CN1144805C - 桥接双哌啶化合物，其制备方法和中间体及用于治疗心律失常的用途 - Google Patents

桥接双哌啶化合物，其制备方法和中间体及用于治疗心律失常的用途 Download PDF

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Publication number
CN1144805C
CN1144805C CNB008116962A CN00811696A CN1144805C CN 1144805 C CN1144805 C CN 1144805C CN B008116962 A CNB008116962 A CN B008116962A CN 00811696 A CN00811696 A CN 00811696A CN 1144805 C CN1144805 C CN 1144805C
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CN
China
Prior art keywords
formula
compound
alkyl
diazabicyclo
nonane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008116962A
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English (en)
Chinese (zh)
Other versions
CN1370167A (zh
Inventor
C
C·阿尔斯特马克
K·安德松
A·比约雷
M·比约斯尼
���˹�ص��ذ���˹����
E·L·林斯特德特阿尔斯特马克
G·尼尔松
M·波拉
G·斯特兰伦德
Y·厄滕格伦
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AstraZeneca AB
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AstraZeneca AB
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Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1370167A publication Critical patent/CN1370167A/zh
Application granted granted Critical
Publication of CN1144805C publication Critical patent/CN1144805C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CNB008116962A 1999-06-16 2000-06-15 桥接双哌啶化合物，其制备方法和中间体及用于治疗心律失常的用途 Expired - Fee Related CN1144805C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9902268A SE9902268D0 (sv) 1999-06-16 1999-06-16 Pharmaceutically active compounds
SE99022683 1999-06-16

Publications (2)

Publication Number Publication Date
CN1370167A CN1370167A (zh) 2002-09-18
CN1144805C true CN1144805C (zh) 2004-04-07

Family

ID=20416100

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008116962A Expired - Fee Related CN1144805C (zh) 1999-06-16 2000-06-15 桥接双哌啶化合物，其制备方法和中间体及用于治疗心律失常的用途

Country Status (24)

Country Link
EP (1) EP1192157A1 (enExample)
JP (1) JP2003502329A (enExample)
KR (1) KR20020010713A (enExample)
CN (1) CN1144805C (enExample)
AR (1) AR024577A1 (enExample)
AU (1) AU761576B2 (enExample)
BR (1) BR0011660A (enExample)
CA (1) CA2375841A1 (enExample)
CZ (1) CZ20014495A3 (enExample)
EE (1) EE200100675A (enExample)
HK (1) HK1045520A1 (enExample)
HU (1) HUP0203959A3 (enExample)
IL (1) IL146754A0 (enExample)
IS (1) IS6201A (enExample)
MX (1) MXPA01012919A (enExample)
NO (1) NO20016117L (enExample)
NZ (1) NZ516013A (enExample)
PL (1) PL354032A1 (enExample)
RU (1) RU2250903C2 (enExample)
SE (1) SE9902268D0 (enExample)
SK (1) SK18272001A3 (enExample)
TR (1) TR200103663T2 (enExample)
WO (1) WO2000077000A1 (enExample)
ZA (1) ZA200109796B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030302A1 (es) * 2000-07-07 2003-08-20 Astrazeneca Ab Compuestos de bispidina, formulacion farmaceutica, uso para la fabricacion de medicamentos, proceso para la preparacion de estos compuestos y compuestos intermediarios
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
TWI499418B (zh) * 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物
JP5955954B2 (ja) * 2011-07-08 2016-07-20 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ ２−アミノ−５−シアノ−ｎ，３−ジメチルベンズアミドを製造する方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1107541A1 (ru) * 1982-12-03 1995-10-20 Институт Тонкой Органической Химии Им.А.Л.Мнджояна 10-нитро-1,6,8-триазатрицикло [6,3,1,1] тридекан-2,5-дион
PT88381B (pt) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
DK588489D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
TW263504B (enExample) * 1991-10-03 1995-11-21 Pfizer
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
JP2003502329A (ja) 2003-01-21
WO2000077000A1 (en) 2000-12-21
SE9902268D0 (sv) 1999-06-16
AU6032400A (en) 2001-01-02
MXPA01012919A (es) 2002-07-30
RU2250903C2 (ru) 2005-04-27
CZ20014495A3 (cs) 2002-05-15
NO20016117L (no) 2002-02-15
KR20020010713A (ko) 2002-02-04
WO2000077000A9 (en) 2003-06-19
IS6201A (is) 2001-12-14
EP1192157A1 (en) 2002-04-03
TR200103663T2 (tr) 2002-05-21
CN1370167A (zh) 2002-09-18
IL146754A0 (en) 2002-07-25
CA2375841A1 (en) 2000-12-21
HUP0203959A3 (en) 2003-04-28
HK1045520A1 (zh) 2002-11-29
NZ516013A (en) 2003-06-30
AU761576B2 (en) 2003-06-05
AR024577A1 (es) 2002-10-16
SK18272001A3 (sk) 2002-12-03
EE200100675A (et) 2003-02-17
ZA200109796B (en) 2003-02-28
NO20016117D0 (no) 2001-12-14
HUP0203959A2 (hu) 2003-03-28
PL354032A1 (en) 2003-12-15
BR0011660A (pt) 2002-03-26

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