JP2023507399A - ６－カルボキシベンゾオキサゾール誘導体を作製するための効率的なプロセス - Google Patents

６－カルボキシベンゾオキサゾール誘導体を作製するための効率的なプロセス Download PDF

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JP2023507399A
JP2023507399A JP2022537301A JP2022537301A JP2023507399A JP 2023507399 A JP2023507399 A JP 2023507399A JP 2022537301 A JP2022537301 A JP 2022537301A JP 2022537301 A JP2022537301 A JP 2022537301A JP 2023507399 A JP2023507399 A JP 2023507399A
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Japan
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compound
formula
dichlorophenyl
acid
carboxy
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JP2022537301A
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Japanese (ja)
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JP2023507399A5 (https=
Inventor
ピーター カラン サイモン
メアリー オニール パドレイ
Original Assignee
ファイザー アイルランド ファーマシューティカルズ
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Publication of JP2023507399A publication Critical patent/JP2023507399A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2022537301A 2019-12-20 2020-12-16 ６－カルボキシベンゾオキサゾール誘導体を作製するための効率的なプロセス Pending JP2023507399A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962951691P 2019-12-20 2019-12-20
US62/951,691 2019-12-20
US202063120426P 2020-12-02 2020-12-02
US63/120,426 2020-12-02
PCT/IB2020/062040 WO2021124158A1 (en) 2019-12-20 2020-12-16 Efficient process for making 6-carboxy benzoxazole derivatives

Publications (2)

Publication Number Publication Date
JP2023507399A true JP2023507399A (ja) 2023-02-22
JP2023507399A5 JP2023507399A5 (https=) 2023-12-12

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JP2022537301A Pending JP2023507399A (ja) 2019-12-20 2020-12-16 ６－カルボキシベンゾオキサゾール誘導体を作製するための効率的なプロセス

Country Status (14)

Country Link
US (1) US12410145B2 (https=)
EP (1) EP4077287B1 (https=)
JP (1) JP2023507399A (https=)
KR (1) KR20220114626A (https=)
CN (1) CN115135639B (https=)
AU (1) AU2020406455B2 (https=)
BR (1) BR112022012097A2 (https=)
CA (1) CA3165298A1 (https=)
ES (1) ES3055912T3 (https=)
HR (1) HRP20251570T1 (https=)
IL (1) IL294115A (https=)
MX (1) MX2022007787A (https=)
TW (1) TWI771827B (https=)
WO (1) WO2021124158A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4077287B1 (en) 2019-12-20 2025-11-19 Pfizer Ireland Pharmaceuticals Unlimited Company Efficient process for making 6-carboxy benzoxazole derivatives
KR102657823B1 (ko) * 2022-03-10 2024-04-16 고려대학교 산학협력단 타파미디스의 신규 합성법
US11970468B1 (en) 2023-10-23 2024-04-30 King Faisal University 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63301884A (ja) * 1987-02-20 1988-12-08 ザ　ウエルカム　フアウンデーション　リミテッド 有害生物防除化合物
JP2006511612A (ja) * 2002-12-19 2006-04-06 ザ スクリップス リサーチ インスティテュート トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法
WO2012132796A1 (ja) * 2011-03-25 2012-10-04 Jnc株式会社 オルトエステル誘導体、液晶組成物および液晶表示素子
WO2013168014A1 (en) * 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of familial amyloid polyneuropathy
JP2019514959A (ja) * 2016-05-05 2019-06-06 クリスタル ファーマテック カンパニー、リミテッドＣｒｙｓｔａｌ Ｐｈａｒｍａｔｅｃｈ Ｃｏ．， Ｌｔｄ． タファミジスメグルミン塩の結晶形ｅ及びその製造方法並びに用途

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
JPS5222642A (en) 1975-08-14 1977-02-21 Kawasaki Heavy Ind Ltd Power generation device by hot water
GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
JP5419545B2 (ja) 2009-05-25 2014-02-19 株式会社トクヤマ オルトエステル化合物の製造方法
US8168683B2 (en) 2009-10-15 2012-05-01 E. I. Du Pont De Nemours And Company Fluorinated vinylidene cationic surfactant
RU2586330C2 (ru) * 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
PT4349406T (pt) * 2014-09-08 2026-02-04 Pfizer Formas sólidas cristalinas de 6-carboxi-2-(3,5-diclorofenil)-benzoxazol para utilização como medicamento
US10766893B2 (en) * 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
EP4077287B1 (en) 2019-12-20 2025-11-19 Pfizer Ireland Pharmaceuticals Unlimited Company Efficient process for making 6-carboxy benzoxazole derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63301884A (ja) * 1987-02-20 1988-12-08 ザ　ウエルカム　フアウンデーション　リミテッド 有害生物防除化合物
JP2006511612A (ja) * 2002-12-19 2006-04-06 ザ スクリップス リサーチ インスティテュート トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法
WO2012132796A1 (ja) * 2011-03-25 2012-10-04 Jnc株式会社 オルトエステル誘導体、液晶組成物および液晶表示素子
WO2013168014A1 (en) * 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of familial amyloid polyneuropathy
JP2019514959A (ja) * 2016-05-05 2019-06-06 クリスタル ファーマテック カンパニー、リミテッドＣｒｙｓｔａｌ Ｐｈａｒｍａｔｅｃｈ Ｃｏ．， Ｌｔｄ． タファミジスメグルミン塩の結晶形ｅ及びその製造方法並びに用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GULLUZAR BASTUG ET AL.: "Functionalized Orthoesters as Powerful Building Blocks for the Efficient Preparation ofHeteroaromati", ORGANIC LETTERS, vol. 14, no. 13, JPN6024053142, 26 June 2012 (2012-06-26), pages 3502 - 3505, ISSN: 0005633692 *

Also Published As

Publication number Publication date
ES3055912T3 (en) 2026-02-16
AU2020406455B2 (en) 2024-02-15
TW202136222A (zh) 2021-10-01
EP4077287A1 (en) 2022-10-26
BR112022012097A2 (pt) 2022-08-30
CN115135639A (zh) 2022-09-30
US20230090609A1 (en) 2023-03-23
EP4077287C0 (en) 2025-11-19
HRP20251570T1 (hr) 2026-01-30
WO2021124158A1 (en) 2021-06-24
EP4077287B1 (en) 2025-11-19
MX2022007787A (es) 2022-07-19
US12410145B2 (en) 2025-09-09
KR20220114626A (ko) 2022-08-17
TWI771827B (zh) 2022-07-21
IL294115A (en) 2022-08-01
CN115135639B (zh) 2025-04-01
AU2020406455A1 (en) 2022-07-14
CA3165298A1 (en) 2021-06-24

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