CN1336381A - 一种天花粉蛋白突变体及制备方法 - Google Patents
一种天花粉蛋白突变体及制备方法 Download PDFInfo
- Publication number
- CN1336381A CN1336381A CN01103102A CN01103102A CN1336381A CN 1336381 A CN1336381 A CN 1336381A CN 01103102 A CN01103102 A CN 01103102A CN 01103102 A CN01103102 A CN 01103102A CN 1336381 A CN1336381 A CN 1336381A
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- CN
- China
- Prior art keywords
- amino
- tcs
- mutant
- mtcs
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
产品 | C端AA变动缺失位置更动位置 | RIP活性* | 抗生育活性** | 体外免疫反应能力IgG*** | 体外免疫反应能力IgE*** |
NTCS1-247 | 0 0 | ++ | ++ | ++ | ++ |
L3TCS1-244 | 247-244 0 | ++ | ++ | ++ | ++ |
L10TCS1-237 | 247-239 0 | ++ | ++ | ++ | ++ |
L14TCS1-232 | 247-233 0 | ++ | ++ | + | + |
L29TCS1-218 | 247-219 0 | + | + | ± | ± |
L46TCS1-201 | 247-202 0 | + | + | ± | ± |
L52TCS1-195 | 247-196 0 | ± | ± | - | - |
L67TCS1-180 | 247-181 0 | - | - | - | - |
L74TCS1-173 | 247-174 0 | - | - | - | - |
L11TCS1-173,181-247 | 174-180 0 | ± | ± | ± | ± |
L52TCS1-173,181-202 | 247-203,180-174 0 | - | - | - | - |
M7TCS1-247 | 0 180-174 | ++ | ++ | ± | ± |
M24TCS1-247 | 0 226-203 | ++ | ++ | ± | ± |
M31TCS1-247 | 0 226-203,180-174 | ++ | ++ | - | - |
原氨基酸残集及其序号 | 优选改造成的氨基酸残基 |
Ala230、Ala238、Ala247 | 缺失 |
Gly231 | 缺失 |
Val232、Val233 | 缺失 |
Thr234 | Gly、Ala |
Ser235 | Gly、Ala |
Asn236、Asn242、Asn244、Asn245 | Lys、Gly |
Ile237 | 缺失 |
Leu239、Leu240、Leu241 | 缺失 |
Arg243 | Glu、Asp、Gly |
Met246 | 缺失 |
Claims (3)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011031026A CN1152051C (zh) | 2000-08-02 | 2001-01-18 | 一种天花粉蛋白突变体及制备方法 |
US09/905,247 US7157552B2 (en) | 2000-08-02 | 2001-07-13 | Mutant trichosanthin |
AU2002214919A AU2002214919A1 (en) | 2000-08-02 | 2001-07-18 | Mutant trichosanthin |
PCT/CN2001/001178 WO2002012537A2 (en) | 2000-08-02 | 2001-07-18 | Mutant trichosanthin |
EP01983407.6A EP1307480B1 (en) | 2000-08-02 | 2001-07-18 | Mutant trichosanthin |
JP2002517821A JP4418155B2 (ja) | 2000-08-02 | 2001-07-18 | 変異天花粉蛋白 |
CNB018167012A CN1208343C (zh) | 2000-08-02 | 2001-07-18 | 天花粉蛋白突变体 |
HK04104880A HK1061872A1 (en) | 2000-08-02 | 2004-07-06 | Mutant trichosanthin. |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN00119553.0 | 2000-08-02 | ||
CN 00119553 CN1283630A (zh) | 2000-08-02 | 2000-08-02 | 一种天花粉蛋白突变体及制备方法 |
CNB011031026A CN1152051C (zh) | 2000-08-02 | 2001-01-18 | 一种天花粉蛋白突变体及制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1336381A true CN1336381A (zh) | 2002-02-20 |
CN1152051C CN1152051C (zh) | 2004-06-02 |
Family
ID=25739487
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB011031026A Expired - Fee Related CN1152051C (zh) | 2000-08-02 | 2001-01-18 | 一种天花粉蛋白突变体及制备方法 |
CNB018167012A Expired - Fee Related CN1208343C (zh) | 2000-08-02 | 2001-07-18 | 天花粉蛋白突变体 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018167012A Expired - Fee Related CN1208343C (zh) | 2000-08-02 | 2001-07-18 | 天花粉蛋白突变体 |
Country Status (7)
Country | Link |
---|---|
US (1) | US7157552B2 (zh) |
EP (1) | EP1307480B1 (zh) |
JP (1) | JP4418155B2 (zh) |
CN (2) | CN1152051C (zh) |
AU (1) | AU2002214919A1 (zh) |
HK (1) | HK1061872A1 (zh) |
WO (1) | WO2002012537A2 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1312175C (zh) * | 2004-09-09 | 2007-04-25 | 北京大学 | 天花粉蛋白突变体及其编码基因 |
CN112501190A (zh) * | 2021-02-04 | 2021-03-16 | 广东药科大学附属第一医院 | 一种重组质粒、美白剂、其制备方法及相关应用 |
CN114317466A (zh) * | 2022-01-04 | 2022-04-12 | 中山大学附属第三医院 | 一种突变acc1蛋白及其用途 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101469016B (zh) * | 2007-12-29 | 2011-09-07 | 上海交通大学医学院 | 天花粉蛋白衍生肽及其应用 |
US20140179677A1 (en) * | 2010-12-29 | 2014-06-26 | Akita University | Therapeutic agent for ectopic pregnancy |
CN110412264A (zh) * | 2019-08-01 | 2019-11-05 | 临沂大学 | 一种用于天花粉真伪鉴定的双抗夹心酶联免疫试剂盒及其使用鉴别方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5128460A (en) | 1989-04-04 | 1992-07-07 | Genelabs Incorporated | Recombinant trichosanthin and coding sequence |
US5077390A (en) | 1989-04-04 | 1991-12-31 | Genelabs, Incorporated | Purified trichosanthin and method of preparation |
EP0580782B1 (en) | 1991-04-15 | 1997-10-08 | New York University | An anti-hiv protein, tap 29, from trichosanthes, dna coding therefor and therapeutic uses thereof |
US5541110A (en) * | 1994-05-17 | 1996-07-30 | Bristol-Myers Squibb | Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica |
-
2001
- 2001-01-18 CN CNB011031026A patent/CN1152051C/zh not_active Expired - Fee Related
- 2001-07-13 US US09/905,247 patent/US7157552B2/en not_active Expired - Fee Related
- 2001-07-18 EP EP01983407.6A patent/EP1307480B1/en not_active Expired - Lifetime
- 2001-07-18 JP JP2002517821A patent/JP4418155B2/ja not_active Expired - Fee Related
- 2001-07-18 AU AU2002214919A patent/AU2002214919A1/en not_active Abandoned
- 2001-07-18 CN CNB018167012A patent/CN1208343C/zh not_active Expired - Fee Related
- 2001-07-18 WO PCT/CN2001/001178 patent/WO2002012537A2/en active Application Filing
-
2004
- 2004-07-06 HK HK04104880A patent/HK1061872A1/xx not_active IP Right Cessation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1312175C (zh) * | 2004-09-09 | 2007-04-25 | 北京大学 | 天花粉蛋白突变体及其编码基因 |
CN112501190A (zh) * | 2021-02-04 | 2021-03-16 | 广东药科大学附属第一医院 | 一种重组质粒、美白剂、其制备方法及相关应用 |
CN114317466A (zh) * | 2022-01-04 | 2022-04-12 | 中山大学附属第三医院 | 一种突变acc1蛋白及其用途 |
CN114317466B (zh) * | 2022-01-04 | 2023-10-27 | 中山大学附属第三医院 | 一种突变acc1蛋白及其用途 |
Also Published As
Publication number | Publication date |
---|---|
JP2004505635A (ja) | 2004-02-26 |
WO2002012537A3 (en) | 2002-05-02 |
EP1307480A2 (en) | 2003-05-07 |
US7157552B2 (en) | 2007-01-02 |
CN1208343C (zh) | 2005-06-29 |
CN1152051C (zh) | 2004-06-02 |
EP1307480A4 (en) | 2005-03-30 |
AU2002214919A1 (en) | 2002-02-18 |
JP4418155B2 (ja) | 2010-02-17 |
US20040197853A1 (en) | 2004-10-07 |
WO2002012537A2 (en) | 2002-02-14 |
EP1307480B1 (en) | 2013-09-18 |
HK1061872A1 (en) | 2004-10-08 |
CN1468257A (zh) | 2004-01-14 |
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Legal Events
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
ASS | Succession or assignment of patent right |
Owner name: BEIJING XIANGTIANMU BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: SHANGHAI INST. OF CYTOBIOLOGY, CHINESE ACADEMY OF SCIENCES Effective date: 20020523 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20020523 Address after: 100076 Beijing city Yuquanying Kowloon Villa Hing yuan No. 5 Building 4 unit Applicant after: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing Address before: 200031 No. 320, Yueyang Road, Shanghai Applicant before: Shanghai Inst. of Cell Biology, Chinese Academy of Sciences |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Wuxi STM Biotechnology Co. Ltd. Assignor: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing Contract record no.: 2011990000172 Denomination of invention: Trichosanthin mutant and its preparing process Granted publication date: 20040602 License type: Exclusive License Open date: 20020220 Record date: 20110321 |
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DD01 | Delivery of document by public notice |
Addressee: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing Document name: Notification to Pay the Fees |
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EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Wuxi STM Biotechnology Co. Ltd. Assignor: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing Contract record no.: 2011990000172 Date of cancellation: 20130220 |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
DD01 | Delivery of document by public notice |
Addressee: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing Document name: Notification to Pay the Fees |
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DD01 | Delivery of document by public notice |
Addressee: Xiangtianmu Biological Science-Technology Co., Ltd., Beijing Document name: Notification of Termination of Patent Right |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040602 Termination date: 20160118 |