2000 mPas or less, and more preferably 1500 mPas or less. The viscosity is measured, for example, by using a spindle No.2 for a B-type viscometer (for example, B8M, manufactured by tokyo koku corporation) at 20 ℃ for the liquid in the present embodiment, at a rotation speed: 12rpm for 5 minutes. The lower limit of the viscosity of the liquid is not particularly limited, but the viscosity is usually 500mPa · s or more since a large amount of saccharide is contained. As the viscosity of the liquid increases, handling becomes difficult when the liquid is added to a cosmetic composition or a food or beverage composition, and the liquid of the present embodiment is preferably adjusted so that the viscosity becomes 2000mPa · s or less, whereby handling becomes easier and uniform mixing with various materials becomes possible.
When the liquid of the present embodiment is added to an external preparation or an oral composition, it can impart a moisturizing effect, a skin texture improving effect, a hair moisture content increasing effect, a hair cuticle protecting effect, a foam improving effect, a deodorizing effect, a cell activating effect, an antioxidant effect, and a melanin production inhibiting effect to them. Accordingly, another embodiment of the present invention provides an external preparation or an oral composition containing the liquid. Examples of the external preparation include drugs, quasi drugs, and cosmetic compositions. Examples of the oral composition include a food or drink composition, a medicine, and a quasi drug.
The amount of the liquid of the present embodiment to be mixed in the cosmetic composition or the food or beverage composition is not particularly limited as long as the effect can be confirmed, and may be, for example, in the range of 0.01mg/g to 400mg/g (denominator represents the weight of the preparation) for external use, or in the range of 0.1mg to 5 g/day in terms of the solid content for oral administration.
Further, the cosmetic composition or the food or beverage composition of the present invention may contain 1 or more selected from the group consisting of organic polymers, oils and fats, waxes, mineral oils, inorganic substances, enzymes, plant, animal, microorganism or an extract thereof or a metabolite thereof, water-soluble particles, water-insoluble particles, binders, coating agents, oils, moisturizers, texture improving agents, surfactants, polymer thickening gelling agents, solvents, propellants, antioxidants, reducing agents, oxidizing agents, antiseptics, antibacterial agents, chelating agents, pH regulators, acids and bases, powdery substances, inorganic salts, ultraviolet absorbers, whitening agents, vitamins and derivatives thereof, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, tightening agents, cold-feeling agents, temperature promoters, wound healing promoters, irritation moderators, analgesics, cell activators, antipruritics, keratolytic agents, antiperspirants, algicides, astringents, enzymes, nucleic acids, perfumes, pigments, dyes, colorants, pigments, and 1 or more than 2 cosmetic or more cosmetic or more than 2 cosmetic compositions in water.
Examples of the preservatives, antimicrobial agents and chelating agents include hydroxybenzoic acids such as methyl paraben, ethyl paraben, propyl paraben and butyl paraben, and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1, 2-diols such as 1, 2-pentanediol and 1, 2-hexanediol; isothiazoline derivatives such as methylchloroisothiazolinone and methylisothiazolinone; an imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, and quaternary ammonium salts; triclocarban, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenol, isopropylphenol, cresol, thymol, p-chlorophenol, phenylphenol, sodium phenylphenol, and other phenols; phenyl ethanol, photoreceptors, antibacterial zeolite and silver ions; edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4 Na; hydroxyethyl ethylenediamine triacetate such as HEDTA3 Na; diethylenetriamine pentaacetate (diethylenetriamine pentaacetate); phytic acid; phosphonic acids such as hydroxyethyldiphosphonic acid and salts such as sodium salts thereof; sodium oxalate; poly-amino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, tartaric acid, etc. In the present invention, as described above, a preservative having a preservative effect at a low concentration is preferable. As the preservative having a preservative effect at a low concentration, parabens, benzoic acid and a salt thereof are preferable, and sodium benzoate is more preferable.
The cosmetic composition of the present invention is not particularly limited in kind, and may be used as an external preparation such as a hair cosmetic, a base cosmetic, a color cosmetic, a fragrance cosmetic, a body cosmetic, etc., or may be used as an oral cosmetic, or may be used as a sanitary product, a sanitary napkin, a wet tissue, etc., and the cosmetic composition of the present invention may be produced by a usual method.
Further, the cosmetic preparation for external use (external preparation) can be used in the form of an ointment, a patch, a lotion, a liniment, a liquid pack, a paste, a tape, a tablet, a patch, an aerosol, or the like. In addition, it can be used as an oral cavity cosmetic such as toothpaste and mouthwash, or as a sanitary product, a sanitary napkin, a wet tissue, or the like.
Preferred examples of the form of the cosmetic composition of the present invention include emulsion-type cosmetics such as oil-in-water (O/W), water-in-oil (W/O), W/O/W, and O/W/O, oil-based cosmetics, solid-state cosmetics, liquid-state cosmetics, cream-type cosmetics, stick-type cosmetics, volatile oil-based cosmetics, powder-type cosmetics, gel-type cosmetics, cream-type cosmetics, emulsion-type polymer-based cosmetics, sheet-type cosmetics, mist-type cosmetics, and spray-type cosmetics.
The kind of the food or drink composition of the present invention is not particularly limited, and the composition can be contained in a food or drink to be eaten as a nutritional supplement food, a health supplement food, a nutritional regulation food, a health function food, a specific health food, a nutritional function food, a functional manifestation food, a tonic food, or a food material, in addition to various nutrition supplements, tonics, fatigue recovery, physical fitness improvement, and the like. The food or beverage composition of the present invention can be produced by a usual method.
In addition to these, known Cosmetic ingredients, pharmaceutical ingredients, food ingredients, and The like, such as ingredients described in The International patent classification, mixing ratio, and mixing amount, may be included in The known International patent classification combinations, mixing ratio, and mixing amount, in The standards of Cosmetic raw materials, the list of component names of The japanese Cosmetic industry association, the INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), the standards of pharmaceutical products and pharmaceutical products raw materials, the japanese pharmacopoeia, the standards of pharmaceutical additives, and The supplement of food additives, and in The classification of The International patent classifications IPC belonging to a61C, a61K, a61P, and a61Q, in japanese and foreign patent publications and patent publications (including The official gazettes and The reexpert tables).
The present invention will be described in further detail with reference to examples, but the present invention is not limited to these examples.
[ examples ] A method for producing a compound
Production example 1
100g of molasses (Baikodo corporation) was mixed and dispersed in 250g of purified water (about 30 ℃ C.) with stirring, and then filtered to obtain about 300g of molasses extract.
Production example 2
100g of sake lees (Zhongye BC Co., ltd.) was mixed and dispersed in 150g of purified water (about 30 ℃ C.) under stirring, and then filtered to obtain about 200g of lees extract.
(production example 3)
100g of the molasses extract of production example 1 and 100g of the distiller's grains extract of production example 2 were mixed, dispersed under stirring, and then filtered to obtain about 150g of the molasses and distiller's grains mixed extract.
Production example 4
100g of molasses (Baikodo corporation) and 25g of sake lees (Zhongye BC corporation) were mixed and dispersed with stirring, and then filtered to obtain about 100g of a molasses lees mixed extract.
(test 1) moisturizing Effect
The skin Moisture content was measured using a skin Moisture distribution/morphology measuring apparatus "Moisture Map MM100 (manufactured by Courage + Khazaka)".
Test method and evaluation method "
The inner part of the forearm of 6 adult men and women (20 to 50 years old) was coated 1 day and 2 times for 5 minutes, and the skin moisture content was measured 1 week later using the skin moisture distribution/morphology measuring apparatus described above. When the relative value is 100, a value greater than 100 means a large skin moisture amount. The results are shown in FIG. 1.
The cosmetic water used for the sample was prepared by mixing 1% of the molasses lees mixed extract obtained in production example 4 of the present invention and diluting the mixture with purified water, and the purified water was applied under the same conditions as a control.
(test results)
As a result, as shown in fig. 1, the relative value of the lotion obtained by mixing 1% of the molasses lees mixed extract of the present invention was 120, and the skin moisture content showed a numerical value of more than 100, and the moisturizing effect was confirmed. Furthermore, skin can be expected to be moist. It should be noted that the comparative purified water had a relative value of 90, which showed a low value and showed no moisturizing effect.
(test 2) skin texture improving action
The texture density of the skin was measured using a skin Moisture distribution/morphology measuring apparatus "Moisture Map MM100 (manufactured by Courage + Khazaka)".
Test method and evaluation method "
The inner part of the forearm of 6 adult men and women (20 to 50 years old) was coated 1 day and 2 times for 5 minutes, and the number of skin texture intersections after 1 week was measured. The measurement was performed using the skin moisture distribution/morphology measurement apparatus 12434. When the relative value is 100, a value greater than 100 means that the skin has a high texture density. The results are shown in FIG. 2.
The sample used was a cosmetic liquid obtained by mixing 1% of the molasses-lees mixed extract obtained in production example 4 of the present invention and diluting the mixture with purified water, and the purified water was applied under the same conditions as the control.
(test results)
As a result, as shown in fig. 2, the relative value of the lotion obtained by mixing 1% of the molasses lees mixed extract of the present invention was 106, and the skin texture density showed a considerably high value higher than 100, and the skin texture improving effect could be confirmed. In addition, prevention of skin dryness is also expected. It should be noted that the comparative value of purified water of the control was 98, which showed a low value, and no skin texture-improving effect was observed.
(test 3) Hair moisture content increasing action
Test method and evaluation method "
Each of the treated samples was allowed to stand in a constant temperature and humidity machine at 20 ℃ and 84% for 24 hours, and then the first distilled water content (%) evaporated at 65 ℃ for 40 minutes was measured by an infrared moisture meter FD-720 (manufactured by Kett scientific research Co., ltd.), and the second distilled water content (%) evaporated at 180 ℃ for 30 minutes was measured immediately. The ratio of the secondary water content in the hair water content was determined by taking the total of the primary steam-dispersed water content and the secondary steam-dispersed water content as the hair water content (%). "reference: j.soc.cosmet.chem.jpn.40 (4) 300-306 (2006) "it is noted that the results are shown in fig. 3.
In addition, healthy hair (hair obtained by applying 10% sodium laureth sulfate to human hair (100% black hair manufactured by beauliax) by pressing 2 times with a pump foam generator, washing, and drying with a dryer), damaged hair (hair obtained by immersing healthy hair in permanent wave 1 solution containing 6.5% ammonium thioglycolate, 0.5% ammonia gas, ph9.2, and 50 ℃ for 1 hour), and treated hair of the present invention (hair obtained by immersing damaged hair in makeup water containing 1% of the molasses lees mixed extract obtained in production example 4 of the present invention for 10 minutes and then drying with a dryer) were used in each sample.
(test results)
As a result, as shown in fig. 3, the treated hair of the present invention showed a very high secondary hair moisture content as compared with damaged hair, and the secondary hair moisture content was almost the same as that of healthy hair, and it was confirmed that the hair moisture content was increased. That is, the higher the moisture content in the hair, the more moisture can be retained in the hair, and the treated hair of the present invention is said to have high moisture retention, and similarly, an effect of preventing hair from drying can be expected.
(test 4) Hair cuticle protecting action
Test method and evaluation method "
The state of the cuticle on the hair surface (repairing effect) was confirmed by observing each sample (healthy hair, damaged hair, treated hair of the present invention) at 1000-fold magnification using a scanning microscope JCM-5700 manufactured by japan electronics corporation. The results are shown in fig. 4 to 6.
The test was carried out using samples in which healthy hair was human hair in a natural state and damaged hair was human hair after heat treatment at 65 ℃ for 40 minutes, and the treated hair of the present invention was obtained by applying a solution obtained by mixing 1% of the molasses-lees mixed extract obtained in production example 4 before heat treatment of healthy hair.
(test results)
As a result, as shown in fig. 4 to 6, it was confirmed that the hair treated with the product of the present invention was covered and protected with a uniform cuticle layer and a uniform size of each cuticle layer film. In contrast, healthy hair has a cuticle layer protecting the hair surface, but the size of each cuticle layer is not uniform, the cuticle layer is damaged by heat and the hair is cracked, and a part of the cuticle layer is even peeled. That is, the present invention can treat hair to protect the cuticle of hair and can be expected to have a hair damage repairing effect.
(test 5) foam quality improving action 1
Test method and evaluation method "
For the foaming test, 50mL of each sample mixed with potassium cocoyl glutamate (final concentration: 0.3%) was stirred with a bench top crusher (manufactured by IWATANI) for 5 seconds, and after standing for 1 minute, the amount of foam (mL) was measured. The foaming properties of the samples were represented by relative values, with the amount of foam (mL) in the control solution being 100%.
The test samples were tested using a 5% mixed solution of the present invention "potassium cocoyl glutamate (final concentration 0.3%), 5% molasses lees mixed extract obtained in preparative example 4, 94% purified water", a 1% mixed solution of the present invention "potassium cocoyl glutamate (final concentration 0.3%), 1% molasses lees mixed extract obtained in preparative example 4, 98% purified water", a 1% mixed solution of glycerin "potassium cocoyl glutamate (final concentration 0.3%), 1% glycerin, 98% purified water", a control "potassium cocoyl glutamate (final concentration 0.3%), and 99% purified water". The results are shown in FIG. 7.
(test results)
As a result, as shown in fig. 7, it was confirmed that the relative values of the foaming properties of the product of the present invention (1% mixed solution or 5% mixed solution) were all high, and the foaming ability was remarkably increased. The relative value of foamability of the glycerin 1% mixed solution did not increase.
(test 6) foam quality improving action 2
Test method and evaluation method "
As a foam viscosity test, a commercially available cleansing agent obtained by mixing the respective samples was foamed in a foam container, and the viscosity (mPa · s) was measured with a B-type viscometer in a 100mL screw bottle filled with foam. The bubble viscosity of each sample is expressed by a relative value with the viscosity (mPa · s) of the control solution set to 100%.
The test pieces were tested using a 1% mixed solution of the present invention "99% commercial facial cleanser", 1% mixed extract of molasses and distiller's grains obtained in production example 4 ", a 1% mixed solution of glycerin" 99% commercial facial cleanser ", 1% glycerin", a control solution "99% commercial facial cleanser" and 1% purified water ". The results are shown in FIG. 8.
(test results)
As a result, as shown in fig. 8, it was confirmed that the foam viscosity of the product of the present invention (1% mixed solution) was significantly increased and the foam viscosity was high. The high bubble viscosity is expected to provide a sustained effect of the bubbles. The foam viscosity of the glycerin 1% mixed solution was not increased.
(test 7) deodorizing action
Test method and evaluation method "
In the deodorizing test, each sample was mixed with each malodorous substance described below, and the deodorizing rate of each malodorous substance was measured using a detector tube (manufactured by GASTEC corporation), and the results are shown in table 1
Each type of malodorous substance was treated with ammonia (using a 10-fold dilution of 28% ammonia), acetic acid (using a 10-fold dilution of glacial acetic acid), methyl mercaptan (using a stock solution of methyl mercaptan (Wako pure chemical industries)), and n-valeric acid (using a 10-fold dilution of n-valeric acid (Tokyo chemical industries)).
The test samples were tested using a 50% mixed solution of the present invention (50% molasses-lees mixed extract obtained in PREPARATIVE EXAMPLE 4 and 50% purified water), a 5% mixed solution of the present invention (5% molasses-lees mixed extract obtained in PREPARATIVE EXAMPLE 4 and 95% purified water), a 1% mixed solution of the present invention (1% molasses-lees mixed extract obtained in PREPARATIVE EXAMPLE 4 and 99% purified water), and a 0.5% mixed solution of the present invention (0.5% molasses-lees mixed extract obtained in PREPARATIVE EXAMPLE 4 and 99.5% purified water).
[ TABLE 1 ]
(test results)
As shown in Table 1, it was confirmed that the solution containing the molasses lees mixed extract of the present invention deodorizes ammonia gas, acetic acid, methyl mercaptan and n-valeric acid at all concentrations.
(test 8) cell activation
The present inventors decided to evaluate cell proliferation based on human skin fibroblasts.
Test method and evaluation method "
Will be 4X 10 3 Fibroblasts from wells (KF-4009, manufactured by Kurabao K.K.) were implanted in 96-Well plates and cultured for 24 hours before. Thereafter, the culture medium was replaced with a fresh one, and the molasses-lees mixed extract (the molasses-lees mixed extract obtained in production example 4) adjusted to the concentrations of 0.01%, 0.1% and 0.5% was added to the culture medium. After the cells were cultured for 3 days, the cells were cultured,absorbance at 450nm was measured using Cellcounting kit-8 (DOJINDO). At this time, the cell growth rate of the control group to which purified water was added was set to 100%, and the cell growth rate (%) was calculated for each concentration. Note that, as the culture medium, a DMEM medium containing 5% of FBS (manufactured by ThermoTrace) was used for the preculture, and as the medium for the present test, a DMEM medium containing 0.25% of FBS was used, and CO was calculated at 5% 2 And cultured at 37 ℃. The results are shown in Table 2.
[ TABLE 2 ]
(test results)
As a result, as shown in table 2, when the control group was compared as 100%, the cell growth rates of the molasses vinasse mixed extract of the present invention at concentrations of 0.01%, 0.1% and 0.5% were high values of 114.5%, 128.9% and 137.1%, respectively, and it was confirmed that the molasses vinasse mixed extract of the present invention has a fibroblast growth promoting effect and can be expected to have a cell activating effect.
(test 9) antioxidant action
The inventors decided to evaluate the antioxidant effect on the basis of the DPPH radical scavenging activity test.
Test method and evaluation method "
To 0.5mL of the molasses and lees mixed extract (the molasses and lees mixed extract obtained in production example 4) adjusted to a concentration of 1%, 2%, 3%, 4%, 5%, 2.5mL of a 0.1M acetate buffer (CH 3COOH/CH3COONa, pH 5.5) was added and stirred. To this was added 2.0mL of a 0.25mM DPPH solution, followed by stirring and standing at room temperature for 10 minutes. After standing, the absorbance at 525nm of ABS was measured, and the radical scavenging rate was calculated from the numerical formula 1. As a comparative sample, purified water was used as a control, and ascorbic acid (manufactured by KISHIDA) adjusted to a concentration of 0.1% was used as a positive control, and the sample was prepared under the same conditions and used in the test. The results are shown in Table 3.
(math figure 1)
Radical clearance (%) = (C-S)/Cx 100
C: absorbance of control-absorbance of positive control
S: absorbance of test sample-Absorbance of Positive control
[ TABLE 3 ]
| Test specimen | DPPH radical scavenging ratio (%) |
| Molasses and lees mixed extract obtained by mixing the product of the present invention at a concentration of 1% | 43.3％ |
| Molasses vinasse mixed extract of the invention was mixed at a concentration of 2% | 73.6％ |
| Molasses vinasse mixed extract mixed with the inventive product at a concentration of 3% | 93.2％ |
| Molasses vinasse mixed extract mixed with the inventive product at a concentration of 4% | 98.4％ |
| Molasses and vinasse mixed extract obtained by mixing the product of the present invention at a concentration of 5% | 98.8％ |
(test results)
As a result, as shown in table 3, the molasses-vinasse mixed extract of the present invention was mixed at concentrations of 1%, 2%, 3%, 4% and 5%, and showed high radical scavenging rates of 43.3%, 73.6%, 93.2%, 98.4% and 98.8% in this order, and it was confirmed that the molasses-vinasse mixed extract of the present invention had DPPH radical scavenging action and was expected to have antioxidant action.
(test 10) test for melanogenesis inhibitory Effect
The present inventors decided to evaluate the melanogenesis inhibitory effect on the basis of B16 melanoma cells.
Test method and evaluation method "
Will be 20X 10 4 Individual B16 melanoma cells were plated in 60mm plastic culture dishes and cultured 24 hours ago. Thereafter, the culture medium was transferred to a fresh medium, and for this purpose, 50ul/Well of the molasses vinasse mixed extract (the molasses vinasse mixed extract obtained in production example 4) adjusted to a concentration of 0.1% and 1.0% was added to the culture medium, and the culture was carried out for 3 days. In addition, the culture medium used was an MEM medium containing 5% fetal bovine serum (manufactured by ThermoTrace), and was subjected to 5% CO 2 And cultured at 37 ℃.
The cultured cells were treated with trypsin, dissolved in 1N-NaOH,10% DMSO solution under heating, and then measured for absorbance at 420 nm. In addition, the MTT reduction activity of the sample-treated cells was calculated by using distilled water as a control instead of the sample, arbutin (manufactured by Sigma) as a positive control instead of the sample, and MTT reduction activity of the sample-added cells by the MTT reduction method (Tim Mosmann; journal of Immunological Methods p55-63 (1983) reference) at the same time, and the MTT reduction activity of the blank cells as 1 unit. The absorbance/MTT reduction activity (1 unit) was calculated as the amount of melanin in the sample, and the inhibition rate (%) of the amount of melanin production relative to the blank cells was determined by equation 2. The results are shown in Table 4.
(math figure 2)
Melanin production inhibition (%) = {1- (sample melanin amount/blank melanin amount) } × 100
[ TABLE 4 ]
| Test specimen | Melanin production inhibition (%) |
| Molasses lees mixed extract of the present invention was mixed at a concentration of 0.1% | 43.9％ |
| Molasses vinasse mixed extract mixed with the product of the present invention at a concentration of 1% | 47.3％ |
| Control (50. Mu.g/ml arbutin) | 71.6％ |
(test results)
As a result, as shown in table 4, the molasses distillers grains mixed extract of the present invention, which was mixed at concentrations of 0.1% and 1%, showed high melanin production inhibition ratios of 43.9% and 47.3% in this order, and it was confirmed that the molasses distillers grains mixed extract of the present invention had a melanin production inhibition effect on B16 melanoma cells, and a whitening effect was expected.
(test 11) feeling of use improvement action
A cosmetic liquid was prepared by mixing 1% of the molasses and lees mixed extract obtained in production example 4 of the present invention, and the effect in actual use was examined. The use test was thus carried out: 20 adult men and women (20-50 years old) are used as group members, and appropriate amount of toning lotion is applied to the whole face 2 times per day in the morning and at night, and 4 weeks are elapsed. The control was changed to glycerin 1% mixed lotion, applied under the same conditions as described above, and the same procedure was used.
In addition, regarding evaluation items, the evaluation items were performed on "dry whole face", "dry eye circumference", "tight feeling after face washing", "open pores", "dark whole face", "black circles under eyes", "small wrinkles around eyes", "tight skin", "state of skin", "moist skin", "smooth skin feeling", "makeup effect"; as for the answer method, the following evaluation of feeling of use was performed for comparison with the state of the skin before the test after the application of the sample.
According to the same conditions as before the test: score 0, which is a little better than the state before the test: score 1, slightly better than the pre-test condition: score 2, which is better than the state before the test: score 3, which is very good compared to the pre-test state: 4 points, very good compared to the pre-test state: point 5, which is worse than the state before the test: score 1, slightly inferior to the pre-test condition: 2 points, which is inferior compared to the pre-test condition: -3 points, very poor compared to the pre-test condition: 4 points, very poor compared to the pre-test condition: 5-five points, the average score of the responses to each evaluation item was determined, and the results are shown in Table 5.
In addition, the composition of the astringent used in the feeling improvement test was prepared by mixing the molasses distillers grains mixed extract obtained in production example 4 with 1% of astringent (water 88.5%, propylene glycol 10.445%, octanoyl hydroxamic acid 0.055%, molasses distillers grains mixed extract obtained in production example 4 1%), as a comparative control: glycerol 1% mixed lotion (water 88.5%, propylene glycol 10.445%, octanoyl hydroxamic acid 0.055%, glycerol 1%)
[ TABLE 5 ]
(test results)
As shown in table 5, it was confirmed that the lotion containing 1% of the molasses-based lees mixed extract of the present invention was higher than the control lotion evaluation in all the evaluation items "dry whole face", "dry eye", "tight feeling after washing", "open pores", "dark skin on whole face", "dark circles under eyes", "small lines around eyes", "tight skin", "state of skin", "moist skin", "smooth skin feeling" and "makeup effect".
(test 12) test of sugar content and preservation Effect of molasses lees Mixed extract
The pH and Brix values of the molasses lees mixed extract obtained in production example 4 and refined honey as a comparative control were measured. The Brix value was measured using an Abbe refractometer (manufactured by NAR-3T. The results are shown in Table 6.
[ TABLE 6 ]
| Test specimen | pH | Brix value |
| Molasses vinasse mixed extract | 4.8 | 72 |
| Refined honey | 4.6 | 78 |
Further, the following test bacterial solutions were added to the sample to conduct the storage effect test.
Test method and evaluation method "
(1) Standard bacteria mixed liquor
Escherichia coli (Escherichia coli NBRC 3972)
Pseudomonas aeruginosa (Pseudomonas aeruginosa NBRC 13275)
Staphylococcus aureus (Staphylococcus aureus NBRC 13276)
(2) Fungus mixed liquor
Aspergillus niger (Aspergillus brasiliensis NBRC 9455)
Candida (Candida albicans NBRC 1594)
Orange peel fungus (Penicillium citrinum NBRC 6352)
Aureobasidium pullulans (Aureobasidium pullulans NBRC 6353)
Samples 20g to 2 sterilized bottles were inoculated with 1 vol% (0.2 mL) of the standard bacterial mixture and 1 vol% (2 mL) of the fungal mixture, respectively. The inoculated sample (1) was stored at 30 ℃ and the inoculated sample (2) was stored at 25 ℃ and the viable cell count was measured on days 7, 14, and 21. The viable cell count was measured by the SCDLP agar medium mixed release method for the bacteria (1) and the GPLP agar medium mixed release method for the fungi (2). The number of bacteria of the inoculated test bacterial solution and the change with time in the number of bacteria in the sample are shown in table 7.
[ TABLE 7 ]
Next, 3 kinds of samples prepared by adding various preservatives to the molasses and lees mixed extract obtained in production example 4 were subjected to the storage effect test in the same manner, and the results are shown in table 8 below. The molasses spent grain mixed extract B was a sample obtained by adding sodium benzoate to 0.1 mass%, the molasses spent grain mixed extract P was a sample obtained by adding polylysine to 0.1 mass%, and the molasses spent grain mixed extract Z was a sample obtained by adding a mixture (containing 92.5 mass% of octanoyloxyoxime acid and 7.5 mass% of propylene glycol) to 1 mass%.
[ TABLE 8 ]
(test results)
As shown in tables 7 and 8, the growth of the standard bacteria and fungi in the test bacterial solution added from the outside was not confirmed in any of the samples, and the number of bacteria during the storage at room temperature was reduced. It was found that the increase/decrease rate of bacteria count in the molasses spent grain mixed extract was reduced compared with the purified honey used as a comparative control (table 7), but the addition of the preservative had the same or higher effect of inhibiting the propagation of nuclear combustion as in the purified honey (table 8).
(test 13) measurement of viscosity of molasses spent grain Mixed extract
The viscosity of the molasses lees mixed extract (2 lots) prepared in the same manner as in production example 4 was measured at 20 ℃ for 5 minutes at 12rpm using a B-type viscometer B8M (Tokyo meter) rotor No.2, and was 720 mPas and 1220 mPas, respectively.
The present invention relates to the following aspects.
An external preparation comprising the liquid according to item 1 or 2.
Item 7. Use of the liquid according to item 1 or 2 for producing an external preparation or an oral composition having skin moisturizing, skin texture improving, hair moisture content increasing, hair cuticle protecting, foam quality improving, deodorizing, cell activating, antioxidant and/or melanin production inhibiting effects.
Industrial applicability of the invention
The present invention may include, for example, saccharides (glucose, fructose, galactose, sucrose, granulated sugar, brown sugar, molasses, brown sugar paste, brown sugar, lactose, maltose) having a value of use or 1 or more kinds of extracts derived from saccharides and distiller's grains (sake, sake blend, powdery sake, miscellaneous alcoholic beverages, cooking liquors, distilled spirits, cooking liquors, fruit wines, whisky, spirits, liqueur beverages, beer, brewer's grains for sparkling liquors) or 1 or more kinds of extracts from distiller's grains, and the present invention may be carried out as a cosmetic composition or a food or beverage composition, and further as a moisturizing agent, a skin texture improving agent, a hair moisture content increasing agent, a hair cuticle protecting agent, a foam improving agent, a deodorant, a cell activating agent, an antioxidant, and a melanin production inhibitor.
Claims (3)
1. Use of a liquid containing molasses or an extract thereof and distiller's grains or an extract thereof for the manufacture of a topical agent.
2. Use according to claim 1, wherein the liquid contains more than 0% by mass and 1% by mass or less of a preservative with respect to the total mass thereof.
3. The use according to claim 1 or 2, wherein the liquid is used for imparting moisturizing effect to the skin, improvement of skin texture, increase of hair moisture amount, hair cuticle protection, improvement of foam quality, deodorization, cell activation, antioxidation and/or melanin production inhibition to the external preparation.
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| JP2018-087222 | 2018-04-27 | ||
| JP2018087222 | 2018-04-27 | ||
| JP2019-028309 | 2019-02-20 | ||
| JP2019028309A JP2019194175A (en) | 2018-04-27 | 2019-02-20 | Liquid containing saccharides and brewing lees of liquors, and external preparation or oral composition containing the same |
| CN201910344024.1A CN110403877A (en) | 2018-04-27 | 2019-04-26 | Liquid containing carbohydrate and vinasse |
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| CN201910344024.1A Division CN110403877A (en) | 2018-04-27 | 2019-04-26 | Liquid containing carbohydrate and vinasse |
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| CN111991326A (en) * | 2020-09-08 | 2020-11-27 | 茅台学院 | Maotai-flavor vinasse extract toning lotion |
| CN112545949A (en) * | 2021-01-15 | 2021-03-26 | 东晟源研究院(广州)有限公司 | Composition with effects of resisting oxidation and homogenizing skin color and preparation method thereof |
| CN113425657A (en) * | 2021-07-29 | 2021-09-24 | 广东丸美生物技术股份有限公司 | Moisturizing, anti-aging and whitening skin-care matrix and preparation method and application thereof |
| CN113693996A (en) * | 2021-08-20 | 2021-11-26 | 上海溪上生物科技有限公司 | Anti-aging composition containing rice wine lees fermentation product and palmitoyl pentapeptide |
| KR102649359B1 (en) * | 2023-07-06 | 2024-03-19 | 주식회사 한미양행 | High-protein functional drink comprising of enzymatic hydrolysated wet-grinding Tenebrio molitor larva |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08168378A (en) * | 1994-01-28 | 1996-07-02 | Kirindou:Kk | Enzyme inhibitor |
| RU2500380C1 (en) * | 2012-08-27 | 2013-12-10 | Надежда Викторовна Сырчина | COSMETIC PRODUCT Dea vita FOR FACE AND BODY SKIN CARE |
| JP2017006104A (en) * | 2015-06-22 | 2017-01-12 | 昌美 中川 | Functional food |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2530439B2 (en) * | 1986-10-30 | 1996-09-04 | 株式会社 大阪薬品研究所 | Bath agent |
| JPH04308516A (en) * | 1991-04-04 | 1992-10-30 | Oozeki Kk | Rice wine less-blended cosmetics |
| JPH07103012B2 (en) * | 1991-09-26 | 1995-11-08 | 太陽化学株式会社 | Cosmetics |
| JP4358957B2 (en) | 2000-01-21 | 2009-11-04 | 三井製糖株式会社 | Agent for scavenging or reducing free radicals or active oxygen |
| JP2002284632A (en) | 2001-03-27 | 2002-10-03 | Japan Natural Laboratory Co Ltd | Extinction substance for superoxide anion extracted from sake lees as effective component |
| JP2002302697A (en) | 2001-04-06 | 2002-10-18 | Kanebo Ltd | Detergent composition |
| JP4880276B2 (en) | 2005-10-06 | 2012-02-22 | 白鶴酒造株式会社 | Estrogen-dependent cell growth promoter and epidermal keratinocyte growth promoter |
| JP5780706B2 (en) | 2010-01-22 | 2015-09-16 | 共栄化学工業株式会社 | Whitening cosmetics |
| JP6166506B2 (en) | 2010-08-19 | 2017-07-19 | 株式会社テクノーブル | Topical skin preparation |
| JP6041375B2 (en) | 2012-03-01 | 2016-12-07 | コスメテックスローランド株式会社 | Skin cleanser composition |
| JP6619548B2 (en) | 2014-06-09 | 2019-12-11 | 共栄化学工業株式会社 | Cosmetics |
| JP2018203628A (en) * | 2017-05-30 | 2018-12-27 | 一丸ファルコス株式会社 | Cosmetic composition or food and drink composition |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08168378A (en) * | 1994-01-28 | 1996-07-02 | Kirindou:Kk | Enzyme inhibitor |
| RU2500380C1 (en) * | 2012-08-27 | 2013-12-10 | Надежда Викторовна Сырчина | COSMETIC PRODUCT Dea vita FOR FACE AND BODY SKIN CARE |
| JP2017006104A (en) * | 2015-06-22 | 2017-01-12 | 昌美 中川 | Functional food |
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| JP2022130566A (en) | 2022-09-06 |
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