CN1152051C - 一种天花粉蛋白突变体及制备方法 - Google Patents
一种天花粉蛋白突变体及制备方法 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
产品 | C端AA变动缺失位置 更动位置 | RIP活性* | 抗生育活性** | 体外免疫反应能力IgG*** | 体外免疫反应能力IgE*** |
NTCS1-247 | 0 0 | ++ | ++ | ++ | ++ |
L3TCS1-244 | 247-244 0 | ++ | ++ | ++ | ++ |
L10TCS1-237 | 247-239 0 | ++ | ++ | ++ | ++ |
L14TCS1-232 | 247-233 0 | ++ | ++ | + | + |
L29TCS1-218 | 247-219 0 | + | + | ± | ± |
L46TCS1-201 | 247-202 0 | + | + | ± | ± |
L52TCS1-195 | 247-196 0 | ± | ± | - | - |
L67TCS1-180 | 247-181 0 | - | - | - | - |
L74TCS1-173 | 247-174 0 | - | - | - | - |
L11TCS1-173,181-247 | 174-180 0 | ± | ± | ± | ± |
L52TCS1-173,181-202 | 247-203,180-174 0 | - | - | - | - |
M7TCS1-247 | 0 180-174 | ++ | ++ | ± | ± |
M24TCS1-247 | 0 226-203 | ++ | ++ | ± | ± |
M31TCS1-247 | 0 226-203,180-174 | ++ | ++ | - | - |
原氨基酸残集及其序号 | 优选改造成的氨基酸残基 |
Ala230、Ala238、Ala247 | 缺失 |
Gly231 | 缺失 |
Val232、Val233 | 缺失 |
Thr234 | Gly、Ala |
Ser235 | Gly、Ala |
Asn236、Asn242、Asn244、Asn245 | Lys、Gly |
Ile237 | 缺失 |
Leu239、Leu240、Leu241 | 缺失 |
Arg243 | Glu、Asp、Gly |
Met246 | 缺失 |
Claims (5)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011031026A CN1152051C (zh) | 2000-08-02 | 2001-01-18 | 一种天花粉蛋白突变体及制备方法 |
US09/905,247 US7157552B2 (en) | 2000-08-02 | 2001-07-13 | Mutant trichosanthin |
PCT/CN2001/001178 WO2002012537A2 (en) | 2000-08-02 | 2001-07-18 | Mutant trichosanthin |
JP2002517821A JP4418155B2 (ja) | 2000-08-02 | 2001-07-18 | 変異天花粉蛋白 |
AU2002214919A AU2002214919A1 (en) | 2000-08-02 | 2001-07-18 | Mutant trichosanthin |
CNB018167012A CN1208343C (zh) | 2000-08-02 | 2001-07-18 | 天花粉蛋白突变体 |
EP01983407.6A EP1307480B1 (en) | 2000-08-02 | 2001-07-18 | Mutant trichosanthin |
HK04104880A HK1061872A1 (en) | 2000-08-02 | 2004-07-06 | Mutant trichosanthin. |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN00119553.0 | 2000-08-02 | ||
CN 00119553 CN1283630A (zh) | 2000-08-02 | 2000-08-02 | 一种天花粉蛋白突变体及制备方法 |
CNB011031026A CN1152051C (zh) | 2000-08-02 | 2001-01-18 | 一种天花粉蛋白突变体及制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1336381A CN1336381A (zh) | 2002-02-20 |
CN1152051C true CN1152051C (zh) | 2004-06-02 |
Family
ID=25739487
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB011031026A Expired - Fee Related CN1152051C (zh) | 2000-08-02 | 2001-01-18 | 一种天花粉蛋白突变体及制备方法 |
CNB018167012A Expired - Fee Related CN1208343C (zh) | 2000-08-02 | 2001-07-18 | 天花粉蛋白突变体 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018167012A Expired - Fee Related CN1208343C (zh) | 2000-08-02 | 2001-07-18 | 天花粉蛋白突变体 |
Country Status (7)
Country | Link |
---|---|
US (1) | US7157552B2 (zh) |
EP (1) | EP1307480B1 (zh) |
JP (1) | JP4418155B2 (zh) |
CN (2) | CN1152051C (zh) |
AU (1) | AU2002214919A1 (zh) |
HK (1) | HK1061872A1 (zh) |
WO (1) | WO2002012537A2 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1312175C (zh) | 2004-09-09 | 2007-04-25 | 北京大学 | 天花粉蛋白突变体及其编码基因 |
CN101469016B (zh) * | 2007-12-29 | 2011-09-07 | 上海交通大学医学院 | 天花粉蛋白衍生肽及其应用 |
WO2012091118A1 (ja) * | 2010-12-29 | 2012-07-05 | 国立大学法人秋田大学 | 子宮外妊娠の治療剤 |
CN110412264A (zh) * | 2019-08-01 | 2019-11-05 | 临沂大学 | 一种用于天花粉真伪鉴定的双抗夹心酶联免疫试剂盒及其使用鉴别方法 |
CN112501190A (zh) * | 2021-02-04 | 2021-03-16 | 广东药科大学附属第一医院 | 一种重组质粒、美白剂、其制备方法及相关应用 |
CN114317466B (zh) * | 2022-01-04 | 2023-10-27 | 中山大学附属第三医院 | 一种突变acc1蛋白及其用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5077390A (en) | 1989-04-04 | 1991-12-31 | Genelabs, Incorporated | Purified trichosanthin and method of preparation |
US5128460A (en) | 1989-04-04 | 1992-07-07 | Genelabs Incorporated | Recombinant trichosanthin and coding sequence |
EP0580782B1 (en) | 1991-04-15 | 1997-10-08 | New York University | An anti-hiv protein, tap 29, from trichosanthes, dna coding therefor and therapeutic uses thereof |
US5541110A (en) * | 1994-05-17 | 1996-07-30 | Bristol-Myers Squibb | Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica |
-
2001
- 2001-01-18 CN CNB011031026A patent/CN1152051C/zh not_active Expired - Fee Related
- 2001-07-13 US US09/905,247 patent/US7157552B2/en not_active Expired - Fee Related
- 2001-07-18 EP EP01983407.6A patent/EP1307480B1/en not_active Expired - Lifetime
- 2001-07-18 CN CNB018167012A patent/CN1208343C/zh not_active Expired - Fee Related
- 2001-07-18 WO PCT/CN2001/001178 patent/WO2002012537A2/en active Application Filing
- 2001-07-18 JP JP2002517821A patent/JP4418155B2/ja not_active Expired - Fee Related
- 2001-07-18 AU AU2002214919A patent/AU2002214919A1/en not_active Abandoned
-
2004
- 2004-07-06 HK HK04104880A patent/HK1061872A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1336381A (zh) | 2002-02-20 |
JP2004505635A (ja) | 2004-02-26 |
CN1468257A (zh) | 2004-01-14 |
US20040197853A1 (en) | 2004-10-07 |
JP4418155B2 (ja) | 2010-02-17 |
EP1307480A4 (en) | 2005-03-30 |
US7157552B2 (en) | 2007-01-02 |
AU2002214919A1 (en) | 2002-02-18 |
EP1307480B1 (en) | 2013-09-18 |
EP1307480A2 (en) | 2003-05-07 |
CN1208343C (zh) | 2005-06-29 |
WO2002012537A2 (en) | 2002-02-14 |
HK1061872A1 (en) | 2004-10-08 |
WO2002012537A3 (en) | 2002-05-02 |
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