CN115135639B - 制备6-羧基苯并噁唑衍生物的有效方法 - Google Patents
制备6-羧基苯并噁唑衍生物的有效方法 Download PDFInfo
- Publication number
- CN115135639B CN115135639B CN202080096991.1A CN202080096991A CN115135639B CN 115135639 B CN115135639 B CN 115135639B CN 202080096991 A CN202080096991 A CN 202080096991A CN 115135639 B CN115135639 B CN 115135639B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- dichlorophenyl
- acid
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962951691P | 2019-12-20 | 2019-12-20 | |
| US62/951,691 | 2019-12-20 | ||
| US202063120426P | 2020-12-02 | 2020-12-02 | |
| US63/120,426 | 2020-12-02 | ||
| PCT/IB2020/062040 WO2021124158A1 (en) | 2019-12-20 | 2020-12-16 | Efficient process for making 6-carboxy benzoxazole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115135639A CN115135639A (zh) | 2022-09-30 |
| CN115135639B true CN115135639B (zh) | 2025-04-01 |
Family
ID=73856234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080096991.1A Active CN115135639B (zh) | 2019-12-20 | 2020-12-16 | 制备6-羧基苯并噁唑衍生物的有效方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US12410145B2 (https=) |
| EP (1) | EP4077287B1 (https=) |
| JP (1) | JP2023507399A (https=) |
| KR (1) | KR20220114626A (https=) |
| CN (1) | CN115135639B (https=) |
| AU (1) | AU2020406455B2 (https=) |
| BR (1) | BR112022012097A2 (https=) |
| CA (1) | CA3165298A1 (https=) |
| ES (1) | ES3055912T3 (https=) |
| HR (1) | HRP20251570T1 (https=) |
| IL (1) | IL294115A (https=) |
| MX (1) | MX2022007787A (https=) |
| TW (1) | TWI771827B (https=) |
| WO (1) | WO2021124158A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4077287B1 (en) | 2019-12-20 | 2025-11-19 | Pfizer Ireland Pharmaceuticals Unlimited Company | Efficient process for making 6-carboxy benzoxazole derivatives |
| KR102657823B1 (ko) * | 2022-03-10 | 2024-04-16 | 고려대학교 산학협력단 | 타파미디스의 신규 합성법 |
| US11970468B1 (en) | 2023-10-23 | 2024-04-30 | King Faisal University | 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101413143A (zh) * | 2002-12-19 | 2009-04-22 | 斯克里普斯研究学院 | 稳定甲状腺素运载蛋白和抑制甲状腺素运载蛋白错折叠的组合物和方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5222642A (en) | 1975-08-14 | 1977-02-21 | Kawasaki Heavy Ind Ltd | Power generation device by hot water |
| GB8703975D0 (en) | 1987-02-20 | 1987-03-25 | Wellcome Found | Pesticidal compounds |
| GB8809316D0 (en) * | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
| JP5419545B2 (ja) | 2009-05-25 | 2014-02-19 | 株式会社トクヤマ | オルトエステル化合物の製造方法 |
| US8168683B2 (en) | 2009-10-15 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Fluorinated vinylidene cationic surfactant |
| TWI550071B (zh) * | 2011-03-25 | 2016-09-21 | 捷恩智股份有限公司 | 原酸酯化合物、液晶組成物及液晶顯示元件 |
| RU2586330C2 (ru) * | 2011-09-16 | 2016-06-10 | Пфайзер Инк. | Твердые формы ингибитора диссоциации транстиретина |
| US9499527B2 (en) * | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| PT4349406T (pt) * | 2014-09-08 | 2026-02-04 | Pfizer | Formas sólidas cristalinas de 6-carboxi-2-(3,5-diclorofenil)-benzoxazol para utilização como medicamento |
| CN107344927A (zh) * | 2016-05-05 | 2017-11-14 | 苏州晶云药物科技有限公司 | Tafamidis葡甲胺盐的晶型E及其制备方法和用途 |
| US10766893B2 (en) * | 2017-12-20 | 2020-09-08 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
| EP4077287B1 (en) | 2019-12-20 | 2025-11-19 | Pfizer Ireland Pharmaceuticals Unlimited Company | Efficient process for making 6-carboxy benzoxazole derivatives |
-
2020
- 2020-12-16 EP EP20828342.4A patent/EP4077287B1/en active Active
- 2020-12-16 WO PCT/IB2020/062040 patent/WO2021124158A1/en not_active Ceased
- 2020-12-16 CA CA3165298A patent/CA3165298A1/en active Pending
- 2020-12-16 TW TW109144467A patent/TWI771827B/zh active
- 2020-12-16 CN CN202080096991.1A patent/CN115135639B/zh active Active
- 2020-12-16 JP JP2022537301A patent/JP2023507399A/ja active Pending
- 2020-12-16 BR BR112022012097A patent/BR112022012097A2/pt not_active Application Discontinuation
- 2020-12-16 MX MX2022007787A patent/MX2022007787A/es unknown
- 2020-12-16 HR HRP20251570TT patent/HRP20251570T1/hr unknown
- 2020-12-16 KR KR1020227024529A patent/KR20220114626A/ko not_active Withdrawn
- 2020-12-16 US US17/757,740 patent/US12410145B2/en active Active
- 2020-12-16 ES ES20828342T patent/ES3055912T3/es active Active
- 2020-12-16 IL IL294115A patent/IL294115A/en unknown
- 2020-12-16 AU AU2020406455A patent/AU2020406455B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101413143A (zh) * | 2002-12-19 | 2009-04-22 | 斯克里普斯研究学院 | 稳定甲状腺素运载蛋白和抑制甲状腺素运载蛋白错折叠的组合物和方法 |
Non-Patent Citations (1)
| Title |
|---|
| Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors;Tim H. M. Jonckers，等;Bioorganic & Medicinal Chemistry Letters;20120616;第22卷(第15期);第5000页表1及第5001页Scheme1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES3055912T3 (en) | 2026-02-16 |
| AU2020406455B2 (en) | 2024-02-15 |
| TW202136222A (zh) | 2021-10-01 |
| EP4077287A1 (en) | 2022-10-26 |
| BR112022012097A2 (pt) | 2022-08-30 |
| JP2023507399A (ja) | 2023-02-22 |
| CN115135639A (zh) | 2022-09-30 |
| US20230090609A1 (en) | 2023-03-23 |
| EP4077287C0 (en) | 2025-11-19 |
| HRP20251570T1 (hr) | 2026-01-30 |
| WO2021124158A1 (en) | 2021-06-24 |
| EP4077287B1 (en) | 2025-11-19 |
| MX2022007787A (es) | 2022-07-19 |
| US12410145B2 (en) | 2025-09-09 |
| KR20220114626A (ko) | 2022-08-17 |
| TWI771827B (zh) | 2022-07-21 |
| IL294115A (en) | 2022-08-01 |
| AU2020406455A1 (en) | 2022-07-14 |
| CA3165298A1 (en) | 2021-06-24 |
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