CN113667696A - 用于高效基因组编辑的腺相关病毒载体变异体和其方法 - Google Patents

用于高效基因组编辑的腺相关病毒载体变异体和其方法 Download PDF

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CN113667696A
CN113667696A CN202110964654.6A CN202110964654A CN113667696A CN 113667696 A CN113667696 A CN 113667696A CN 202110964654 A CN202110964654 A CN 202110964654A CN 113667696 A CN113667696 A CN 113667696A
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amino acid
seq
capsid protein
aav
acid corresponding
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S·查特瑞
L·史密斯
K·王
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City of Hope
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CN202110964654.6A 2014-09-24 2015-09-23 用于高效基因组编辑的腺相关病毒载体变异体和其方法 Pending CN113667696A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462054899P 2014-09-24 2014-09-24
US62/054,899 2014-09-24
US201462063587P 2014-10-14 2014-10-14
US62/063,587 2014-10-14
US201562209862P 2015-08-25 2015-08-25
US62/209,862 2015-08-25
CN201580063926.8A CN107295802B (zh) 2014-09-24 2015-09-23 用于高效基因组编辑的腺相关病毒载体变异体和其方法

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US (6) US9890396B2 (https=)
EP (2) EP3198018B1 (https=)
JP (3) JP6683691B2 (https=)
KR (2) KR102526711B1 (https=)
CN (2) CN113667696A (https=)
AU (2) AU2015320694B2 (https=)
BR (1) BR112017005892A2 (https=)
CA (1) CA2961555A1 (https=)
DK (1) DK3198018T3 (https=)
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CN115896135A (zh) * 2022-11-02 2023-04-04 苏州诺洁贝生物技术有限公司 优化的pah基因和表达盒及其用途
CN115948408A (zh) * 2022-09-23 2023-04-11 上海信致医药科技有限公司 改进的人凝血因子viii基因表达盒及其应用
CN116726198A (zh) * 2023-03-13 2023-09-12 陕西师范大学 一种抗肿瘤药物及其在脑胶质瘤治疗中的应用
WO2025015774A1 (zh) * 2023-07-17 2025-01-23 苏州吉恒基因科技有限公司 单链单极DNA重组腺相关病毒的cis包装元件、spAAV载体和应用

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US9839696B2 (en) 2010-04-30 2017-12-12 City Of Hope Recombinant adeno-associated vectors for targeted treatment
US10323236B2 (en) 2011-07-22 2019-06-18 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
AU2014235096B2 (en) 2013-03-15 2020-03-19 The Trustees Of The University Of Pennsylvania Compositions and methods for treating MPSI
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
EA201792500A1 (ru) 2015-05-13 2018-04-30 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Aav-опосредованная экспрессия антител против гриппа и способы их использования
US10966414B2 (en) 2015-05-26 2021-04-06 California Institute Of Technology Population control using engineered translocations
ES2865487T3 (es) 2015-09-28 2021-10-15 Univ North Carolina Chapel Hill Métodos y composiciones para vectores virales que evaden los anticuerpos
IL310721B2 (en) 2015-10-23 2025-11-01 Harvard College Nucleobase editors and uses thereof
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