CN1142164C - 具有能产生旋光活性的7-吡咯烷取代基的旋光活性喹啉羧酸衍生物及其制备方法 - Google Patents

具有能产生旋光活性的7-吡咯烷取代基的旋光活性喹啉羧酸衍生物及其制备方法 Download PDF

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Publication number
CN1142164C
CN1142164C CNB008094705A CN00809470A CN1142164C CN 1142164 C CN1142164 C CN 1142164C CN B008094705 A CNB008094705 A CN B008094705A CN 00809470 A CN00809470 A CN 00809470A CN 1142164 C CN1142164 C CN 1142164C
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CN
China
Prior art keywords
formula
compound
optically active
acid
quinolinecarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB008094705A
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English (en)
Chinese (zh)
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CN1358185A (zh
Inventor
���ɿ������޹�˾
尹晟俊
郑龙浩
李致雨
李振洙
金南斗
陈允豪
宋完珍
金翼会
梁王龙
崔东洛
申定翰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EU BIOTECH DEVELOPMENT Ltd
Original Assignee
Dong Wha Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020000024657A external-priority patent/KR20010029698A/ko
Application filed by Dong Wha Pharm Co Ltd filed Critical Dong Wha Pharm Co Ltd
Publication of CN1358185A publication Critical patent/CN1358185A/zh
Application granted granted Critical
Publication of CN1142164C publication Critical patent/CN1142164C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB008094705A 1999-05-20 2000-05-18 具有能产生旋光活性的7-吡咯烷取代基的旋光活性喹啉羧酸衍生物及其制备方法 Expired - Lifetime CN1142164C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR19990018158 1999-05-20
KR1999/18158 1999-05-20
KR2000/24657 2000-05-09
KR1020000024657A KR20010029698A (ko) 1999-05-20 2000-05-09 광학활성을 유발하는 7-피롤리딘 치환체를 갖는광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법

Publications (2)

Publication Number Publication Date
CN1358185A CN1358185A (zh) 2002-07-10
CN1142164C true CN1142164C (zh) 2004-03-17

Family

ID=37040873

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008094705A Expired - Lifetime CN1142164C (zh) 1999-05-20 2000-05-18 具有能产生旋光活性的7-吡咯烷取代基的旋光活性喹啉羧酸衍生物及其制备方法

Country Status (11)

Country Link
US (2) US6649763B1 (enExample)
EP (1) EP1187835B1 (enExample)
JP (2) JP2003500406A (enExample)
KR (1) KR100497942B1 (enExample)
CN (1) CN1142164C (enExample)
AT (1) ATE382047T1 (enExample)
AU (1) AU757272B2 (enExample)
CA (1) CA2374767C (enExample)
DE (1) DE60037587T2 (enExample)
ES (1) ES2296618T3 (enExample)
WO (1) WO2000071541A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589978B2 (en) * 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
US7642355B2 (en) * 2005-03-10 2010-01-05 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101353348A (zh) * 2008-07-28 2009-01-28 南京明生医药技术有限公司 7-[4-(胺甲基)-4-氟-3-(烷氧亚氨基)吡咯烷-1-基]取代的喹啉羧酸衍生物及其制备方法
KR101468659B1 (ko) 2009-07-27 2014-12-05 주식회사 아리바이오 Ｒ-7-(3-아미노메틸-4-메톡시이미노-3-메틸-피롤리딘-1-일)-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1,8]나프티리딘-3-카르복실산 ｌ-아스파르트산염, 이의 제조방법 및 이를 포함하는 항균용 약학적 조성물
KR20220135949A (ko) 2021-03-31 2022-10-07 주식회사 이큐인베스트먼트 차트 유사도 분석을 이용한 주식 거래 인공신경망 장치 및 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276041A (en) * 1991-11-08 1994-01-04 Kaken Pharmaceutical Co., Ltd. Oxime derivatives
DK0688772T3 (da) * 1994-06-16 1999-11-01 Lg Chemical Ltd Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling
IT234996Y1 (it) 1994-06-22 2000-03-31 Bocchiotti Soc Ind Elettrotec Imballaggio per profilati metallici.
DE4422237A1 (de) * 1994-06-24 1996-01-04 Gruenenthal Gmbh Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
KR0174373B1 (ko) * 1995-08-03 1999-02-18 성재갑 7-(4-아미노메틸-4-알킬-3-알킬옥심)피롤리딘 치환체를 갖는 신규 퀴놀린 카르복실산 유도체 및 그의 제조방법
US6313299B1 (en) 1997-06-26 2001-11-06 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives

Also Published As

Publication number Publication date
JP5276255B2 (ja) 2013-08-28
CA2374767A1 (en) 2000-11-30
JP2006232842A (ja) 2006-09-07
CA2374767C (en) 2007-05-15
US6753430B2 (en) 2004-06-22
ES2296618T3 (es) 2008-05-01
AU757272B2 (en) 2003-02-13
EP1187835A1 (en) 2002-03-20
US20040029915A1 (en) 2004-02-12
AU4620900A (en) 2000-12-12
EP1187835B1 (en) 2007-12-26
DE60037587T2 (de) 2008-04-30
KR100497942B1 (ko) 2005-06-29
JP2003500406A (ja) 2003-01-07
US6649763B1 (en) 2003-11-18
DE60037587D1 (de) 2008-02-07
EP1187835A4 (en) 2003-01-29
CN1358185A (zh) 2002-07-10
WO2000071541A1 (en) 2000-11-30
KR20020002461A (ko) 2002-01-09
ATE382047T1 (de) 2008-01-15

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C10 Entry into substantive examination
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Owner name: EU BIOTECHNOLOGY DEVELOPMENT CO., LTD.

Free format text: FORMER OWNER: DOWA PHARMACEUTICAL INDUSTRY CO., LTD.

Effective date: 20091113

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20091113

Address after: British Glasgow

Patentee after: EU biotech development Ltd

Address before: Seoul

Patentee before: Dong Wha Pharm. Co., Ltd.

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20040317