KR100497942B1 - 광학활성을 유발하는 7-피롤리딘 치환체를 갖는 광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법 - Google Patents

광학활성을 유발하는 7-피롤리딘 치환체를 갖는 광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법 Download PDF

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Publication number
KR100497942B1
KR100497942B1 KR10-2001-7014647A KR20017014647A KR100497942B1 KR 100497942 B1 KR100497942 B1 KR 100497942B1 KR 20017014647 A KR20017014647 A KR 20017014647A KR 100497942 B1 KR100497942 B1 KR 100497942B1
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South Korea
Prior art keywords
compound
formula
optically active
carboxylic acid
methyl
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Expired - Lifetime
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KR10-2001-7014647A
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English (en)
Korean (ko)
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KR20020002461A (ko
Inventor
윤성준
정용호
이치우
이진수
김남두
진윤호
송완진
김익회
양왕용
최동락
신정한
Original Assignee
동화약품공업주식회사
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Priority claimed from KR1020000024657A external-priority patent/KR20010029698A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR10-2001-7014647A 1999-05-20 2000-05-18 광학활성을 유발하는 7-피롤리딘 치환체를 갖는 광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법 Expired - Lifetime KR100497942B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1019990018158 1999-05-20
KR19990018158 1999-05-20
KR1020000024657A KR20010029698A (ko) 1999-05-20 2000-05-09 광학활성을 유발하는 7-피롤리딘 치환체를 갖는광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법
KR1020000024657 2000-05-09

Publications (2)

Publication Number Publication Date
KR20020002461A KR20020002461A (ko) 2002-01-09
KR100497942B1 true KR100497942B1 (ko) 2005-06-29

Family

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KR10-2001-7014647A Expired - Lifetime KR100497942B1 (ko) 1999-05-20 2000-05-18 광학활성을 유발하는 7-피롤리딘 치환체를 갖는 광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법

Country Status (11)

Country Link
US (2) US6649763B1 (enExample)
EP (1) EP1187835B1 (enExample)
JP (2) JP2003500406A (enExample)
KR (1) KR100497942B1 (enExample)
CN (1) CN1142164C (enExample)
AT (1) ATE382047T1 (enExample)
AU (1) AU757272B2 (enExample)
CA (1) CA2374767C (enExample)
DE (1) DE60037587T2 (enExample)
ES (1) ES2296618T3 (enExample)
WO (1) WO2000071541A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589978B2 (en) * 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
US7642355B2 (en) * 2005-03-10 2010-01-05 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101353348A (zh) * 2008-07-28 2009-01-28 南京明生医药技术有限公司 7-[4-(胺甲基)-4-氟-3-(烷氧亚氨基)吡咯烷-1-基]取代的喹啉羧酸衍生物及其制备方法
KR101468659B1 (ko) 2009-07-27 2014-12-05 주식회사 아리바이오 Ｒ-7-(3-아미노메틸-4-메톡시이미노-3-메틸-피롤리딘-1-일)-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1,8]나프티리딘-3-카르복실산 ｌ-아스파르트산염, 이의 제조방법 및 이를 포함하는 항균용 약학적 조성물
KR20220135949A (ko) 2021-03-31 2022-10-07 주식회사 이큐인베스트먼트 차트 유사도 분석을 이용한 주식 거래 인공신경망 장치 및 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0174373B1 (ko) * 1995-08-03 1999-02-18 성재갑 7-(4-아미노메틸-4-알킬-3-알킬옥심)피롤리딘 치환체를 갖는 신규 퀴놀린 카르복실산 유도체 및 그의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276041A (en) * 1991-11-08 1994-01-04 Kaken Pharmaceutical Co., Ltd. Oxime derivatives
DK0688772T3 (da) * 1994-06-16 1999-11-01 Lg Chemical Ltd Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling
IT234996Y1 (it) 1994-06-22 2000-03-31 Bocchiotti Soc Ind Elettrotec Imballaggio per profilati metallici.
DE4422237A1 (de) * 1994-06-24 1996-01-04 Gruenenthal Gmbh Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
US6313299B1 (en) 1997-06-26 2001-11-06 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0174373B1 (ko) * 1995-08-03 1999-02-18 성재갑 7-(4-아미노메틸-4-알킬-3-알킬옥심)피롤리딘 치환체를 갖는 신규 퀴놀린 카르복실산 유도체 및 그의 제조방법

Also Published As

Publication number Publication date
JP5276255B2 (ja) 2013-08-28
CA2374767A1 (en) 2000-11-30
JP2006232842A (ja) 2006-09-07
CA2374767C (en) 2007-05-15
US6753430B2 (en) 2004-06-22
ES2296618T3 (es) 2008-05-01
AU757272B2 (en) 2003-02-13
EP1187835A1 (en) 2002-03-20
US20040029915A1 (en) 2004-02-12
AU4620900A (en) 2000-12-12
EP1187835B1 (en) 2007-12-26
DE60037587T2 (de) 2008-04-30
JP2003500406A (ja) 2003-01-07
US6649763B1 (en) 2003-11-18
DE60037587D1 (de) 2008-02-07
EP1187835A4 (en) 2003-01-29
CN1358185A (zh) 2002-07-10
CN1142164C (zh) 2004-03-17
WO2000071541A1 (en) 2000-11-30
KR20020002461A (ko) 2002-01-09
ATE382047T1 (de) 2008-01-15

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