MX2022007787A - Proceso eficiente para elaborar derivados de 6-carboxi-benzoxazol. - Google Patents

Proceso eficiente para elaborar derivados de 6-carboxi-benzoxazol.

Info

Publication number
MX2022007787A
MX2022007787A MX2022007787A MX2022007787A MX2022007787A MX 2022007787 A MX2022007787 A MX 2022007787A MX 2022007787 A MX2022007787 A MX 2022007787A MX 2022007787 A MX2022007787 A MX 2022007787A MX 2022007787 A MX2022007787 A MX 2022007787A
Authority
MX
Mexico
Prior art keywords
sup
efficient process
carboxy
making
benzoxazole derivatives
Prior art date
Application number
MX2022007787A
Other languages
English (en)
Inventor
Padraig Mary O'neill
Simon Peter Curran
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Publication of MX2022007787A publication Critical patent/MX2022007787A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se dirige a un proceso eficiente para preparar derivados de benzoxazol que comprende la etapa de hacer reaccionar un compuesto del ácido 4-amino-3-hidroxibenzoico de la Fórmula III con un compuesto del ortoéster de 3,5-diclorofenilo de la Fórmula II para proporcionar el compuesto de la Fórmula I (ver Fórmula) en donde R1, R2a, R2b y R2c son como se describen en la presente.
MX2022007787A 2019-12-20 2020-12-16 Proceso eficiente para elaborar derivados de 6-carboxi-benzoxazol. MX2022007787A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962951691P 2019-12-20 2019-12-20
US202063120426P 2020-12-02 2020-12-02
PCT/IB2020/062040 WO2021124158A1 (en) 2019-12-20 2020-12-16 Efficient process for making 6-carboxy benzoxazole derivatives

Publications (1)

Publication Number Publication Date
MX2022007787A true MX2022007787A (es) 2022-07-19

Family

ID=73856234

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022007787A MX2022007787A (es) 2019-12-20 2020-12-16 Proceso eficiente para elaborar derivados de 6-carboxi-benzoxazol.

Country Status (12)

Country Link
US (1) US20230090609A1 (es)
EP (1) EP4077287A1 (es)
JP (1) JP2023507399A (es)
KR (1) KR20220114626A (es)
CN (1) CN115135639A (es)
AU (1) AU2020406455B2 (es)
BR (1) BR112022012097A2 (es)
CA (1) CA3165298A1 (es)
IL (1) IL294115A (es)
MX (1) MX2022007787A (es)
TW (1) TWI771827B (es)
WO (1) WO2021124158A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11970468B1 (en) 2023-10-23 2024-04-30 King Faisal University 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5222642A (en) 1975-08-14 1977-02-21 Kawasaki Heavy Ind Ltd Power generation device by hot water
GB8703975D0 (en) 1987-02-20 1987-03-25 Wellcome Found Pesticidal compounds
PT1587821E (pt) * 2002-12-19 2008-09-23 Scripps Research Inst Composições e métodos para estabilização da transtirretina e inibição do enrolamento incorrecto da transtirretina
JP5419545B2 (ja) 2009-05-25 2014-02-19 株式会社トクヤマ オルトエステル化合物の製造方法
US8168683B2 (en) 2009-10-15 2012-05-01 E. I. Du Pont De Nemours And Company Fluorinated vinylidene cationic surfactant
SG2014013270A (en) 2011-09-16 2014-05-29 Pfizer Solid forms of a transthyretin dissociation inhibitor
US9499527B2 (en) * 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
ES2975633T3 (es) 2014-09-08 2024-07-10 Pfizer Formas sólidas cristalinas de 6-carboxi-2-(3,5-diclorofenil)-benzoxazol para su uso como medicamento
CN107344927A (zh) * 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途
US10766893B2 (en) * 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

Also Published As

Publication number Publication date
JP2023507399A (ja) 2023-02-22
TWI771827B (zh) 2022-07-21
AU2020406455A1 (en) 2022-07-14
KR20220114626A (ko) 2022-08-17
IL294115A (en) 2022-08-01
EP4077287A1 (en) 2022-10-26
WO2021124158A1 (en) 2021-06-24
US20230090609A1 (en) 2023-03-23
TW202136222A (zh) 2021-10-01
BR112022012097A2 (pt) 2022-08-30
CN115135639A (zh) 2022-09-30
AU2020406455B2 (en) 2024-02-15
CA3165298A1 (en) 2021-06-24

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