BR112018000497A2 - processo para preparação de um composto - Google Patents

processo para preparação de um composto

Info

Publication number
BR112018000497A2
BR112018000497A2 BR112018000497A BR112018000497A BR112018000497A2 BR 112018000497 A2 BR112018000497 A2 BR 112018000497A2 BR 112018000497 A BR112018000497 A BR 112018000497A BR 112018000497 A BR112018000497 A BR 112018000497A BR 112018000497 A2 BR112018000497 A2 BR 112018000497A2
Authority
BR
Brazil
Prior art keywords
derivative
compound
cannabidiol compound
dihalo
cannabidiol
Prior art date
Application number
BR112018000497A
Other languages
English (en)
Inventor
Petrovic Denis
Dialer Lukas
Weigl Ulrich
Original Assignee
Noramco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57730761&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112018000497(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Noramco Inc filed Critical Noramco Inc
Publication of BR112018000497A2 publication Critical patent/BR112018000497A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

a presente revelação se refere à preparação de um composto de canabidiol ou um derivado do mesmo. o composto de canabidiol, ou derivados do mesmo, pode ser preparado por meio de uma reação catalisada por ácido de um di-halo-olivetol adequadamente selecionado e substituído, ou um derivado do mesmo, com um alceno cíclico adequadamente selecionado e substituído para produzir um composto de dihalo-canabidiol ou um derivado do mesmo. o composto de dihalo-canabidiol ou o derivado do mesmo pode ser produzido com alto rendimento, alta estereoespecificidade ou ambos. o mesmo pode ser, então, convertido sob condições redutoras em um composto de canabidiol ou derivados do mesmo.
BR112018000497A 2015-07-10 2016-07-01 processo para preparação de um composto BR112018000497A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562191097P 2015-07-10 2015-07-10
US15/199,528 US10059683B2 (en) 2015-07-10 2016-06-30 Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
PCT/US2016/040635 WO2017011210A1 (en) 2015-07-10 2016-07-01 Process for the production of cannabidiol and delta-9-tetrahydrocannabinol

Publications (1)

Publication Number Publication Date
BR112018000497A2 true BR112018000497A2 (pt) 2018-09-11

Family

ID=57730761

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018000497A BR112018000497A2 (pt) 2015-07-10 2016-07-01 processo para preparação de um composto

Country Status (21)

Country Link
US (4) US20170008869A1 (pt)
EP (2) EP3319952B8 (pt)
JP (2) JP6810842B2 (pt)
CN (1) CN108137526A (pt)
AU (2) AU2016294264B2 (pt)
BR (1) BR112018000497A2 (pt)
CA (1) CA2992043C (pt)
CL (2) CL2018000079A1 (pt)
CO (1) CO2018001290A2 (pt)
CR (1) CR20180094A (pt)
DK (1) DK3319952T3 (pt)
EC (1) ECSP18010065A (pt)
ES (1) ES2784881T3 (pt)
HK (1) HK1255390A1 (pt)
IL (1) IL256750A (pt)
MX (1) MX2018000354A (pt)
MY (1) MY182971A (pt)
NZ (1) NZ738925A (pt)
PH (1) PH12018500093A1 (pt)
PT (1) PT3319952T (pt)
WO (1) WO2017011210A1 (pt)

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CA3111788A1 (en) * 2018-09-05 2020-03-12 Purisys Llc Cannabidiol compositions having modified cannabinoid profiles
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WO2020214574A1 (en) 2019-04-15 2020-10-22 Trustees Of Boston University One-step flow-mediated synthesis of cannabidiol (cbd) and derivatives
CN111943813B (zh) * 2019-05-17 2023-04-14 上海特化医药科技有限公司 大麻二酚类化合物的制备方法
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CN113087599A (zh) * 2020-01-08 2021-07-09 成都百裕制药股份有限公司 大麻二酚衍生物及其制备方法和在医药上的应用
CN113087741B (zh) * 2020-01-08 2023-04-28 成都百裕制药股份有限公司 大麻二酚衍生物及其制备方法和在医药上的应用
CN113087743B (zh) * 2020-01-08 2023-04-28 成都百裕制药股份有限公司 四氢大麻酚衍生物及其制备方法和在医药上的应用
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CA3177186A1 (en) * 2020-03-31 2021-10-07 Phytotherapeutix Ltd Terpenophenolic compounds and their use
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CN112094257B (zh) * 2020-08-19 2023-08-22 公安部禁毒情报技术中心 一种△-9四氢大麻酚的制备方法
CN112811980B (zh) * 2020-12-01 2022-03-25 山东金城金奥医药科技有限公司 一种绿色光氧化连续制备大麻二酚中间体的方法
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Also Published As

Publication number Publication date
AU2016294264B2 (en) 2019-06-13
AU2016294264A1 (en) 2018-02-01
DK3319952T3 (da) 2020-03-23
EP3319952A1 (en) 2018-05-16
CN108137526A (zh) 2018-06-08
MY182971A (en) 2021-02-05
EP3319952B1 (en) 2020-02-05
MX2018000354A (es) 2018-08-15
CA2992043C (en) 2020-04-14
US20170008868A1 (en) 2017-01-12
EP3319952B8 (en) 2020-03-11
JP2020037596A (ja) 2020-03-12
US20180319763A1 (en) 2018-11-08
ECSP18010065A (es) 2018-05-31
JP2018522944A (ja) 2018-08-16
CL2019003154A1 (es) 2020-03-06
US10059683B2 (en) 2018-08-28
US20170008869A1 (en) 2017-01-12
AU2019229416A1 (en) 2019-10-03
PH12018500093A1 (en) 2018-07-09
ES2784881T3 (es) 2020-10-01
PT3319952T (pt) 2020-04-22
HK1255390A1 (zh) 2019-08-16
CR20180094A (es) 2018-06-14
EP3722276A1 (en) 2020-10-14
IL256750A (en) 2018-03-29
WO2017011210A1 (en) 2017-01-19
CO2018001290A2 (es) 2018-04-19
US10844035B2 (en) 2020-11-24
NZ738925A (en) 2019-05-31
US20210061781A1 (en) 2021-03-04
CL2018000079A1 (es) 2018-08-24
CA2992043A1 (en) 2017-01-19
JP6810842B2 (ja) 2021-01-13

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Ipc: C07D 311/04 (2006.01), C07D 311/80 (2006.01), C07D

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Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
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