BR112023022116A2 - Uma forma em estado sólido de tafamidis e um processo para sua preparação - Google Patents

Uma forma em estado sólido de tafamidis e um processo para sua preparação

Info

Publication number
BR112023022116A2
BR112023022116A2 BR112023022116A BR112023022116A BR112023022116A2 BR 112023022116 A2 BR112023022116 A2 BR 112023022116A2 BR 112023022116 A BR112023022116 A BR 112023022116A BR 112023022116 A BR112023022116 A BR 112023022116A BR 112023022116 A2 BR112023022116 A2 BR 112023022116A2
Authority
BR
Brazil
Prior art keywords
preparation
tafamidis
solid state
state form
crystalline
Prior art date
Application number
BR112023022116A
Other languages
English (en)
Inventor
Daniele Pengo
Giuseppe Barreca
Liming Huang
Luca Carcone
Massimo Zampieri
Piero Paravidino
Original Assignee
Quim Sintetica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quim Sintetica S A filed Critical Quim Sintetica S A
Publication of BR112023022116A2 publication Critical patent/BR112023022116A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

uma forma em estado sólido de tafamidis e um processo para sua preparação. são descritos uma forma cristalina de ácido 2-(3,5-diclorofenil)-1,3-benzoxazol-6-carboxílico e um método para sua preparação. a forma cristalina é adicionalmente adequada como composto intermediário para se preparar a forma 1, a forma 4 e a forma m com estabilidade e pureza melhoradas.
BR112023022116A 2021-04-26 2022-04-22 Uma forma em estado sólido de tafamidis e um processo para sua preparação BR112023022116A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21382362.8A EP4083027A1 (en) 2021-04-26 2021-04-26 A solid state form of tafamidis and a process for its preparation
PCT/EP2022/060716 WO2022229026A1 (en) 2021-04-26 2022-04-22 A solid state form of tafamidis and a process for its preparation

Publications (1)

Publication Number Publication Date
BR112023022116A2 true BR112023022116A2 (pt) 2024-01-09

Family

ID=75746555

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023022116A BR112023022116A2 (pt) 2021-04-26 2022-04-22 Uma forma em estado sólido de tafamidis e um processo para sua preparação

Country Status (8)

Country Link
US (1) US20240208915A1 (pt)
EP (2) EP4083027A1 (pt)
JP (1) JP2024515770A (pt)
CN (1) CN117255781A (pt)
BR (1) BR112023022116A2 (pt)
CA (1) CA3216325A1 (pt)
MX (1) MX2023012460A (pt)
WO (1) WO2022229026A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023091534A1 (en) * 2021-11-17 2023-05-25 Teva Pharmaceuticals International Gmbh Solid state form of tafamidis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2510455C (en) 2002-12-19 2013-03-12 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
WO2013038351A1 (en) 2011-09-16 2013-03-21 Pfizer Inc. Solid forms of a transthyretin dissociation inhibitor
PL3977993T3 (pl) 2014-09-08 2024-05-06 Pfizer Inc. Stałe krystaliczne formy 6-karboksy-2-(3,5-dichlorofenylo)-benzoksazolu do zastosowania jako lek
GB2571950A (en) 2018-03-13 2019-09-18 Azad Pharma Ag New polymorph and new path to synthesize tafamidis
KR20220017932A (ko) 2019-05-16 2022-02-14 테바 파마슈티컬스 인터내셔널 게엠베하 타파미디스 및 그 염의 고상형
US20220251052A1 (en) * 2019-07-04 2022-08-11 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid or its pharmaceutically acceptable salts and polymorphs thereof
WO2021019448A1 (en) 2019-08-01 2021-02-04 Honour (R&D) Process for the preparation of transthyretin dissociation inhibitor

Also Published As

Publication number Publication date
EP4083027A1 (en) 2022-11-02
MX2023012460A (es) 2023-12-14
EP4330237A1 (en) 2024-03-06
JP2024515770A (ja) 2024-04-10
US20240208915A1 (en) 2024-06-27
CA3216325A1 (en) 2022-11-03
CN117255781A (zh) 2023-12-19
WO2022229026A1 (en) 2022-11-03

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