BR112022012097A2 - Processo eficiente para a produção de derivados de 6-carbóxi benzoxazol - Google Patents

Processo eficiente para a produção de derivados de 6-carbóxi benzoxazol

Info

Publication number
BR112022012097A2
BR112022012097A2 BR112022012097A BR112022012097A BR112022012097A2 BR 112022012097 A2 BR112022012097 A2 BR 112022012097A2 BR 112022012097 A BR112022012097 A BR 112022012097A BR 112022012097 A BR112022012097 A BR 112022012097A BR 112022012097 A2 BR112022012097 A2 BR 112022012097A2
Authority
BR
Brazil
Prior art keywords
efficient process
carboxy
production
benzoxazole derivatives
formula
Prior art date
Application number
BR112022012097A
Other languages
English (en)
Inventor
Peter CURRAN Simon
Mary O'neill Padraig
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Publication of BR112022012097A2 publication Critical patent/BR112022012097A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCESSO EFICIENTE PARA A PRODUÇÃO DE DERIVADOS DE 6-CARBÓXI BENZOXAZOL. A presente invenção refere-se a um processo eficiente para a preparação de derivados de benzoxazol compreendendo a etapa de reação de um composto de ácido 4-amino-3-hidroxibenzoico de Fórmula III com um composto de orto éster 3,5-diclorofenílico de Fórmula II para fornecer o composto de Fórmula I em que R1, R2a, R2b e R2c são como aqui descritos.
BR112022012097A 2019-12-20 2020-12-16 Processo eficiente para a produção de derivados de 6-carbóxi benzoxazol BR112022012097A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962951691P 2019-12-20 2019-12-20
US202063120426P 2020-12-02 2020-12-02
PCT/IB2020/062040 WO2021124158A1 (en) 2019-12-20 2020-12-16 Efficient process for making 6-carboxy benzoxazole derivatives

Publications (1)

Publication Number Publication Date
BR112022012097A2 true BR112022012097A2 (pt) 2022-08-30

Family

ID=73856234

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022012097A BR112022012097A2 (pt) 2019-12-20 2020-12-16 Processo eficiente para a produção de derivados de 6-carbóxi benzoxazol

Country Status (12)

Country Link
US (1) US20230090609A1 (pt)
EP (1) EP4077287A1 (pt)
JP (1) JP2023507399A (pt)
KR (1) KR20220114626A (pt)
CN (1) CN115135639A (pt)
AU (1) AU2020406455B2 (pt)
BR (1) BR112022012097A2 (pt)
CA (1) CA3165298A1 (pt)
IL (1) IL294115A (pt)
MX (1) MX2022007787A (pt)
TW (1) TWI771827B (pt)
WO (1) WO2021124158A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11970468B1 (en) 2023-10-23 2024-04-30 King Faisal University 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5222642A (en) 1975-08-14 1977-02-21 Kawasaki Heavy Ind Ltd Power generation device by hot water
GB8703975D0 (en) 1987-02-20 1987-03-25 Wellcome Found Pesticidal compounds
ATE405840T1 (de) 2002-12-19 2008-09-15 Scripps Research Inst Zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung
JP5419545B2 (ja) 2009-05-25 2014-02-19 株式会社トクヤマ オルトエステル化合物の製造方法
US8168683B2 (en) 2009-10-15 2012-05-01 E. I. Du Pont De Nemours And Company Fluorinated vinylidene cationic surfactant
CA2847293C (en) 2011-09-16 2017-03-28 Richard Frederic Labaudiniere Solid forms of a transthyretin dissociation inhibitor
WO2013168014A1 (en) * 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of familial amyloid polyneuropathy
CN106715405A (zh) * 2014-09-08 2017-05-24 辉瑞公司 6‑羧基‑2‑(3,5‑二氯苯基)苯并噁唑的结晶固体形式
CN107344927A (zh) 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途
US10766893B2 (en) * 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

Also Published As

Publication number Publication date
TW202136222A (zh) 2021-10-01
US20230090609A1 (en) 2023-03-23
EP4077287A1 (en) 2022-10-26
MX2022007787A (es) 2022-07-19
JP2023507399A (ja) 2023-02-22
IL294115A (en) 2022-08-01
AU2020406455B2 (en) 2024-02-15
CA3165298A1 (en) 2021-06-24
AU2020406455A1 (en) 2022-07-14
CN115135639A (zh) 2022-09-30
TWI771827B (zh) 2022-07-21
KR20220114626A (ko) 2022-08-17
WO2021124158A1 (en) 2021-06-24

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