MX2022007787A - Proceso eficiente para elaborar derivados de 6-carboxi-benzoxazol. - Google Patents
Proceso eficiente para elaborar derivados de 6-carboxi-benzoxazol.Info
- Publication number
- MX2022007787A MX2022007787A MX2022007787A MX2022007787A MX2022007787A MX 2022007787 A MX2022007787 A MX 2022007787A MX 2022007787 A MX2022007787 A MX 2022007787A MX 2022007787 A MX2022007787 A MX 2022007787A MX 2022007787 A MX2022007787 A MX 2022007787A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- efficient process
- carboxy
- making
- benzoxazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se dirige a un proceso eficiente para preparar derivados de benzoxazol que comprende la etapa de hacer reaccionar un compuesto del ácido 4-amino-3-hidroxibenzoico de la Fórmula III con un compuesto del ortoéster de 3,5-diclorofenilo de la Fórmula II para proporcionar el compuesto de la Fórmula I (ver Fórmula) en donde R1, R2a, R2b y R2c son como se describen en la presente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962951691P | 2019-12-20 | 2019-12-20 | |
US202063120426P | 2020-12-02 | 2020-12-02 | |
PCT/IB2020/062040 WO2021124158A1 (en) | 2019-12-20 | 2020-12-16 | Efficient process for making 6-carboxy benzoxazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022007787A true MX2022007787A (es) | 2022-07-19 |
Family
ID=73856234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022007787A MX2022007787A (es) | 2019-12-20 | 2020-12-16 | Proceso eficiente para elaborar derivados de 6-carboxi-benzoxazol. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230090609A1 (es) |
EP (1) | EP4077287A1 (es) |
JP (1) | JP2023507399A (es) |
KR (1) | KR20220114626A (es) |
CN (1) | CN115135639A (es) |
AU (1) | AU2020406455B2 (es) |
BR (1) | BR112022012097A2 (es) |
CA (1) | CA3165298A1 (es) |
IL (1) | IL294115A (es) |
MX (1) | MX2022007787A (es) |
TW (1) | TWI771827B (es) |
WO (1) | WO2021124158A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11970468B1 (en) | 2023-10-23 | 2024-04-30 | King Faisal University | 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5222642A (en) | 1975-08-14 | 1977-02-21 | Kawasaki Heavy Ind Ltd | Power generation device by hot water |
GB8703975D0 (en) | 1987-02-20 | 1987-03-25 | Wellcome Found | Pesticidal compounds |
PT1587821E (pt) * | 2002-12-19 | 2008-09-23 | Scripps Research Inst | Composições e métodos para estabilização da transtirretina e inibição do enrolamento incorrecto da transtirretina |
JP5419545B2 (ja) | 2009-05-25 | 2014-02-19 | 株式会社トクヤマ | オルトエステル化合物の製造方法 |
US8168683B2 (en) | 2009-10-15 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Fluorinated vinylidene cationic surfactant |
SG2014013270A (en) | 2011-09-16 | 2014-05-29 | Pfizer | Solid forms of a transthyretin dissociation inhibitor |
US9499527B2 (en) * | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
ES2975633T3 (es) | 2014-09-08 | 2024-07-10 | Pfizer | Formas sólidas cristalinas de 6-carboxi-2-(3,5-diclorofenil)-benzoxazol para su uso como medicamento |
CN107344927A (zh) * | 2016-05-05 | 2017-11-14 | 苏州晶云药物科技有限公司 | Tafamidis葡甲胺盐的晶型E及其制备方法和用途 |
US10766893B2 (en) * | 2017-12-20 | 2020-09-08 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
-
2020
- 2020-12-16 CA CA3165298A patent/CA3165298A1/en active Pending
- 2020-12-16 JP JP2022537301A patent/JP2023507399A/ja active Pending
- 2020-12-16 BR BR112022012097A patent/BR112022012097A2/pt unknown
- 2020-12-16 US US17/757,740 patent/US20230090609A1/en active Pending
- 2020-12-16 TW TW109144467A patent/TWI771827B/zh active
- 2020-12-16 EP EP20828342.4A patent/EP4077287A1/en active Pending
- 2020-12-16 AU AU2020406455A patent/AU2020406455B2/en active Active
- 2020-12-16 KR KR1020227024529A patent/KR20220114626A/ko unknown
- 2020-12-16 MX MX2022007787A patent/MX2022007787A/es unknown
- 2020-12-16 CN CN202080096991.1A patent/CN115135639A/zh active Pending
- 2020-12-16 WO PCT/IB2020/062040 patent/WO2021124158A1/en active Application Filing
- 2020-12-16 IL IL294115A patent/IL294115A/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023507399A (ja) | 2023-02-22 |
TWI771827B (zh) | 2022-07-21 |
AU2020406455A1 (en) | 2022-07-14 |
KR20220114626A (ko) | 2022-08-17 |
IL294115A (en) | 2022-08-01 |
EP4077287A1 (en) | 2022-10-26 |
WO2021124158A1 (en) | 2021-06-24 |
US20230090609A1 (en) | 2023-03-23 |
TW202136222A (zh) | 2021-10-01 |
BR112022012097A2 (pt) | 2022-08-30 |
CN115135639A (zh) | 2022-09-30 |
AU2020406455B2 (en) | 2024-02-15 |
CA3165298A1 (en) | 2021-06-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2010141941A (ru) | Способ получения фторсодержащего производного ацилуксусной кислоты, способ получения фторсодержащего производного сложного эфира пиразолкарбоновой кислоты и способ получения фторсодержащего пиразолкарбоновой кислоты | |
CL2009000089A1 (es) | Procesos de preparacion de un derivado del acido y-amino-o-bifenil-x-metil-pentanoico;compuestos intermediarios y su proceso de preparacion; uso de los compuestos en la sintesis de compuestos inhibidores de nep, utiles en enfermedades cardiovasculares, tales como hipertension, insuficiencia cardiaca congestiva, entre otras. | |
NZ600035A (en) | Method for preparing pyrrolobenzodiazepines, particularly zc-423 | |
PE20070051A1 (es) | Serin-amidas sustituidas con heteroaroilo | |
CY1119452T1 (el) | Μια μεθοδος παρασκευης 2-αιθοξυ-1-(2'-((υδροξυamino) ιμινομεθυλο) διφαινυλ-4-υλο) μεθυλο)-1η- βενζο (d) ιμιδαζολο-7-καρβοξυλικο οξυ και τους εστερες αυτου | |
MX2022007787A (es) | Proceso eficiente para elaborar derivados de 6-carboxi-benzoxazol. | |
EP3560929A3 (en) | Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same | |
MX2018014130A (es) | Procedimiento e intermedios para la 6,7-alfa-epoxidacion de 4,6-dienos esteroideos. | |
SI1601653T1 (sl) | Postopek za pripravo substituiranih estrov nikotinske kisline | |
EA202192581A1 (ru) | Композиции d-метирозина и способы их получения | |
WO2023156386A3 (en) | Pharmaceutical compound | |
GB799271A (en) | Production of intermediates for the synthesis of reserpine and allied compounds | |
CR20200618A (es) | Derivados de tetrahidrotienopiridina n-sustituidos y sus usos | |
GEP20125681B (en) | A one-pot process for preparing 3-(2,2,2-trimethylhydrazinium) propionate dihydrate | |
AR106475A1 (es) | Derivados de piridina o de pirimidina | |
MX2020005544A (es) | Metodo para preparar acetato de salicilamina. | |
RU2013110311A (ru) | Синтез соединений тиазолидиндиона | |
BR112023022116A2 (pt) | Uma forma em estado sólido de tafamidis e um processo para sua preparação | |
MX2022002043A (es) | Proceso para la preparacion de derivados de acido carboxilico de 3-bromo-4,5-dihidro-1h-pirazoles. | |
MX2023005713A (es) | Nuevo proceso para la elaboracion de derivados de tetrazol. | |
MX2022009603A (es) | Preparacion de 3-aril-5-trifluorometil-1,2,4-oxadiazoles sustituidos. | |
SE7510787L (sv) | Nya kvevehaltiga, polycykliska foreningar, salter derav och deras optiska antipoder, jemte sett for deras framstellning | |
AR064326A1 (es) | Un metodo para preparar derivados de taxano y compuestos intermedios utilizados en el mismo | |
MX2022009789A (es) | Proceso para preparar s-beflubutamid mediante la resolucion de acido 2-bromobutanoico. | |
AR120240A1 (es) | Métodos para la preparación de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico |