CN112142740B8 - 亚胺培南的制备方法 - Google Patents

亚胺培南的制备方法 Download PDF

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Publication number
CN112142740B8
CN112142740B8 CN201910573610.3A CN201910573610A CN112142740B8 CN 112142740 B8 CN112142740 B8 CN 112142740B8 CN 201910573610 A CN201910573610 A CN 201910573610A CN 112142740 B8 CN112142740 B8 CN 112142740B8
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imipenem
filtering
solution
filtrate
preparation
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CN112142740B (zh
CN112142740A (zh
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孟俊丽
白文钦
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Lunan Pharmaceutical Group Corp
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Lunan Pharmaceutical Group Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

本发明属于药物化学合成领域，涉及了一种高纯度亚胺培南的制备方法，具体将亚胺培南粗品溶解在氯化铵-氨水无机缓冲溶液中得溶解液；将活性炭加入所得溶解液中，降温，搅拌，过滤得滤液；将亚胺培南从滤液中析出，过滤，得亚胺培南纯品；该方法克服了杂质II无法有效去除和亚胺培南容易降解产生新杂质的问题，并且该方法操作简单、收率高、产品纯度高、成本低，适合工业化生产。
CN201910573610.3A 2019-06-28 2019-06-28 亚胺培南的制备方法 Active CN112142740B8 (zh)

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CN201910573610.3A CN112142740B8 (zh) 2019-06-28 2019-06-28 亚胺培南的制备方法

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CN201910573610.3A CN112142740B8 (zh) 2019-06-28 2019-06-28 亚胺培南的制备方法

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CN112142740A CN112142740A (zh) 2020-12-29
CN112142740B CN112142740B (zh) 2023-02-21
CN112142740B8 true CN112142740B8 (zh) 2023-06-20

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114671877B (zh) * 2022-02-18 2023-05-16 珠海联邦制药股份有限公司 亚胺培南的精制方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114671877A (zh) * 2022-02-18 2022-06-28 珠海联邦制药股份有限公司 亚胺培南的精制方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114671877A (zh) * 2022-02-18 2022-06-28 珠海联邦制药股份有限公司 亚胺培南的精制方法

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CN112142740B (zh) 2023-02-21
CN112142740A (zh) 2020-12-29

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CI03 Correction of invention patent

Correction item: Inventor

Correct: Meng Junli|Bai Wenqin

False: Bai Wenqin|Meng Junli

Number: 08-01

Volume: 39

Correction item: Inventor

Correct: Meng Junli|Bai Wenqin

False: Bai Wenqin|Meng Junli

Number: 08-01

Page: The title page

Volume: 39

CI03 Correction of invention patent
OR01 Other related matters
OR01 Other related matters