CN1121388C - 制备罗哌卡因盐酸盐—水合物的新方法 - Google Patents

制备罗哌卡因盐酸盐—水合物的新方法 Download PDF

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Publication number
CN1121388C
CN1121388C CN96195279A CN96195279A CN1121388C CN 1121388 C CN1121388 C CN 1121388C CN 96195279 A CN96195279 A CN 96195279A CN 96195279 A CN96195279 A CN 96195279A CN 1121388 C CN1121388 C CN 1121388C
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CN
China
Prior art keywords
water
pipecoloxylidide
product
salt
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96195279A
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English (en)
Chinese (zh)
Other versions
CN1189822A (zh
Inventor
P·雅克斯赫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
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Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of CN1189822A publication Critical patent/CN1189822A/zh
Application granted granted Critical
Publication of CN1121388C publication Critical patent/CN1121388C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
CN96195279A 1995-05-16 1996-04-30 制备罗哌卡因盐酸盐—水合物的新方法 Expired - Lifetime CN1121388C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE95018081 1995-05-16
SE9501808A SE9501808D0 (sv) 1995-05-16 1995-05-16 New process

Publications (2)

Publication Number Publication Date
CN1189822A CN1189822A (zh) 1998-08-05
CN1121388C true CN1121388C (zh) 2003-09-17

Family

ID=20398325

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96195279A Expired - Lifetime CN1121388C (zh) 1995-05-16 1996-04-30 制备罗哌卡因盐酸盐—水合物的新方法

Country Status (33)

Country Link
US (1) US5959112A (enExample)
EP (1) EP0828711B1 (enExample)
JP (1) JP3079112B2 (enExample)
KR (1) KR100425232B1 (enExample)
CN (1) CN1121388C (enExample)
AR (1) AR002737A1 (enExample)
AT (1) ATE207900T1 (enExample)
AU (1) AU696875B2 (enExample)
BR (1) BR9608820A (enExample)
CA (1) CA2219308C (enExample)
CZ (1) CZ290576B6 (enExample)
DE (1) DE69616543T2 (enExample)
DK (1) DK0828711T3 (enExample)
EE (1) EE03394B1 (enExample)
ES (1) ES2166888T3 (enExample)
HU (1) HU221793B1 (enExample)
IL (1) IL118178A (enExample)
IN (1) IN185146B (enExample)
IS (1) IS1832B (enExample)
MY (1) MY115018A (enExample)
NO (1) NO309035B1 (enExample)
NZ (1) NZ308249A (enExample)
PL (1) PL184767B1 (enExample)
PT (1) PT828711E (enExample)
RU (1) RU2167153C2 (enExample)
SA (1) SA96160764B1 (enExample)
SE (1) SE9501808D0 (enExample)
SK (1) SK281812B6 (enExample)
TR (1) TR199701362T1 (enExample)
TW (1) TW340841B (enExample)
UA (1) UA46770C2 (enExample)
WO (1) WO1996036606A1 (enExample)
ZA (1) ZA963545B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69824632T2 (de) 1997-11-12 2005-06-09 Mitsubishi Chemical Corp. Purinderivate und medikamente, welche dieselben als aktiven bestandteil enthalten
WO2000068231A1 (en) 1999-05-11 2000-11-16 Mitsubishi Chemical Corporation Purine derivative dihydrate, drugs containing the same as the active ingredient and intermediate in the production thereof
AU1037701A (en) * 1999-10-20 2001-04-30 Smithkline Beecham Plc Process for the preparation of 4-(fluorophenyl)piperidine esters
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20060270708A1 (en) * 2005-05-25 2006-11-30 Navinta Llc Novel process for preparation of isotonic aqueous injection of ropivacaine
WO2009044404A1 (en) * 2007-10-01 2009-04-09 Ramniwas Goel Process for the preparation of (s)-ropivacaine hydrochloride monohydrate
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法
WO2014009964A1 (en) * 2012-07-11 2014-01-16 Neon Laboratories Limited Process for enantiomeric enrichment of 2 ', 6 ' - pipecoloxylidide
CN103086954A (zh) * 2013-02-04 2013-05-08 山东省医药工业研究所 一种制备罗哌卡因的方法
CN104003930B (zh) * 2014-06-13 2016-06-08 山东金诃药物研究开发有限公司 一种盐酸罗哌卡因的制备方法
CN113105386B (zh) * 2021-04-10 2022-11-25 河北一品制药股份有限公司 一种盐酸罗哌卡因一水合物工业化的制备方法
CN114524763A (zh) * 2022-03-11 2022-05-24 山东科源制药股份有限公司 一种制备盐酸罗哌卡因杂质(r)-n-(2,6-二甲苯基)哌啶-2-甲酰胺方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1180712A (en) * 1967-05-18 1970-02-11 Sterling Drug Inc Novel levo-1-n-butyl-2',6'-pipecoloxylidide and the Preparation Thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560367B2 (en) * 1983-08-01 1987-04-02 Astra Lakemedel Aktiebolag L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
SU1579455A3 (ru) * 1987-07-01 1990-07-15 Астра Лекемедель Актиеболаг (Фирма) Способ получени оптически чистого моногидрата S-(-)-1-пропил-2 @ ,6 @ -пипеколоксилидид гидрохлорида

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1180712A (en) * 1967-05-18 1970-02-11 Sterling Drug Inc Novel levo-1-n-butyl-2',6'-pipecoloxylidide and the Preparation Thereof

Also Published As

Publication number Publication date
MY115018A (en) 2003-03-31
EP0828711B1 (en) 2001-10-31
ATE207900T1 (de) 2001-11-15
ES2166888T3 (es) 2002-05-01
HUP9900327A3 (en) 2001-05-28
AU5783296A (en) 1996-11-29
IL118178A0 (en) 1996-09-12
JPH11505242A (ja) 1999-05-18
KR19990014827A (ko) 1999-02-25
NO975220D0 (no) 1997-11-13
CA2219308C (en) 2007-12-18
SK281812B6 (sk) 2001-08-06
EE9700301A (et) 1998-06-15
PT828711E (pt) 2002-04-29
ZA963545B (en) 1996-11-18
DE69616543D1 (de) 2001-12-06
TW340841B (en) 1998-09-21
HK1009805A1 (en) 1999-06-11
IN185146B (enExample) 2000-11-25
TR199701362T1 (xx) 1998-05-21
IS1832B (is) 2002-10-30
IS4607A (is) 1997-11-04
JP3079112B2 (ja) 2000-08-21
SK151297A3 (en) 1998-05-06
UA46770C2 (uk) 2002-06-17
BR9608820A (pt) 1999-06-15
CZ290576B6 (cs) 2002-08-14
NO309035B1 (no) 2000-12-04
IL118178A (en) 2003-07-31
CN1189822A (zh) 1998-08-05
SE9501808D0 (sv) 1995-05-16
DE69616543T2 (de) 2002-06-27
NO975220L (no) 1997-11-13
RU2167153C2 (ru) 2001-05-20
EP0828711A1 (en) 1998-03-18
AU696875B2 (en) 1998-09-17
CA2219308A1 (en) 1996-11-21
NZ308249A (en) 1998-08-26
PL184767B1 (pl) 2002-12-31
SA96160764B1 (ar) 2006-07-30
HUP9900327A2 (hu) 1999-05-28
PL323461A1 (en) 1998-03-30
US5959112A (en) 1999-09-28
EE03394B1 (et) 2001-04-16
HU221793B1 (hu) 2003-01-28
KR100425232B1 (ko) 2004-05-20
CZ345297A3 (cs) 1998-03-18
DK0828711T3 (da) 2002-02-11
WO1996036606A1 (en) 1996-11-21
AR002737A1 (es) 1998-04-29

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C06 Publication
PB01 Publication
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Owner name: ASTRAZENECA AB

Free format text: FORMER NAME: ASTRA AKTIEBOLAG

CP01 Change in the name or title of a patent holder

Address after: Swedish Sodertalje

Patentee after: Astrazeneca (Sweden) AB

Address before: Swedish Sodertalje

Patentee before: Astra Aktiebolag

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Granted publication date: 20030917

EXPY Termination of patent right or utility model