CN1247794C - 人角质细胞生长因子-2的生产方法 - Google Patents
人角质细胞生长因子-2的生产方法 Download PDFInfo
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- CN1247794C CN1247794C CN 02110808 CN02110808A CN1247794C CN 1247794 C CN1247794 C CN 1247794C CN 02110808 CN02110808 CN 02110808 CN 02110808 A CN02110808 A CN 02110808A CN 1247794 C CN1247794 C CN 1247794C
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Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
成分 | 1 | 2 | 3 | 4 | 5 | 6 |
胰蛋白胨 | 16 | 10 | 5 | 16 | 10 | |
酵母提取物 | 5 | 10 | 5 | 10 | 10 | 2 |
K2HPO4 | 7 | 2 | 5 | |||
KH2PO4 | 8 | 1 | 3 | 2.7 | ||
Na2HPO4 | 2.5 | 6 | 28.6 | |||
(NH4)2SO4 | 5 | 0.6 | ||||
MgSO4·7H2O | 2 | 1 | 2.5 | 2mM | ||
葡萄糖 | 5 | 5 | 2 | 10 | ||
NH4Cl | 0.1 | 0.7 | ||||
NaCl | 5 | 0.5 | 5 | |||
柠檬酸钠 | 1.7 | |||||
pH | 7.0 |
方法一 | 方法二 | |
KGF-2表达水平(占全菌蛋白比例) | 18% | 7.2% |
Claims (11)
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CN105925647A (zh) * | 2016-06-24 | 2016-09-07 | 成都远睿生物技术有限公司 | 一种重组人角质细胞生长因子-2工程菌的发酵方法及发酵培养基 |
CN106676121B (zh) * | 2017-01-25 | 2020-04-07 | 江苏易肌雪生物科技股份有限公司 | 一种简便制备活性人kgf-2d31的方法 |
CN108686201A (zh) * | 2018-06-29 | 2018-10-23 | 上海新生源医药集团有限公司 | 用于治疗口腔黏膜炎的kgf-2及其制剂 |
CN115282260A (zh) * | 2021-12-24 | 2022-11-04 | 温州医科大学 | Kgf-2制备治疗皮肤功能障碍药物中的应用 |
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Free format text: CORRECT: ADDRESS; FROM: 200233 TOWER A, 4/F, NO.398, TIANLIN ROAD, SHANGHAI TO: 202174 YIQIU COMPLEX BUILDING, NEIGHBOREHOOD 5, CHANGZHENG FARM, CHONGMING COUNTY, SHANGHAI |
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Address after: 200233, Tianlin Road, Shanghai, No. 398, 4, block A Patentee after: Shanghai Newsummit Biopharma Co.,Ltd. Address before: 200233, Tianlin Road, Shanghai, No. 398, 4, block A Patentee before: SHANGHAI XINSHENGYUAN MEDICINE RESEARCH Co.,Ltd. |
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Effective date of registration: 20100907 Address after: 202174 Shanghai Chongming County Long March Farm 5 neighborhood 1 Qiu complex Patentee after: Shanghai city xinshengyuan Pharmaceutical Co.,Ltd. Address before: 200233, Tianlin Road, Shanghai, No. 398, 4, block A Patentee before: Shanghai Newsummit Biopharma Co.,Ltd. |
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Owner name: WUHAN GUANGGU NEWSUMMIT BIO-PHARMACEUTICAL CO., LT Free format text: FORMER NAME: SHANGHAI NEWSUMMIT PHARMACEUTICAL CO., LTD. |
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Address after: 430000, Hubei Wuhan New Technology Development Zone, East Lake Hi Road bio pharmaceutical park small and medium-sized enterprise Park Service Center (building A-7) Patentee after: Wuhan Optics Valley xinshengyuan Biological Pharmaceutical Co.,Ltd. Address before: 202174 Shanghai Chongming County Long March Farm 5 neighborhood 1 Qiu complex Patentee before: Shanghai city xinshengyuan Pharmaceutical Co.,Ltd. |
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Owner name: ANHUI XINHUAKUN BIOLOGICAL ENGINEERING CO., LTD. Free format text: FORMER OWNER: WUHAN GUANGGU NEWSUMMIT BIO-PHARMACEUTICAL CO., LTD. Effective date: 20140530 |
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Effective date of registration: 20140530 Address after: High tech Zone Customs Road Hefei city Anhui province 230000 No. 9 biotechnology A Building Room 601 Patentee after: ANHUI XINHUAKUN BIOENGINEERING Co.,Ltd. Address before: 430000, Hubei Wuhan New Technology Development Zone, East Lake Hi Road bio pharmaceutical park small and medium-sized enterprise Park Service Center (building A-7) Patentee before: Wuhan Optics Valley xinshengyuan Biological Pharmaceutical Co.,Ltd. |
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Effective date of registration: 20180822 Address after: 325600 Yueqing City, Zhejiang Province, Hongqiao Town South Village, Yueqing City Science and Technology Incubation and Entrepreneurship Service Center, Life and Health Industrial Park, a comprehensive office building, 8th floor A Patentee after: Zhejiang thirty thousand Pharmaceutical Co.,Ltd. Address before: 230000 Room 601, Anke bio A, 9 Customs Road, hi tech Zone, Hefei, Anhui. Patentee before: ANHUI XINHUAKUN BIOENGINEERING Co.,Ltd. |
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Effective date of registration: 20190116 Address after: 430000 Room 536, Block B1, Biological Innovation Park, 666 High-tech Avenue, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee after: Wuhan Guanggu Asia-Pacific Pharmaceutical Co.,Ltd. Address before: 325600 Yueqing City, Zhejiang Province, Hongqiao Town South Village, Yueqing City Science and Technology Incubation and Entrepreneurship Service Center, Life and Health Industrial Park, a comprehensive office building, 8th floor A Patentee before: Zhejiang thirty thousand Pharmaceutical Co.,Ltd. |
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Granted publication date: 20060329 |