CN111566113B - 大环化合物及其用途 - Google Patents

大环化合物及其用途 Download PDF

Info

Publication number
CN111566113B
CN111566113B CN201880085912.XA CN201880085912A CN111566113B CN 111566113 B CN111566113 B CN 111566113B CN 201880085912 A CN201880085912 A CN 201880085912A CN 111566113 B CN111566113 B CN 111566113B
Authority
CN
China
Prior art keywords
cancer
compound
tumor
pharmaceutically acceptable
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201880085912.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN111566113A (zh
Inventor
Y.岸
吉良和信
伊藤宪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Harvard University
Original Assignee
Eisai R&D Management Co Ltd
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd, Harvard University filed Critical Eisai R&D Management Co Ltd
Priority to CN202311787191.6A priority Critical patent/CN117924310A/zh
Publication of CN111566113A publication Critical patent/CN111566113A/zh
Application granted granted Critical
Publication of CN111566113B publication Critical patent/CN111566113B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201880085912.XA 2017-11-15 2018-11-15 大环化合物及其用途 Active CN111566113B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311787191.6A CN117924310A (zh) 2017-11-15 2018-11-15 大环化合物及其用途

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762586416P 2017-11-15 2017-11-15
US62/586,416 2017-11-15
US201862765310P 2018-08-20 2018-08-20
US62/765,310 2018-08-20
PCT/US2018/061250 WO2019099646A1 (en) 2017-11-15 2018-11-15 Macrocyclic compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202311787191.6A Division CN117924310A (zh) 2017-11-15 2018-11-15 大环化合物及其用途

Publications (2)

Publication Number Publication Date
CN111566113A CN111566113A (zh) 2020-08-21
CN111566113B true CN111566113B (zh) 2024-01-09

Family

ID=64664436

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201880085912.XA Active CN111566113B (zh) 2017-11-15 2018-11-15 大环化合物及其用途
CN202311787191.6A Pending CN117924310A (zh) 2017-11-15 2018-11-15 大环化合物及其用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202311787191.6A Pending CN117924310A (zh) 2017-11-15 2018-11-15 大环化合物及其用途

Country Status (6)

Country Link
US (3) US11407762B2 (https=)
EP (2) EP3710454B1 (https=)
JP (2) JP7353281B2 (https=)
CN (2) CN111566113B (https=)
ES (1) ES2974243T3 (https=)
WO (1) WO2019099646A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
ES2931533T3 (es) 2017-04-05 2022-12-30 Harvard College Compuesto macrocíclico y usos del mismo
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
CN111566113B (zh) * 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
WO2016003975A1 (en) * 2014-06-30 2016-01-07 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
WO2016176560A1 (en) * 2015-04-30 2016-11-03 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
US9938288B1 (en) * 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
WO2018187331A1 (en) * 2017-04-05 2018-10-11 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
CN111433211A (zh) * 2017-07-06 2020-07-17 哈佛大学的校长及成员们 软海绵素的合成

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK187280A (da) 1980-04-30 1981-10-31 Novo Industri As Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode
JPS61191687A (ja) 1985-02-20 1986-08-26 Fujisawa Pharmaceut Co Ltd ハリコンドリンｂ
US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
GB9206244D0 (en) 1992-03-23 1992-05-06 Pharma Mar Sa Cytotoxic compound from a marine sponge
DE4229425A1 (de) 1992-09-03 1994-03-10 Kodak Ag Vorrichtung zum stapelweisen Ablegen und Ausrichten von einzeln zugeführten Blättern
US5426194A (en) 1993-01-19 1995-06-20 Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 1
US5352804A (en) 1993-01-19 1994-10-04 Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 2
JP2818381B2 (ja) 1994-01-18 1998-10-30 帝人株式会社 ７−チアプロスタグランジン類およびその製造法
US5519050A (en) * 1995-04-07 1996-05-21 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structural elucidation of halistatin 3
US6214865B1 (en) 1998-06-17 2001-04-10 Eisai Co., Ltd. Macrocyclic analogs and methods of their use and preparation
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
US8097648B2 (en) 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
JP2001305734A (ja) 2000-04-20 2001-11-02 Fuji Photo Film Co Ltd 光重合性組成物
JP2003261447A (ja) 2002-03-07 2003-09-16 Kyosei Seiyaku Kk 抗腫瘍剤
EP2522663B1 (en) 2004-06-03 2015-04-01 Eisai R&D Management Co., Ltd. Intermediates for the preparation of halichondrin B
EP1831697A4 (en) 2004-12-09 2011-01-26 Eisai R&D Man Co Ltd SEARCH FOR TUBULINISOTYPES IN CANCER THERAPY USING HALICHONDRIN B ANALOG
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
MY153742A (en) 2007-03-07 2015-03-13 Interdigital Tech Corp Method and apparatus for generating and processing a mac-ehs protocol data unit
US20100254996A1 (en) 2007-06-18 2010-10-07 Medimmune, Llc Synergistic treatment of cells that express epha2 and erbb2
RU2489437C2 (ru) 2007-10-03 2013-08-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Промежуточные соединения и способы синтеза аналогов галихондрина в
RU2010118063A (ru) 2007-11-16 2011-12-27 ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) Новое промежуточное соединение для синтеза аналога галихондрина в и новая реакция десульфонилирования, применяемая для получения промежуточного соединения
CN105801599A (zh) 2008-04-04 2016-07-27 卫材R&D管理有限公司 软海绵素b类似物
WO2011094339A1 (en) 2010-01-26 2011-08-04 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
WO2012096926A2 (en) 2011-01-10 2012-07-19 President And Fellows Of Harvard College Method for delivering agents into cells using bacterial toxins
WO2012147900A1 (en) 2011-04-28 2012-11-01 Eisai R&D Management Co., Ltd. Microreactor process for halichondrin b analog synthesis
CN104024237B (zh) 2011-12-16 2016-02-24 阿方拉研究股份有限公司 用于制备3-((2s,5s)-4-亚甲基-5-(3-氧代丙基)四氢呋喃-2-基)丙醇衍生物的方法及其有用的中间体
CN104080793B (zh) 2011-12-29 2017-09-19 阿方拉研究股份有限公司 2‑((2s,3s,4r,5r)‑5‑((s)‑3‑氨基‑2‑羟基丙‑1‑基)‑4‑甲氧基‑3‑(苯磺酰甲基)四氢呋喃‑2‑基)乙醛衍生物以及它们的制备方法
WO2013142999A1 (en) 2012-03-30 2013-10-03 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
AR096238A1 (es) 2013-05-15 2015-12-16 Alphora Res Inc Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo
CA2916537C (en) 2013-07-03 2021-07-27 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein including intermediates containing -so2-(p-tolyl) groups
EP3689881B1 (en) 2013-11-04 2022-01-12 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b
MX384292B (es) 2013-12-06 2025-03-14 Eisai R&D Man Co Ltd Metodos utiles en la sintesis de analogos de halicondrina b.
WO2016038624A1 (en) 2014-09-09 2016-03-17 Cipla Limited "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof"
KR102743950B1 (ko) 2015-05-07 2024-12-18 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
EP3423105B1 (en) 2016-03-02 2021-05-05 Eisai R&D Management Co., Ltd. Eribulin-based antibody-drug conjugates and methods of use
WO2018008667A1 (ja) 2016-07-07 2018-01-11 新日本理化株式会社 動力伝達用潤滑油基油
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
JP2020508315A (ja) 2017-02-20 2020-03-19 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ がんを治療するための薬剤組合せ
JP2019013861A (ja) 2017-07-03 2019-01-31 住友化学株式会社 ガス分離膜エレメント、ガス分離膜モジュール、及びガス分離装置
WO2019009956A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College SUMMARY OF MEDIUM MEDIATED KETONE
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
US20230135188A1 (en) 2017-07-06 2023-05-04 President And Fellows Of Harvard College Fe/cu-mediated ketone synthesis
CN111566113B (zh) * 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
WO2016003975A1 (en) * 2014-06-30 2016-01-07 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
WO2016176560A1 (en) * 2015-04-30 2016-11-03 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
US9938288B1 (en) * 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
WO2018187331A1 (en) * 2017-04-05 2018-10-11 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
CN110831946A (zh) * 2017-04-05 2020-02-21 哈佛大学的校长及成员们 大环化合物及其用途
CN111433211A (zh) * 2017-07-06 2020-07-17 哈佛大学的校长及成员们 软海绵素的合成

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
A total synthesis of norhalichondrin B;Jackson, Katrina L.;《Angewandte Chemie International Edition》;20090310;第48卷(第13期);2346-2350 *
Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp;Pettit, George R.;Journal of Medicinal Chemistry;第34卷;3339-3340 *
Antitumor polyether macrolides: new and hemisynthetic halichondrins from the New Zealand deep-water sponge Lissodendoryx sp.;Litaudon, Marc;《Journal of Organic Chemistry》;19970301;第62卷(第6期);1868-1871 *
Antitumour polyether macrolides: Four new halichondrins from the New Zealand deep-water marine sponge Lissodendoryx sp.;Hickford, Sarah J. H.;《Bioorganic & Medicinal Chemistry》;20090315;第17卷(第6期);2199-2203 *
Halichondrins-antitumor polyether macrolides from a marine sponge;HIRATA, Y;PURE AND APPLIED CHEMISTRY;第58卷;701-710 *
Highly functionalized pyranopyrans from furans: a synthesis of the C27-C38 and C44-C53 subunits of norhalichondrin B;Henderson, James A.;《Organic Letters》;20071114;第9卷(第25期);5299-5302 *
HIRATA, Y.Halichondrins-antitumor polyether macrolides from a marine sponge.PURE AND APPLIED CHEMISTRY.1986,第58卷701-710. *
Isohomohalichondrin B, a new antitumor polyether macrolide from the New Zealand deep-water sponge Lissodendoryx sp;Litaudon, Marc;Tetrahedron Letters;第35卷;9435-9438 *
Macrocyclic ketone analogues of halichondrin B;Zheng, Wanjun;Bioorganic & Medicinal Chemistry Letters;第14卷;5551-5554 *
Synthetic studies towards halichondrins: synthesis of the left halves of norhalichondrins and homohalichondrins;Fang, Francis G.;《Tetrahedron Letters》;19920301;第33卷(第12期);1557-1560 *
The Halichondrins and E7389;Jackson, Katrina L.;《Chemical Reviews》;20090617;第109卷(第7期);3044-3079 *
Total Synthesis of Halichondrin A, the Missing Member in the Halichondrin Class of Natural Products;Ueda, Atsushi;《Journal of the American Chemical Society》;20140319;第136卷(第13期);5171-5176 *
Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel-Mediated One-Pot Ketone Synthesis as the Final Coupling Reaction;Yahata, Kenzo;《Angewandte Chemie International Edition》;20170828;第56卷(第36期);10796-10800 *

Also Published As

Publication number Publication date
US20200325152A1 (en) 2020-10-15
ES2974243T3 (es) 2024-06-26
EP3710454B1 (en) 2024-01-03
EP3710454A1 (en) 2020-09-23
JP2023156359A (ja) 2023-10-24
CN111566113A (zh) 2020-08-21
WO2019099646A1 (en) 2019-05-23
US20240309014A1 (en) 2024-09-19
US11407762B2 (en) 2022-08-09
WO2019099646A8 (en) 2020-01-23
US11814398B2 (en) 2023-11-14
EP4403560A2 (en) 2024-07-24
CN117924310A (zh) 2024-04-26
EP4403560A3 (en) 2024-10-23
US20230016686A1 (en) 2023-01-19
JP7353281B2 (ja) 2023-09-29
JP2021512046A (ja) 2021-05-13

Similar Documents

Publication Publication Date Title
CN111566113B (zh) 大环化合物及其用途
AU2025230659A1 (en) Hdac6 inhibitors and uses thereof
JP7696416B2 (ja) 大環状化合物およびその使用
JP6408478B2 (ja) トリオキサカルシン、トリオキサカルシン−抗体複合体、およびその用途
KR20160101162A (ko) 코르티스타틴 유사체 및 그의 합성 및 용도
JP7675070B2 (ja) 治療、特にｍｙｄ８８変異疾患における使用のためのｈｃｋ阻害剤としてのピラゾロピリミジン誘導体
JP2018531987A (ja) Ｍａｌｔ１阻害剤およびその使用
JP2017520586A (ja) ハリコンドリン類似体の合成およびその使用
JP2024518089A (ja) Ｎａｍｐｔ阻害剤とその使用
AU2019318046A1 (en) Histone demethylase 5 inhibitors and uses thereof
WO2019032961A1 (en) TRIOXACARCIN-ANTIBODY CONJUGATES AND USES THEREOF
WO2025165908A1 (en) Bifunctional tead degraders
WO2021142115A1 (en) Sanglifehrin analogs and uses thereof
HK40025968A (en) Macrocyclic compound and uses thereof
HK40025968B (en) Macrocyclic compound and uses thereof
BR112019020208B1 (pt) Composto macrocíclico, composição farmacêutica e uso dos mesmos

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant