KR20220114626A - 6-카르복시 벤족사졸 유도체의 효율적인 제조 방법 - Google Patents

6-카르복시 벤족사졸 유도체의 효율적인 제조 방법 Download PDF

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Publication number
KR20220114626A
KR20220114626A KR1020227024529A KR20227024529A KR20220114626A KR 20220114626 A KR20220114626 A KR 20220114626A KR 1020227024529 A KR1020227024529 A KR 1020227024529A KR 20227024529 A KR20227024529 A KR 20227024529A KR 20220114626 A KR20220114626 A KR 20220114626A
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KR
South Korea
Prior art keywords
formula
compound
dichlorophenyl
acid
carboxy
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English (en)
Korean (ko)
Inventor
사이먼 피터 커랜
파드리그 메리 오닐
Original Assignee
화이자 아일랜드 파마슈티컬즈
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Publication of KR20220114626A publication Critical patent/KR20220114626A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020227024529A 2019-12-20 2020-12-16 6-카르복시 벤족사졸 유도체의 효율적인 제조 방법 Withdrawn KR20220114626A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962951691P 2019-12-20 2019-12-20
US62/951,691 2019-12-20
US202063120426P 2020-12-02 2020-12-02
US63/120,426 2020-12-02
PCT/IB2020/062040 WO2021124158A1 (en) 2019-12-20 2020-12-16 Efficient process for making 6-carboxy benzoxazole derivatives

Publications (1)

Publication Number Publication Date
KR20220114626A true KR20220114626A (ko) 2022-08-17

Family

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KR1020227024529A Withdrawn KR20220114626A (ko) 2019-12-20 2020-12-16 6-카르복시 벤족사졸 유도체의 효율적인 제조 방법

Country Status (14)

Country Link
US (1) US12410145B2 (https=)
EP (1) EP4077287B1 (https=)
JP (1) JP2023507399A (https=)
KR (1) KR20220114626A (https=)
CN (1) CN115135639B (https=)
AU (1) AU2020406455B2 (https=)
BR (1) BR112022012097A2 (https=)
CA (1) CA3165298A1 (https=)
ES (1) ES3055912T3 (https=)
HR (1) HRP20251570T1 (https=)
IL (1) IL294115A (https=)
MX (1) MX2022007787A (https=)
TW (1) TWI771827B (https=)
WO (1) WO2021124158A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4077287B1 (en) 2019-12-20 2025-11-19 Pfizer Ireland Pharmaceuticals Unlimited Company Efficient process for making 6-carboxy benzoxazole derivatives
KR102657823B1 (ko) * 2022-03-10 2024-04-16 고려대학교 산학협력단 타파미디스의 신규 합성법
US11970468B1 (en) 2023-10-23 2024-04-30 King Faisal University 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5222642A (en) 1975-08-14 1977-02-21 Kawasaki Heavy Ind Ltd Power generation device by hot water
GB8703975D0 (en) 1987-02-20 1987-03-25 Wellcome Found Pesticidal compounds
GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
CA2800237C (en) * 2002-12-19 2016-05-17 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
JP5419545B2 (ja) 2009-05-25 2014-02-19 株式会社トクヤマ オルトエステル化合物の製造方法
US8168683B2 (en) 2009-10-15 2012-05-01 E. I. Du Pont De Nemours And Company Fluorinated vinylidene cationic surfactant
TWI550071B (zh) * 2011-03-25 2016-09-21 捷恩智股份有限公司 原酸酯化合物、液晶組成物及液晶顯示元件
RU2586330C2 (ru) * 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
US9499527B2 (en) * 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
PT4349406T (pt) * 2014-09-08 2026-02-04 Pfizer Formas sólidas cristalinas de 6-carboxi-2-(3,5-diclorofenil)-benzoxazol para utilização como medicamento
CN107344927A (zh) * 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途
US10766893B2 (en) * 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
EP4077287B1 (en) 2019-12-20 2025-11-19 Pfizer Ireland Pharmaceuticals Unlimited Company Efficient process for making 6-carboxy benzoxazole derivatives

Also Published As

Publication number Publication date
ES3055912T3 (en) 2026-02-16
AU2020406455B2 (en) 2024-02-15
TW202136222A (zh) 2021-10-01
EP4077287A1 (en) 2022-10-26
BR112022012097A2 (pt) 2022-08-30
JP2023507399A (ja) 2023-02-22
CN115135639A (zh) 2022-09-30
US20230090609A1 (en) 2023-03-23
EP4077287C0 (en) 2025-11-19
HRP20251570T1 (hr) 2026-01-30
WO2021124158A1 (en) 2021-06-24
EP4077287B1 (en) 2025-11-19
MX2022007787A (es) 2022-07-19
US12410145B2 (en) 2025-09-09
TWI771827B (zh) 2022-07-21
IL294115A (en) 2022-08-01
CN115135639B (zh) 2025-04-01
AU2020406455A1 (en) 2022-07-14
CA3165298A1 (en) 2021-06-24

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