CN115103912A - 一种质粒组合及其在制备经修饰的免疫细胞中的应用 - Google Patents

一种质粒组合及其在制备经修饰的免疫细胞中的应用 Download PDF

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CN115103912A
CN115103912A CN202080015297.2A CN202080015297A CN115103912A CN 115103912 A CN115103912 A CN 115103912A CN 202080015297 A CN202080015297 A CN 202080015297A CN 115103912 A CN115103912 A CN 115103912A
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cells
cell
immune effector
effector cell
lymphoma
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CN115103912B (zh
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刘芸
石琳
吕璐璐
谢攀
曹蒙蒙
杨旺
杨家兴
王飞
王瑞
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Heyuan Biotechnology Tianjin Co ltd
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Abstract

本申请提供采用四质粒系统制备修饰的免疫效应细胞的方法。所述方法包括在293T细胞内四个质粒形成慢病毒，提取获得慢病毒，再用慢病毒转染免疫效应细胞，表达嵌合抗原受体。本申请还提供使用所述方法获得的免疫效应细胞、包含所述免疫效应细胞的组合物的用途。

Description

PCT国内申请，说明书已公开。

Claims (36)

  1. PCT国内申请，权利要求书已公开。
CN202080015297.2A 2019-12-17 2020-12-15 一种质粒组合及其在制备经修饰的免疫细胞中的应用 Active CN115103912B (zh)

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CN201911301518 2019-12-17
CN2019113015188 2019-12-17
CN2020112748108 2020-11-16
CN202011274810.8A CN112079934B (zh) 2019-12-17 2020-11-16 一种靶向cd19的嵌合抗原受体及其用途
CN2020114336719 2020-12-10
CN202011433671.9A CN112226463B (zh) 2019-12-17 2020-12-10 一种质粒组合及其在制备经修饰的免疫细胞中的应用
PCT/CN2020/136542 WO2021121227A1 (zh) 2019-12-17 2020-12-15 一种质粒组合及其在制备经修饰的免疫细胞中的应用

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CN112079934B (zh) * 2019-12-17 2021-01-29 合源生物科技(天津)有限公司 一种靶向cd19的嵌合抗原受体及其用途
CN115466331B (zh) 2021-11-18 2023-05-30 合源生物科技(天津)有限公司 靶向bcma的嵌合抗原受体及其应用
CN116410331B (zh) * 2021-12-31 2024-01-30 合源生物科技(天津)有限公司 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用

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