JP2530439B2 - Bath agent - Google Patents

Description

TECHNICAL FIELD The present invention relates to a bath agent, and an object thereof is to prevent allergic dermatitis caused by dyes and fragrances contained in the bath agent, Moreover, it is to provide a bath preparation having a high body temperature retention effect, a high body odor removal effect, and a high skin wetting effect.

(Prior Art and Its Deficiencies) Conventionally, the composition of the bath agent is configured to include geraniol as a fragrance and uranicon as a dye.

Many of the fragrances and dyes mixed in such bath agents often act as allergens, and it is easy to cause allergic dermatitis on the skin of a bather who entered a bathtub containing a bath agent, It has the drawback that people with eczema, skin inflammation, etc. cannot use it.

In addition, many conventional bath agents simply enjoy the color and scent of hot water when taking a bath, and none of them have a concrete effect of removing the skin and health of bathers and removing body odor.

(Progress of the invention) Therefore, the inventors of the present invention have conducted diligent research in order to eliminate the above-mentioned drawbacks. As a result, the mechanism of dyes and fragrances as an allergen can be surprisingly suppressed, and the effect of increasing skin health can be obtained. I found a bath agent. That is, a bath agent having an essential component that is adsorbed to a non-polar adsorbent by contacting an aqueous solution of unpurified sugar such as crude sugar and molasses with an adsorbent that is an allergic skin caused by a dye or fragrance in the bath agent The inventors have found that the present invention has a great effect on prevention of flames and suppression of deterioration, and also has an excellent effect of retaining body temperature, and has the effect of moisturizing the skin and removing body odor.

Conventionally, unpurified sugar such as crude sugar and molasses is decolorized and then used as edible food as purified sugar.However, the components adsorbed by the adsorbent obtained during purification are simply discarded as unnecessary substances and used as bath salts. It was not known at all that it has the effects of preventing allergies, removing body odor, and retaining heat when used.

However, in the process of deepening the research on bath agents, the present inventors
It has been found that the drawbacks of conventional bath agents can be eliminated by preparing a bath agent by contacting an aqueous solution of unpurified sugar such as crude sugar and molasses with a non-polar adsorbent and using the components adsorbed by the adsorbent as essential components. Reached

(Solution) That is, the present invention relates to a bath agent that contains an aqueous solution of unpurified sugar such as crude sugar and molasses in contact with a non-polar adsorbent, and the component adsorbed by the adsorbent is an essential component.

(Structure of the Invention) The component adsorbed to the adsorbent by bringing the aqueous solution of the unpurified sugar such as crude sugar and molasses into contact with the nonpolar adsorbent used in the present invention means the component obtained by the following method.

First, crude sugar (so-called sucrose unrefined product) or unpurified sugar such as molasses is prepared and prepared from sugar cane or sugar beet by a conventional method. Next, this crude sugar or other unpurified sugar is dissolved in an appropriate amount of water, and this is contacted with the adsorbent, and then the adsorbent is washed with water to further remove sugar, and then the adsorbed component is eluted from the adsorbent with a solvent. To do. Usually, this elution operation is performed by a column chromatography method packed with an adsorbent.

As the adsorbent used in the present invention, nonpolar polystyrene-based resin adsorption such as Amberlite XAD-1, Amberlite XAD-2 (made by Rohm, And, Haas) and Selvachrome YAD-2 (made by Selva) are suitable. is there.
still. From the viewpoint of yield, cervachrome YAD-2 is most preferable.

The eluate from the adsorbent obtained at this stage can also be used as a bath agent in the present invention. That is, the effluent may be concentrated under reduced pressure and used as a flow extract, soft extract, or dry extract.

The adsorbent is used in an amount of 30 to 300 times (by weight), preferably 50 to 200 times, the amount of the adsorbed component. In addition, when eluting the adsorbed components, it is advisable to wash and wash out the sugars sufficiently before the elution until the washing liquid has no sweetness.

The elution of the dye component is preferably performed with a lower alcohol having a concentration of 20% or more, such as methanol or ethanol. In practice, it is preferable to first elute with a low-concentration lower alcohol of 20 to 30%, and after the coloring of the falling liquid is hardly observed, further elute with a high-concentration lower alcohol of about 95 to 99%. Elution with only a high-concentration lower alcohol is not preferable because the yield decreases.

The eluent thus obtained is evaporated to dryness, and then purified and fractionated by a silica gel column to obtain a white phenylglucose compound powder. In the present invention, this phenyl glucose compound is also used as a bath agent. The phenylglucose compound is a specific oligosaccharide contained in a component adsorbed to the adsorbent by contacting an aqueous solution of unpurified sugar such as crude sugar or molasses with the nonpolar adsorbent.

The specific oligosaccharides thus obtained contained 40% or more by weight of phenylglucose, and particularly 3,4-dimethoxyphenyl-OD-glucose contained 20% of the specific oligosaccharides.
Or more, or 3,4,6-trimethoxy-OD-
Contains about 10% phenyl glucose.

The internal acting components of the components adsorbed by this adsorbent are mainly specific oligosaccharides, of which phenylglucose is
It accounts for 40% or more, and 3,4-dimethoxyphenyl-OD-glucose and 3,4,6-trimethoxy-OD-phenylglucose account for 15% or more in phenylglucose.

This experimental knowledge was obtained by qualitative and quantitative analysis by conventional methods such as GLC, TLC, NMR, IR, and UV.

In the present invention, the phenyl glucose compound may be one in which a phenyl group and a glucose group are chemically ether-bonded by an organic synthesis method, and the synthesis method is not particularly limited.

If the methoxyl group as a functional group is C3 and C4
A 3,4-methoxyphenyl group substituted at the C6 position or 3,
A phenylglucose compound synthesized by a synthetic method in which a 4,6-methoxyphenyl group and a glucose group are ether-bonded may be used.

The phenylglucose compound which is the specific oligosaccharide used in the present invention is represented by the following formula.

3,4-dimethoxyphenyl-O-D-glucose was converted to (formula I) with 3,4,6-trimethoxyphenyl-OD-
It is represented by glucose (formula II).

In the present invention, the phenylglucose compound may be obtained by either synthetic method or natural product extraction method, or both may be mixed. Moreover, you may add another component as needed.

Examples of other components include loofah, papaya enzyme, licorice, citrus and army cucumber.

The loofah used in the present invention refers to all of the conventionally known loofahs, for example, Daruma seeds, Nagaitouri seeds, tocad loofah seeds, and the like, which are preferably used in the present invention (Luff
a cylindrica) parts of whole grass, fruits, young fruits,
Seeds, vines, and loofah water are all preferred, and fruits (including seeds) are most desirable.

To mix such loofah with a bath agent, dry powder,
It may be in the form of extract liquid, extract powder, squeezed juice or the like.

For the extract, an aliphatic organic solvent having 1 to 9 carbon atoms such as lower aliphatic alcohol and ethers can be effectively used.

In order to obtain the extract powder from such extract liquid, any drying means such as freeze-drying, reduced pressure drying, and spray drying may be adopted.

Licorice used in the present invention is scientifically named GLYCYRRH-IZAE.
It is called RADIX, a legume (Leguminosae) peanut licorice (northwest licorice) Glycyrrhiza glabra L.var.glan duli
fera Reg.et Herd (= G.glandu-lifera Waldstein et
Kitaibel) and Uralkanzo (Tohoku licorice) Glycyrrhiz
The dried roots and stron of a uralensis Fisch.et DC. are preferably used.

In the present invention, the licorice may be incorporated into the bath agent in the form of licorice powder or hot water extract.

Armored crane (Gynostemmap-ent) used in this invention
As aphyllum Makino), all parts above ground or below ground, or seeds of army vine can be preferably used.

In order to use them as the compounding ingredients of the present invention, they are first ground as they are and pressed to obtain juice. This squeezing may be carried out by mixing armchair or may be separately processed. This squeezed juice can be used by diluting it, or can be used in powder form by freeze-drying or spray-drying. Alternatively, these raw materials may be air dried or hot air dried to obtain a dry powder.

Furthermore, the extract may be used as a powder by extraction with a solvent such as a lower hydrous alcohol and concentrating or diluting the extract, and further by spray drying, freeze drying or the like.

Citrus citrus (Citrus Kinokuni Hort.ex Tana) can be used as a citrus compound in the present invention.
ka), Unshu mikan (Citrusunshu Marc.), Kunebo (Citrus nobilis Lour), Yuzu (Citrus junos Si)
eb.ex Tanaka), Citrus iyo Hort.ex Tan
aka), Navel (Cit-rus sinensis Osheck var bras
iliensis Tanaka), Daidai (Citrus aurantium LF)
Kabos Y. Tan-aka), etc. can all be suitably used.

The powder of the dried product of the outer skin of these citrus fruits is more desirable as a compounding ingredient.

As described above, in order to obtain the bath agent according to the present invention by using the compounding ingredients according to the present invention, a known extender, a fragrance, and an additive for a dye are added according to a conventional method, and any bathing agent form is added. It may be prepared.

To prepare the bath agent according to the present invention, for example, sodium lauryl sulfate 40 g, lauryl dimethylamino acetic acid betaine 20 g, purified water 35 g, perfume 1 g, dye suitable amount, 0.01-1 g of white powder, preferably 0.02 g, phenyl If it is a glucose compound, 0.005 g to 1 g, preferably 0.01 g is blended, and if a papaya enzyme is blended, 1 to 5 g, preferably 2 g.
g, when blending luffa sapotin with extract powder
0.5 to 5 g, preferably 1 g, natural dry powder 2 to 8 g preferably 5 g when licorice is blended, extract extract powder 2 to 4 g preferably 3 g when armature is blended, and yuzu peel of yuzu is blended The amount of dry powder is 2 to 6 g, preferably 3 g.

(Effect) As described in detail above, the bath agent according to the present invention weakens the mechanism of the allergenic dye or fragrance contained in the bath agent as an allergen, and is excellent in body temperature retention property and has a moisturizing effect on the skin. It has the effect of removing body odor.

Hereinafter, the excellent effects of the present invention will be further clarified by describing Examples and Test Examples of the present invention.

(Example) 5 kg of brown sugar from Okinawa was dissolved in 25 water, and polystyrene resin (Cervachrome XAD-2.300 g) was dispersed in 1 water and poured into a packed column having an inner diameter of 8 cm, followed by flowing at a rate of 20 ml / min. Then, the pigment component of brown sugar is adsorbed.

Next, water is poured down and washed with water until the sweetness is completely removed to remove sugar sufficiently.

After the flow-through solution has no sweetness at all, 20% methanol is injected and the dye is eluted from the adsorbent at a flow rate of 10 ml / min.

 Continue to flow down until there is no color in the flow-through.

Both eluents flowing down are combined and evaporated to dryness under reduced pressure below 60 ° C. to obtain 16 g of a brown residue.

This product was dissolved in 2 pure ethanol by heating, and after cooling, the precipitated turbid substance was filtered off and evaporated to dryness under reduced pressure at 60 ° C or lower, and the residue was dried at 60 ° C or lower to have no sweetness. 15 g of white powder are obtained.

In the white powder obtained by the above-described operation, phenylglucose was the active ingredient from the RF value and the absorption value of the infrared absorption spectrum of the following thin layer chromatography.

Thin-layer chromatography: When 10 mg is dissolved in 1 ml of water and tested by the Japanese Pharmacopoeia General Test Method Section 26 thin-layer chromatography under the following conditions, a single red-colored spot is shown at an RF value of 0.6.

Amount of sample attached: 10μ Carrier: Silica gel 60F254 (Merck 0.25 mm thickness) Developing solvent: Chloroform / methanol / water (65:35:10)
Lower layer Development distance: 10 cm Detection: P-anisaldehyde After test spraying, heating at 105 ° C. for 5 minutes This spot was the same spot as the mixture of 3,4-methoxyphenyl glucose and 3,4,6-methoxyphenyl glucose.

Infrared absorption spectrum; νmax (nujol): 3300, 1590, 1020 and 720 cm -1 This infrared absorption spectrum shows phenyl glucose substituted with methoxyl.

 The method for identifying this substance will be described in detail later.

The brown powder obtained was dissolved in 500 cc of methanol, and purified by column chromatography using a silica gel column using a flowing solution of a mixture of chloroform, methanol, and water.
It was fractionated into methoxyphenyl-OD-glucose and 3,4,6-methoxyphenyl-OD-glucose.

The above white powder and 3,4-methoxyphenyl-OD-
The following bath preparation was prepared using glucose and 3,4,6-methoxyphenyl-OD-glucose.

(Example 1) A loofah fruit is cut and immersed in ethanol to extract loofah saponin, and the extract is dried under reduced pressure to obtain loofah extract powder.

The extract powder, papaya enzyme and white powder are blended as described below to obtain a bath agent.

Sodium lauryl sulfate 40.0 g Betaine lauryldimethylaminoacetate 20.0 g Purified water 35.0 g Geraniol (fragrance) 1.0 g Uranine conc (dye) Appropriate amount Luffa extract extract powder 1.0 g Papaya enzyme 2.0 g White powder 0.05 g (Example 2) Natural licorice After drying by drying, it is ground.

The above licorice powder and white powder were blended as described below to obtain a bath agent.

Sodium lauryl sulphate 40.0 g Lauryl dimethylaminoacetic acid betaine 20.0 g Purified water 35.0 g Geraniol 1.0 g Uranine conc (dye) Appropriate amount Licorice powder 5 g White powder 0.02 g (Example 3) It is immersed in hot water to elute the hot water extraction extract being cut into hot water and then filtered to obtain a filtrate.

The filtrate is concentrated and then dried under reduced pressure to obtain hot water extract powder.

The above powdered armchair and 3,4-methoxyphenyl-O
-D-Glucose was blended as described below to obtain a bath agent.

Sodium lauryl sulphate 40.0 g Lauryl dimethylamino acetic acid betaine 20.0 g Purified water 35.0 g Geraniol (fragrance) 1.0 g Uranine conc (dye) Appropriate amount of armchaise powder 3.0 g 3,4-dimethoxyphenyl-OD-glucose 0.01 g (Example 4) ) The yuzu hull was dried and then pulverized.

This Yuzu powder and 3,4,6-trimethoxyphenyl-O-
D-Glucose was blended as described below to obtain a bath preparation.

Sodium lauryl sulfate 40.0 g Betaine lauryl dimethylaminoacetate 20.0 g Purified water 35.0 g Geraniol (fragrance) 1.0 g Uranine conc (dye) Appropriate amount Yuzu powder 3.0 g 3,4,6-Trimethoxyphenyl-OD-glucose 0.0
1 g (Comparative Example 1) The product obtained by removing the white powder from Example 1 was used.

(Comparative Example 2) The product obtained by removing the white powder from Example 2 was used.

(Comparative Example 3) The one obtained by removing 3,4-dimethoxyphenyl-OD-glucose from Example 3 was used.

The above bath agents were tested on 20 females (18-45 years old) with chilling who had a relatively body odor for 3 days, 15 days in total.

 The concentration was about 0.01 wt% dissolved in bath water.

 The results are shown in Tables 1 and 2.

From the above results, it can be seen that the bath preparation according to the present invention has a surprising effect of preventing allergic dermatitis, an excellent heat retaining effect, a body odor eliminating effect, and a skin moisturizing effect.

Claims (2)

(57) [Claims] 1. A bath agent comprising as an essential component a component which is adsorbed on a non-polar adsorbent by bringing an aqueous solution of unpurified sugar such as crude sugar and molasses into contact with the non-polar adsorbent. 2. A component adsorbed to the adsorbent by contacting the aqueous solution of the unpurified sugar such as the crude sugar or molasses according to claim 1 with the nonpolar adsorbent is 3,4-dimethoxyphenyl-O-. D-glucose and / or 3,4,6-trimethoxyphenyl-O
The bath agent according to claim 1, which is -D-glucose.