CN1131867C - 一种诱导编程性细胞死亡的化合物、其制备方法及其组合物 - Google Patents

一种诱导编程性细胞死亡的化合物、其制备方法及其组合物 Download PDF

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CN1131867C
CN1131867C CN99809417XA CN99809417A CN1131867C CN 1131867 C CN1131867 C CN 1131867C CN 99809417X A CN99809417X A CN 99809417XA CN 99809417 A CN99809417 A CN 99809417A CN 1131867 C CN1131867 C CN 1131867C
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compound
formula
anhydrogalactose
composition
activity
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Expired - Fee Related
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CN1312813A (zh
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榎龙嗣
友野润
小山信人
猪饲胜重
佐川裕章
加藤郁之进
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Takara Bio Inc
Takara Holdings Inc
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Takara Shuzo Co Ltd
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    • C07—ORGANIC CHEMISTRY
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CN99809417XA 1998-06-09 1999-06-08 一种诱导编程性细胞死亡的化合物、其制备方法及其组合物 Expired - Fee Related CN1131867C (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP175295/1998 1998-06-09
JP17529598 1998-06-09
JP223723/1998 1998-07-24
JP22372398 1998-07-24
JP1163999 1999-01-20
JP11639/1999 1999-01-20
PCT/JP1999/003058 WO1999064424A1 (en) 1998-06-09 1999-06-08 Therapeutic agents

Publications (2)

Publication Number Publication Date
CN1312813A CN1312813A (zh) 2001-09-12
CN1131867C true CN1131867C (zh) 2003-12-24

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CN99809417XA Expired - Fee Related CN1131867C (zh) 1998-06-09 1999-06-08 一种诱导编程性细胞死亡的化合物、其制备方法及其组合物

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US (1) US6531148B1 (https=)
EP (1) EP1086952B1 (https=)
JP (2) JP3779153B2 (https=)
KR (3) KR100735139B1 (https=)
CN (1) CN1131867C (https=)
AT (1) ATE370144T1 (https=)
AU (1) AU764582B2 (https=)
CA (1) CA2334249A1 (https=)
DE (1) DE69936855T2 (https=)
TW (1) TWI244484B (https=)
WO (1) WO1999064424A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001181191A (ja) * 1999-12-24 2001-07-03 Cci Corp 慢性関節リウマチ疾患予防および治療剤
CN1418207A (zh) * 2000-01-13 2003-05-14 宝生物工程株式会社 基因表达调节失常矫正剂
AU2001294173A1 (en) * 2000-10-03 2002-04-15 Takara Bio Inc. Method of screening physiologically active substance
KR100373776B1 (ko) * 2000-12-27 2003-02-26 한불화장품주식회사 화장료 조성물
CH692180A5 (it) * 2001-06-22 2002-03-15 Gecomwert Anstalt Preparato cosmetico con azione antirughe.
WO2003024446A1 (en) * 2001-09-11 2003-03-27 Mitsubishi Pharma Corporation Oxidation stress inhibitor and method of measuring oxidation stress
US20050063995A1 (en) * 2001-10-25 2005-03-24 Spaner David E Compositions and methods for selected tumour treatment
TW200403067A (en) * 2002-04-17 2004-03-01 Takara Bio Inc Remedies
US7309589B2 (en) 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
CA2611121C (en) * 2005-05-31 2014-01-28 Arla Foods Amba Phosphatidylserine enriched milk fractions for the formulation of functional foods
WO2012148023A1 (ko) * 2011-04-29 2012-11-01 바이올시스템즈 주식회사 무수갈락토스의 분리정제 방법
CN102321153B (zh) * 2011-09-06 2013-06-05 中国科学院成都生物研究所 一种新奥苷肽粉状固体的制备方法
KR101525298B1 (ko) * 2012-01-18 2015-06-03 고려대학교 산학협력단 3,6-안하이드로-l-갈락토오스의 제조방법 및 이의 용도
JP6241644B2 (ja) * 2013-06-05 2017-12-06 伊那食品工業株式会社 ＰＰＡＲγ発現向上剤、並びにそれを含む基礎代謝向上剤、筋肉疲労回復向上剤、ＰＰＡＲγ発現向上用医薬組成物及びＰＰＡＲγ発現向上用飲食品
KR102011721B1 (ko) * 2017-11-28 2019-08-19 고려대학교 산학협력단 포도상구균의 생육을 억제하는 한천 유래 올리고당의 용도
CN108776121B (zh) * 2018-04-08 2021-07-30 广州卡马生物科技有限公司 一种基于荧光猝灭原理对药材中抗氧剂的高通量筛选方法
CN112375110A (zh) * 2020-11-20 2021-02-19 西安乐析医疗科技有限公司 一种化合物3,4-dge的制备方法
KR102608602B1 (ko) * 2020-11-27 2023-12-01 (주)헬스코치생명공학 Ahg를 이용한 자외선에 의한 피부 주름 개선용 조성물
KR102537335B1 (ko) * 2022-08-10 2023-05-26 경북대학교 산학협력단 Ｌ­ａｈｇ를 포함하는 면역 억제용 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05565A (ja) * 1991-06-21 1993-01-08 Toyo Ink Mfg Co Ltd 皮膜形成方法
CN1075635A (zh) * 1992-02-06 1993-09-01 石原产业株式会社 免疫抑制剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1202286B (de) * 1962-08-04 1965-10-07 Huels Chemische Werke Ag Verfahren zur Herstellung von beta-Pyronen
US3230233A (en) * 1964-03-04 1966-01-18 American Cyanamid Co Novel substituted 2, 3-dihydro-9-carbamo-yloxymethyl-6-methyl-pyrrolo[1, 2-a] indole-5, 8-diones
FR2541307A1 (fr) * 1983-02-23 1984-08-24 Korano Substance gelifiante semi-synthetique, son procede de preparation et ses applications, notamment dans les milieux de culture pour microorganismes
JPS62210958A (ja) * 1986-03-13 1987-09-17 Meiji Seika Kaisha Ltd 澱粉含有組成物の老化防止方法
JPH04316593A (ja) * 1991-02-21 1992-11-06 Japan Tobacco Inc Ｄ−アロサンの製造方法
EP0873691A3 (en) * 1992-05-15 1999-07-14 Ina Food Industry Co., Ltd. Food comprising a low gel strength agar
AU666577B2 (en) * 1992-08-19 1996-02-15 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
JP3193480B2 (ja) * 1992-09-03 2001-07-30 石原産業株式会社 免疫機能抑制剤
JP3266343B2 (ja) * 1992-12-17 2002-03-18 芝浦メカトロニクス株式会社 クリームはんだ印刷装置
JP3865801B2 (ja) * 1995-04-27 2007-01-10 株式会社ヤクルト本社 新規なβ−アガラーゼ，その製造方法及びその用途
US5834257A (en) * 1995-11-06 1998-11-10 Japan Tobacco Inc. α-agarase and production process of oligosaccharides and monosaccharides
AU727026B2 (en) * 1996-11-08 2000-11-30 Takara Bio Inc. Apoptosis inducing agent
US6809091B1 (en) * 1998-01-19 2004-10-26 Takara Bio Inc. Substances capable of inducing apoptosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05565A (ja) * 1991-06-21 1993-01-08 Toyo Ink Mfg Co Ltd 皮膜形成方法
CN1075635A (zh) * 1992-02-06 1993-09-01 石原产业株式会社 免疫抑制剂

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EP1086952B1 (en) 2007-08-15
WO1999064424A8 (en) 2000-04-06
DE69936855T2 (de) 2008-05-15
KR20010025107A (ko) 2001-03-26
ATE370144T1 (de) 2007-09-15
KR100620409B1 (ko) 2006-09-13
KR100735139B1 (ko) 2007-07-03
KR20060116034A (ko) 2006-11-13
KR100696404B1 (ko) 2007-03-20
DE69936855D1 (de) 2007-09-27
TWI244484B (en) 2005-12-01
JP3779153B2 (ja) 2006-05-24
CA2334249A1 (en) 1999-12-16
CN1312813A (zh) 2001-09-12
EP1086952A4 (en) 2005-02-02
AU764582B2 (en) 2003-08-21
AU4060699A (en) 1999-12-30
US6531148B1 (en) 2003-03-11
WO1999064424A1 (en) 1999-12-16
JP2006117662A (ja) 2006-05-11
KR20060086454A (ko) 2006-07-31
EP1086952A1 (en) 2001-03-28

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