CN111710687B - 基于入射光子到达时间的识别、成像、测序法及存储介质 - Google Patents
基于入射光子到达时间的识别、成像、测序法及存储介质 Download PDFInfo
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Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015074001A1 (en) | 2013-11-17 | 2015-05-21 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
AU2015300778B2 (en) | 2014-08-08 | 2021-02-25 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting, and analyzing molecules |
MX2021007934A (es) | 2014-08-08 | 2023-01-17 | Quantum Si Inc | Dispositivo integrado para el depósito temporal de fotones recibidos. |
MX2017001808A (es) | 2014-08-08 | 2018-02-08 | Quantum Si Inc | Dispositivo integrado con fuente de luz externa para el sondeo, deteccion y analisis de moleculas. |
KR101725099B1 (ko) * | 2014-12-05 | 2017-04-26 | 삼성전자주식회사 | 컴퓨터 단층 촬영장치 및 그 제어방법 |
US10174363B2 (en) | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
AU2015203591A1 (en) * | 2015-06-26 | 2017-01-19 | Canon Kabushiki Kaisha | System and method for object matching |
JP2017098809A (ja) * | 2015-11-26 | 2017-06-01 | キヤノン株式会社 | 光電変換装置、および、撮像システム |
CN108780044A (zh) * | 2016-02-17 | 2018-11-09 | 泰斯艾科特健康公司 | 用于寿命成像和检测应用的传感器和设备 |
JP6931665B2 (ja) * | 2016-06-01 | 2021-09-08 | クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated | パルス決定器及び塩基決定器 |
US10341571B2 (en) * | 2016-06-08 | 2019-07-02 | Invisage Technologies, Inc. | Image sensors with electronic shutter |
JP6908819B2 (ja) * | 2016-09-29 | 2021-07-28 | ミツミ電機株式会社 | 近接センサ |
EP3305170B1 (de) * | 2016-10-04 | 2020-12-02 | ams AG | Fluoreszenzlebensdauersensormodul und verfahren zur bestimmung einer fluoreszenzlebensdauer mit einem sensormodul |
JP6808463B2 (ja) * | 2016-11-30 | 2021-01-06 | キヤノン株式会社 | 光電変換装置および光電変換システム |
US10731209B2 (en) | 2016-12-19 | 2020-08-04 | Quantum-Si Incorporated | Loading molecules into sample wells for analysis |
KR102560427B1 (ko) | 2016-12-22 | 2023-07-28 | 퀀텀-에스아이 인코포레이티드 | 직접 비닝 픽셀을 갖는 집적 광검출기 |
GB201622429D0 (en) | 2016-12-30 | 2017-02-15 | Univ Court Of The Univ Of Edinburgh The | Photon sensor apparatus |
US11224878B2 (en) | 2017-05-05 | 2022-01-18 | Quantum-Si Incorporated | Substrates having modified surface reactivity and antifouling properties in biological reactions |
AU2018307742A1 (en) * | 2017-07-24 | 2020-01-30 | Quantum-Si Incorporated | Optical rejection photonic structures |
US10817780B2 (en) | 2017-10-29 | 2020-10-27 | Christopher J. Rourk | Electron transport gate circuits and methods of manufacture, operation and use |
EP3701568A4 (de) * | 2017-10-29 | 2021-08-04 | Christopher J. Rourk | Elektronentransport-gate-schaltungen und herstellungsverfahren, betrieb und verwendung |
EP3582491B1 (de) * | 2017-10-30 | 2021-08-25 | Sony Semiconductor Solutions Corporation | Festkörperbildaufnahmeelement |
US11538556B2 (en) | 2018-01-26 | 2022-12-27 | Quantum-Si Incorporated | Machine learning enabled pulse and base calling for sequencing devices |
WO2019241733A1 (en) * | 2018-06-15 | 2019-12-19 | Quantum-Si Incorporated | Data acquisition control for advanced analytic instruments having pulsed optical sources |
JP7460555B2 (ja) | 2018-06-22 | 2024-04-02 | クアンタム-エスアイ インコーポレイテッド | 様々な検出時間の電荷貯蔵ビンを有する集積光検出器 |
CN112567632B (zh) * | 2018-07-16 | 2024-03-22 | 吉加焦特技术公司 | 具有非雪崩光电检测器的高灵敏度深度传感器 |
CN108760641B (zh) * | 2018-08-17 | 2023-05-16 | 龙岩学院 | 基于单光子探测的熔焊过程监测装置及监测方法 |
US20200072752A1 (en) * | 2018-08-29 | 2020-03-05 | Quantum-Si Incorporated | System and methods for detecting lifetime using photon counting photodetectors |
JP2020072317A (ja) * | 2018-10-30 | 2020-05-07 | ソニーセミコンダクタソリューションズ株式会社 | センサ及び制御方法 |
KR20210091243A (ko) | 2018-11-15 | 2021-07-21 | 퀀텀-에스아이 인코포레이티드 | 단백질 시퀀싱을 위한 방법 및 조성물 |
US11607119B2 (en) * | 2018-12-17 | 2023-03-21 | Qatar University | Fluorescence lifetime spectroscopy based capsule endoscopy |
DE102018222118A1 (de) * | 2018-12-18 | 2020-06-18 | Robert Bosch Gmbh | CCD-Photodetektor und zugehöriges Verfahren zum Betrieb |
US11423306B2 (en) * | 2019-05-16 | 2022-08-23 | Illumina, Inc. | Systems and devices for characterization and performance analysis of pixel-based sequencing |
DE112020003368T5 (de) * | 2019-07-12 | 2022-04-07 | Sony Group Corporation | Halbleitervorrichtung |
JP2022551523A (ja) | 2019-10-11 | 2022-12-09 | クアンタム-エスアイ インコーポレイテッド | 気相における表面修飾 |
CN110579460B (zh) * | 2019-10-14 | 2023-04-18 | 深圳大学 | 一种寻址扫描快速荧光寿命显微成像系统及方法 |
EP4088351A1 (de) * | 2020-01-14 | 2022-11-16 | Quantum-si Incorporated | Amplitudenmodulierter laser |
US11885744B2 (en) | 2020-01-14 | 2024-01-30 | Quantum-Si Incorporated | Sensor for lifetime plus spectral characterization |
IL294731A (en) | 2020-01-14 | 2022-09-01 | Quantum Si Inc | Integrated sensor for life time characterization |
EP4111178A1 (de) | 2020-03-02 | 2023-01-04 | Quantum-si Incorporated | Integrierter sensor zur mehrdimensionalen signalanalyse |
EP4133524A2 (de) * | 2020-04-08 | 2023-02-15 | Quantum-si Incorporated | Integrierter sensor mit reduzierter schräglage |
US11532150B1 (en) * | 2020-06-02 | 2022-12-20 | Honeywell Federal Manufacturing & Technologies, Llc | Method for determining a histogram of variable sample rate waveforms |
US11935311B2 (en) | 2020-06-11 | 2024-03-19 | Nautilus Subsidiary, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
US11714001B2 (en) * | 2020-10-22 | 2023-08-01 | Quantum-Si Incorporated | Integrated circuit with sequentially-coupled charge storage and associated techniques comprising a photodetection region and charge storage regions to induce an intrinsic electric field |
EP4217716A1 (de) * | 2020-10-27 | 2023-08-02 | Quantum-si Incorporated | Kalibrierung eines einzelmoleküldetektionssystems |
IL303570A (en) * | 2020-12-11 | 2023-08-01 | Quantum Si Inc | An integrated circuit with improved charge transfer efficiency and related methods |
EP4281775A1 (de) | 2021-01-21 | 2023-11-29 | Nautilus Subsidiary, Inc. | Systeme und verfahren zur biomolekülherstellung |
IL305336A (en) | 2021-03-11 | 2023-10-01 | Nautilus Subsidiary Inc | Systems and methods for the preservation of biomolecules |
CN113268142B (zh) * | 2021-06-09 | 2024-04-02 | 江苏集萃脑机融合智能技术研究所有限公司 | 基于直接测量飞行时间技术的脑机接口系统、脑机接口穿戴设备及其控制方法 |
WO2023038859A1 (en) | 2021-09-09 | 2023-03-16 | Nautilus Biotechnology, Inc. | Characterization and localization of protein modifications |
CA3227592A1 (en) | 2021-09-22 | 2023-03-30 | Gregory KAPP | Methods and systems for determining polypeptide interactions |
US20230149883A1 (en) | 2021-11-03 | 2023-05-18 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
WO2023192917A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
WO2024019988A1 (en) * | 2022-07-18 | 2024-01-25 | Cellsbin, Inc. | Devices for biological analysis |
US20240088178A1 (en) * | 2022-08-19 | 2024-03-14 | Quantum-Si Incorporated | Backside illuminated structures with parallel charge transfer |
WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6825921B1 (en) * | 1999-11-10 | 2004-11-30 | Molecular Devices Corporation | Multi-mode light detection system |
EP2182523A1 (de) * | 2008-10-31 | 2010-05-05 | CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement | Ladungssamplingvorrichtung und Verfahren mit MOS-transmission Leitung |
CN102150037A (zh) * | 2008-07-11 | 2011-08-10 | 康奈尔大学 | 集成电荷传感器的纳米流体通道及基于该纳米流体通道的方法 |
Family Cites Families (212)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
US5355165A (en) | 1992-08-06 | 1994-10-11 | Princeton Scientific Instruments, Inc. | Very high frame rate CCD imager |
JPH08506664A (ja) | 1993-02-01 | 1996-07-16 | セック,リミテッド | Dna配列決定の方法および装置 |
US5471515A (en) | 1994-01-28 | 1995-11-28 | California Institute Of Technology | Active pixel sensor with intra-pixel charge transfer |
US6456326B2 (en) | 1994-01-28 | 2002-09-24 | California Institute Of Technology | Single chip camera device having double sampling operation |
AU2317995A (en) | 1994-05-27 | 1995-12-21 | Novartis Ag | Process for detecting evanescently excited luminescence |
US5912155A (en) | 1994-09-30 | 1999-06-15 | Life Technologies, Inc. | Cloned DNA polymerases from Thermotoga neapolitana |
US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
US6261797B1 (en) | 1996-01-29 | 2001-07-17 | Stratagene | Primer-mediated polynucleotide synthesis and manipulation techniques |
US5990506A (en) | 1996-03-20 | 1999-11-23 | California Institute Of Technology | Active pixel sensors with substantially planarized color filtering elements |
US6198869B1 (en) | 1996-11-18 | 2001-03-06 | Novartis Ag | Measuring device and its use |
WO1998035012A2 (en) | 1997-02-12 | 1998-08-13 | Chan Eugene Y | Methods and products for analyzing polymers |
IT1290553B1 (it) | 1997-02-27 | 1998-12-10 | Ist Nazionale Fisica Nucleare | Rivelatore dell'energia e della posizione di incidenza di radiazioni elettromagnetiche o di particelle ionizzanti a deriva controllata |
AU743025B2 (en) | 1997-03-12 | 2002-01-17 | Applera Corporation | DNA polymerases having improved labeled nucleotide incorporation properties |
US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
DE19748211A1 (de) | 1997-10-31 | 1999-05-06 | Zeiss Carl Fa | Optisches Array-System und Reader für Mikrotiterplatten |
EP0921196A1 (de) | 1997-12-02 | 1999-06-09 | Roche Diagnostics GmbH | Modifizierte DNA Polymerase aus Carboxydothermus hydrogenoformans und deren Verwendung für gekoppelte reverse Transkription und Polymerase-kettenreaktion |
DE19810879A1 (de) | 1998-03-13 | 1999-09-16 | Roche Diagnostics Gmbh | Polymerasenchimären |
AU3199699A (en) | 1998-03-23 | 1999-10-18 | Invitrogen Corporation | Modified nucleotides and methods useful for nucleic acid sequencing |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
CA2330673C (en) | 1998-05-01 | 2009-05-26 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and dna molecules |
GB9810350D0 (en) | 1998-05-14 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
US6716394B2 (en) | 1998-08-11 | 2004-04-06 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
US6210896B1 (en) | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
US6280939B1 (en) | 1998-09-01 | 2001-08-28 | Veeco Instruments, Inc. | Method and apparatus for DNA sequencing using a local sensitive force detector |
JP4326050B2 (ja) | 1998-09-22 | 2009-09-02 | ハイスペック合資会社 | 高速撮像素子 |
AU2180200A (en) | 1998-12-14 | 2000-07-03 | Li-Cor Inc. | A heterogeneous assay for pyrophosphate detection |
US6445491B2 (en) | 1999-01-29 | 2002-09-03 | Irma America, Inc. | Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification |
ATE397092T1 (de) | 1999-03-10 | 2008-06-15 | Asm Scient Inc | Methode zur direkten sequenzierung von nukleinsäuren |
EP1681356B1 (de) | 1999-05-19 | 2011-10-19 | Cornell Research Foundation, Inc. | Methode zur Nukleinsäurensequenzierung |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US6137117A (en) | 1999-06-21 | 2000-10-24 | The United States Of America As Represented By The Secretary Of The Navy | Integrating multi-waveguide sensor |
CN2433618Y (zh) * | 1999-10-29 | 2001-06-06 | 中国科学院上海原子核研究所 | 基因芯片检测装置 |
US6399335B1 (en) | 1999-11-16 | 2002-06-04 | Advanced Research And Technology Institute, Inc. | γ-phosphoester nucleoside triphosphates |
JP4433347B2 (ja) * | 2000-01-17 | 2010-03-17 | 富士フイルム株式会社 | 蛍光撮像装置 |
WO2001084197A1 (en) | 2000-04-28 | 2001-11-08 | Edgelight Biosciences, Inc. | Micro-array evanescent wave fluorescence detection device |
US6917726B2 (en) | 2001-09-27 | 2005-07-12 | Cornell Research Foundation, Inc. | Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes |
US6936702B2 (en) | 2000-06-07 | 2005-08-30 | Li-Cor, Inc. | Charge-switch nucleotides |
EP2226330B1 (de) | 2000-06-07 | 2013-09-18 | Pacific Biosciences of California, Inc. | Ladeschaltungs-Nukleotide |
US6975898B2 (en) | 2000-06-19 | 2005-12-13 | University Of Washington | Medical imaging, diagnosis, and therapy using a scanning single optical fiber system |
WO2002001194A1 (en) | 2000-06-25 | 2002-01-03 | Affymetrix, Inc. | Optically active substrates |
FR2813121A1 (fr) | 2000-08-21 | 2002-02-22 | Claude Weisbuch | Dispositif perfectionne de support d'elements chromophores |
AU2001286963A1 (en) | 2000-08-30 | 2002-03-13 | University Of Rochester | Method of performing reverse transcription reaction using reverse transcriptase encoded by non-ltr retrotransposable element |
WO2002023167A1 (en) | 2000-09-11 | 2002-03-21 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Fluidics system |
EP1207387A1 (de) | 2000-11-20 | 2002-05-22 | Institut Curie | Multiphotonabbildungsvorrichtung |
JP4270742B2 (ja) | 2000-11-30 | 2009-06-03 | Necエレクトロニクス株式会社 | 固体撮像装置 |
WO2002086088A2 (en) | 2001-04-24 | 2002-10-31 | Li-Cor, Inc. | Polymerases with charge-switch activity and methods of generating such polymerases |
US7668697B2 (en) | 2006-02-06 | 2010-02-23 | Andrei Volkov | Method for analyzing dynamic detectable events at the single molecule level |
US7244566B2 (en) | 2001-08-29 | 2007-07-17 | Ge Healthcare Bio-Sciences Corp. | Analyte detection |
US7052839B2 (en) | 2001-08-29 | 2006-05-30 | Amersham Biosciences Corp | Terminal-phosphate-labeled nucleotides and methods of use |
US7727722B2 (en) | 2001-08-29 | 2010-06-01 | General Electric Company | Ligation amplification |
US7033762B2 (en) | 2001-08-29 | 2006-04-25 | Amersham Biosciences Corp | Single nucleotide amplification and detection by polymerase |
US7223541B2 (en) | 2001-08-29 | 2007-05-29 | Ge Healthcare Bio-Sciences Corp. | Terminal-phosphate-labeled nucleotides and methods of use |
EP1421213B1 (de) | 2001-08-29 | 2010-02-17 | Amersham Biosciences Corp. | Markierte nukleosidpolyphosphate |
US7256019B2 (en) | 2001-08-29 | 2007-08-14 | Ge Healthcare Bio-Sciences Corp. | Terminal phosphate blocked nucleoside polyphosphates |
US20070020622A1 (en) | 2001-09-14 | 2007-01-25 | Invitrogen Corporation | DNA Polymerases and mutants thereof |
US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
GB2382648B (en) | 2001-12-11 | 2003-11-12 | Amersham Pharm Biotech Uk Ltd | System and method for time correlated multi-photon counting measurements |
CN1138862C (zh) * | 2002-01-28 | 2004-02-18 | 国前 | 一种核酸分析用收集装置及其应用方法 |
US7179654B2 (en) | 2002-03-18 | 2007-02-20 | Agilent Technologies, Inc. | Biochemical assay with programmable array detection |
US6924887B2 (en) | 2002-03-27 | 2005-08-02 | Sarnoff Corporation | Method and apparatus for generating charge from a light pulse |
US8238993B2 (en) | 2002-04-04 | 2012-08-07 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence lifetime |
US20040144927A1 (en) * | 2003-01-28 | 2004-07-29 | Auner Gregory W. | Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays |
US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
US20040106163A1 (en) | 2002-11-12 | 2004-06-03 | Workman Jerome James | Non-invasive measurement of analytes |
AU2003294365A1 (en) | 2002-11-19 | 2004-06-15 | Safetzone Technologies Corporation | Guest communication system and method |
US7393640B2 (en) | 2003-02-05 | 2008-07-01 | Ge Healthcare Bio-Sciences Corp. | Terminal-phosphate-labeled nucleotides with new linkers |
WO2004092331A2 (en) | 2003-04-08 | 2004-10-28 | Li-Cor, Inc. | Composition and method for nucleic acid sequencing |
US7078670B2 (en) * | 2003-09-15 | 2006-07-18 | Imagerlabs, Inc. | Low noise charge gain circuit and CCD using same |
WO2005073407A1 (en) | 2003-10-07 | 2005-08-11 | Ut-Battelle, Llc | Advanced integrated circuit biochip |
KR20060105747A (ko) | 2003-10-18 | 2006-10-11 | 바이엘 헬스케어 아게 | 형광 수명 측정에 의한 생물학적 시험 시스템 중 분자개질의 직접적인 관찰 |
DE10348949A1 (de) * | 2003-10-18 | 2005-05-19 | Bayer Healthcare Ag | Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
WO2005069737A2 (en) | 2004-01-27 | 2005-08-04 | Ramot At Tel Aviv University Ltd. | Method and system for detecting analytes |
ATE463584T1 (de) | 2004-02-19 | 2010-04-15 | Helicos Biosciences Corp | Verfahren zur analyse von polynukleotidsequenzen |
EP1583150A1 (de) | 2004-03-31 | 2005-10-05 | CSEM Centre Suisse d'Electronique et de Microtechnique SA | Bildsensor mit grossflächigen, hochgeschwindigen, hochempfindlichen Pixeln |
US20060019265A1 (en) | 2004-04-30 | 2006-01-26 | Kimberly-Clark Worldwide, Inc. | Transmission-based luminescent detection systems |
US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
EP1622200A1 (de) | 2004-07-26 | 2006-02-01 | CSEM Centre Suisse d'Electronique et de Microtechnique SA | Festkörper-Fotodetektor-Pixel und Fotodetektionsverfahren |
US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
US7302146B2 (en) | 2004-09-17 | 2007-11-27 | Pacific Biosciences Of California, Inc. | Apparatus and method for analysis of molecules |
US7345764B2 (en) | 2005-02-07 | 2008-03-18 | Vladimir Bulovic | Apparatus and method for a slim format spectrometer |
US20060223067A1 (en) | 2005-03-31 | 2006-10-05 | Paolo Vatta | Mutant DNA polymerases and methods of use |
US7365299B2 (en) | 2005-05-09 | 2008-04-29 | Sensors Unlimited, Inc. | Method and apparatus for providing flexible photodetector binning |
US7738086B2 (en) | 2005-05-09 | 2010-06-15 | The Trustees Of Columbia University In The City Of New York | Active CMOS biosensor chip for fluorescent-based detection |
US7645866B2 (en) | 2005-06-28 | 2010-01-12 | Life Technologies Corporation | Methods of producing and sequencing modified polynucleotides |
EP1920072A2 (de) | 2005-07-01 | 2008-05-14 | Dako Denmark A/S | In-situ erkennungsverfahren der hydrodisierung |
US7426322B2 (en) | 2005-07-20 | 2008-09-16 | Searete Llc. | Plasmon photocatalysis |
US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
WO2007070542A2 (en) | 2005-12-12 | 2007-06-21 | The Government Of The United States Of America As Represented By The Secretary Of The Deptartment Ofhealth And Human Services | Nanoprobes for detection or modification of molecules |
CN101365807A (zh) | 2005-12-22 | 2009-02-11 | 加利福尼亚太平洋生物科学股份有限公司 | 用于掺入核苷酸类似物的聚合酶 |
AU2006331512B2 (en) | 2005-12-22 | 2012-02-23 | Pacific Biosciences Of California, Inc. | Active surface coupled polymerases |
US7995202B2 (en) | 2006-02-13 | 2011-08-09 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US7715001B2 (en) | 2006-02-13 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US7692783B2 (en) | 2006-02-13 | 2010-04-06 | Pacific Biosciences Of California | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US20080050747A1 (en) | 2006-03-30 | 2008-02-28 | Pacific Biosciences Of California, Inc. | Articles having localized molecules disposed thereon and methods of producing and using same |
US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
WO2007119626A1 (ja) | 2006-03-31 | 2007-10-25 | National University Corporation Shizuoka University | 半導体測距素子及び固体撮像装置 |
DE102006030541B4 (de) | 2006-06-23 | 2010-05-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Optische Anordnung |
AU2007289057C1 (en) | 2006-09-01 | 2014-01-16 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
US8207509B2 (en) | 2006-09-01 | 2012-06-26 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
EP2089517A4 (de) | 2006-10-23 | 2010-10-20 | Pacific Biosciences California | Polymeraseenzyme und reagenzien für erweiterte nukeinsäuresequenzierung |
FR2908888B1 (fr) | 2006-11-21 | 2012-08-03 | Centre Nat Rech Scient | Dispositif pour la detection exaltee de l'emission d'une particule cible |
JP5270835B2 (ja) | 2006-12-29 | 2013-08-21 | パナソニック株式会社 | 光検出素子、空間情報の検出装置 |
US8174696B2 (en) | 2007-03-22 | 2012-05-08 | Universite De Strasbourg | Device for sorting and concentrating electromagnetic energy and apparatus comprising at least one such device |
EP2134871B1 (de) | 2007-03-30 | 2012-03-07 | Pacific Biosciences of California, Inc. | System und verfahren zur verstärkung von fluoreszenzsignalen |
US7873085B2 (en) | 2007-10-23 | 2011-01-18 | Andrei Babushkin | Method and device for controlling optical output of laser diode |
WO2009082706A1 (en) | 2007-12-21 | 2009-07-02 | The Trustees Of Columbia University In The City Of New York | Active cmos sensor array for electrochemical biomolecular detection |
US20110165652A1 (en) | 2008-01-14 | 2011-07-07 | Life Technologies Corporation | Compositions, methods and systems for single molecule sequencing |
EP2252625B1 (de) | 2008-02-07 | 2017-12-20 | Pacific Biosciences of California, Inc. | In linker eingebundene, cis-reaktive sauerstoffquencher |
US8652781B2 (en) | 2008-02-12 | 2014-02-18 | Pacific Biosciences Of California, Inc. | Cognate sampling kinetics |
CA2715385A1 (en) | 2008-02-12 | 2009-08-20 | Pacific Biosciences Of California, Inc. | Compositions and methods for use in analytical reactions |
US7968702B2 (en) | 2008-03-13 | 2011-06-28 | Pacific Biosciences Of California, Inc. | Labeled reactants and their uses |
US7973146B2 (en) | 2008-03-26 | 2011-07-05 | Pacific Biosciences Of California, Inc. | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing |
CN102084001B (zh) | 2008-03-28 | 2015-03-18 | 加利福尼亚太平洋生物科学股份有限公司 | 用于核酸测序的组合物和方法 |
US8143030B2 (en) | 2008-09-24 | 2012-03-27 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
US8236499B2 (en) | 2008-03-28 | 2012-08-07 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
US9127259B2 (en) | 2008-03-31 | 2015-09-08 | Pacific Biosciences Of California, Inc. | Enzymes resistant to photodamage |
US8420366B2 (en) | 2008-03-31 | 2013-04-16 | Pacific Biosciences Of California, Inc. | Generation of modified polymerases for improved accuracy in single molecule sequencing |
EP2942404B1 (de) | 2008-03-31 | 2016-11-23 | Pacific Biosciences of California, Inc. | Erzeugung modifizierter polymerasen für erhöhte genauigkeit bei einzelmolekülsequenzierungen |
US8999676B2 (en) | 2008-03-31 | 2015-04-07 | Pacific Biosciences Of California, Inc. | Recombinant polymerases for improved single molecule sequencing |
EP2274446B1 (de) | 2008-03-31 | 2015-09-09 | Pacific Biosciences of California, Inc. | Systeme und verfahren für polymeraseenzymreaktionen in zwei langsamen schritten |
EP2881736B1 (de) | 2008-03-31 | 2017-06-07 | Pacific Biosciences of California, Inc. | Verfahren und Zusammensetzungen zur Ladung von Einzelpolymerase |
JP5283216B2 (ja) * | 2008-07-31 | 2013-09-04 | 国立大学法人静岡大学 | 高速電荷転送フォトダイオード、ロックインピクセル及び固体撮像装置 |
US8760549B2 (en) * | 2008-08-28 | 2014-06-24 | Mesa Imaging Ag | Demodulation pixel with daisy chain charge storage sites and method of operation therefor |
EP2326733A2 (de) | 2008-09-05 | 2011-06-01 | Pacific Biosciences of California, Inc. | Manipulierte polymerasen und reaktionsbedingungen für modifzierte einbringungseigenschaften |
AU2009292629B2 (en) | 2008-09-16 | 2014-03-20 | Pacific Biosciences Of California, Inc. | Substrates and optical systems and methods of use thereof |
US8481264B2 (en) | 2008-09-19 | 2013-07-09 | Pacific Biosciences Of California, Inc. | Immobilized nucleic acid complexes for sequence analysis |
US8921046B2 (en) | 2008-09-19 | 2014-12-30 | Pacific Biosciences Of California, Inc. | Nucleic acid sequence analysis |
US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
US8383369B2 (en) | 2008-09-24 | 2013-02-26 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
WO2010039199A2 (en) | 2008-09-30 | 2010-04-08 | Pacific Biociences Of California, Inc. | Ultra-high multiplex analytical systems and methods |
US8367813B2 (en) | 2008-11-17 | 2013-02-05 | Pacific Biosciences Of California, Inc. | Phospholink nucleotides for sequencing applications |
WO2010073136A2 (en) | 2008-12-22 | 2010-07-01 | Koninklijke Philips Electronics N.V. | High dynamic range light sensor |
US8338248B2 (en) * | 2008-12-25 | 2012-12-25 | National University Corporation Shizuoka University | Semiconductor element and solid-state imaging device |
JP2012516145A (ja) | 2009-01-30 | 2012-07-19 | オックスフォード ナノポア テクノロジーズ リミテッド | ハイブリダイゼーションリンカー |
US9658440B2 (en) | 2009-03-12 | 2017-05-23 | Rsp Systems A/S | Optical probe for measuring light signals in vivo |
US20110014612A1 (en) | 2009-03-27 | 2011-01-20 | Life Technologies Corporation | Polymerase compositions & methods |
WO2010117420A2 (en) | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
JP5415805B2 (ja) | 2009-03-31 | 2014-02-12 | オリンパスメディカルシステムズ株式会社 | 診断支援装置 |
EP2419716B1 (de) * | 2009-04-15 | 2012-08-22 | Koninklijke Philips Electronics N.V. | Vorrichtung für zeitgesteuerte fluoreszenzdetektion |
EP2443427B1 (de) | 2009-06-17 | 2014-04-02 | Ingeneron, Inc. | Verfahren und vorrichtung zur quantitativen mikroabbildung |
US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
US9698196B2 (en) * | 2009-08-14 | 2017-07-04 | Heptagon Micro Optics Pte. Ltd. | Demodulation pixel incorporating majority carrier current, buried channel and high-low junction |
WO2011040971A2 (en) | 2009-09-30 | 2011-04-07 | Pacific Biosciences Of California, Inc. | Generation of modified polymerases for improved accuracy in single molecule sequencing |
US9231006B2 (en) | 2009-10-05 | 2016-01-05 | National University Corporation Shizuoka University | Semiconductor element and solid-state imaging device |
US8278728B2 (en) | 2009-10-17 | 2012-10-02 | Florida Institute Of Technology | Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels |
WO2011068569A1 (en) | 2009-12-04 | 2011-06-09 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
JP6017107B2 (ja) | 2009-12-28 | 2016-10-26 | ソニー株式会社 | イメージセンサ及びその製造方法、並びにセンサデバイス |
US20110236983A1 (en) | 2009-12-29 | 2011-09-29 | Joseph Beechem | Single molecule detection and sequencing using fluorescence lifetime imaging |
EP2362207A1 (de) | 2010-01-28 | 2011-08-31 | F. Hoffmann-La Roche AG | Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung |
CA2789932A1 (en) | 2010-02-19 | 2011-08-25 | Glysure Ltd | Intravascular glucose sensor |
AU2011217862B9 (en) | 2010-02-19 | 2014-07-10 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
US8994946B2 (en) | 2010-02-19 | 2015-03-31 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
EP2550523A4 (de) | 2010-03-25 | 2018-01-24 | Mocon, Inc. | Leuchtdauerbasierte analyterfassungsinstrumente und kalibrierverfahren dafür |
WO2011150431A1 (en) | 2010-05-28 | 2011-12-01 | The Regents Of The University Of Colorado, A Body Corporate | Multi-photon tissue imaging |
US8865078B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
US8865077B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
JP2012132741A (ja) | 2010-12-21 | 2012-07-12 | Fujifilm Corp | 時間分解蛍光測定装置、及び方法 |
US8946845B1 (en) | 2011-02-02 | 2015-02-03 | Aptina Imaging Corporation | Stacked pixels for high resolution CMOS image sensors with BCMD charge detectors |
WO2012129242A2 (en) | 2011-03-23 | 2012-09-27 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
WO2013040058A1 (en) | 2011-09-12 | 2013-03-21 | Jian Guo | Imaging fluorescence or luminescence lifetime |
US20130090537A1 (en) | 2011-10-07 | 2013-04-11 | 2M Engineering Limited | Blood glucose sensor |
EP3305400A3 (de) | 2011-10-28 | 2018-06-06 | Illumina, Inc. | System und verfahren zur herstellung von mikroarrays |
WO2013066959A1 (en) | 2011-10-31 | 2013-05-10 | The Trustees Of Columbia University In The City Of New York | Systems and methods for imaging using single photon avalanche diodes |
US9606060B2 (en) * | 2012-01-13 | 2017-03-28 | California Institute Of Technology | Filterless time-domain detection of one or more fluorophores |
US8906660B2 (en) | 2012-02-01 | 2014-12-09 | Pacific Biosciences Of California, Inc. | Recombinant polymerases with increased phototolerance |
EP3590948A1 (de) | 2012-02-15 | 2020-01-08 | Pacific Biosciences of California, Inc. | Polymeraseenzymsubstrate mit proteinabschirmung |
DE102012206089B4 (de) | 2012-03-15 | 2017-02-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Halbleiterstruktur, verfahren zum betreiben derselben und herstellungsverfahren |
CN102914525B (zh) | 2012-04-10 | 2016-06-01 | 广东工业大学 | 基于光学加法外差调制的新型荧光寿命显微成像装置及方法 |
WO2013171197A1 (en) | 2012-05-15 | 2013-11-21 | Ait Austrian Institute Of Technology Gmbh | Compact plasmon-enhanced fluorescence biosensor |
US9372308B1 (en) | 2012-06-17 | 2016-06-21 | Pacific Biosciences Of California, Inc. | Arrays of integrated analytical devices and methods for production |
WO2014031157A1 (en) * | 2012-08-20 | 2014-02-27 | Illumina, Inc. | Method and system for fluorescence lifetime based sequencing |
JP6281771B2 (ja) | 2012-10-30 | 2018-02-21 | パナソニックIpマネジメント株式会社 | 蛍光検出装置 |
NL2011568A (en) | 2012-10-31 | 2014-05-06 | Asml Netherlands Bv | Sensor and lithographic apparatus. |
US9223084B2 (en) | 2012-12-18 | 2015-12-29 | Pacific Biosciences Of California, Inc. | Illumination of optical analytical devices |
GB201302664D0 (en) | 2013-02-15 | 2013-04-03 | Cmosis Nv | A pixel structure |
JP6363114B2 (ja) | 2013-02-28 | 2018-07-25 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | Cmosセンサによる声帯のビデオストロボスコピー |
US9741754B2 (en) | 2013-03-06 | 2017-08-22 | Apple Inc. | Charge transfer circuit with storage nodes in image sensors |
KR102007277B1 (ko) | 2013-03-11 | 2019-08-05 | 삼성전자주식회사 | 3차원 이미지 센서의 거리 픽셀 및 이를 포함하는 3차원 이미지 센서 |
WO2015006345A2 (en) | 2013-07-09 | 2015-01-15 | Nd Industries, Inc. | Multi-row magnetic dial for the conveyance of workpieces and related method |
US20150042954A1 (en) | 2013-08-08 | 2015-02-12 | University Of Rochester | System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics |
WO2015074001A1 (en) | 2013-11-17 | 2015-05-21 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
CN103728446B (zh) * | 2013-12-11 | 2016-02-24 | 天津大学 | 光子计数型多通道时间分辨荧光免疫分析系统及计数方法 |
US9736388B2 (en) | 2013-12-13 | 2017-08-15 | Bio-Rad Laboratories, Inc. | Non-destructive read operations with dynamically growing images |
WO2015163957A2 (en) | 2014-01-31 | 2015-10-29 | The General Hospital Corporation | System and method for photoluminescence detection |
US9765395B2 (en) | 2014-04-28 | 2017-09-19 | Nanomedical Diagnostics, Inc. | System and method for DNA sequencing and blood chemistry analysis |
KR20150134543A (ko) | 2014-05-22 | 2015-12-02 | 삼성전자주식회사 | 소자 제조용 기판 및 반도체 소자 |
CA2955976A1 (en) | 2014-07-24 | 2016-01-28 | University Health Network | Collection and analysis of data for diagnostic purposes |
MX2017001808A (es) | 2014-08-08 | 2018-02-08 | Quantum Si Inc | Dispositivo integrado con fuente de luz externa para el sondeo, deteccion y analisis de moleculas. |
MX2021007934A (es) | 2014-08-08 | 2023-01-17 | Quantum Si Inc | Dispositivo integrado para el depósito temporal de fotones recibidos. |
AU2015300778B2 (en) | 2014-08-08 | 2021-02-25 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting, and analyzing molecules |
EP3235000B1 (de) | 2014-12-19 | 2021-01-13 | G-ray Switzerland SA | Verfahren zur herstellung eines monolithischen, cmos-integrierten pixeldetektors |
US9871065B2 (en) | 2014-12-22 | 2018-01-16 | Google Inc. | RGBZ pixel unit cell with first and second Z transfer gates |
US9666748B2 (en) | 2015-01-14 | 2017-05-30 | International Business Machines Corporation | Integrated on chip detector and zero waveguide module structure for use in DNA sequencing |
WO2016128198A1 (de) | 2015-02-09 | 2016-08-18 | Espros Photonics Ag | Tof entfernungssensor |
WO2016149397A1 (en) | 2015-03-16 | 2016-09-22 | Pacific Biosciences Of California, Inc. | Integrated devices and systems for free-space optical coupling |
TWI569008B (zh) | 2015-04-27 | 2017-02-01 | 財團法人工業技術研究院 | 尿素濃度檢測元件以及尿素濃度檢測方法 |
US10246742B2 (en) | 2015-05-20 | 2019-04-02 | Quantum-Si Incorporated | Pulsed laser and bioanalytic system |
US10174363B2 (en) | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
EP3298389B1 (de) | 2015-05-20 | 2021-09-29 | Quantum-Si Incorporated | Verfahren zur bestimmung der sequenz einer kernsäure mit zeitaufgelöster lumineszenz |
US10976257B2 (en) | 2015-06-08 | 2021-04-13 | The Regents Of The University Of Michigan | Pixel circuit and method for optical sensing |
CN105300949B (zh) | 2015-11-26 | 2019-06-11 | 浙江大学 | 一种荧光寿命测量方法及装置 |
CN108780044A (zh) | 2016-02-17 | 2018-11-09 | 泰斯艾科特健康公司 | 用于寿命成像和检测应用的传感器和设备 |
JP6931665B2 (ja) | 2016-06-01 | 2021-09-08 | クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated | パルス決定器及び塩基決定器 |
US10249656B2 (en) | 2016-06-07 | 2019-04-02 | Semiconductor Components Industries, Llc | Charge packet signal processing using pinned photodiode devices |
KR102560427B1 (ko) | 2016-12-22 | 2023-07-28 | 퀀텀-에스아이 인코포레이티드 | 직접 비닝 픽셀을 갖는 집적 광검출기 |
JP7460555B2 (ja) | 2018-06-22 | 2024-04-02 | クアンタム-エスアイ インコーポレイテッド | 様々な検出時間の電荷貯蔵ビンを有する集積光検出器 |
US20200072752A1 (en) | 2018-08-29 | 2020-03-05 | Quantum-Si Incorporated | System and methods for detecting lifetime using photon counting photodetectors |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6825921B1 (en) * | 1999-11-10 | 2004-11-30 | Molecular Devices Corporation | Multi-mode light detection system |
CN102150037A (zh) * | 2008-07-11 | 2011-08-10 | 康奈尔大学 | 集成电荷传感器的纳米流体通道及基于该纳米流体通道的方法 |
EP2182523A1 (de) * | 2008-10-31 | 2010-05-05 | CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement | Ladungssamplingvorrichtung und Verfahren mit MOS-transmission Leitung |
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