BR112017001847A2 - processo para a preparação de um composto de fórmula (i), mistura, composição e composto de fórmula (ii) - Google Patents

processo para a preparação de um composto de fórmula (i), mistura, composição e composto de fórmula (ii)

Info

Publication number
BR112017001847A2
BR112017001847A2 BR112017001847A BR112017001847A BR112017001847A2 BR 112017001847 A2 BR112017001847 A2 BR 112017001847A2 BR 112017001847 A BR112017001847 A BR 112017001847A BR 112017001847 A BR112017001847 A BR 112017001847A BR 112017001847 A2 BR112017001847 A2 BR 112017001847A2
Authority
BR
Brazil
Prior art keywords
compound
formula
mixture
preparation
composition
Prior art date
Application number
BR112017001847A
Other languages
English (en)
Inventor
Schreiner Erwin
Richter Frank
Spitzenstätter Hans-Peter
SCHÖNE Olga
Wilhelm Thorsten
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of BR112017001847A2 publication Critical patent/BR112017001847A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6521—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65324—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

um processo para a preparação de um composto de fórmula (i), incluindo todos os isômeros, estereoisômeros, enantiômeros e diastereômeros do mesmo e sais dos mesmos; o processo compreende prover uma mistura compreendendo um composto de fórmula (ii) e um composto de fórmula (iii) submetendo a mistura provida em a) a condições de reação na presença de um ou mais ácidos de lewis à mistura provida em a), obtendo-se uma mistura compreendendo o composto de fórmula (i).
BR112017001847A 2014-07-31 2015-07-31 processo para a preparação de um composto de fórmula (i), mistura, composição e composto de fórmula (ii) BR112017001847A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14179385 2014-07-31
PCT/EP2015/067720 WO2016016447A1 (en) 2014-07-31 2015-07-31 Synthesis of phosphoramidates

Publications (1)

Publication Number Publication Date
BR112017001847A2 true BR112017001847A2 (pt) 2018-02-27

Family

ID=51257395

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017001847A BR112017001847A2 (pt) 2014-07-31 2015-07-31 processo para a preparação de um composto de fórmula (i), mistura, composição e composto de fórmula (ii)

Country Status (9)

Country Link
US (1) US20170218006A1 (pt)
EP (1) EP3174892A1 (pt)
JP (1) JP2017522343A (pt)
CN (1) CN106661074A (pt)
AU (1) AU2015295274A1 (pt)
BR (1) BR112017001847A2 (pt)
CA (1) CA2954940A1 (pt)
MX (1) MX2017001459A (pt)
WO (1) WO2016016447A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ307789B6 (cs) * 2014-04-15 2019-05-09 Zentiva, K.S. Způsob výroby biologicky účinných fosforamidátových léčiv
EP3154526B1 (en) 2014-06-13 2019-03-06 ratiopharm GmbH Solid state forms of sofosbuvir
CN105461774B (zh) * 2014-09-30 2020-11-24 江苏豪森药业集团有限公司 索非布韦的制备方法
US10251903B2 (en) * 2014-10-20 2019-04-09 Merck Sharp & Dohme Corp. Process for making nucleoside phosphoramidate compounds
WO2016160646A1 (en) * 2015-04-02 2016-10-06 Merck Sharp & Dohme Corp. Process for making phosphoramidate protected nucleoside compounds
WO2016196735A2 (en) 2015-06-03 2016-12-08 Teva Pharmaceuticals International Gmbh Improved processes for the preparation of sofosbuvir and intermediates thereof
US11053188B2 (en) * 2017-11-16 2021-07-06 Syngenta Participations Ag Process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE026235T2 (en) * 2010-03-31 2016-06-28 Gilead Pharmasset Llc Crystalline (S) -isopropyl 2 - (((S) - (((2R, 3R, 4R, 5R) -5- (2,4-dioxo-3,4-dihydropyrimidin-1 (2H) -IL) - 4-Fluoro-3-hydroxy-4-methyltetrahydrofuran-2-IL) methoxy) (phenoxy) phosphoryl) amino) propanoate
TW201136945A (en) * 2010-03-31 2011-11-01 Pharmasset Inc Purine nucleoside phosphoramidate
JP2016506371A (ja) * 2012-11-16 2016-03-03 ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド ヌクレオシドプロドラッグを調製する方法
GB201221064D0 (en) * 2012-11-23 2013-01-09 Secr Defence A deformable element
US9347383B2 (en) * 2013-02-26 2016-05-24 Jacobs Vehicle Systems, Inc. Intra-cylinder auxiliary actuation of engine valves through selective discontinuation of main valve events
WO2014164533A1 (en) * 2013-03-11 2014-10-09 Vertex Pharmaceuticals Incorporated Methods of stereoselective synthesis of substituted nucleoside analogs
BR112015025766A2 (pt) * 2013-04-12 2017-10-17 Achillion Pharmaceuticals Inc derivado de nucleosídeo altamente ativo para o tratamento de hcv
EP3303360A1 (en) * 2015-05-26 2018-04-11 Sandoz AG Selective process for synthesis of nucleoside phosphoramidates

Also Published As

Publication number Publication date
CA2954940A1 (en) 2016-02-04
WO2016016447A1 (en) 2016-02-04
MX2017001459A (es) 2017-05-23
JP2017522343A (ja) 2017-08-10
EP3174892A1 (en) 2017-06-07
US20170218006A1 (en) 2017-08-03
CN106661074A (zh) 2017-05-10
AU2015295274A1 (en) 2017-01-12

Similar Documents

Publication Publication Date Title
BR112017001847A2 (pt) processo para a preparação de um composto de fórmula (i), mistura, composição e composto de fórmula (ii)
CL2019002204A1 (es) Compuestos inhibidores del vih.
CL2019003154A1 (es) Proceso de preparación de un compuesto intermediario de fórmula (vi) para la preparación de compuestos de cannabidiol. (divisional solicitud 201800079)
CO2018007528A2 (es) Compuestos heterocíclicos como inmunomoduladores
CL2018001230A1 (es) Tratamiento de osteoartritis
GT201700189A (es) Derivados de nucleósidos sustituidos útiles como agentes antineoplásicos
UY37272A (es) Piridinas sustituidas con heteroarilo y métodos de uso
BR112018001400A2 (pt) compostos, processo para a síntese dos compostos, composição, utilização de um composto, método para o combate dos fungos e sementes
BR112018069612A2 (pt) compostos de pirroltriazina como inibidores de tam
BR112016025132A2 (pt) compostos polifluorados agindo como inibidores de tirosina quinase de bruton
BR112017009701A2 (pt) composto e métodos para a preparação de um composto
EA201890124A1 (ru) Новые гидроксикислотные производные, способ их получения и фармацевтические композиции, содержащие их
EA201890052A1 (ru) Регуляторы nrf2
CL2017002813A1 (es) Proceso para preparar 4-amino-piridazinas
UY35263A (es) Compuestos terapéuticos
CR20190504A (es) COMPUESTO DE AMIDA (Divisional 2015-0454)
BR112016015706A8 (pt) composto, uso do mesmo e composição farmacêutica
CL2015001667A1 (es) Derivados de manosa para tratar infecciones bacterianas.
BR112017023740A2 (pt) ?forma sólida de um composto, processo para a preparação de uma forma sólida, composição farmacêutica, método para o tratamento ou prevenção de doenças e utilização de uma forma sólida?
EA201890592A1 (ru) Жидкие фармацевтические композиции, содержащие ингибиторы sglt-2
BR112017010311A2 (pt) 4-oxo-3,4-dihidro-1,2,3-benzotriazinas como moduladores de gpr139
EA201790570A1 (ru) Модуляторы р2х7
BR112018010140A8 (pt) compostos de fórmula, composição, utilização de um composto de fórmula, método para o combate de fungos fitopatogênicos e semente
EA201790496A1 (ru) Соединения 1-алкил-6-оксо-1,6-дигидропиридин-3-ила и применение в качестве модуляторов sgrm
EA201791896A1 (ru) Дезацетокситубулизин н и его аналоги

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2594 DE 24-09-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.