CN1152051C - 一种天花粉蛋白突变体及制备方法 - Google Patents

一种天花粉蛋白突变体及制备方法 Download PDF

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Publication number
CN1152051C
CN1152051C CNB011031026A CN01103102A CN1152051C CN 1152051 C CN1152051 C CN 1152051C CN B011031026 A CNB011031026 A CN B011031026A CN 01103102 A CN01103102 A CN 01103102A CN 1152051 C CN1152051 C CN 1152051C
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CN
China
Prior art keywords
mtcs
tcs
gly
mutant
cell
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Expired - Fee Related
Application number
CNB011031026A
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English (en)
Chinese (zh)
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CN1336381A (zh
Inventor
柯一保
聂慧玲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xiangtianmu Biological Science-Technology Co., Ltd., Beijing
Original Assignee
XIANGTIANMU BIOLOGICAL SCIENCE-TECHNOLOGY Co Ltd BEIJING
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from CN 00119553 external-priority patent/CN1283630A/zh
Application filed by XIANGTIANMU BIOLOGICAL SCIENCE-TECHNOLOGY Co Ltd BEIJING filed Critical XIANGTIANMU BIOLOGICAL SCIENCE-TECHNOLOGY Co Ltd BEIJING
Priority to CNB011031026A priority Critical patent/CN1152051C/zh
Priority to US09/905,247 priority patent/US7157552B2/en
Priority to HK04104880.1A priority patent/HK1061872B/xx
Priority to JP2002517821A priority patent/JP4418155B2/ja
Priority to EP01983407.6A priority patent/EP1307480B1/en
Priority to CNB018167012A priority patent/CN1208343C/zh
Priority to AU2002214919A priority patent/AU2002214919A1/en
Priority to PCT/CN2001/001178 priority patent/WO2002012537A2/en
Publication of CN1336381A publication Critical patent/CN1336381A/zh
Publication of CN1152051C publication Critical patent/CN1152051C/zh
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB011031026A 2000-08-02 2001-01-18 一种天花粉蛋白突变体及制备方法 Expired - Fee Related CN1152051C (zh)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CNB011031026A CN1152051C (zh) 2000-08-02 2001-01-18 一种天花粉蛋白突变体及制备方法
US09/905,247 US7157552B2 (en) 2000-08-02 2001-07-13 Mutant trichosanthin
EP01983407.6A EP1307480B1 (en) 2000-08-02 2001-07-18 Mutant trichosanthin
JP2002517821A JP4418155B2 (ja) 2000-08-02 2001-07-18 変異天花粉蛋白
HK04104880.1A HK1061872B (en) 2000-08-02 2001-07-18 Mutant trichosanthin
CNB018167012A CN1208343C (zh) 2000-08-02 2001-07-18 天花粉蛋白突变体
AU2002214919A AU2002214919A1 (en) 2000-08-02 2001-07-18 Mutant trichosanthin
PCT/CN2001/001178 WO2002012537A2 (en) 2000-08-02 2001-07-18 Mutant trichosanthin

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN00119553.0 2000-08-02
CN 00119553 CN1283630A (zh) 2000-08-02 2000-08-02 一种天花粉蛋白突变体及制备方法
CNB011031026A CN1152051C (zh) 2000-08-02 2001-01-18 一种天花粉蛋白突变体及制备方法

Publications (2)

Publication Number Publication Date
CN1336381A CN1336381A (zh) 2002-02-20
CN1152051C true CN1152051C (zh) 2004-06-02

Family

ID=25739487

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB011031026A Expired - Fee Related CN1152051C (zh) 2000-08-02 2001-01-18 一种天花粉蛋白突变体及制备方法
CNB018167012A Expired - Fee Related CN1208343C (zh) 2000-08-02 2001-07-18 天花粉蛋白突变体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB018167012A Expired - Fee Related CN1208343C (zh) 2000-08-02 2001-07-18 天花粉蛋白突变体

Country Status (6)

Country Link
US (1) US7157552B2 (enExample)
EP (1) EP1307480B1 (enExample)
JP (1) JP4418155B2 (enExample)
CN (2) CN1152051C (enExample)
AU (1) AU2002214919A1 (enExample)
WO (1) WO2002012537A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1312175C (zh) 2004-09-09 2007-04-25 北京大学 天花粉蛋白突变体及其编码基因
CN101469016B (zh) * 2007-12-29 2011-09-07 上海交通大学医学院 天花粉蛋白衍生肽及其应用
US20140179677A1 (en) * 2010-12-29 2014-06-26 Akita University Therapeutic agent for ectopic pregnancy
CN110412264A (zh) * 2019-08-01 2019-11-05 临沂大学 一种用于天花粉真伪鉴定的双抗夹心酶联免疫试剂盒及其使用鉴别方法
CN112501190A (zh) * 2021-02-04 2021-03-16 广东药科大学附属第一医院 一种重组质粒、美白剂、其制备方法及相关应用
CN114317466B (zh) * 2022-01-04 2023-10-27 中山大学附属第三医院 一种突变acc1蛋白及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077390A (en) 1989-04-04 1991-12-31 Genelabs, Incorporated Purified trichosanthin and method of preparation
US5128460A (en) 1989-04-04 1992-07-07 Genelabs Incorporated Recombinant trichosanthin and coding sequence
WO1992018148A1 (en) 1991-04-15 1992-10-29 New York University An anti-hiv protein, tap 29, from trichosanthes, dna coding therefor and therapeutic uses thereof
US5541110A (en) * 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica

Also Published As

Publication number Publication date
HK1061872A1 (en) 2004-10-08
US7157552B2 (en) 2007-01-02
EP1307480A2 (en) 2003-05-07
EP1307480B1 (en) 2013-09-18
CN1336381A (zh) 2002-02-20
US20040197853A1 (en) 2004-10-07
WO2002012537A3 (en) 2002-05-02
CN1468257A (zh) 2004-01-14
JP2004505635A (ja) 2004-02-26
WO2002012537A2 (en) 2002-02-14
EP1307480A4 (en) 2005-03-30
CN1208343C (zh) 2005-06-29
JP4418155B2 (ja) 2010-02-17
AU2002214919A1 (en) 2002-02-18

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ASS Succession or assignment of patent right

Owner name: BEIJING XIANGTIANMU BIOTECHNOLOGY CO., LTD.

Free format text: FORMER OWNER: SHANGHAI INST. OF CYTOBIOLOGY, CHINESE ACADEMY OF SCIENCES

Effective date: 20020523

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20020523

Address after: 100076 Beijing city Yuquanying Kowloon Villa Hing yuan No. 5 Building 4 unit

Applicant after: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing

Address before: 200031 No. 320, Yueyang Road, Shanghai

Applicant before: Shanghai Inst. of Cell Biology, Chinese Academy of Sciences

C14 Grant of patent or utility model
GR01 Patent grant
EE01 Entry into force of recordation of patent licensing contract

Assignee: Wuxi STM Biotechnology Co. Ltd.

Assignor: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing

Contract record no.: 2011990000172

Denomination of invention: Trichosanthin mutant and its preparing process

Granted publication date: 20040602

License type: Exclusive License

Open date: 20020220

Record date: 20110321

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Addressee: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing

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Assignor: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing

Contract record no.: 2011990000172

Date of cancellation: 20130220

LICC Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model
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CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040602

Termination date: 20160118