JP7330472B2 - Liquids containing saccharides and sake brewer's lees, and external preparations or oral compositions containing the same - Google Patents

Description

The present invention comprises one or more useful sugars (glucose, fructose, galactose, sucrose, sugar, brown sugar, molasses, blackstrap molasses, raw sugar, lactose, maltose) or sugar extracts, and sake brewer's lees (refined sake). , synthetic sake, powdered sake, miscellaneous sake, cooking sake, shochu, mirin, fruit liquors, whiskeys, spirits, liqueurs, beer, brewer's lees of low-malt beer) or brewer's lees extract and liquids and external preparations or oral compositions containing the liquids.

Carbohydrates and saccharides have been used for various purposes for a long time. A nutritious food composition containing casein, whole milk powder, amino acids, etc. (Patent Document 2) is known. and the use of a fermented liquid obtained by alcoholic fermentation of a mixture of saccharified rice bran and sake lees as a nutrient liquid (Patent Document 4) for various food raw materials and bath agents.

Japanese Patent Laid-Open No. 56-30910 Japanese Patent Application Laid-Open No. 57-110176 Japanese Patent Laid-Open No. 60-126161 Japanese Patent Laid-Open No. 61-187777

Therefore, the problem to be solved by the present invention is a substance that has various favorable effects on the skin and hair when externally or internally used, specifically, a substance that has a very good touch and feel on use to the skin and hair. It is to provide a substance to a cosmetic composition or a food and drink composition.

In order to solve the above-mentioned problems, the present inventors conducted intensive studies and found that a natural product obtained by combining a saccharide or a saccharide extract with sake brewer's lees or sake brewer's lees extract can be used as an external preparation or an oral composition. When added, it can impart various favorable effects to the skin and hair, and it can be used to provide a novel cosmetic composition or food and drink composition. Arrived.

That is, the present invention includes the following embodiments.
(1) A liquid containing molasses or its extract and sake brewer's lees or its extract and having a sugar content of 60 to 85.
(2) The liquid according to (1), which contains 1% by mass or less of preservatives relative to the total mass.
(3) The liquid according to (1) or (2), which has a viscosity of 2000 mPa·s or less as measured at 20° C. with a Brookfield viscometer.
(4) An external preparation containing the liquid according to any one of (1) to (3).
(5) An oral composition containing the liquid according to any one of (1) to (3).
(6) imparting skin moisturizing, skin texture improvement, hair moisture content increase, hair cuticle protection, foam quality improvement, deodorant, cell activation, antioxidant and/or melanin production inhibitory effects to external preparations or oral compositions; The liquid according to any one of (1) to (3) for

The present invention provides an external preparation, an oral composition, or a raw material thereof that has various favorable effects on the skin and hair when externally or internally used, and, for example, has a very good feeling on the skin and hair and a feeling of use. can be provided.

Fig. 2 shows the moisturizing action of a lotion containing 1% of the molasses-sake lees mixed extract of the present invention and purified water as a control. FIG. 2 is a diagram showing skin texture-improving effects of a lotion containing 1% of the molasses sake lees mixed extract of the present invention and purified water as a control. FIG. 3 is a diagram showing the secondary moisture content (%) of healthy hair, damaged hair, and hair treated with the product of the present invention. It is an electron microscope observation photograph of healthy hair. It is an electron microscope observation photograph of damaged hair. 1 is an electron micrograph of hair treated with the product of the present invention. FIG. 3 is a diagram showing the foaming property of the foam quality improving action of the present invention compounded solution, the 1% glycerin compounded solution, and the control solution. FIG. 3 is a diagram showing the foam viscosity of the foam quality-improving action of a solution containing the product of the present invention, a solution containing 1% glycerin, and a control solution.

In one embodiment of the present invention, a liquid containing saccharides or extracts thereof and brewer's grains of alcoholic beverages or extracts thereof is provided. Here, sugars are, for example, glucose, fructose, galactose, sucrose, sugar, brown sugar, molasses, blackstrap molasses, raw sugar, lactose, maltose and the like. Brown sugar is a type of dense sugar, also called brown sugar, and is a crude black lumpy sugar rich in iron, calcium, and other minerals.

Molasses, for example, is a by-product that is produced when sugar is refined from raw materials (sugar cane, sugar beets). It is a dark brown, highly viscous liquid containing sugar and minerals, and is also called blackstrap molasses. There is Also, raw sugar is a type of sugar that is in the processing stage. Molasses can be produced by, for example, the same process as brown sugar production halfway through, but sugar cane or sugar beet juice is pre-processed, crystallized, and molasses (= blackstrap molasses) is separated using a centrifuge or the like. It is a manufacturing method that separates to some extent and the remaining crystals become raw sugar. This separated molasses can be used in the present invention. In addition, examples of the origin of molasses include Shiroshita sugar and Wasanbon.

Among the above sugars, it is preferable to use molasses or its extract. As used herein, "molasses" is a broad concept that means a liquid containing the above sugars, and includes, but is not limited to, molasses, blackstrap molasses, and molasses, which are by-products that appear when sugars are refined from raw materials. However, for example, Wasanbon molasses can be mentioned. A molasses extract is an extract obtained by alcoholic fermentation of molasses, or an extract obtained by chilling or digesting molasses in a solvent such as water, methanol, or ethanol, followed by filtration and concentration.

The sake brewer's lees in the present embodiment refers to brewers' lees of sake, synthetic sake, powdered sake, miscellaneous sake, shochu, cooking sake, mirin, fruit liquors, whiskeys, spirits, liqueurs, beer, and low-malt beer. In addition, sake brewer's lees are alcoholic beverages stipulated in the Liquor Tax Law, namely sake, synthetic sake, shochu, miso, beer, fruit liquors, whiskeys, spirits, liqueurs, and brewer's lees of miscellaneous sake. It refers to the filtration residue of various edible raw materials containing starch that have been fermented with alcohol by microorganisms. In addition, various raw materials (rice, wheat, sweet potato, potato, corn, kouriyan, potato, malt, hops, grapes, various fruits, various grains, etc.) are saccharified by microorganisms, etc., and the residue after alcohol fermentation. Either one may be used. The brewer's lees extract refers to an extract obtained by chilling or soaking the brewer's lees in a solvent such as water, methanol, or ethanol, followed by filtration and concentration.

In a preferred embodiment of the present invention, the liquid contains molasses or its extract and sake brewer's lees or its extract and has a sugar content of 60-85. Since this liquid is rich in nutrients such as sugars, amino acids, and vitamins, it preferably has a sugar content of 60 or more, more preferably 65 or more, and even more preferably 70, from the viewpoint of preventing contamination by microorganisms. That's it. On the other hand, if the sugar content is too high, for example, the viscosity of the liquid increases, making it difficult to handle when blended into external preparations and various compositions. More preferably, the sugar content is 80 or less, and still more preferably 75 or less.

As used herein, the sugar content means the Brix value. Here, the Brix value is a unit for measuring the gram amount of soluble solids (sugars, etc.) contained in 100 g of solution. The Brix value can be measured using a commercially available refractometer or saccharimeter. Specifically, when 1 gram of sucrose is dissolved in 100 grams of an aqueous solution at 20 ° C., the Brix value of the solution is 1 degree, and the same sugar content refractometer value as this sucrose solution The Brix value of the indicated solution is defined as 1 degree. According to this definition, the Brix value does not necessarily mean the mass percentage of sucrose in the sample solution.

Furthermore, the liquid of the present embodiment preferably contains 1% by mass or less of preservative with respect to its total mass. Here, the preservative is not particularly limited as long as it is a preservative that is added to the cosmetic composition described later. , it is desired to reduce the amount used as much as possible. Since the liquid of the present embodiment has a high sugar content, the growth of microorganisms is suppressed. The antiseptic property of the liquid is ensured. Therefore, it is possible to produce an external preparation composition that can be used by people with sensitive skin who feel skin irritation with conventional amounts of preservatives without feeling irritation. Therefore, there is no lower limit concentration when adding a preservative, and it is sufficient that it exceeds 0% by mass. The upper limit concentration is 1% by mass, preferably 0.5% by mass, more preferably 0.1% by mass. As the antiseptic agent having antiseptic action at a low concentration, for example, parabens, benzoic acid and its salts are preferable, and sodium benzoate is more preferable.

The liquid in the present embodiment is a substance that is fluid at room temperature, and includes paste or slurry. The liquid in the present embodiment has a viscosity at 20° C. of 10000 mPa·s or less, preferably 7000 mPa·s or less, preferably 5000 mPa·s or less, preferably 2000 mPa·s or less, more preferably 1500 mPa·s or less. It is desirable to be For example, the viscosity of the liquid in the present embodiment is measured at 20° C. using a Brookfield viscometer (eg, B8M, manufactured by Tokyo Keiki Co., Ltd.) with a rotor No. 2. Number of revolutions: Determined by measuring at 12 rpm for 5 minutes. Although the lower limit of the viscosity of this liquid is not particularly limited, it is usually 500 mPa·s or more because it contains a large amount of saccharides. As the viscosity of the liquid increases, it becomes more difficult to handle when adding it to a cosmetic composition or a food or drink composition. It is easier to handle and more homogeneously mixed with various materials.

When added to an external preparation or oral composition, the liquid of the present embodiment has a moisturizing effect, a skin texture improving effect, a hair moisture increasing effect, a hair cuticle protecting effect, a foam quality improving effect, a deodorizing effect, and a cell An activation effect, an antioxidant effect, and an inhibitory effect on melanin production can be imparted. Therefore, another embodiment of the present invention provides an external preparation or oral composition containing the liquid. Examples of external preparations include pharmaceuticals, quasi-drugs, and cosmetic compositions. Oral compositions include, for example, food and drink compositions, pharmaceuticals, and quasi-drugs.

The amount of the liquid of the present embodiment to be added to the cosmetic composition or food and drink composition is not particularly limited as long as it can be confirmed to have an effect. It may be in the range of 0.01 mg/g to 400 mg/g (the denominator indicates the weight of the preparation), and for oral administration, it is preferably in the range of 0.1 mg to 5 g/day in terms of solid content.

Further, the cosmetic composition or food and drink composition of the present invention may further contain organic polymers, oils and fats, waxes, mineral oils, inorganic substances, enzymes, plants, animals, microorganisms or extracts thereof, or Its metabolites, water-soluble particles, water-insoluble particles, binders, coating agents, oils, moisturizing agents/texture improvers, surfactants, polymers/thickening/gelling agents, solvents/propellants, antioxidants agents, reducing agents, oxidizing agents, preservatives, antibacterial agents, chelating agents, pH adjusters, acids, alkalis, powders, inorganic salts, ultraviolet absorbers, whitening agents, vitamins and their derivatives, antiphlogistic agents, anti-inflammatory agents. agent, hair growth agent, blood circulation promoter, stimulant, hormones, anti-wrinkle agent, anti-aging agent, tightening agent, cooling agent, warming agent, wound healing accelerator, stimulant, analgesic, cell activator , antipruritics, exfoliating agents, keratolytic agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, fragrances, dyes, coloring agents, dyes, pigments, and water It can also be used as a cosmetic composition or a food and drink composition.

Examples of organic polymers include cellulose, crystalline cellulose, powdered cellulose, cationized cellulose, cellulose acetate, ethyl cellulose, nitrocellulose, methyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl ethyl cellulose, hydroxypropyl methyl cellulose, and stear. hydroxypropylmethylcellulose, cetylhydroxyethylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, polyethyleneimine, polyvinylpyrrolidone, polyvinylpyrrolidone-vinylacetate copolymer, polyethylene glycol, high polymer polyethylene glycol, polyvinyl alcohol, polyvinyl methyl ether , polyacrylic acid, polyacrylamide, carboxyvinyl polymer, gum arabic, arabinogalactan, carrageenan, karaya gum, benzoin gum, dammar gum, aguyac butter, Irish moss, karaya gum, curdlan, guar gum, cationized guar gum, tragacanth gum, furcelleran, carob gum , quince seed, xanthan gum, tamarind gum, tara gum, jalan gum, roasted bean gum, mannan, galactomannan, konjac mannan, agar, dextrin, gelatin, pectin, sodium pectate, alginic acid, sodium alginate, cyclodextrin, starch (red bean starch, oat starch, wheat starch, corn starch, rice starch, tapioca starch, potato starch, cornstarch), keratin, glycogen, agarose, chitin, chitosan, collagen, hyaluronic acid, mucin, proteoglycan, xyloglucan, lignin, silk, Ceramic, polylysine, albumin, casein, globulin, dextran, pullulan, polyethylene, polystyrene, polyvinyl chloride, polyester, polypropylene, polycarbonate, polyamide, nylon, silicone, polyvinylidene fluoride, polyurethane, polysiloxane, molecular weight of 10,000 or more proteins, natural ceramides (types 1, 2, 3, 4, 5, 6), ceramides such as hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides and sugar-ceramide-containing extracts, nucleic acids, deoxyribonucleic acids, ribonucleic acids, Charcoal (charcoal, activated carbon, medicinal charcoal, Bincho charcoal), shellac resin, acrylic resin, polystyrene resin, (meth)acrylate/styrene copolymer resin, polyolefin resin, vinyl acetate resin, ethylene/vinyl acetate copolymer resin, Polycarbonate resin, ABS resin, polyamide resin, polyvinyl butyrate resin, vinyl chloride resin, silicone resin, cellulose resin, phenol resin, urea resin, melamine resin, derivatives thereof, and the like.

Oils and fats include avocado oil, linseed oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange rough oil, cacao butter, chamomile oil, carrot oil, cucumber oil, cucumber oil, kukui nut oil, walnut oil, Wheat germ oil, sesame oil, rice oil, rice bran oil, sasanqua oil, safflower oil, salad oil, shea butter, soybean oil, tea oil, evening primrose oil, camellia oil, corn oil, rapeseed oil, persic oil, safflower oil, castor oil, sunflower oil, grape seed oil, hazelnut oil, macadamia nut oil, cottonseed oil, meadowfoam oil, peanut oil, rosehip oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, Japanese magnolia, coconut oil, Fish oil, whale oil, shark oil, liver oil, beef tallow, lard, chicken oil, rabbit fat, mutton fat, horse fat, hydrogenated products of these fats and oils, and derivatives thereof.

Waxes include beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, shellac wax, rice wax, squalene, squalane, pristane, rice bran wax, sugarcane wax, palm wax, ivory wax, wool wax, ceresin. , ozokerite, montan wax, hydrogenated products of these waxes, derivatives thereof, and the like.

Mineral oils include paraffin (paraffin wax), liquid paraffin, petrolatum, paraffin-paraffin petrolatum, wax, ozokeride, ceresin, microcrystalline wax, mineral oil or these mineral oils or hydrogenated products or derivatives thereof.

Inorganic substances include silica, hydrated silica, silicic anhydride, silicic acid, aluminum silicate, calcium silicate, magnesium silicate, magnesium aluminum silicate, zirconium silicate, magnesium aluminometasilicate, montmorillite, hectorite, Bentonite, zeolite, vermiculite, dicalcium phosphate, zinc carbonate, calcium carbonate, magnesium carbonate, alumina, talc, titanium oxide, titanium dioxide, lithium cobalt titanate, mica, mica, titanium mica, kaolin, red iron oxide, gunjo, zinc oxide, Zirconium oxide, iron oxide, yellow iron oxide, black iron oxide, chromium oxide, chromium hydroxide, carbon black, calamine, quartz, bismuth oxychloride, calcium phosphate, calcium hydrogen phosphate, anhydrous calcium hydrogen phosphate, calcium carbonate, heavy Examples include calcium carbonate, magnesium carbonate, heavy magnesium carbonate, sulfur, feldspar, apatite, glass, ceramics, inorganic salts thereof, and crystalline or amorphous substances thereof.

Enzymes include hydrolases (protease, amylase, diastase, dextranase, lipase, cellulase, lysozyme), oxidoreductases (laccase, peroxidase, catalase, lactate oxidase, glucose oxidase, galactose oxidase, pyruvate oxidase, aldehyde oxidase, monoamine oxidase, ureate oxidase) and the like.

Plants, animals, microorganisms or their extracts or their metabolites include almonds (amberjack), ai (indigo leaves), blue vines (seifu wisteria), aoki (aoki), Aogiri or Kenashiaogiri (goto), Aotsuzurafuji ), Aotemma, Acacia, Red pepper (Akashoma), Red currant "fruit", Red clover, Red grape, Akaminoki (logwood), Akamegashiwa (Red bud Kashiwa), Akaminomadane or madder or madder (madder grass root), redyacht or rhododendron (ground yellow) , Agi (Awei), Aki larch, Akikinre (elm bark), Aguai guassu, Aguaje (Omi long-nosed palm), Akebi (wooden), Asa (hemp seed), Maruba morning glory or morning glory (Kenyuko), Hydrangea (hydrangea) , Angelica keiskei (Tomorrow's leaf), Azuki (Red adzuki bean), Asunaro, Acerola, Asenyaku (Asenyaku), Achira (Shokuyo canna), Anise, Abiou, Aviurana, Rapeseed, Abemaki "fruit", Avocado, Flax, Amacha (sweet tea) , Gynostemma pentaphyllum, Amadokoro (ball bamboo), Amana (Kojiko), Amaranthus , Aristolomelia, Arcana, Algarrobo, Althea, Arnica, Alpinia or Katsumadai, Aloe, Aloe Vera, Angelica, Apricot or Honanzu, Ansokkou, Yellow sapote, bristle bristle head, epimedium or yachimata kaede (Inyoukaku), rush (wicking grass), Japanese knotweed (tiger cane root), yew (first place), strawberry, fig (fruit, leaf), ichihatsu ( first), velvet (winter), ichiyakuso (one medicinal herb), ginkgo biloba (seeds, leaves), itohimehagi (enshi), locust bean, dog thaliana (teirekishi), barnacle (Honagaiyu), rice (seeds, seed coat) , Ind "seeds", Thymus vulgaris, Stinging nettle, Ylang-ylang, Sardine tobacco (rock), Selaginella or Iwamatsu (maki-kashiwa), Kidney bean, Oolong tea, Fennel (Fennel), Wheat (Chibusanoki), Ukiyagara (three-ridged), Warbler "Fruit", cinnamon, turmeric (depression), duckweed (floating 萍), eucalyptus or keirin saisin or eucalyptus saicin (spicy), eucalyptus, eucalyptus eucalyptus, coriander orchid, nepenthes (summer dry grass), udo or shishiudo ( Kangkatsu, Dokatsu, Todokukatsu), Unyadegato (Uncaria, Cat's Claw), Uba tea, Ume (Ubai "seeds, pulp"), Urajirogashi, Uwaurushi (Lanberry), Unshu mandarin orange (Chen peel), Unboku, Estragon, Eleuthero (Ezogo) ), Yezo Lily of the Valley, Echinashi (Hosobamurasakibarangiku), Cysticidae, Enokitake (Enokitake), Ebisgusa or Cassia Tora (December), Ercampre, Elderberry "Fruit", Elemi, Eringii or Prelotus Eringi, Pagoda (Sophora sophora, Sophorae flower rice), peas, Astragalus or Astragalus membranaceus (Astragalus membranaceus), Narco lily or Kagikuraba Naruko lily (Yellow lily), Ohisasanoyuki or Sasanoyuki, Japanese coptis (Huangren), Ogatahoken, Oogata gourd (Caracon), Ooguruma (Doboku incense), Oh Tsuzurafuji (self-defense), plantain (car front grass, car front grass), carp thistle (Keishu koreshi, white head), carpenter's thistle (Hinko), carp cactus, carpenter's widow or okera (white oak), carpenter's berry (banaba), carpenter's shabushi "Fruit", oyster mushroom, hosigus grass (grain grass), hollyhock, or hawthorn (mountain), oyster palm, barley (barley), okra, okazeri (snake bed), okra "fruit", oguruma (twirl), oak Blackberry (Ushu Rokuro, Aizashi head), Panax ginseng or Tochiban ginseng (carrot), Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (Otogirisou), Dead nettle (continuous cut), Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyara (Tenma), Tiger lily or Sasa lily or Hakata lily (Lily), Orchid onoeran, Ononis, Halibut, Ominaeshi, Oyuko, Dutch mustard (Watercress), Dutch jelly, Dutch beer, Netherlands Japanese honeysuckle, olive "fruit, seed, leaf", oregano, orange "fruit, peel", Kaikeijou (ripe yellow), cacao "fruit, peel, seed", oyster (persimmon "leaf"), Kagikazura (fish wisteria hook) ), persimmon or licorice (lotus root), oyster orchid, hydrangea hydrangea, cassia, cassava (kozo nut "fruit"), zedoary, oak tree, oak tree, cascara, cascara sagrada, gypsophila, cassava , Kanikusa (golden sand), kaniwa, carnation, valerian (valerian root), birch, birch anatake, birch or weeping birch (white birch), gerbera, pumpkin, kapok-no-ki "seed", Kahokusansho (Shochu pepper), cattail Chamomile or roman chamomile, chamomile or Roman chamomile, chamomile (traditional grass), camo camo (camo camo), karagwa or yamaguwa (mulberry mulberry), collar, karakusakeman, Japanese gourd or Chinese gourd (king melon), karasubishaku (half summer), oats, guarana "seeds", karaho ( karaya, garyu, quince, garcinia, kawamidori, kawara psycho, kawajisha, kawaratake, kawara dianthus (stone bamboo) or ezo kawara dianthus (barley, barley), kawara carrot (green)蒿), Kawara mugwort (茵?蒿), kansui, licorice, licorice, candelilla, canto, canna, perilla, raspberry (Ezo strawberry, Dutch strawberry, Shrimp-red strawberry, Nawashi strawberry, Momiji strawberry, European raspberry), kiwi "fruit, leaf", Kikara gourd (urion), bellflower (bellflower, bellflower root), chrysanthemum (chrysanthemum flower, sycamore, bellflower root), chrysanthemum (chrysanthemum flower, sycamore, sycamore), chrysanthemum, kisage (Azusa fruit), gishigishi (yotei root), pheasant (Kojitsu), kizuta, aloe vera, mint, cinchona , cinchona (cincona, red kinchona), quinoa (quinoa), yellowfin tuna (yellow oak), pigeon pea, gymnema sylvestre, kimenekaku, cabbage, cabbage, cabbage, caraway, cucumber, gourd saponaria, quillaya, kiransou, kumquat "fruit", kinkiju, ginsekai, kinbusen, betel, agrimonger, golden orchid, silver orchid, kinryohen, guapeba vermelha, guava "fruit", guayule, quercs infe Cthoria (gallic), kukui nut, kugenumaran, wolfberry (salmon, scutellaria, scutellaria leaf, ground bone skin), Chinese vine (Tianmon winter), kudzu (kudzu root), camphor tree, gooseberry "fruit", ginseng (yellow flower), Kutiti River, Gardenia, Sawtooth Oak, Cupuaçu, Cubaba, Kumazasa, Vervain, Clara, Cranberry "Fruit", Chestnut "Seed, Fruit, Astringent Bark", Curculigo latifolia "Fruit", Grapefruit "Fruit/Leaf", Buckthorn, Kuroganemochi (Rescue), Kameba Hikiokoshi or Kurobana Hikiokoshi or Hikiokoshi (Longevity Grass), Clove (Clove, Clove), Gumbai Nazuna (Sekimei, Sekimeishi), Keigai ear), cockscomb (rooster crown flower, cockroach), geccavidin, bay laurel (laurel), Kenashisarutoriibara (doll, yamakirai), gentian, gennoshouko (old bellflower), kenponashi (kigusi), koukisekoku, mandarin orange (kouji, Tachibana, Oobeni mikan, Fukure mikan, Sagamikouji, Ponkan, Santara (tachibana skin)), Koshinbara (Monthly flower), Kosuimint, Kozo fruit, Kocha (black tea), Kouhone (river bone), Kouhon (straw book, Karawara book) , sorghum, koryang (Koura ginger), cilantro (fruit), koouren (Huhuangren), scutellaria baicalensis (yellow goon), cowberry (Koshi Tachibana), coconut palm (fruit), goshuyu (goshuyu), gosho strawberry (bokubonzi), pepper (pepper), cosmos, copaiba balsam, coffee "seeds, leaves", Kofukisarokoshika (plum-parasitized), Kobushi or magnolia (spicy), burdock (burdock, burdock root), Kotan crane, sesame (sesame), Scrophulariaceae (root) , Gomishi (Schisandra officinalis), Sanekazura or Binangkazura or Matsubusa, Wheat (Wheat), Rice or Rice Bran "Red Bran, White Bran", Rice Oil, Cola Acuminata "Seed", Cola Bella "Seed", Coleus Forskohlii, Colonilla, Fenugreek "fruit", colombo, konzurango, kelp, konnyaku, comfrey (finned grass), sisal (sisal hemp), rhinoceros hiran, sakaneran (ezosakaneran), Sakishima button crane or Chinese button crane or cinnamon grass (weireisen), cherry tree (Oshima cherry tree, Yamazakura, Oyamazakura, Edohigashi, Mamezakura, Miyamazakura, Somei Yoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura [leaf, flower, fruit, bark (cherry bark)]), cherry, pomegranate, sasa, sabaginran, sasanqua, sagemodaka ( sage), sweet potato, sugar cane, sugar beet, sanebuto jujube (sanajuhito), saffron (safflower, safflower), sapodilla, sapote amariyo, pomelo "fruit", soapwort, salmonberry "fruit", white ginger (masuma), Saranshito (sand indigo), salvia (sage), sawa gikyo (wild bok choy), sawa walnut (mountain walnut), sankaku cactus, sangre de grad (croton), sanshikuyouso, Sanshichininjin (37 carrots), sansuyu (mountain) ), Sansho (Japanese pepper), Sanzukon (Yamame root), Shea (Kalite), Cyanogi "fruit", Shiitake (Shiitake), Shion (Shion), Winged bean, Digitalis, Shikunshi (Shikunshi), Perilla or Aojiso or Chirimenjiso Or katamenjiso (perilla leaf, perilla), rosewood, linden tree, linden tree, Chinese forsythia (forsythia), shimeji mushrooms (hinshimeji mushrooms, shakashimeji mushrooms, hatakeshimeji mushrooms, oshiroishimeji mushrooms, bunashimeji mushrooms, honjimeshi mushrooms, white hyacinth mushrooms), shimokuren (shini), meadowsweet, potatoes, Peony, Shajin, Jasmine, Janohige, Long bean, Gypsophila, Shukshamitsu, Juzdama, palm "fruit", Syunran, Red palm, Ginger, Hydrangea japonicum (Tsuneyama), Shobu (iris, iris root), Shozuku "fruit", White oak "seed", Silang (Byakkyu), White-faced butterfly "seed", White clover (clover), white azuki (chicken) Bone grass), white banyan squirrel (smell iris), white flower ivy "flower", white banana lupin, white minanten (nanten fruit), cinchona saxyl bra, daphne clove (azuki, azuki flower, cinnamon flower), cinnamon, cinnamomum cassia (cinnamon bark), watermelon (watermelon), honeysuckle (golden and silver flowers, winter), sorrel (acid imitation), swimberry "fruit", star apple, stevia, strawberry "fruit", sycophagus (Xu Changqing), horsetail (horsetail), purslane (horse tooth ken, horse tooth Kenko), plum "fruit", sorghum (oran), red pine "conifer", larch, ivy, walnut, hawthorn, wildflower, dandelion, horse chestnut (horse chestnut), pear "fruit ”, sagebrush, Sambucus nigra (elder), juniper (juniper, juniper), yarrow (milfoil), rose, sagebrush, mistletoe, mint or mint, horseradish, stone root , Dendrobium (Sakura Dendrobium, Kouki Dendrobium, Oobana Dendrobium, Okinawa Dendrobium, Hondendron Dendrobium, Phalaenopsis Dendrobium, Rhodendron Dendrobium, Yellow Dendrobium) (Dendrobium, Stone Depth), Cedron (Boshu Boku), Mallow, Broadhead Senega, Senega, Ari, Celery, Cnidium ( River cucumber), Sensinren (Senshinren), Chinese chinaberry, Sennin cactus, Senna "fruit, leaf", Senninsou (Otate), Japanese juniper (this drug), Senboku, Souka (grass and fruit), Zougechu, Chinese allspice, buckwheat "seed ”, Somemonoimo, Broad Bean, Rhubarb (Rhubarb), Japanese Radish, Soybean, Daidai (Orange Peel, Rhubarb), Takasagoru Higotai (Southeast Indigo Sashimi Head), Takasa Blow (Dry Lotus Grass), Taka Todai (Large), Takabracken ), dark sweet cherry "fruit", hollyhock, thyme (thyme, hyacinth), hollyhock (hikai), hollyhock, tamarind "seed", onion, tamarind (spicy), taranogi "fruit, leaf, root bark", tarayou ( Large leaf winter blue, one leaf tea, kuchocha, bitter tea), dahlia (Tenjikubotan), tarwi, tankurimame, tanshiu chiwa, tanjin (tanjin), dandelion (Kankoei) or whitebana dandelion or moko dandelion, danmaru, cherry "fruit", Chigaya "Fruit, Root, Bud", Chikusetsu Ginseng, Chicory, Chancapiedra, Tulip, Choconostay, Artichoke, Datura Rhizome, Korean Elm , Mugwort (Mugwort Leaf), Chorei Maitake (Boar), Chinese Artifact, Tsukimisou, Tsukushisakaneran, Tsukuritake (Mushroom), Tsuchiakebi, Camellia, Centella asiatica, Clover (lacquer grass), Commelia (duck grass), Tsuruazuki (red adzuki bean) , Tsurutsuchiakebi, Tsurudokudami (Manchuria), Tsuruna (apricot), Tsuruninjin (four-leaf ginseng), Wild soybean, Tsuwabuki, Deiko, Teuchi walnut, Dewberry "Fruit", Agaricus, Tencha (sweet tea), Tendaiyaku (mushroom), Pepper (winter melon) child), Tokagikazura, Togarashi (Bansho pepper), Toki (Toki), Calendula officinalis (Marigold), Tosaikachi, Tounabena (Kawadan), Corn or Corn hair (Nanban hair), Ligustrum (Mesako), Tou Gentian or Gentian Gentian (Rindo), Horsetail (Bokuzoku), Houttuynia (Ten Medicines), Tokon (Ton), Toshishi or Mamedaoshi or Custard Vine, Eucommia (Eucommia "bark, leaves, roots"), Ash (Chinese Bark), Tomato, Tragacanth, triacanthus "seed", truffle (Short mushroom), Lisianthus, tormentilla, peonies, tororo-aoi, tonka bean, Neisseria berry "fruit", Chinese yam or yam (wild herb), Nagi squid (butcher bloom), Naginata kouju, Shepherd's purse , Rapeseed, Natamame or Tatehaki (sword beans), Natsumikan, Jujube (large jujube), Naniwabara (Kinzakura), Nabena (continuous cut), Nameko, Nankin pea (peanut), Nanten (nanten fruit), Nanban ramie (ramie), Violet odor, Nigaki (bitter tree), Wormwood (bitter), Nutmeg, Kay or Cinnamomum or Ceylon cinnamon or Japanese cinnamon (cinnamon bark) or cinnamon twig (cinnamon twig), New plover, Chive (Nira), Elderberry (boned tree "fruit, Flowers, stems, leaves”), garlic (garlic), nurde (fivefold), green onion, silk tree or nebu or nebbi or silk tree or gigokubana (gehuan), wild thistle (large thistle), rose rose, trumpet vine (Lingxiao flower), Nogeitou , Yarrow, Nodake (Maehu), Nobara, Nomomo, Pineapple "Fruit", Hibiscus (Bussouge, Fuurinbussouge, Roselle), Higentou, Hauchiwa, Pau Doce, Hakamauraboshi (Bone Crushing), Chinese White Plover, Chinese Plover, Chinese White Plover (ringworm skin), huckleberry "fruit", chickweed, hazel, sycamore root, basil, lotus (lotus, lotus pulp, lotus root), parsley (Dutch jelly), naked barley, batata, honeycomb or Madake (boiled bamboo), patchouli, mint (mint, mint leaves), Mucuna pruriens, pearl barley (yokuinin), hanasuge (chimbo), banana, hanahakka, hanabisi (shitsurishi, shishitsuri), vanilla bins, papaya, hahakogusa (mouse koji grass) , Paharobobo, habu "whole plant, stem, leaf", paprika, Hamakakiran, Hamagou or Mitsuba Hamagou (vine thorn), Hamasuge (Kabushi), Tribulus terrestris (Shitsuriko), Hamanasu (Maikai flower), Hamabofu (Hamafufu), Hamamelis, palm, rose (rose), balata, balata rubber tree, agaricus (agaricus, white agaricus, leopard), harran, pariurus, parietalia, harcanran, balsamina (mongrel, bitter gourd), har elm (elm bark, elm white) skin, lily leaf), barbasco, gentian, handaikai (胖大海), breadfruit, blackberry (scarred), lizard vine, pecan nuts, amaryllis (Hishimi), Pistachio, Beet, Hitotuba (Stone Reed), Hitotsubae Nishida, Daisy (Daisy), Hinata Nokozuchi (Ox Knee), Hinachiyodori, Hinoki, Hiba, Castor, Sunflower, Bell Pepper, Himeuzu (heavenly), Tyrannosaurus ( Kofu), Himematsutake (Kawariharatake, Hiromatsutake), Himemujoran, Pimenta "fruit", Juniper, Byakukyu, Hiyu "fruit", chickpea, lentil, velvet aoi, broadleaf pasque (white head), loquat "fruit, leaf, stem", Betel nut (large cloth skin, betel nut), pu-erh tea Tea), Dermatophyllum (southern rattan), Butterbur, Coltsfoot dandelion (sub-winter flower, sub-winter leaf), Fujibakama (orchid grass), Fujimame (wisteria bean), Fujimodoki (choji-zakura, clove), grape "fruit, pericarp, seed, leaf", beech , Cordyceps, Brazilian Glycyrrhiza, Brazilian Carrot, Brazilian Palm, Brazilian Elephant Palm, Black Currant 'Fruit', Blackberry, Branien, Plum 'Fruit', Furcellaria, Blueberry (Helix Hemp), Prunes , Floral Blanca, Blond Psyllium, Bundou (Mung Bean), Hazelnut, Loofah, Hetu Karan, Safflower (Safflower), Heneken, Belladonna, Berry "Fruits", Persea, Peruvian Berg, Pereschia Grandifolia, Crassulacea or Stickweed Boysenberry "Fruit", Houki or Niwakusa or Nendou or Toothpaste, Kochia (ground skin), Hosai orchid, Garden Balsam (Pouteria sapota, Pouteria lucuma), Pouteria sapota, Pouteria lucuma, Japanese magnolia, Spinach, Physalis alba (Toro) root), magnolia (Japanese magnolia, magnolia), quince (wood melon), hosoba abragiiku (bitter), hosoba oguruma, hosobanaokera (condense), hosobano giraffe (Keiten Sanshichi), hosoba baeng, bodaiju (bodaiju), button (peony "flowers, leaves, stems, bark"), botanpi (peony bark), hops, jojoba, borage (borage), Bordeaux, whiteberry "fruit", hongeonik (meat juice, daigei), hongseok (iron) Skin stone, Jakuyama stone), Maizuru tennansho (Tennansei), Maitake mushroom (Maitake), Ephedra (Ephedra), Maca, Macadamia nuts, Margaret (Mokushungiku), Macri (fisherman grass), Magwa (mulberry white bark) Bark, leaves"), Magnolia splengeri, Masaranduba, Masalanzuba de Cearar, Masheira de Boi, Mashua (Tamanousenhallen, Cucumber nasturtium), Actinidia (tree heaven), Matsukasa, Pine "Leaves, bark, Root", Matta Oryo, Matsutake (Matsutake Mushroom), Matsuhodo (Fruit), Matico (Cordoncillo), Mayoram (Hanahakka), Malvanojazin (Vegetable), Mulberry "Fruit", Quince, Mullein (Mullein), Mango, Mangosteen , Mansanya (Andean chamomile), Manshu walnut, Mandarin "fruit", Ganoderma lucidum (Ganoderma lucidum), Pheasant (Kojitsu "fruit"), Mishima psycho (Shibako), Mizu plantain or Mizu morning glory (Dragon tongue grass), Mizokakushi (half-sided lotus) ), Misohagi (Thousand greens), Michiyanagi or Niwayagi (Historical), Mitsugashiwa, Mitsuba, Green sapote, Midorimint, Mimosa, Myoga, Miracle fruit "fruit", Myrrh, Myrobalan, Chrysanthemum, Mukuge (woody bark), Mukunoki, Sapindaceae ( Life-prolonging skin), muña, purple (purple root), purple or purple pearl (purple), purple corn, purple nutfuji (Kunming chicken blood wisteria), megacantha opuntica, meshimakobu (mulberry yellow), mehajiki (benefit mother grass), basil, Evening Primrose (Evening Primrose), Melaleuca, Melissa, Melilot, Melon "Fruit", Mugwort, Mulberry, Mokurin, Moje (Pepperwood), Ilex, Mokko (wood Scent), Rhubarb Rhubarb, Peach (Peach "Leaves, Seeds, Flowers, Fruit"), bean sprouts, Morello cherry "fruit", Moroheiya (jute), Yakawa purple sweet potato, Yakuchi (Mitsuchi), Yakuyo gallega, Cornflower (cornflower), Monarda, Yacon, Yaba Santa, Yashabushi (arrow wheel) or Himeyashabushi or Ooba Yashabushi "Fruit, Pericarp, Ear", Willow, Fatsia (Octagonal Gold Plate), Mistletoe (willow parasite), Willow , Oba willow, Tile willow, Fox willow, Doronoki), Willow weed "leaf, stem", Yaba santa, Yabu mustard, Yabu koji (Purple gold cow), Yabu tobacco (Crane louse, Amanei), Wild pokeweed (selling land), Boletus edulis (porcini, cep) , Steinpilz), sycamore, bayberry, bayberry, sagebrush, eucalyptus, saxifrage (tiger ear grass), yucca or phlebifolia, yuzu fruit, lily, artichoke, mugwort, ligan ), lime "fruit", rye, rakanka "fruit", raspberry "leaf, fruit", latania (crameria), shallot or shallot (white), lavender, longan (longan flesh), agave (Aono agave, fukurin agave), ryokucha (green tea), apple "fruits, seeds, leaves, roots", gentian, rubus or suabisimus (sweet), borage thistle, lychee (lychee, lychee nucleus), lettuce (chisha), Red currant "fruit", red pitaya, lemon "fruit", lemongrass, forsythia or Chinese forsythia (forsythia), Astragalus, Japanese allspice, wax palm, lokon, loganberry "fruit", rosemary (Mannenrou), rosehip (Novara), wasabi, cotton wisteria (mitsumou flower), burnet (earth), and various parts of each plant body (flower, flower head, flower spike, ear, cob, pericarp, Endocarp, fruit, pulp, capsule, cone, kernel, bud, stem, tuber, leaf, branch, foliage, stem, bark, root, rhizome, root bark, seed, cap, stalk, fruiting body, mycelium, sclerotia, whole plant), and various pulp plants (fir, pine, eucalyptus, poplar, paper mulberry, mitsumata, wheat, barley, rye, oat, rice, sugarcane, reed, kefuna, corn, cotton, cottonseed, mulberry) Also, as seaweeds, seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usuba Aonori, Sujiaonori, Hiraaonori, Bouaonori, Hosoedaonori)], seaweed [brown algae: kelp (Makonbu , Risiliconbu, Hosome kelp, Honey kelp), Wakame, Hirome, Green seaweed, Giant kelp (Macrocystis pyrifera, Macrocystis integrifolia, Neocytis ruetokeana), Hijiki, Hibamata], Seaweed [Red algae: Hijirimen, Maxa ( Agaricus), Nettle, Onyksa, Ginkgo sorghum, Polygonum spp., Yatabegusa, Yuikiri, Shimaji agaricus, Tosaka nori, Thorny murine, Amakusaki eucheuma, Eucheuma muricatum, Juniper eucheuma, Tsunomata, Oobatsunomata, Tochaka (Yahazutsunomata), Ezotsunomata, Thornythorn, Hirakotoji, Kotojitsu Nomata, Suginori, Shikinnori, Kainori, Ibotsumata, Yareusubanori, Kagiusubanori, Suziusubanori, Hyusubanori, Akamomijinori], and other algae and green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Quanomimo: Quanomimo, Volvox) Genus: Helianthus annuus, Volvox, Palmera genus, Yotsumemo genus, Aomidoro genus: Hizaori, Aomidoro, Tsurugimidoro genus, Hibimidoro genus: Hibimidoro, Ulva genus: Annaaosa, Amiosa, Nagaaosa, Kawanori genus: Kawanori, Fritchiera genus, Cladophora genus: Giant shiogusa, Asa Agrophora, river sedge, marimo, genus Baronia: Tamago baronia, tamabaronia, genus Malaga: genus Ivy, genus Ivy: Phyllanthus ivy, thoracic ivy, larch ivy, black ivy, genus Ivy, genus Mil: mil, cromil, sakibutymil, long mil, giltmil, genus Lapis officinalis: Papaveraceae, Juzmo genus: Lithospermum, Tamajusumo, Mizojusumo, Mikazukimo genus, Korechaete genus, Tsutsumimo genus, Kickwort genus: Kiko-wossa, Tomatoegusa genus: Hitoegusa, Hirohanohitoegusa, Ushitoegusa, Motsukihitoe, Sayamidoro genus, Sunflower genus, Violet genus: Violets, genus Hosimidoro, genus Fushina-shimidoro, etc.), blue-green algae (genus Amphitheatre: genus Aphanophyllum, genus Algae, genus Nostalgia: kawatake mushroom, jellyfish, hassai, genus Euremo, genus Spirulina: spirulina, genus Trichodesmium (iacacia), etc.), brown algae Genus Piraella: Piraella, Genus Shiomidoro: Nagamishiomidoro, Genus Isograss: Isogrape, Genus Isogawara: Isogawara, Genus Kurogashira: Gunsen Kurogashira, Genus Kashirazaki: Kashirazaki, Genus Muchimo: Muchimo, Hiramuchimo, Keberigusa, Myrthygusa: Myrthygusa, Sakibiroamiji, Tapestry genus: Tapestry, Fuchriniamidi, Common grass genus: Common moss, Rhododendron genus: Sargassum spp. , Genus Navarimo: Nabarimo, genus: Motsukichasoumen, genus Matsumo: matsumo, genus Nagamatsumo: Nagamatsumo, genus Okinawan mozuku: Okinawa mozuku, genus Nisefuto mozuku, genus Myotozuku: Mythospermum spp. , Nemacystus decipiens: Nemacystus decipiens, Ishige genus: Ishige, Iroro, Ichimegasa genus: Ichimegasa, Zebra genus: Pelagic spp. Habanori, Habanori: Habanori, Common Bukuro: Common Bukuro, Ezobukuro: Ezobukuro, Fuchronori: Fuchronori, Cotton, Chishimafukuronori: Chishimafukuronori, Kagome-no-ri: Kagome-no-ri, Muraridori: Murachidori, Samezugusa: Samezugusa, Scalloped genus : Iwahige, Yokojima nori : Yokojima nori, Kayamonori : Kayamonori , Fennel genus : Fennel, Tsurumo genus : Tsurumo , Anagenus : Aname, Corridor genus : Sujime , Lamola genus : Mithia kelp, Atsubami konbu , Lamina genus : Laminaria kelp, Kakijima kelp, Lamb genus , Goheikombu, Long kelp, Pea kelp, Ochijimi kelp, Tororokonbu genus: Tororokonbu, Antokume genus: Antokume, Ecklonia genus: Ecklonia japonica, Tsuruarame, Kurome, Kikuishikonbu genus: Kikuishikonbu, Nejirekonbu genus: Nejirekonbu, Blackiome genus: Kuroshiome, Nekoashikonbu genus: Nekoashikonbu , Arame genus: Arame, Ainuwakame genus: Ainu seaweed, Chigaiso, Oniwakame , red moku, fern, hondawara, nejimoku, narassamo, mame-me-tawara, tatsukuri, yatsumatamoku, sea-tornado, obamoku, fushizushimoku, hahakimoku, thorns, yoremoku, saw-tree, oba-no-ko-girimoku, Sugimoku: Sugimoku, Ukimo: Oukimo, Buruukimo: Blue Kimo, Kayamonori genus: Kayamonori, etc.), red algae (genus Bovine: Ushikenori, Funori no Ushike, Amanori: Asakusanori, Susabinori, Uppuruinori, Oniamanori, Tasa, Firitasa, Benitasa, Rhodocorton genus: Mirunobeni, Akebonomozuku: Akebonomozuku, Konahada genus: Haikonahada , White-spotted seaweed, Aokonahada, Sea elephant genus: Sea elephant, Tsukumonori, Dactylophyllum, Benimozuku genus: Benimozuku, Hosobenimozuku, Lizard pine genus: Lizard pine, Fusanori genus: Fusanori, Nisefusanori genus: Nisefusanori, Sodegarami genus: Sodegarami, Rattle genus: Rattle, Hira rattle, big pigeon Genus: Bighead, Tamaitanda: Tamaitandaki, Kagikenori: Kaginori, Kagikenori, Agaricus: Agaricus, Agaricus, Oobusa, Nambugusa, Kohira, Yohira, Agaricus, Hibiroudo: Hibiroudo, Himehibiroudo, Isomu-memodoki: Isomu-memodoki, Mijigaesou: Rhinoceros spp., Rhinoceros genus: Rhymonia, Heraryum, Rhinoceros genus: Rhinoceros spp., Rhinoceros genus: Rhododendron genus, Okitsubara genus: Phyllanthus spp., Akaba genus: Akaba, Marba-akaba, Naminohana genus: Hosoba-naminohana, Naminohana, Coral genus: Rattlespot, Cladophora genus: Shiogusagoromo, I Genus Wanokawa: Etsuki Wanokawa, Kainokawa, genus: Kainokawa, Kaninota, genus: Kaninota, Coral genus: Coral, Mukadenori: Mukadenori, Susimkade, Katanori, Hiramukade, Kyounohimo, Kyuno Himo, Sakuranori, Tambanori, Slin Hana, Snowa Hana. , Kuronurakusa, Omukadenori, Hirakintuki genus : Black-pink, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Kome-no-ri, Crested pine, Hitotsumatsu, Kakureito: Oobakintoki, Itofunori: Itofunori, Nagaoban: Long-leaved, Funori: Hanafunori, fukurofunori, mafunori, karekigusa Genus: Calexaceae, Crested Squash Menia, Hounoo genus: Hounoo, Lycopophyllum genus: Lycopoides genus, Usuginu, Poison genus: Phylum genus: Venisnago genus: Vennisnago, Suskakebeni genus: Suskakebeni, Okamuragusa genus: Yamadagusa, Mirin genus: Mirin, Hosobamyrin, Tosaka nori genus: Kikutosaka, Ezonameshi genus: Ezonameshi , Genus Isomocca: Iomocca, Genus Eucalyptus: Yukari, Hosoyukari, Genus Ibaranori: Ibaranori, Rhinoceros rosea, Tachiibara, Kagiibaranaori, Genus Pheasant: Pheasant, Genus Isodantsu: Isodantsuu, Genus Atsubanori: Atsubanori, Genus Gracilaria: Gracilaria, Tsurushiramo, Whitebait, Ogonori, Mizokonori, Birch, Agaricus genus: Bee agaricus, Fushiklenori genus: Fushikurenori, Namiiwatake genus: Namiiwatake, Kaimenso genus: Kaimensou, Okitsunori genus: Okitsunori, Rhododendron spp. squid reeds, hosoibonori, bonori, black-capped genus: black-capped leucanthemum, red-capped genus: akabag-namental genus, herbaceous genus: red-faced black, spotted genus: thorn-and-spotted butterflies, octopus genus: Taoyagi-sou, Hana-sakura, Osmolaceous genus: possum, sujikonori, Genus Hana-noeda: Hana-no-eda, Genus Oysteria: Oyster-yellow-yellow, Genus Duluth: Duluth, Thread-of-thorns, Anadarus, Genus Uebagusa: Uebagusa, Genus Benifukuronori: Benifukuronori, Fushitsuji Genus: Fushitsunagi, Hime-fushitsuagi, Hiroha-fushutsunagi, Watatsunagi spp. Genus Aegis: Aegis, Keigis, Hariigisu, Hanei-gisu, Amixa, Styrax: Egonori, Futoigisu, Saeda: Saeda, Chirimomiji: Chirimomiji, Conohanidae: Habutaenori, Conohanori, Suzushironori, Usubeni: Usubeni, Hasujiginu: Hasujiginu, Nagakonohanori Genus: Nagakonohanori, Sujiginu: Sujiginu, Atsubasujiginu, Haiusubanori: Kagiusubanori, Yareusubanori, Sujiusubanori, Haiusubanori, Usubanorimodoki , Simadazia, Dajimodoki: Djimodoki, Dajimodoki, Itogusa: Moroitogusa, Futohigusa, Makuri: Makuri, Makuri, Makuri, Makuri, Yunaginori, Motsure Yuna, Benijanagi Kori, Sasabaya Nori, Sasabaya Nori, Sozono: Croosozo, Hanesozo, Hanesozo, Hanesoso , Sozonohana, Hanegusa genus : Staphylococcus aureus, Rhododendron spp., Kozanemo genus: Kozanemo, Isomurasaki, Hsokozanemo, Lesser moss genus: Pleurotus moss, Black moss, Black moss spp. Genus: Fujimatsumo , Sawtooth genus: Hakesa mushroom Girihiba, Kawamozuku genus: Kawamozuku, Aokawamozuku, Himekawamozuku, Idyukogome genus: Idyukogome, Okichimozuku genus: Okitimozuku, Tortoise genus, Chinorimo genus: Chinorimo, Chisujinori genus: Chisujinori, etc.), Axillary algae , All parts of seaweeds such as genus Shiratamamo, Genus Hoshitsurimo: Hoshitsurimo, Lycnotamnus, Flaskmo: Himefrasmo, Chaboflasmo, Tripella), yellow algae (Hikarimo: Hikarimo), or humans, monkeys, pigs, Cows, horses, sheep, goats, chickens, ducks, ostriches, domestic ducks, quails, dogs, cats, rabbits, mice, rats, hamsters, fish, birds, mollusks, etc., and various parts of each animal body, such as placentas, Skin, stomach, intestines (small intestine, large intestine, duodenum, etc.), liver, gallbladder, pancreas, spleen, kidney, gallbladder, lung, urinary tract, reproductive organs, digestive system, bones, muscles, blood, nails, head and neck (scalp, calvaria) , superior sagittal sinus, frontal sinus, sphenoid sinus, cerebrum, corpus callosum, septum pellucidum, arch, choroid plexus of third cortex, thalamus, anterior commissure, optic nerve chiasm, pituitary gland, pineal gland, Posterior commissure, cerebellum, third cortex, fourth cortex, midbrain, pons, medulla oblongata, spinal cord, atlas, axis, nasal bone, nasal cavity, superior nasal concha, middle nasal concha, inferior nasal concha, opening of auditory canal , pharyngeal tonsil, hard palate, soft palate, palatine tonsil, tongue, genioglossus muscle, geniohyoid muscle, mylohyoid muscle, hyoid bone, hyoid jawbone, epiglottis, thyroid cartilage, cricoid cartilage, laryngeal vestibule, laryngeal vestibular fold, vocal cord folds, glotoglossal cavity, nasopharynx, oropharynx, laryngopharynx), etc., or microorganisms such as eubacteria, archaebacteria, protozoa, fungi, etc. (lactic acid bacteria, yeast, natto, koji, mushrooms bacteria etc.)” and the like.

Water-soluble particles include organic acids or inorganic acids or salts thereof (formic acid, acetic acid, citric acid, oxalic acid, sodium citrate, sodium carbonate, sodium acetate, sodium chloride, potassium chloride, magnesium chloride, ammonium chloride, ammonium sulfate, Ammonium nitrate, potassium nitrate, sodium nitrate, calcium nitrate, ammonium sulfate, magnesium sulfate, potassium sulfate, ammonium phosphate, ammonium acetate, sodium hydrogen carbonate, potassium hydrogen carbonate, ammonium hydrogen carbonate, sodium benzoate, tin chloride, lead nitrate, silver nitrate, sulfuric acid Copper, iron chloride, nickel chloride, platinum chloride, palladium chloride, potassium chloroplatinate, calcium stearate, magnesium stearate), water-soluble polymeric substances (methylcellulose, carboxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, hydroxypropylethylcellulose, hydroxy Propyl methylcellulose, stearoxyhydroxypropylmethylcellulose, cetylhydroxyethylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, polyethyleneimine, polyvinylpyrrolidone, polyvinylpyrrolidone-vinylacetate copolymer, polyethylene glycol, high polymer polyethylene glycol, polyvinyl alcohol , polyvinyl methyl ether, polyacrylic acid, polyacrylamide, carboxyvinyl polymer, gum arabic, arabinogalactan, carrageenan, karaya gum, benzoin gum, dammar gum, aguyac butter, Irish moss, karaya gum, curdlan, guar gum, cationized guar gum, tragacanth gum , furcelleran, carob gum, quince seed, xanthan gum, tamarind gum, tara gum, jalan gum, roasted bean gum, mannan, galactomannan, konnyakumannan, agar, dextrin, gelatin, pectin, sodium pectate, alginic acid, sodium alginate, cyclodextrin), Monosaccharides (glucose, lactose, threose, arabinose, xylose, galactose, ribose, glucose, sorbose, fructose, mannose), disaccharides (sucrose (sucrose), lactose (milk sugar), maltose (maltose), trehalose, cellobiose, iso maltose, isotrehalose, neotrehalose, neolactose, turanose, palatinose), other polysaccharides (trisaccharides: raffinose, melezitose, maltotriose, tetrasaccharides: acarbose, stachyose, glycogen, solubilized starch, amylose, dextrin, glucan , β1,3-glucan, fructan, N-acetylglucosamine, chitin, chitosan), sugar alcohols (xylitol, sorbitol, erythritol, mannitol, maltitol), oligosaccharides (raffinose, panose, maltotriose, melezitose, gentianose, stachyose, cyclodextrin, xylooligosaccharide, cellulose oligosaccharide, lactooligosaccharide, fructooligosaccharide, galactooligosaccharide, mannan oligosaccharide), mucopolysaccharides or sulfates thereof (hyaluronic acid, chondroitin, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin, heparan sulfate), glycoproteins (mucin, proteoglycan), amino sugars (glucosamine, N-acetylglucosamine, sialic acid), amino acids or their salts (tryptophan, lysine, methionine, phenylalanine, threonine, valine, leucine, isoleucine, histidine, alanine Arginine, asparagine, serine, aspartic acid, cysteine, glutamine, glycine, proline, tyrosine, cystine, hydroxyproline, hydroxylysine, thyroxine, phosphoserine, desmosine, β-alanine, sarcosine, ornithine, creatine, γ-aminobutyric acid, opine, theanine , tricolominic acid, kainate, domoic acid, ibotenic acid, acromelic acid), water-soluble vitamins (vitamin B group: thiamine, riboflavin, niacin, pantothenic acid, biotin, folic acid, cyanocobalamin, vitamin C group: ascorbic acid, dehydroascorbine) acid), other water-soluble particles (chitin, chitosan or salts thereof, sodium glutamate, trimethylglycine, urea, allantoin, resorcin), and the like.

Water-insoluble particles include inorganic substances (silica, hydrated silica, silicic anhydride, silicic acid, aluminum silicate, calcium silicate, magnesium silicate, magnesium aluminum silicate, zirconium silicate, magnesium aluminometasilicate, Montmorinite, hectorite, bentonite, zeolite, vermiculite, dicalcium phosphate, zinc carbonate, calcium carbonate, magnesium carbonate, alumina, talc, titanium oxide, titanium dioxide, lithium cobalt titanate, mica, mica, mica titanium, kaolin, red iron oxide, Gunjo, zinc oxide, zirconium oxide, iron oxide, yellow iron oxide, black iron oxide, chromium oxide, chromium hydroxide, carbon black, calamine, quartz, bismuth oxychloride, calcium phosphate, calcium hydrogen phosphate, anhydrous calcium hydrogen phosphate, Calcium carbonate, ground calcium carbonate, magnesium carbonate, ground magnesium carbonate, sulfur, feldspar, apatite, glass, charcoal (charcoal, activated charcoal, medicinal charcoal, binchotan charcoal), ceramics or their inorganic salts, or their crystals or Amorphous substances), water-insoluble polymeric substances (cellulose, crystalline cellulose, powdered cellulose, cationized cellulose, cellulose acetate, ethyl cellulose, nitrocellulose, polyethylene, polystyrene, polyvinyl chloride, polyester, polypropylene, polycarbonate, polyamide, nylon , silicone (silicon), polyvinylidene fluoride, polyurethane, polysiloxane, protein with a molecular weight of 10,000 or more, zein, nucleic acid, deoxyribonucleic acid, ribonucleic acid, shellac resin, acrylic resin, polystyrene resin, (meth)acrylic acid ester・Styrene copolymer resin, polyolefin resin, vinyl acetate resin, ethylene/vinyl acetate copolymer resin, polycarbonate resin, ABS resin, polyamide resin, polyvinyl butyrate resin, vinyl chloride resin, silicone resin, cellulose resin, phenol resin, urea resin , melamine resins or derivatives thereof, and other water-insoluble particles.

Binders include gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, dextrin, gelatin, pectin, sodium pectate, starch, sodium alginate, carrageenan, xanthan gum. and other natural organic polymer compounds. Also, polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetate copolymer, polyethylene glycol, polyvinyl alcohol, polyvinyl methyl ether, sodium polyacrylate, carboxyvinyl polymer, polyethyleneimine, methylcellulose, ethylcellulose, acetylcellulose, nitrocellulose, vinyl acetate resin, Crystalline cellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxypropylmethylcellulose, stearoxyhydroxypropylmethylcellulose, cetylhydroxyethylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, cellulose acetate, phthalate, cellulose acetate Pionate phthalate, cellulose acetate maleate, polyvinyl alcohol phthalate, styrene-acrylic acid copolymer, methyl acrylate-methacrylic acid copolymer, vinyl pyridine or alkyl vinyl pyridine and other vinyl monomer polymers, cellulose acetate Diethylaminoacetate, polyvinylacetate diethylaminoacetate, polyvinylaminoacetal, dimethylaminomethacrylate-methylmethacrylate copolymer, copolymer of vinylpyridine or alkylvinylpyridine and acrylic acid, or ternary system with other vinyl monomers Semi-synthetic/synthetic polymer compounds such as copolymers, inorganic compounds such as montmorillite, kaolin, hydrated silica, magnesium aluminum silicate, calcium carbonate, and hectorite, various proteins (zein, etc.), waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, shellac wax, rice wax, squalene, squalane, pristane, rice bran wax, sugarcane wax, palm wax, ivory wax, wool wax, ceresin, ozokerite, Montan wax or hydrogenated products or derivatives thereof), oils and fats (avocado oil, linseed oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange rough oil, cacao butter, chamomile oil, carrot oil, cucumber oil, kyonin oil, kukui nut oil, walnut oil, wheat germ oil, sesame oil, rice oil, rice bran oil, sasanqua oil, safflower oil, salad oil, shea butter, soybean oil, tea oil, evening primrose oil, camellia oil, corn oil, rapeseed oil, persic Oil, safflower oil, castor oil, sunflower oil, grape seed oil, hazelnut oil, macadamia nut oil, cottonseed oil, meadowfoam oil, peanut oil, rosehip oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm oil kernel oil, Japanese wax, coconut oil, fish oil, whale oil, shark oil, cod liver oil, beef tallow, lard, chicken oil, rabbit fat, mutton fat, horse fat, or hydrogenated products of these fats or their derivatives).

Coating agents include hydroxypropylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxybutylcellulose, hydroxypentylcellulose, hydroxypropylmethylcellulose, hydroxypropylbutylcellulose, hydroxypropylpentylcellulose, stearoxyhydroxypropylmethylcellulose, cetylhydroxyethylcellulose, methylcellulose, ethylcellulose. , cellulose, crystalline cellulose, powdered cellulose, aminoalkyl methacrylate polymer, methacrylic acid copolymer, hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, carboxymethylethylcellulose, polyvinylpyrrolidone, polyvinylacetal diethylaminoacetate, polyvinylpyrrolidone/vinyl acetate, Polyvinyl alcohol, polyethylene glycol, polyvinyl alcohol-polyethylene glycol copolymer, carboxyvinyl polymer, various acrylic resins such as carboxyvinyl polymer, shellac, carnauba wax, pullulan, gelatin, sucrose, sucrose fatty acid ester, erythritol, mannitol, trehalose, Mica, mica titanium, bismuth oxychloride, fish scale foil (guanine), aluminum powder, silica, dimethyl silylated silica, talc, hydrogenated oil, pearl, silicic acid, aluminum silicate, calcium silicate, silicone, stearic acid, stearic acid Magnesium, calcium stearate, sodium stearyl fumarate, myristic acid, magnesium myristate, zinc myristate, palmitic acid, magnesium palmitate, evening primrose oil, hydrogenated evening primrose oil, various proteins (twein, etc.), oils and fats (avocado) oil, linseed oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange rough oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, cucumber oil, kukui nut oil, walnut oil, wheat germ oil, sesame oil, Rice oil, rice bran oil, sasanqua oil, safflower oil, salad oil, shea butter, soybean oil, tea oil, evening primrose oil, camellia oil, corn oil, rapeseed oil, persic oil, safflower oil, castor oil, sunflower oil, grape seed oil , hazelnut oil, macadamia nut oil, cottonseed oil, meadowfoam oil, peanut oil, rosehip oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, Japanese wax, coconut oil, fish oil, whale oil, shark oil , cod liver oil, beef tallow, lard, chicken oil, rabbit fat, mutton fat, horse fat, or hydrogenated products of these fats and oils or their derivatives), waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, shellac wax, rice wax, squalene, squalane, pristane, rice bran wax, sugarcane wax, palm wax, ivory wax, wool wax, ceresin, ozokerite, montan wax, or hydrogenated products of these waxes or their derivatives), etc. .

Oil agents include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, cerachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2- Higher alcohols such as octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmito Oleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, 18-methyleicosanoic acid, long-chain branched fatty acids, dimer acid, hydrogenation Higher fatty acids such as dimer acid, metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts thereof, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, Carbons such as light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, vaseline, solid paraffin; candelilla wax, carnauba wax, rice wax, Japan wax, Waxes such as beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, Castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, Vegetable oils such as sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, and hydrogenated jojoba oil; Animal oils and fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, and turtle oil; animal waxes such as whale wax, lanolin, and orange roughy oil; liquid lanolin, reduced lanolin, adsorbed refined lanolin, and acetic acid lanolin , acetic acid liquid lanolin, hydroxyl lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate alcohol, lanolins such as acetic acid (cetyl-lanolyl) ester; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, Sphingophospholipids such as phosphatidylglycerol, phosphatidylinositol and sphingomyelin; phospholipids such as phosphatidic acid and lysolecithin; phospholipid derivatives; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, sterols such as cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di(cholesteryl/behenyl/octyldodecyl) N-lauroyl-L-glutamate, di(cholesteryl/octyldodecyl) N-lauroyl-L-glutamate, di(phytosteryl/behenyl/octyldodecyl) N-lauroyl-L-glutamate, N - lauroyl-L-glutamic acid di(phytosteryl/octyldodecyl), acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid, phytosteryl macadamia nut oil fatty acid, phytosteryl isostearate, soft lanolin fatty acid sterol esters such as cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid/cholesterol complex and phospholipid/phytosterol complex; Hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, neopentanoic acid Isotridecyl, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, oleic acid Ethyl, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, adipic acid monoalcohol carboxylic acid esters such as diisobutyl, dioctyl succinate, and triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, and hydrogenated castor oil monoisostearate; glyceryl trioctanoate, glyceryl trioleate, Glyceryl Triisostearate, Glyceryl Diisostearate, Caprylic/Capric Triglyceride, Caprylic/Capric/Myristic/Stearic Triglyceride, Hydrogenated Rosin Triglyceride (Hydrogenated Ester Gum), Rosin Triglyceride (Ester) gum), eicosanedioic acid glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propane dioctoate Diol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearate/sebacate), pentaerythrityl triethylhexanoate, (hydroxystearate) / stearic acid / rosin acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate -10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl Oligoesters, polyhydric alcohol fatty acid esters such as glycol distearate (ethylene glycol distearate); diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, di(isostearyl/phytosteryl) dimer dilinoleate, dimer dilinol acid (phytosteryl/behenyl), dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl), dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl diisostearate, hydrogenated rosin condensate of dimer dilinoleyl, Derivatives of dimer acid or dimer diol such as dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl dimer dilinoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanol Amide (Lauramide MEA), Lauric Acid Diethanolamide (Lauramide DEA), Lauric Acid Monoisopropanolamide (Lauramide MIPA), Palmitic Acid Monoethanolamide (Partamide MEA), Palmitic Acid Diethanolamide (Partamide DEA), Coconut Fatty Acid Methylethanolamide Fatty acid alkanolamides such as (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, Phenyl dimethicone, stearoxypropyl dimethylamine, (aminoethylaminopropyl methicone/dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, dimethicone Polyether-modified silicone such as polyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone Silicones such as silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, polysiloxane/oxyalkylene copolymer; perfluorodecane, perfluorooctane , perfluoropolyether and other fluorine-based oils.

As a moisturizing agent/texture improving agent, water (as water, in addition to ordinary water, purified water, hard water, soft water, natural water, deep sea water, hot spring water, electrolytic alkaline ion water, electrolytic acidic ion water, ion water, cluster water), glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane , pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, polyols such as ethylene glycol/propylene glycol copolymers and polymers thereof; diethylene glycol monoethyl ether (ethoxydi glycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether and other glycol alkyl ethers; sorbitol, xylitol, erythritol, mannitol, maltitol and other sugar alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin and/or maltosylated, hydroxyalkylated modified cyclodextrin, etc.), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, sugars such as glucosylethyl methacrylate polymer or copolymer and derivatives thereof Hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoidin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; white fungus extract, white fungus polysaccharide; fucoidan; tuberose polysaccharide, natural polysaccharide; 2-pyrrolidone-5-carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, Amino acids such as β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, Elastin, Collagen Degradation Peptide, Hydrolyzed Collagen, Hydroxypropylammonium Chloride Hydrolyzed Collagen, Elastin Degradation Peptide, Keratin Degradation Peptide, Hydrolyzed Keratin, Conchiolin Degradation Peptide, Hydrolyzed Conchiolin, Silk Proteolytic Peptide, Hydrolyzed Silk, Lauroyl Hydrolyzed Silk sodium, various proteins (zein, etc.), soybean proteolytic peptides, wheat proteolytic peptides, hydrolyzed wheat proteins, hydrolyzed eggshell membranes, casein-degradable peptides, acylated peptides and other protein peptides and their derivatives; palmitoyl Acylated peptides such as oligopeptide, palmitoyl pentapeptide, and palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture medium, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin , whey; choline chloride, phosphorylcholine; placental extract, elastin, collagen, lactoferrin, aloe extract, hamamelis water, loofah water, chamomilla extract, licorice extract, comfrey extract, silk extract, rose rose extract, yarrow extract, eucalyptus Animal and plant extracts such as extracts and melilot extracts, natural ceramides (types 1, 2, 3, 4, 5 and 6), ceramides such as hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides and extracts containing sugar ceramides etc.

Examples of surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; Ethylene alkyl sulfate; Acyl N-, such as sodium cocoyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, lauroyl sarcosine triethanolamine, sodium methyl alanine lauroyl glutamate, etc. Methyl amino acid salts; Acyl amino acid salts such as sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoyl alanine triethanolamine; Oxyethylene alkyl ether acetates; succinate ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; Fatty acid glyceride sulfates such as sodium fatty acid glycerol sulfate; alkylbenzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; sulfosuccinic acid Alkyl ether sulfosuccinates such as disodium laureth, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; Salt; Alkyl naphthalene sulfonate; Alkane sulfonate; α-sulfo fatty acid methyl ester salt; Acyl isethionate; Alkyl glycidyl ether sulfonate; , Alkyl ether phosphates such as sodium monooleth phosphate; Alkyl phosphates such as potassium lauryl phosphate; Sodium caseinate; Alkyl aryl ether phosphates; Fatty acid amide ether phosphates; Phospholipids such as; carboxylic acid-modified silicone, phosphoric acid-modified silicone, anionic surfactants such as silicone-based anionic surfactants such as sulfate-modified silicone; laureth (polyoxyethylene lauryl ether), ceteth (poly oxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), beheneth (polyoxyethylene behenyl ether), isosteareth (polyoxyethylene isostearyl ether), octyldodeceth (polyoxyethylene octyldodecyl ether), etc. Polyoxyethylene alkyl ethers of various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ether; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated Castor oil and hydrogenated castor oil derivatives such as castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; Oxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene/polyoxypropylene cetyl ether, polyoxyethylene/polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene/polyoxypropylene monobutyl ether, Polyoxyethylene/polyoxypropylene hydrogenated lanolin, polyoxyethylene/polyoxypropylene alkyl ether such as polyoxyethylene/polyoxypropylene glycerin ether; polyoxyethylene/polyoxypropylene glycol; ) glycerol polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil, monocottonseed glycerin, glyceryl monoerucate, glyceryl sesquioleate, α, α' - Glyceryl fatty acid partial esters such as glyceryl pyroglutamate oleate, glyceryl monostearate malic acid; , 10, polyglyceryl-2 tristearate, polyglyceryl-10 destearate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 10, polyglyceryl-2 diisostearate (diisostearate diglyceryl), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl decaisostearate-10, polyglyceryl-2 oleate, 3, 4, 5, 6, the same 8, 10, polyglycerin fatty acid esters such as polyglyceryl-6 dioleate, polyglyceryl trioleate, polyglyceryl-10 decooleate; ethylene glycol mono fatty acid esters such as ethylene glycol monostearate; propylene glycol monostearate and the like Propylene glycol mono fatty acid ester; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid ester; maltitol partial fatty acid ester; maltitol ether; Sorbitan fatty acid esters such as stearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methylglucoside fatty acid ester, trehalose undecylenate Alkyl glucosides such as caprylyl glucoside; Alkyl polyglycosides; Lanolin alcohol; Reduced lanolin; Polyoxyethylene distearate, Polyethylene glycol diisostearate, Polyoxyethylene monooleate, Polyoxyethylene Polyoxyethylene fatty acid mono- and diesters such as dioleate; polyoxyethylene/propylene glycol fatty acid ester; Polyoxyethylene glycerin fatty acid ester such as oxyethylene monooleate; Polyoxyethylene sorbitan such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate Fatty acid ester; polyoxyethylene sorbitol fatty acid ester such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid ester ; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; Alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol, and batyl alcohol; polyoxyethylene alkylamine; tetrapolyoxyethylene/tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amide; coconut oil fatty acid monoethanolamide (cocamide MEA), Coconut Fatty Acid Diethanolamide (Cocamide DEA), Lauric Acid Monoethanolamide (Lauramide MEA), Lauric Acid Diethanolamide (Lauramide DEA), Lauric Acid Monoisopropanolamide (Lauramide MIPA), Palmitic Acid Monoethanolamide (Partamide MEA), Palmitin Fatty acid alkanolamides such as acid diethanolamide (partamide DEA) and coconut oil fatty acid methylethanolamide (cocamide methyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide and behenamine oxide; alkylethoxy Dimethylamine oxide; polyoxyethylene alkyl mercaptan; polyether-modified silicone such as dimethicone copolyol; Ionic surfactants; cationic surfactants include alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride and lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; Dialkyldimethylammonium chlorides such as stearyldimonium chloride and dicocodimonium chloride; fatty acid amide amines such as stearamidopropyldimethylamine and stearamidoethyldiethylamine and salts thereof; alkyl ether amines such as stearoxypropyldimethylamine and salts thereof or quaternary Salts; fatty acid amide type quaternary ammonium salts such as long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium ethyl sulfate and lanolin fatty acid aminopropylethyldimethylammonium ethyl sulfate; polyoxyethylene alkylamines and their salts or quaternary salts Alkylamine salts; Fatty acid amide guanidinium salts; Alkyl ether amine monium salts; Alkyltrialkylene glycol ammonium salts; Benzalkonium salts; Benzethonium salts; Dialkylmorphonium salts; Polyamine fatty acid derivatives; Silicone cations such as amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones surfactants; N-alkyl-N,N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N,N-dimethylamino acids such as cocamidopropyl betaine and lauramidopropyl betaine betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; Sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin; Phospholipids; Amphoteric surfactants such as silicone-based amphoteric surfactants; Polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid/methacrylate alkyl copolymers; Polymer interfaces such as various silicone-based surfactants activators and the like.

Polymer/thickening/gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, gum arabic, tara gum, tamarind, farcereran, karaya gum, tororo mallow, cara gum, tragacanth gum, pectin, pectic acid and sodium salt. salts such as alginic acid and sodium salts, mannan; starches of rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin , chitosan, agar, cassava extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, stearoxyhydroxypropylmethylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate Cellulose and its derivatives such as phosphate, cetyl hydroxyethyl cellulose, carboxymethyl cellulose and sodium salts thereof, methyl hydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethylammonium sulfate cellulose, crystalline cellulose, cellulose powder; soluble starch, carboxymethyl starch, methyl Starch polymers such as hydroxypropyl starch and methyl starch; starch derivatives such as hydroxypropyltrimonium chloride starch and corn starch aluminum octenyl succinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; (PVA), vinylpyridone/vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene/polyoxypropylene copolymer; (methacryloyloxyethyl carboxybetaine/alkyl methacrylate) copolymer, (acrylates/acrylic amphoteric methacrylic acid ester copolymers such as stearyl acid/methacrylic acid ethylamine oxide) copolymer; (dimethicone/vinyl dimethicone) crosspolymer, (alkyl acrylate/diacetone acrylamide) copolymer, (alkyl acrylate/diacetone acrylamide) copolymer AMP partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylic acid such as polyethyl acrylate Ester copolymer, carboxyvinyl polymer, polyacrylic acid and its salt such as sodium salt, acrylic acid/methacrylic acid ester copolymer; acrylic acid/methacrylic acid alkyl copolymer; cationized cellulose such as polyquaternium-10 , diallyldimethylammonium chloride/acrylamide copolymers such as polyquaternium-7, acrylic acid/diallyldimethylammonium chloride copolymers such as polyquaternium-22, acrylic acid/diallyldimethylammonium chloride/acrylamide copolymers such as polyquaternium-39, Acrylic acid/cationized methacrylic acid ester copolymer, acrylic acid/cationized methacrylic acid amide copolymer, acrylic acid/methyl acrylate/methacrylamidopropyltrimethylammonium chloride copolymer such as polyquaternium-47, methacryl chloride acid choline ester polymers; cationized polysaccharides such as cationized oligosaccharides, cationized dextran, guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymers; Copolymer with acid butyl copolymer, etc. Polymer emulsion such as acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethane and various copolymers; various silicones; various silicone copolymers such as acrylic-silicone graft copolymer; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin palmitate, dextrin myristate, etc. dextrin fatty acid ester; silicic anhydride, fumed silica (ultrafine silicic anhydride), aluminum magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sho sugar fatty acid esters, fructo-oligosaccharide fatty acid esters, and the like.

Solvents/propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol, and glycerin; Glycols; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl Glycol ethers such as ethers; Glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate and propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation Freon; LPG, dimethyl ether, carbon dioxide gas, and the like.

Antioxidants, reducing agents, and oxidizing agents include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and/or derivatives thereof; erythorbic acid and its derivatives; sulfites such as sodium sulfite; hydrogen sulfites such as sodium hydrogen sulfite; thiosulfates such as sodium thiosulfate; metabisulfite; thiotaurine, hypotaurine; cysteine hydrochloride, thioglycolic acid, cysteine, cysteamine; hydrogen peroxide, ammonium persulfate, sodium bromate, percarbonate and the like.

Preservatives, antibacterial agents, and chelating agents include hydroxybenzoic acid and its salts or esters such as methylparaben, ethylparaben, propylparaben, and butylparaben; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-diols such as 2-hexanediol; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and salts thereof; phenols; Acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenol, isopropylphenol, cresol, thymol, para Other phenols such as chlorophenol, phenylphenol, phenylphenol sodium; phenylethyl alcohol, photosensitive elements, antibacterial zeolites, silver ions; hydroxyethylethylenediamine triacetate such as pentetate (diethylenetriamine pentaacetate); phytic acid; phosphonic acid such as etidronic acid and salts such as sodium salt thereof; sodium oxalate; class; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, tartaric acid and the like.

pH adjusters, acids and alkalis include sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl- 1,3-propanediol, guanidine carbonate, ammonium carbonate, ammonia, aqueous ammonia, triethanolamine, dimethylamine, diethylamine, trimethylamine, triethylamine, triisopropanolamine, trisodium phosphate, disodium hydrogen phosphate, dihydrogen phosphate potassium, alkali metal hydroxides such as monoethanolamine, diethanolamine, triethanolamine, triisopropanolamine, isopropanolamine, diisopropanolamine, and polyethanolamine; alkalis such as tertiary alkylamines or primary, secondary and tertiary alkanolamines, citric acid, tartaric acid, lactic acid, glycolic acid, hydrochloric acid, nitric acid, sodium citrate, sodium lactate, succinic acid, Acids such as acetic acid, sodium acetate, fumaric acid, sulfuric acid, malic acid, phosphoric acid, alginic acid, polyglutamic acid, polyaspartic acid, starch-acrylic acid graft polymer, polyacrylic acid, polyvinyl acetate-crotonic acid copolymer, acetic acid Vinyl-(meth)acrylic acid copolymer, vinyl acetate-crotonic acid copolymer, polyvinylsulfonic acid, polyitaconic acid, styrene-maleic anhydride copolymer, acrylamide-acrylic acid copolymer, etc. Examples include polymers shown in FIG.

Powders and inorganic salts include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, and aluminum silicate. , barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, Dirt, metal soaps (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine blue, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, Zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine phlogopite, charcoal (charcoal, activated carbon, medicinal charcoal, Binchotan charcoal), fine particle composite powders, inorganic powders of various sizes and shapes such as gold and aluminum, or coloring agents for these inorganic powders (iron oxide-coated mica titanium, chromium oxide-coated mica titanium, konjo coated mica titanium, carmine-conjo coated mica titanium, gunjo coated mica titanium, etc.), and these are treated with silicone such as hydrogen silicone, cyclic hydrogen silicone, or other silane or various surface treatment agents such as titanium coupling agents. Inorganic powders such as powders hydrophobized or hydrophilic by hydrophobization; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine Resin powder, polyethylene terephthalate/polymethyl methacrylate laminate powder, polyethylene terephthalate/aluminum/epoxy laminate powder, urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders of various sizes and shapes and surface treatments Powder, organic-inorganic composite powder; salts containing sodium chloride such as table salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate , aluminum sulfate, aluminum sulfate/potassium (alum), aluminum/ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na, and 3Na phosphate phosphates, potassium phosphates, calcium phosphates, magnesium phosphates, and the like.

UV absorbers include para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxy para-aminobenzoic acid ethyl ester, N,N-diethoxy para-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid ethyl ester. Benzoic acid-based UV absorbers such as esters, N,N-dimethylpara-aminobenzoic acid butyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester; Anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid and salicylic acid UV absorbers such as sodium salts thereof, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl -2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxy Cinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Cinnamic acid-based UV absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and derivatives thereof;2, 4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-Methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' -phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, and other benzophenone UV absorbers; 3-(4'-methylbenzylidene)-d, l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'- t-octylphenyl)benzotriazole; 2-(2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentane-2- dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole , 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, hydantoin derivatives such as 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, phenylbenzimidasozole sulfonic acid, tele phthalylidendicane fursulfonic acid, drometrisol trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, leprotite, biotite, Permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxy Apatite, ceramic powder, bentonite, smectite, clay, mud, metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine blue, Prussian blue, carbon black , titanium oxide, fine and ultrafine titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic Inorganic powders of various sizes and shapes such as fluorine phlogopite, charcoal (charcoal, activated carbon, medicinal charcoal, bincho charcoal), fine particle composite powder, gold, aluminum, etc., and hydrogen silicone, cyclic hydrogen Inorganic powders such as powders made hydrophobic or hydrophilic by treatment with silicones such as silicones or various surface treatment agents such as other silanes or titanium coupling agents; starch, cellulose, nylon powder, polyethylene powder, polymethacryl Methyl acid powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, benzoguanamine resin powder, polyethylene terephthalate/polymethyl methacrylate laminate powder, polyethylene terephthalate/aluminum/epoxy laminate powder, urethane powder, silicone powder, Organic powders of various sizes and shapes such as Teflon (registered trademark) powders, surface-treated powders, organic-inorganic composite powders; Salts containing sodium chloride such as table salt, ordinary salt, rock salt, sea salt, natural salt; Potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, potassium aluminum sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate , zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na, and 3Na phosphate, potassium phosphates, calcium phosphates, magnesium phosphates, guaiazulene, shikonin, baicalin, baicalein, berberine, scutellaria root, and bark , yarrow, aloe, velvet holly, burdock, salvia, horse chestnut, safflower, rice bran, and the like.

Whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; Ascorbic acid fatty acid esters such as tetraisopalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid sulfates, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as; kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile, oil-soluble licorice, Coptis, Scutellaria root, Hypericum perforatum, dead nettle, Kudzu root, chamomile, chamomilla, licorice, Gennosho, rice bran, Nishikawayanagi, saishin, peony, artichoke thistle, calendula officinalis, rose fruit, hamamelis, peony bark, saxifrage, wild thyme and other plant extracts, royal jelly, royal jelly extract, etc. be done.

Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, B vitamins such as choline; vitamin Cs such as ascorbic acid and salts thereof such as sodium; vitamin D; Vitamin E such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate salts such as ascorbyl phosphate sodium salt and ascorbyl phosphate magnesium salt, ascorbic acid tetra Ascorbic acid fatty acid esters such as isopalmitate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbyl ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside, and fatty acid esters thereof , ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopheryl acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate; and tocotrienols.

Anti-inflammatory agent, anti-inflammatory agent, hair growth agent, blood circulation promoter, stimulant, hormones, anti-wrinkle agent, anti-aging agent, firming agent, cooling agent, warming agent, wound healing accelerator, stimulant, pain reliever Glycyrrhizic acid and its derivatives, glycyrrhizic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, calamine, indomethacin, zinc oxide, aluminum chloride, hydrocortisone acetate, prednisone, diphedramine hydrochloride, and chlorphenyne maleate as agents and cell activators. Ramin: plant extracts and tinctures such as peach leaf, mugwort leaf, white birch, japonica, hot pepper tincture, ginger tincture, ginger extract, cantharis tincture; cepharanthine, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid and nicotinic acid amide, benzyl nicotinate, inositol hexanicotin derivatives such as nitrate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and its glycosides, minoxidil; estradiol, estrone, ethinyl estradiol, Cortisone, hydrocortisone, prednisone; retinols, retinoic acids, tocopheryl retinoate; lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and derivatives such as glycosides and esters thereof, hydroxycapric acid, long-chain α-hydroxy fatty acids , long-chain α-hydroxy fatty acid cholesteryl and other α- or β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; creatine; ceramides, sphingosines; caffeine, xanthine etc. and derivatives thereof; antioxidants and active oxygen scavenging agents such as coenzyme Q10, carotene, lycopene, astaxanthin; catechins; flavones such as quercetin; isoflavones; Acids, polyphenols such as apple polyphenol; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; , gingerol; flavoring substances such as menthol, camphor, cedrol, and derivatives thereof; capsaicin, vanillin, etc. and their derivatives; insect repellents such as diethyltoluamide;

Antipruritics, exfoliants, keratolytics, antiperspirants, cooling agents, astringents, enzymes, nucleic acids such as diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitors; salicylic acid, sulfur, resorcinol, Selenium sulfide, pyridoxine; chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenolsulfonate; menthol, methyl salicylate, etc.; citric acid, tartaric acid, lactic acid, aluminum/potassium sulfate, tannic acid; superoxide dismutase, catalase, lysozyme chloride , lipase, papain, pancreatin, protease; ribonucleic acid and its salts, deoxyribonucleic acid and its salts, disodium adenosine triphosphate.

Fragrances include acetylcedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, iso-e-super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecenal, Estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl Acetate, Geranyl Acetate, Dimethylbenzylcarbyl Acetate, Styraryl Acetate, Cedryl Acetate, Terpinel Acetate, pt-Butylcyclohexyl Acetate, Betiveryl Acetate, Benzyl Acetate, Linalyl Acetate, Isopentyl Salicylate, Benzyl Salicylate, Sandalwood Oil, Santa roll, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineol, cinnamaldehyde, Styrax resinoid, cedarwood oil, cedren, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-nonadienol, nonalactone , patchouli alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil , vetiverol, peppermint oil, pepper oil, heliotropine, bergamot oil, benzyl benzoate, borneol, myresinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-mentone, eucalyptus oil, β-ionone, Lime oil, lavender oil, D-limonene, linalool, lyral, lyreal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils such as synthetic fragrances, natural fragrances and various compounded fragrances.

Colorants/colorants/dyes/pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203 and Blue No. 204. , Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red No. 104-1 , Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213 , Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1 , Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505 , Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1 , Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow Legal dyes such as No. 407 and Yellow No. 5; Other acid dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red Nitro dyes such as 3,4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26; disperse dyes; titanium dioxide, zinc oxide Inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and ocher; Inorganic black pigments such as titanium suboxide; Inorganic purple pigments such as mango violet and cobalt violet; Inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; Inorganic blue pigments such as ultramarine blue and Prussian blue; Titanium-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, pearl pigments such as fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; surface-treated inorganic and Metal powder pigments; Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow 401 Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Organic pigments such as yellow No. 203, green No. 3, blue No. 1 zirconium, barium or aluminum lakes; surface-treated organic pigments; , quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin and other naphthoquinones, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, rutin and other natural pigments and dyes; p-phenylenediamine, toluene-2, Oxidation dyes such as 5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine and salts thereof intermediates and couplers; autoxidative dyes such as indoline; dihydroxyacetone and the like.

Examples of water include ordinary water, purified water, hard water, soft water, natural water, deep sea water, hot spring water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, cluster water, and the like.

The extracts of plants, animals, and microorganisms used in the present invention contain water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, and isobutanol, or water-containing lower alcohols, propylene glycol, 1 , 3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1, Polyhydric alcohols or hydrous polyhydric alcohols such as 3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 100,000), acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene , chloroform, carbon tetrachloride, phenol, toluene and other organic solvents, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.), and preferably one or more selected from water, ethanol and 1,3-butylene glycol. . However, if the inclusion of a solvent is not desirable depending on the application, use only water, or perform extraction using a highly volatile solvent that makes it easy to remove the solvent after extraction, and dissolve in water, etc. after removing the solvent. Such a method is also possible.

As for the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, and the extraction time can also be arbitrarily set for various raw materials and solvents to be used. The temperature of the solvent can be arbitrarily set within the range of -4°C to 100°C. Also, the weight ratio of the solvent to the raw material can be arbitrarily set, for example, within the range of 4:1 to 1:100 (raw material:solvent), with a weight ratio of 1:1 to 1:20 being particularly preferred.

Furthermore, after solvent extraction, it is also possible to perform a further purification operation as appropriate. etc.) decomposition by addition, fermentation or metabolic conversion by microorganisms, component adsorption by ion exchange resin, activated carbon, diatomaceous earth, etc., various separation modes (ion exchange, hydrophilic adsorption, hydrophobic adsorption, size exclusion, ligand exchange , affinity, etc.), filtration using filter paper, membrane filters, ultrafiltration membranes, etc., pressurization or pressure reduction, heating or cooling, drying, pH adjustment, deodorization, decolorization, long time can be exemplified, and it is possible to arbitrarily select and combine these for treatment.

Similarly, metabolites of plants, animals, and microorganisms used in the present invention include commonly used microorganisms such as eubacteria, archaea, protists, fungi, etc. (lactic acid bacteria, yeasts, natto bacteria, koji bacteria, It may be fermented or metabolically converted by "mushrooms, etc.", and optionally processed according to the form (for example, pulverization, milling, washing, hydrolysis, purification, compression, extraction, fractionation, etc.) A treatment that selects and combines drawing, filtration, drying, sterilization, pH adjustment, deodorization, decolorization, etc.) can be performed.

The type of the cosmetic composition of the present invention is not particularly limited, but it is an external preparation such as a hair cosmetic, a basic cosmetic, a make-up cosmetic, an aromatic cosmetic, a body cosmetic, or an oral cosmetic. The cosmetic composition of the present invention can be produced according to a conventional method.

To explain the types of the cosmetic composition of the present invention in more detail, hair cosmetics include shampoos such as oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, rinse-integrated shampoos; , treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tick, hair cream, hair blow, split end coat, hair oil , permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color aftertreatment, perm pretreatment, perm aftertreatment, hair manicure, and hair restorer.

Basic cosmetics include cleansing foam, cleansing powder, facial cleansing powder, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask; Lotions such as lotions; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizing emulsion, massage lotion, cleansing lotion, protective emulsion, sun protection, sun protector, UV care Emulsion such as milk, sunscreen, make-up lotion, keratin smoother, elbow lotion, hand lotion, body lotion; emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, make-up cream , base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream; Soaps such as liquid soaps, shaving soaps, and synthetic toilet soaps; packs and masks such as peel-off packs, powder packs, washing packs, oil packs, and cleansing masks; essences such as moisturizing essences, whitening essences, and anti-ultraviolet essences; and liposome lotions are preferred.

Preferred examples of makeup cosmetics include powders/powder powders, foundations, lipsticks, lip glosses, blushers, eyeliners, mascara, eyeshadows, eyebrows, eyebrows, nail enamels, enamel removers, and nail treatments.

Perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, paste perfume, fragrant powder, perfumed soap, body lotion, and bath oil are preferable examples of fragrant cosmetics.

Body cleansing agents such as body shampoo; deodorant cosmetics such as deodorant lotion, deodorant powder, deodorant spray, and deodorant stick; Repellers are preferred.

In addition, external cosmetics (external preparations) include ointments, patches, lotions, liniments, liquid coatings, poultices, plasters, tapes, sheets, patches, aerosols, and the like. It can also be used as It can also be used as oral cosmetics such as toothpaste and mouthwash, sanitary products, sanitary cottons, wet tissues and the like.

The formulation of the cosmetic composition of the present invention includes emulsified cosmetics such as oil-in-water (O/W) type, water-in-oil (W/O) type, W/O/W type, and O/W/O type. Cosmetics, Oily Cosmetics, Solid Cosmetics, Liquid Cosmetics, Paste Cosmetics, Stick Cosmetics, Volatile Oil Cosmetics, Powder Cosmetics, Jelly Cosmetics, Gel Cosmetics, Paste Cosmetics , emulsified polymer-type cosmetics, sheet-like cosmetics, mist-like cosmetics, spray-type cosmetics and the like are preferred.

The type of the food and drink composition of the present invention is not particularly limited. It is eaten as a food, a nutritionally balanced food, a food with health claims, a food for specified health uses, a food with nutrient function claims, a food with function claims, a supplement, and a food ingredient. The food/beverage composition of the present invention can be produced according to a normal method.

Food and drink compositions can be used as they are or in addition to various nutritional supplements, nutritive tonics, recovery from fatigue, constitutional improvement, etc., and can be incorporated into food and drink as nutritional supplements, health supplements, nutritious foods, and foods with health claims. , Food for Specified Health Uses, Food with Nutrient Function Claims, Food with Function Claims, Supplements, and food ingredients. For example, after adding the appropriate auxiliaries described above, a conventional means may be used to form a form suitable for food, such as granules, granules, tablets, capsules, pastes, etc., and may be used for food. In addition, various foods, for example, processed fish paste products such as kamaboko and chikuwa, livestock products such as sausages and ham, western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, noodles such as buckwheat, sauces, soy sauce, sauces, Seasonings such as sugar, honey, powdered candy, starch syrup, spices such as curry powder, mustard powder, pepper powder, jams, marmalades, chocolate spreads, pickles, greens, furikake, canned and bottled products of various vegetables and fruits, etc. processed vegetables and fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey drinks, soft drinks, alcoholic beverages, liquid foods, etc. It can also be used as pet food, animal and plant feed, and the like. Moreover, it can also be used as an oral drug, a quasi-drug, and the like.

In addition, in food and drink compositions, in addition to effects such as nutritional supplementation, recovery from fatigue, tonic, and health benefits such as cell activation (anti-aging), taste improvement, color tone and aroma, imparting luster, stabilization, and thickening It can be used for purposes such as Furthermore, in addition to this, various medicinal effects of known nuclear raw materials are expected, and by combining these, the effects aimed at by the present invention can be enhanced, and multifunctional drugs can be obtained. It is also possible to make a product expecting a good effect.

In addition to these, the Standards for Cosmetic Ingredients, Standards for Ingredients by Cosmetic Type, List of Ingredients Displayed by the Japan Cosmetic Industry Association, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Standards for Quasi-drug Ingredients, Japanese Pharmacopoeia, Pharmaceutical Additives Ingredients listed in standards, food additives compendium, etc., and Japanese and foreign patent publications and patent publications (published publications / republished publications) Including), known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc. can be contained in known international patent classification combinations and blending ratios and amounts.

EXAMPLES The present invention will be described in more detail with reference to Examples below, but the present invention is not limited to these.

(Production example 1)
100 g of molasses (Baikodo Co., Ltd.) was mixed with 250 g of purified water (about 30° C.), stirred and dispersed, and filtered to obtain about 300 g of molasses extract.

(Production example 2)
After 100 g of sake lees (Nakano BC Co., Ltd.) was mixed and dispersed with stirring in 150 g of purified water (about 30° C.), the mixture was filtered to obtain about 200 g of sake lees extract.

(Production example 3)
100 g of the molasses extract of Production Example 1 and 100 g of the sake lees extract of Production Example 2 were mixed, stirred and dispersed, and filtered to obtain about 150 g of the molasses-sake lees mixed extract.

(Production example 4)
100 g of molasses (Baikodo Co., Ltd.) and 25 g of sake lees (Nakano BC Co., Ltd.) were mixed, stirred and dispersed, and then filtered to obtain about 100 g of molasses-sake lees mixed extract.

(Test 1) Moisturizing effect The skin moisture content was measured using a skin moisture distribution/form measuring device "Moisture Map MM100 (manufactured by Courage + Khazaka)".
"Test method and evaluation method"
The composition was applied to the inside of the forearm of 6 adult men and women (ages 20 to 50) twice a day for 5 minutes, and after 1 week, the skin moisture content was measured using the above skin moisture distribution/morphology analyzer. Assuming that the relative value is 100, a numerical value larger than 100 means that the skin moisture content is large. The results are shown in FIG.
As a sample, a lotion containing 1% of the molasses sake lees mixed extract obtained in Production Example 4 of the present invention and diluted with purified water was used, and as a control, purified water was applied under the same conditions.

(Test results)
As shown in FIG. 1, the lotion containing 1% of the molasses-sake lees mixed extract of the present invention showed a relative value of 120, indicating a skin moisture content greater than 100, confirming its moisturizing action. In addition, moisturizing of the skin can also be expected. The purified water used as a control showed a low relative value of 90, showing no moisturizing effect.

(Test 2) Skin Texture Improving Action Skin texture density was measured using a skin moisture distribution/morphology measuring device "MoistureMap MM100 (manufactured by Courage+Khazaka)".
"Test method and evaluation method"
The composition was applied to the inside of the forearm of 6 adult men and women (ages 20 to 50) twice a day for 5 minutes, and after one week the number of skin texture intersections was measured. It was measured using the skin moisture distribution/morphology measuring device described above. Assuming that the relative value is 100, a numerical value greater than 100 means that the texture density of the skin is high. The results are shown in FIG.
As a sample, a lotion containing 1% of the molasses sake lees mixed extract obtained in Production Example 4 of the present invention and diluted with purified water was used, and as a control, purified water was applied under the same conditions.

(Test results)
As shown in FIG. 2, the lotion containing 1% of the molasses sake lees mixed extract of the present invention showed a relative value of 106, which means that the skin texture density was considerably higher than 100, and the skin texture improving effect was confirmed. Ta. Moreover, prevention of skin drying can also be expected. The purified water used as a control showed a low relative value of 98, showing no improvement in skin texture.

(Test 3) Effect of increasing hair moisture content “test method and evaluation method”
After each treated sample is placed in a thermo-hygrostat at 20°C and 84% for 24 hours, it evaporates at 65°C for 40 minutes with an infrared moisture meter FD-720 (manufactured by Kett Science Laboratory Co., Ltd.). Primary transpiration After measuring the water content (%), immediately measure the secondary evaporated water content (%) that evaporates at 180°C for 30 minutes. The sum of the primary evaporated water content and the secondary evaporated water content was defined as the hair moisture content (%), and the ratio of the secondary moisture content to the hair moisture content was obtained. "Reference: J. Soc. Cosmet. Chem. Jpn. 40 (4) 300-306 (2006)" The results are shown in FIG.
Among the various samples, healthy hair (human hair (100% black hair manufactured by Beaulux) was applied with 2 pushes of 10% sodium laureth sulfate using a pump foamer, washed, and then dried with a dryer), damaged hair (healthy hair) 6.5% ammonium thioglycolate / 0.5% ammonia / pH 9.2 / immersed in 50°C perm solution 1 for 1 hour), and hair treated with the present invention (damaged hair, production example 4 of the present invention) The lotion containing 1% of the molasses sake lees mixed extract obtained in 1. was immersed for 10 minutes and then dried with a dryer).

(Test results)
As shown in FIG. 3, the hair treated with the product of the present invention has a significantly higher secondary moisture content than the damaged hair, and exhibits a secondary moisture content that is almost the same as that of the healthy hair. , it can be confirmed that the moisture content of the hair has increased. That is, the higher the moisture content in the hair, the more moisture is retained in the hair, and it can be inferred that the hair treated with the product of the present invention has a high moisturizing property.

(Test 4) Hair cuticle protection action "test method and evaluation method"
For each sample (healthy hair, damaged hair, hair treated with the present invention), using a scanning microscope JCM-5700 manufactured by JEOL Ltd., by observing at 1000 times, the state of the cuticle on the hair surface (repaired hair) effect) was confirmed. The results are shown in FIGS. 4-6.
In each sample, healthy hair is human hair in a natural state, damaged hair is human hair that has been heat-treated at 65°C for 40 minutes, and hair treated with the product of the present invention is treated in Production Example 4 before the healthy hair is heat-treated. A test was carried out using a sample coated with a solution containing 1% of the obtained molasses sake lees mixed extract.

(Test results)
As shown in FIGS. 4 to 6, it can be confirmed that the hair treated with the product of the present invention has a uniform cuticle on the surface of the hair and the size of each cuticle film is uniform to cover and protect the hair. In comparison, although the surface of healthy hair is protected by cuticles, the size of individual cuticle membranes is uneven. It's getting to the point of falling. In other words, the hair treated with the product of the present invention can be expected to protect the cuticle of the hair and have the effect of repairing damage to the hair.

(Test 5) Foam quality improvement action 1
"Test method and evaluation method"
As a foaming test, 50 mL of each sample mixed with cocoyl glutamic acid K (final concentration 0.3%) was stirred for 5 seconds with a tabletop grinder (manufactured by IWATANI), left to stand for 1 minute, and then the foam volume (mL) was measured. It was measured. The foaming property of each sample is shown as a relative value, with the foam volume (mL) of the control solution being 100%.
The sample was a solution containing 5% of the product of the present invention, "Cocoyl glutamic acid K (final concentration: 0.3%), 5% of the mixed extract of molasses sake lees obtained in Production Example 4, 94% of purified water," and 1% of the product of the present invention. Mixed solution "cocoyl glutamic acid K (final concentration 0.3%), 1% mixed extract of molasses sake lees obtained in Production Example 4, purified water 98%", glycerin 1% mixed solution "cocoyl glutamic acid K (final concentration 0 .3%), 1% glycerin, 98% purified water", and a control solution "K cocoyl glutamate (final concentration 0.3%), 99% purified water". The results are shown in FIG.

(Test results)
The results are shown in FIG. 7, and both the products of the present invention (1% compounded solution or 5% compounded solution) have a high relative value of foaming property, which is greatly increased, and it can be confirmed that the foaming ability is high. Ta. In addition, the 1% glycerin mixed solution did not increase the relative value of the foamability.

(Test 6) Foam quality improvement action 2
"Test method and evaluation method"
As a foam viscosity test, a commercially available facial cleanser mixed with each sample was foamed in a foam container, and the viscosity (mPa·s) was measured with a Brookfield viscometer in a state in which a 100 mL screw tube bottle was filled with foam. The viscosity (mPa·s) of the control solution was defined as 100%, and the foam viscosity of each sample was shown as a relative value.
The samples were a 1% compounding solution of the product of the present invention "99% commercial facial cleanser, 1% compounded with molasses sake lees mixed extract obtained in Production Example 4", and a 1% glycerin compounding solution "99% commercial facial cleanser, 1% glycerin". , using a control solution "99% commercially available facial cleanser, 1% purified water". The results are shown in FIG.

(Test results)
As shown in FIG. 8, the foam viscosity of the product of the present invention (1% solution) was significantly increased, confirming that the viscosity of the foam was high. High foam viscosity means that the effect of sustaining foam can be expected. No increase in foam viscosity was observed in the 1% glycerin mixed solution.

(Test 7) Deodorant action "test method and evaluation method"
In the deodorization test, various malodorous substances described below were mixed with each sample, and using a detector tube (manufactured by Gastech), the deodorizing rate of various malodorous substances was measured.
Various malodorous substances are ammonia (using 10-fold dilution of 28% ammonia water), acetic acid (using 10-fold dilution of glacial acetic acid), methyl mercaptan (using methyl mercaptan standard solution (Wako Pure Chemical) undiluted solution), n - valeric acid (n-valeric acid (Tokyo Kasei Kogyo) 10-fold dilution was used).
The samples were a 50% blended solution of the product of the present invention (50% blend of molasses sake lees mixed extract obtained in Production Example 4, 50% purified water), a 5% blended solution of the product of the present invention (molasses sake lees obtained in Production Example 4). 5% mixed extract, 95% purified water), 1% mixed extract of the present invention (1% molasses sake lees mixed extract obtained in Production Example 4, 99% purified water), 0.5% of the present invention A test was conducted using a compounded solution (containing 0.5% of the molasses sake lees mixed extract obtained in Production Example 4 and 99.5% of purified water).

(Test results)
As shown in Table 1, it was confirmed that the solution containing the molasses sake lees mixed extract of the present invention deodorized ammonia, acetic acid, methyl mercaptan, and n-valeric acid at all various concentrations.

(Test 8) Cell Activation Action The present inventor decided to evaluate the cell proliferation action based on human skin fibroblasts.
"Test method and evaluation method"
4×10 ³ cells/well of fibroblasts (KF-4009 manufactured by Kurabo Industries) were planted in a 96-well plate and precultured for 24 hours. After that, the medium was replaced with a fresh medium, and the molasses-sake lees mixed extract (the molasses-sake lees mixed extract obtained in Production Example 4) adjusted to concentrations of 0.01%, 0.1%, and 0.5% was added to the medium, respectively. added inside. After culturing the cells for 3 days, the absorbance at 450 nm was measured using Cell counting kit-8 (DOJINDO). At that time, the cell proliferation rate of the control group to which purified water was added was set at 100%, and the cell proliferation rate (%) was calculated for each concentration. As the culture solution, a DMEM medium containing 5% FBS (manufactured by ThermoTrace) was used as a preculture medium, and a DMEM medium containing 0.25% FBS was used as a medium for this test, and 5% CO was used. ^2. Cultured at 37°C. The results are shown in Table 2.

(Test results)
The results are as shown in Table 2. Compared with the control group at 100%, the cell growth rate of the molasses sake lees mixed extracts containing 0.01%, 0.1%, and 0.5% concentrations of the product of the present invention was as follows: The molasses sake lees mixed extract of the present invention shows a high numerical value of 114.5%, 128.9%, and 137.1% in order, and it can be confirmed that the molasses sake lees mixed extract of the present invention has a fibroblast proliferation-promoting effect, and a cell activation effect can be expected. .

(Test 9) Antioxidant action The present inventors evaluated the antioxidant action based on the DPPH radical scavenging activity test.
"Test method and evaluation method"
1%, 2%, 3%, 4%, 0.1M acetate buffer (CH3COOH/CH3COONa, pH 5.5) was added and stirred. 2.0 mL of 0.25 mM DPPH solution was added thereto, stirred, and allowed to stand at room temperature for 10 minutes. After standing, the absorbance at ABS 525 nm was measured, and the radical scavenging rate was calculated from Equation 1. As a comparative sample, purified water was prepared as a control, and ascorbic acid (manufactured by Kishida Co., Ltd.) adjusted to a concentration of 0.1% was prepared as a positive control under the same conditions and used for the test. The results are shown in Table 3.

(Number 1)
Radical scavenging rate (%) = (CS) / C × 100
C: absorbance of control - absorbance of positive control S: absorbance of test sample - absorbance of positive control

(Test results)
The results are shown in Table 3. The radical scavenging rates of the molasses sake lees mixed extracts containing 1%, 2%, 3%, 4% and 5% of the product of the present invention were 43.3% and 73.6%, respectively. , 93.2%, 98.4%, and 98.8%, indicating that the molasses-sake lees mixed extract of the present invention has a DPPH radical scavenging rate action and is expected to have an antioxidant action.

(Test 10) Melanogenesis inhibitory activity test The present inventor decided to evaluate melanogenesis inhibitory activity based on B16 melanoma cells.
"Test method and evaluation method"
20×10 ⁴ B16 melanoma cells were implanted in a 60 mm plastic petri dish and precultured for 24 hours. Then, it was transferred to a fresh medium, and 50 ul/well of molasses-sake lees mixed extract (molasses-sake lees mixed extract obtained in Production Example 4) adjusted to concentrations of 0.1% and 1.0% was added to the culture medium. and incubate for 3 days. A MEM medium containing 5% fetal bovine serum (manufactured by ThermoTrace) was used as the culture solution, and the cells were cultured under the conditions of 5% CO ² and 37°C.
Next, the culture-treated cells are treated with trypsin, dissolved by heating with a 1N-NaOH, 10% DMSO solution, and the absorbance at 420 nm is measured. Instead of the sample, distilled water was used as a control and arbutin (manufactured by Sigma) was used as a positive control, and the cells to which the sample was added at the same time were subjected to the MTT reduction method (Tim Mosmann; Journal of Immunological Methods p55-63 (1983). Reference), and the MTT-reducing activity of the sample-loaded cells was calculated using the MTT-reducing activity of the blank cells as 1 unit. The amount of melanin in the sample was calculated as absorbance/MTT reduction activity (1 unit), and the inhibition rate (%) relative to the amount of melanin produced in blank cells was determined by Equation 2. The results are shown in Table 4.

(Number 2)
Melanin production inhibition rate (%) = {1-(sample melanin amount/blank melanin amount)} x 100

(Test results)
As shown in Table 4, the melanin formation inhibition rate of the molasses sake lees mixed extracts containing 0.1% and 1% concentrations of the product of the present invention were 43.9% and 47.3%, respectively. It can be confirmed that the molasses sake lees mixed extract of the present invention has an inhibitory effect on melanogenesis in B16 melanoma cells, and is expected to have a whitening effect.

(Test 11) Effect of Improving Usability A lotion containing 1% of the molasses sake lees mixed extract obtained in Production Example 4 of the present invention was prepared, and the effects of actual use were examined. The use test was conducted by using a panel of 20 adult men and women (ages 20 to 50), taking an appropriate amount of the lotion twice daily, morning and night, and applying it over the entire face for four weeks. As a control, a lotion containing 1% glycerin was applied under the same conditions as above, and the same procedure was performed.
In addition, the evaluation items are "dryness of the entire face", "dryness of the eyes", "tightness after washing the face", "open pores", "darkness of the entire face", "dark circles under the eyes", "fine wrinkles around the eyes", "tension of the skin", " Skin condition, moist feeling, smooth skin feeling, and makeup application were evaluated, and the skin condition after application of the sample and before the test was evaluated for the following feeling during use.
Same as before test: 0 points, slightly better than before test: 1 point, slightly better than before test: 2 points, relatively better than before test: 3 points, better than before test Very good: 4 points, much better than before the test: 5 points, slightly worse than before the test: -1 point, slightly worse than before the test: -2 points, relatively better than before the test Bad: -3 points, much worse than the state before the test: -4 points, much worse than the state before the test: -5 points. .
In addition, the composition of the lotion used in the usability improvement test, a lotion containing 1% of the molasses sake lees mixed extract obtained in Production Example 4 (water 88.5%, propanediol 10.445%, caprylhydroxamic acid 0.055% %, molasses sake lees mixed extract obtained in Production Example 4 1%), object: lotion containing 1% glycerin (88.5% water, 10.445% propanediol, 0.055% caprylhydroxamic acid, 1% glycerin)

(Test results)
As shown in Table 5, the lotion containing 1% of the molasses sake lees mixed extract of the present invention was evaluated for the evaluation items "dryness of the entire face", "dryness around the eyes", "tight feeling after washing", "open pores", and "darkness of the entire face". ”, “dark circles under the eyes”, “fine wrinkles around the eyes”, “skin tension”, “skin tone”, “skin moistness”, “skin smoothness”, and “makeup glue” are all evaluated higher than the target lotion. was confirmed.

(Test 12) Sugar content and preservation efficacy test of molasses sake lees mixed extract The pH and Brix value of the molasses sake lees mixed extract obtained in Production Example 4 and refined honey as a comparative control were measured. The Brix value was measured using an Abbe refractometer (NAR-3T: manufactured by Atago Co., Ltd.). Table 6 shows the results.

Furthermore, a preservative efficacy test was performed by adding the following test bacterial solution to this sample.

"Test method and evaluation method"
(1) Standard bacterial mixture Escherichia coli NBRC3972
Pseudomonas aeruginosa (Pseudomonas aeruginosa NBRC13275)
Staphylococcus aureus NBRC13276
(2) Fungal mixture Aspergillus brasiliensis NBRC9455
Candida (Candida albicans NBRC1594)
Blue mold (Penicillium citrinum NBRC6352)
Aureobacidium pullulans NBRC6353

A 20 g sample was placed in two sterilized vials, and (1) standard bacterial mixture and (2) fungal mixture were each inoculated at 1% by volume (0.2 mL). The sample inoculated with (1) was stored at 30°C, and the sample inoculated with (2) was stored at 25°C. The number of viable bacteria was measured by the SCDLP agar medium pour method for bacteria (1), and by the GPLP agar medium pour method for fungi (2). Table 7 shows the number of bacteria in the inoculated test bacterial solution and the change over time in the number of these bacteria in the sample.

Next, three types of samples prepared by adding various preservatives to the molasses sake lees mixed extract obtained in Production Example 4 were subjected to a preservative efficacy test in the same manner, and the results are shown in Table 8 below. . Sodium benzoate is added to molasses-sake lees mixed extract B to be 0.1% by mass, molasses-sake lees mixed extract P is added polylysine to 0.1% by mass, and molasses-sake lees mixed extract Z is , 1% by mass (a mixture containing 92.5% by mass of caprylhydroxamic acid and 7.5% by mass of propanediol) was added.

(Test results)
As shown in Tables 7 and 8, no growth of standard bacteria or fungi was observed in the externally added test bacterial solution for any of the samples, and the number of bacteria decreased during the storage period at room temperature. Compared to the purified honey used as a comparison control, the bacterial count reduction rate in the molasses sake lees mixed extract is slightly lower (Table 7), but it was found that the addition of preservatives has a growth inhibitory effect greater than that of purified honey. (Table 8).

(Test 13) Viscosity measurement of molasses sake lees mixed extract The viscosity of the molasses sake lees mixed extract (2 lots) prepared in the same manner as in Production Example 4 was measured using a Brookfield viscometer B8M (Tokyo Keiki) rotor No. 2 at 20° C. and 12 rpm for 5 minutes, the results were 720 mPa·s and 1220 mPa·s, respectively.

(Prescription Examples) Production of Cosmetic Compositions or Food and Beverage Compositions Preparations of various dosage forms according to the present invention were produced. The formulation examples are shown below, but each formulation example can be produced by a conventional method in the production of each product, and only the compounding amount is shown. The present invention is not limited to these.

(Prescription example 1) Emulsion mass%
1. Squalane 5.0
2. Cetanol 1.5
3. Polyoxyethylene (20) sorbitan monooleate 2.0
4.1,3-butylene glycol 1.0
5. Sodium malate 1.0
6. Molasses sake lees mixed extract of Production Example 3 of the present invention 5.0
7. Remaining purified water 100

(Prescription Example 2) Emulsion mass%
1. Squalane 5.0
2. Cetanol 1.5
3. Polyoxyethylene (20) sorbitan monoole 2.0
4.1,3-butylene glycol 1.0
5. Sodium malate 1.0
6. Molasses sake lees mixed extract of Production Example 4 of the present invention 5.0
7. Remaining purified water 100

(Prescription example 3) Hair lotion mass%
1. Ethanol 50.0
2. Polyoxyethylene (50EO) hydrogenated castor oil 3.0
3.1,3-butylene glycol 5.0
4. Molasses sake lees mixed extract of Production Example 3 of the present invention 5.0
5. Remaining purified water 100

(Prescription Example 4) Hair lotion mass%
1. Ethanol 50.0
2. Polyoxyethylene (50EO) hydrogenated castor oil 3.0
3.1,3-butylene glycol 5.0
4. Molasses sake lees mixed extract of Production Example 4 of the present invention 5.0
5. Remaining purified water 100

(Prescription example 5) Supplement (soft capsule)
The molasses-sake lees mixed extract of Production Example 4 of the present invention was filled in a soft capsule shell composed of the following components by a conventional method to obtain soft capsules weighing 300 mg each.
Contents 40 mg of molasses sake lees mixed extract of Production Example 4 of the present invention
Edible oil 130 mg
Shell Gelatin 100mg
30 mg of glycerin

(Prescription example 6) Supplement (soft capsule)
The molasses-sake lees mixed extract of Production Example 3 was filled in a soft capsule shell composed of the following components by a conventional method to obtain soft capsules weighing 300 mg each.
Contents 40 mg of molasses sake lees mixed extract of Production Example 4 of the present invention
Edible oil 130 mg
Shell Gelatin 100mg
30 mg of glycerin

(Prescription Example 7) Emulsion mass%
1. Squalane 5.0
2. Olive oil 5.0
3. Jojoba oil 5.0
4. Cetanol 1.5
5. Glycerin monostearate 2.0
6. Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) sorbitan monooleate 2.0
8.1,3-butylene glycol 1.0
9. Glycerin 2.0
10. Sodium malate 1.0
11. Molasses sake lees mixed extract of Production Example 4 of the present invention 5.0
12. Preservative (paraoxybenzoic acid ester) Appropriate amount 13. Perfume appropriate amount 14. Remaining purified water 100

(Prescription Example 8) Milky lotion for whitening mass%
1. Squalane 8.0
2. Jojoba oil 7.0
3. Cetyl alcohol 2.0
4. Glycerin monostearate 2.0
5. Polyoxyethylene (20) cetyl ether 3.0
6.1,3-butylene glycol 1.0
7. Glycerin 1.0
8. Molasses sake lees mixed extract of Production Example 4 of the present invention 3.0
9. Antiseptic (methyl paraoxybenzoate) Appropriate amount 10. Remaining purified water 100

(Prescription Example 9) Cold cream mass%
1. Bleached Beeswax 11.0
2. Liquid paraffin 22.0
3. Lanolin 10.0
4. Olive oil 5.0
5. Chamomile oil 5.0
6. palm oil 5.0
7. Borax 0.5
8. Lemongrass leaf or stem extract 2.0
(Ethanol: 1,3-butylene glycol = 1:1 extraction solvent)
9. Yarrow whole plant extract 2.0
(Ethanol: 1,3-butylene glycol = 1:1 extraction solvent)
10. Raw sugar sake lees mixed extract of the present invention 3.0
11. Dipotassium glycyrrhizinate 0.1
12. Preservative (Acrynol) 0.1
13. Perfume (lavender water) Appropriate amount 14. Remaining purified water 100

(Prescription Example 10) Emollient cream mass%
1. stearic acid 2.0
2. Stearyl alcohol 7.0
3. Reduced Lanolin 2.0
4. Squalane 5.0
5. Octyldodecanol 6.0
6. Polyoxyethylene cetyl ether (25E.3.0
7. Lipophilic glyceryl monostearate 2.0
8. Propylene glycol 2.0
9.1,2-pentanediol 2.0
10. Perilla leaf 50% propylene glycol extract 2.0
11. Pig placenta enzymatic decomposition solution 1.0
12. Raw sugar sake lees mixed extract of the present invention 1.0
13. Antibacterial (lactoferrin solution) 0.5
14. Antibacterial/preservative (zinc pyridione) Appropriate amount 15. Fragrance (unshu mandarin peel) appropriate amount 16. Remaining purified water 100

(Prescription Example 11) Moisturizing serum mass%
1. Xanthan gum 0.4
2. Hydroxyethyl cellulose 0.2
3. Carpoxyvinyl polymer 0.2
4. Potassium hydroxide 0.02
5.1,3-butylene glycol 5.0
6. Molasses sake lees mixed extract of Production Example 4 of the present invention 5.0
7. Orange 50% glycerin extract 1.0
8. Dipotassium glycyrrhizinate 0.2
9. Antiseptic (isopropylmethylphenol) Appropriate amount 10. Perfume (Mugwort water) Appropriate amount 11. Remaining purified water 100

(Prescription Example 12) Flexible lotion mass%
1. Glycerin 5.0
2.1,3-butylene glycol 5.0
3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4. Ethanol 15.0
5. Molasses sake lees mixed extract of Production Example 4 of the present invention 5.0
6. Artichoke thistle 50% ethanol extract 1.0
7. Chlorella 30% ethanol extract 1.0
8. Antibacterial/preservative (thiamine lauryl sulfate) appropriate amount 9. Perfume (Ambergris) Appropriate amount 10. Remaining purified water 100

(Prescription Example 13) Astringent lotion mass%
1. Sorbit 2.0
2. POE (20) oleyl alcohol 1.0
3. Ethanol 15.0
4. Molasses sake lees mixed extract of Production Example 4 of the present invention 5.0
5. 50% 1,2-pentanediol extract 2.0
6. Green tea 50% ethanol extract 1.0
7. Allantoin 0.2
8. Astringent (zinc sulfocarbonate) 0.2
9. Antiseptic (Photosensitizer No. 201) Appropriate amount 10. Perfume (sage water) Appropriate amount 11. Remaining purified water 100

(Prescription example 14) body lotion mass%
1. Polyvinyl alcohol 15.0
2. Carboxymethylcellulose sodium 5.0
3. Glycerin 3.0
4. Ethanol 10.0
5. Cornflower 30% 1,2-butylene glycol extract 5.0
6. 50% propylene glycol extract of okra 1.0
7. Brown sugar (Wasanbon) sake lees mixed extract of the present invention 1.0
8. Allantoin 0.1
9. Antiseptic (butyl paraoxybenzoate) Appropriate amount 10. Fragrance (mint oil) Appropriate amount

(Prescription Example 15) Pack mass %
1. Polyvinyl alcohol 15.0
2. Carboxymethylcellulose sodium 5.0
3. Propylene glycol 3.0
4. Ethanol 10.0
5. Cornflower 30% 1,2-butylene glycol extract 5.0
6. 50% propylene glycol extract of okra 1.0
7. Lactose shochu lees extract of the present invention 1.0
8. Antiseptic (isopropylmethylphenol) Appropriate amount9. Fragrance (orange peel oil) Appropriate amount

(Prescription Example 16) Massage cream (W/O type) % by mass
1. Microcrystalline wax 9.0
2. Solid paraffin 2.0
3. Beeswax 3.0
4. Vaseline 5.0
5. Squalane 34.0
6. Propylene glycol 5.0
7. Glycerol monooleate 3.5
8. Molasses sake lees mixed extract of Production Example 3 of the present invention 2.0
9. Antiseptic (ethyl paraoxybenzoate) Appropriate amount 10. Remaining purified water 100

(Prescription Example 17) Cleansing cream (O/W type) % by mass
1. Squalane 85.0
2. Sorbitan monooleate 5.0
3. Molasses sake lees mixed extract of Production Example 4 of the present invention 3.0
4. Walnut endocarp 2.0
5. Preservative (butyl paraoxybenzoate) Appropriate amount 6. Remaining purified water 100

(Prescription Example 18) Facial cleansing cream mass%
1. Myristic acid 25.0
2. Stearic acid 5.0
3. Propylene glycol 10.0
4. Potassium hydroxide 6.0
5. Brown sugar shochu lees mixed extract of the present invention 2.0
6. Burdock root 50% 1,3-butylene glycol extract 1.0
7. Glycyrrhizic acid 1.0
8. Walnut shell grain 0.1
9. Antibacterial/preservative (2-phenoxyethanol) 0.1
10. Remaining purified water 100

(Prescription Example 19) Body soap mass%
1. Potassium Laurate 15.0
2. Potassium myristate 5.0
3. Propylene glycol 5.0
4. Sisal hemp fruit or flower 70% 2,3-butylene glycol extract 1.0
5. Ginseng ginseng fruit or flower 70% 2,3-butylene glycol extract 1.0
6. Toki rhizome 70% 2,3-butylene glycol extract 0.5
7. Kudzu root 70% 1,3-butylene glycol extract 0.5
8. 50% Ethanol extract from flower or fruit of Natuyukiso 0.5
9. Whole nettle plant 70% 1,3-butylene glycol extract 0.5
10. Psyllium whole plant 50% ethanol extract 0.5
11. Hydrolyzed collagen solution derived from fish (salmon or flounder, sea bream) 0.5
12. Raw sugar sake lees mixed extract of the present invention 0.5
13. Amino acids (glutamine, proline, lysine, etc.) 0.5
14. Monoammonium glycyrrhizinate 0.1
15. Antibacterial / preservative (undecylenic acid, phenoxyethanol Appropriate amount 16. pH adjuster Appropriate amount 17. Perfume (orange water) Appropriate amount 18. Purified water Remaining to 100

(Prescription Example 20) Cream foundation (O/W type) % by mass
1. Stearic acid 4.0
2. Glyceryl monostearate 3.0
3. Cetanol 1.5
4. Isopropyl myristate 7.0
5. Liquid paraffin 10.0
6. Bleached Beeswax 3.0
7. Triethanolamine 1.5
8. Glycerin 3.0
9. Bentonite 1.0
10. Titanium oxide 8.0
11.2,4-dihydroxybenzophenone 8.0
12. Kaolin 3.0
13. Talc 3.0
14. Coloring pigment (yellow iron oxide) 1.0
15. Wenzhou mandarin orange peel and fruit hot water extract dry powder 0.2
16. Molasses sake lees mixed extract dry powder of Production Example 4 of the present invention 0.2
17. Preservative (phenoxyethanol) 0.1
18. Perfume (Rose steam distilled water) Appropriate amount 19. Remaining purified water 100

(Prescription Example 21) Sunscreen cosmetics (oil type) % by mass
1. Liquid paraffin 70.0
2. Tetrahydroxybenzophenone 1.0
3. cetyl octanoate 24.0
4. Lemongrass leaf or stem 30% 1,3-butylene glycol extract 1.0
5. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0
6. Coix seeds 50% 1,3-butylene glycol extract 0.5
7. 30% butanol extract of fennel fruit 0.5
8. Paeonia root or leaf hot water extract 0.5
9. Molasses sake lees mixed extract of Production Example 4 of the present invention 0.2
10. Ethyl para-aminobenzoate 0.2
11. Antioxidant (butylhydroxytoluene) Appropriate amount 12. Fragrance (cornflower water) Appropriate amount

(Prescription Example 22) Sunscreen cream mass%
1. Hydrophobized zinc oxide 20.0
2. Hydrophobized titanium oxide 2.0
3. Ethylhexyl methoxycinnamate 7.0
4. Decamethylcyclopentasiloxane 10.0
5. Isopropyl myristate 5.0
6. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0
7. Molasses sake lees mixed extract of Production Example 4 of the present invention 0.2
8. Glycerin 2.5
9.1,3-butylene glycol 5.0
10. Ethanol 5.0
11. Phenoxyethanol 0.5
12. Perfume (lavender water) Appropriate amount

(Prescription Example 23) Cream foundation mass%
1. Stearic acid 4.0
2. Glyceryl monostearate 3.0
3. Cetanol 1.5
4. Isopropyl myristate 7.0
5. Liquid paraffin 10.0
6. Bleached Beeswax 3.0
7. Bentonite 1.0
8. Titanium oxide 8.0
9. Talc 3.0
10. Coloring pigment (yellow iron oxide) 1.0
11. Raw sugar sake lees mixed extraction dry powder of the present invention 0.5
12. Scutellaria root 70% ethylene glycol extract dry powder 0.5
13. Antiseptic (ethyl paraoxybenzoate) Appropriate amount 14. Fragrance (Eucalyptus oil) Appropriate amount 15. Remaining purified water 100

(Prescription Example 24) Styling gel mass%
1. Carboxyvinyl polymer 0.1
2. Acrylic acid/alkyl methacrylate copolymer 0.1
3. sodium hydroxide 0.08
4. Vinyl pyrrolidone/vinyl acetate copolymer liquid 10.0
5. sodium hydroxide 0.05
6. Sodium pyrrolidonecarboxylate 0.1
7. Molasses sake lees mixed extract of Production Example 4 of the present invention 2.0
8. Antiseptic (butyl paraoxybenzoate) Appropriate amount9. Remaining purified water 100

(Prescription Example 25) Eye shadow mass%
1. Mica 10.0
2. Titanium 10.0
3. Talc 5.0
4. Dimethylpolysiloxane 3.0
5. Magnesium Stearate 2.0
6. Zinc Laurate 3.0
7. Liquid paraffin 10.0
8. Maltose mirin lees mixed extract of the present invention 2.0
9. Preservatives (propylparaben, isobutylparaben) Appropriate amount 10. Remaining purified water 100

(Prescription Example 26) Lipstick mass%
1. Candelilla wax 10.0
2. Carnauba wax 3.0
3. Microcrystalline wax 3.0
4. Lanolin 11.0
5. Liquid paraffin 10.0
6. Glyceryl tri-2-ethylhexanoate 40.0
7. Molasses sake lees mixed extract of Production Example 4 of the present invention 3.0
8. isostearyl alcohol 15.0

(Prescription Example 27) Shampoo mass %
1. Lauryl sulfate triethanolamine 5.0
2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-butylene glycol 4.0
4. Lauric acid diethanolamide 2.0
5. Disodium edetate 0.1
6. 30% ginger 1,2-butylene glycol extract 2.0
7. Brown sugar (Wasanbon) sake lees mixed extract of the present invention 5.0
8. Maltose extract of the present invention 1.0
9. Antibacterial / antiseptic agent (thiamine lauryl sulfate) appropriate amount 10. pH adjuster appropriate amount 11. Perfume (Musk) Appropriate amount 12. Remaining purified water 100

(Prescription Example 28) Rinse Mass %
1. Stearyltrimethylammonium chloride 2.0
2. Cetostearyl alcohol 2.0
3. Polyoxyethylene lanolin ether 3.0
4. Propylene glycol 5.0
5. Molasses sake lees mixed extract of Production Example 4 of the present invention 5.0
6. Antibacterial / antiseptic agent (benzalkonium chloride) appropriate amount 7. Perfume (Civet) Appropriate amount 8. Remaining purified water 100

(Prescription Example 29) Rinse Mass %
1. Ethanol 40.0
2. Ethyl oleate 1.0
3. Polyoxyethylene (40) hydrogenated castor oil 2.0
4. Sucrose of the present invention Raw sugar sake lees mixed extract of the present invention 1.0
5. Comfrey 60% ethanol extract 3.0
6. Preservative (ethyl paraoxybenzoate) Appropriate amount7. Fragrance (lavender oil) Appropriate amount8. Remaining purified water 100

(Prescription Example 30) Hair restorer/hair tonic mass %
1. Ethanol 60.0
2. Vitamin E derivative 0.5
3. Capsicum tincture 0.5
4. Dipotassium glycyrrhizinate 0.5
5. Maltose mirin lees mixed extract of the present invention 1.0
6. Antibacterial/preservative (paraben) 0.1
7. Perfume (rosemary water) Appropriate amount8. Remaining purified water 100

(Prescription Example 31) Hair dye Mass%
First Agent 1. Para-phenylenediamine 1.0
2. Isopropanol 9.0
3. Oleic acid 15.0
4. Sodium sulfite 0.1
5. Ammonia water (28%) 10.0
6. Molasses sake lees mixed extract of Production Example 3 of the present invention 3.0
7. Purified water Remainder of 100 second agent 1. Hydrogen peroxide solution (35%) 5.0
2. Hydrogen peroxide stabilizer Appropriate amount 3. Remaining purified water 100

(Prescription Example 32) Toothpaste % by mass
1. Dibasic calcium phosphate 40.0
2. Glycerin 20.0
3. Carrageenan 1.0
4. Sodium lauryl sulfate 1.5
5. Saccharin 0.2
6. Molasses sake lees mixed extract of Production Example 4 of the present invention 1.0
7. Chlorhexidine digluconate 0.1
8. Antiseptic (butyl paraoxybenzoate) Appropriate amount9. Perfume (apple water) Appropriate amount 10. Coloring agent appropriate amount 11. Remaining purified water 100

(Prescription Example 33) Mouth freshener mass%
1. Ethanol 20.0
2. Glycerin 15.0
3. Polyoxyethylene hydrogenated castor oil 1.0
4. Saccharin 0.2
5. Chlorhexidine 0.01
6. Raw sugar sake lees mixed extract of the present invention 1.0
7. Grapefruit fruit hot water extract 0.5
8. Antiseptic (methylparaben) Appropriate amount 9. Coloring agent appropriate amount 10. Remaining purified water 100

(Prescription Example 34) Chewing gum mass%
1. Board gum base 50.0
2. Starch syrup 20.0
3. Brown sugar (Wasanbon) sake lees mixed extract of the present invention 10.0
4. Preservative (methylparaben) Appropriate amount 5. Fragrance (apple extract) Appropriate amount 6. Remaining purified water 100

(Prescription Example 35) Beverage % by mass
1. Raw sugar sake lees mixed extract of the present invention 20.0
2. Maltose extract of the present invention 10.0
3. Grapefruit juice 60.0
4. Orange fruit hot water extract dry powder 5.0
5. Mucopolysaccharide solution 3.0
6. Iyokan Fruit Juice 2.0
7. Fragrance (strawberry extract) Appropriate amount 8. Appropriate amount of acidulant

(Prescription Example 36) Supplement Mass%
1. Molasses sake lees mixed dry powder of Production Example 3 of the present invention 5.0
2. Proteoglycan-containing salmon nasal cartilage extract 2.0
3. Chondroitin sulfate 10.0
4. Hyaluronic Acid 10.0
5. N-Acetylglucosamine 20.0
6. Crystalline cellulose 40.0
7. Fine silicon oxide 3.0
8. Appropriate amount of acidulant

The present invention includes, for example, one or more useful sugars (glucose, fructose, galactose, sucrose, sugar, brown sugar, molasses, blackstrap molasses, raw sugar, lactose, maltose) or extracts from sugars, and alcoholic beverages Brewer's lees (refined sake, synthetic sake, powdered sake, miscellaneous sake, cooking sake, shochu, mirin, fruit liquors, whiskeys, spirits, liqueurs, beer, fermented liquor brewer's lees) or one kind of brewer's lees extract A cosmetic composition or food and drink composition containing the above, a moisturizer, a skin texture improving agent, a hair moisture content increasing agent, a hair cuticle protecting agent, a foam quality improving agent, a deodorant, a cell activator, and an antioxidant. It can be used as a melanin production inhibitor.

Claims (4)

A liquid containing molasses or its extract and sake brewer's lees or its extract, said liquid being contained in an external preparation. 2. A liquid according to claim 1, comprising not more than 1% by weight (but excluding 0%) of preservatives relative to the total weight of the liquid. The liquid is used to impart skin moisturizing, skin texture improvement, hair moisture content increase, hair cuticle protection, foam quality improvement, deodorant, cell activation, antioxidant and/or melanin production inhibitory effects to the external preparation. 3. The liquid according to Item 1 or 2. An external preparation containing the liquid according to any one of claims 1 to 3.