IL118178A - Process for the preparation of ropivacaine hydrochloride monohydrate - Google Patents

Process for the preparation of ropivacaine hydrochloride monohydrate

Info

Publication number
IL118178A
IL118178A IL11817896A IL11817896A IL118178A IL 118178 A IL118178 A IL 118178A IL 11817896 A IL11817896 A IL 11817896A IL 11817896 A IL11817896 A IL 11817896A IL 118178 A IL118178 A IL 118178A
Authority
IL
Israel
Prior art keywords
preparation
hydrochloride monohydrate
ropivacaine hydrochloride
ropivacaine
monohydrate
Prior art date
Application number
IL11817896A
Other languages
English (en)
Other versions
IL118178A0 (en
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of IL118178A0 publication Critical patent/IL118178A0/xx
Publication of IL118178A publication Critical patent/IL118178A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
IL11817896A 1995-05-16 1996-05-07 Process for the preparation of ropivacaine hydrochloride monohydrate IL118178A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9501808A SE9501808D0 (sv) 1995-05-16 1995-05-16 New process

Publications (2)

Publication Number Publication Date
IL118178A0 IL118178A0 (en) 1996-09-12
IL118178A true IL118178A (en) 2003-07-31

Family

ID=20398325

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11817896A IL118178A (en) 1995-05-16 1996-05-07 Process for the preparation of ropivacaine hydrochloride monohydrate

Country Status (34)

Country Link
US (1) US5959112A (xx)
EP (1) EP0828711B1 (xx)
JP (1) JP3079112B2 (xx)
KR (1) KR100425232B1 (xx)
CN (1) CN1121388C (xx)
AR (1) AR002737A1 (xx)
AT (1) ATE207900T1 (xx)
AU (1) AU696875B2 (xx)
BR (1) BR9608820A (xx)
CA (1) CA2219308C (xx)
CZ (1) CZ290576B6 (xx)
DE (1) DE69616543T2 (xx)
DK (1) DK0828711T3 (xx)
EE (1) EE03394B1 (xx)
ES (1) ES2166888T3 (xx)
HK (1) HK1009805A1 (xx)
HU (1) HU221793B1 (xx)
IL (1) IL118178A (xx)
IN (1) IN185146B (xx)
IS (1) IS1832B (xx)
MY (1) MY115018A (xx)
NO (1) NO309035B1 (xx)
NZ (1) NZ308249A (xx)
PL (1) PL184767B1 (xx)
PT (1) PT828711E (xx)
RU (1) RU2167153C2 (xx)
SA (1) SA96160764B1 (xx)
SE (1) SE9501808D0 (xx)
SK (1) SK281812B6 (xx)
TR (1) TR199701362T1 (xx)
TW (1) TW340841B (xx)
UA (1) UA46770C2 (xx)
WO (1) WO1996036606A1 (xx)
ZA (1) ZA963545B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024432A1 (en) 1997-11-12 1999-05-20 Mitsubishi Chemical Corporation Purine derivatives and medicine containing the same as the active ingredient
US6660745B1 (en) 1999-05-11 2003-12-09 Mitsubishi Chemical Corporation Purine derivative dihydrate, drugs containing the same as the active ingredient and intermediate in the production thereof
AU1037701A (en) * 1999-10-20 2001-04-30 Smithkline Beecham Plc Process for the preparation of 4-(fluorophenyl)piperidine esters
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20060270708A1 (en) * 2005-05-25 2006-11-30 Navinta Llc Novel process for preparation of isotonic aqueous injection of ropivacaine
WO2009044404A1 (en) * 2007-10-01 2009-04-09 Ramniwas Goel Process for the preparation of (s)-ropivacaine hydrochloride monohydrate
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法
WO2014009964A1 (en) * 2012-07-11 2014-01-16 Neon Laboratories Limited Process for enantiomeric enrichment of 2 ', 6 ' - pipecoloxylidide
CN103086954A (zh) * 2013-02-04 2013-05-08 山东省医药工业研究所 一种制备罗哌卡因的方法
CN104003930B (zh) * 2014-06-13 2016-06-08 山东金诃药物研究开发有限公司 一种盐酸罗哌卡因的制备方法
CN113105386B (zh) * 2021-04-10 2022-11-25 河北一品制药股份有限公司 一种盐酸罗哌卡因一水合物工业化的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE341404B (xx) * 1967-05-18 1971-12-27 Sterling Drug Inc
EP0151110B1 (en) * 1983-08-01 1989-03-01 Astra Läkemedel Aktiebolag L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning

Also Published As

Publication number Publication date
JP3079112B2 (ja) 2000-08-21
DE69616543D1 (de) 2001-12-06
NO975220L (no) 1997-11-13
CA2219308C (en) 2007-12-18
PT828711E (pt) 2002-04-29
JPH11505242A (ja) 1999-05-18
TR199701362T1 (xx) 1998-05-21
SE9501808D0 (sv) 1995-05-16
ZA963545B (en) 1996-11-18
IN185146B (xx) 2000-11-25
IL118178A0 (en) 1996-09-12
EP0828711A1 (en) 1998-03-18
IS1832B (is) 2002-10-30
NO309035B1 (no) 2000-12-04
MY115018A (en) 2003-03-31
US5959112A (en) 1999-09-28
NZ308249A (en) 1998-08-26
EE9700301A (et) 1998-06-15
BR9608820A (pt) 1999-06-15
SK281812B6 (sk) 2001-08-06
UA46770C2 (uk) 2002-06-17
PL323461A1 (en) 1998-03-30
SA96160764B1 (ar) 2006-07-30
HUP9900327A2 (hu) 1999-05-28
AU5783296A (en) 1996-11-29
HK1009805A1 (en) 1999-06-11
WO1996036606A1 (en) 1996-11-21
CZ345297A3 (cs) 1998-03-18
ES2166888T3 (es) 2002-05-01
KR19990014827A (ko) 1999-02-25
TW340841B (en) 1998-09-21
PL184767B1 (pl) 2002-12-31
CA2219308A1 (en) 1996-11-21
AU696875B2 (en) 1998-09-17
AR002737A1 (es) 1998-04-29
HUP9900327A3 (en) 2001-05-28
KR100425232B1 (ko) 2004-05-20
CN1121388C (zh) 2003-09-17
IS4607A (is) 1997-11-04
CZ290576B6 (cs) 2002-08-14
SK151297A3 (en) 1998-05-06
DE69616543T2 (de) 2002-06-27
CN1189822A (zh) 1998-08-05
DK0828711T3 (da) 2002-02-11
EP0828711B1 (en) 2001-10-31
NO975220D0 (no) 1997-11-13
EE03394B1 (et) 2001-04-16
HU221793B1 (hu) 2003-01-28
ATE207900T1 (de) 2001-11-15
RU2167153C2 (ru) 2001-05-20

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Legal Events

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KB Patent renewed
KB Patent renewed
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