CN111163755A - 包含植物来源的胞外囊泡的组合物 - Google Patents
包含植物来源的胞外囊泡的组合物 Download PDFInfo
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- CN111163755A CN111163755A CN201880063858.9A CN201880063858A CN111163755A CN 111163755 A CN111163755 A CN 111163755A CN 201880063858 A CN201880063858 A CN 201880063858A CN 111163755 A CN111163755 A CN 111163755A
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- plant
- extracellular vesicles
- wild ginseng
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- skin
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Abstract
本发明涉及包含植物来源的胞外囊泡的组合物的各种用途。
Description
技术领域
本发明涉及包含植物来源的胞外囊泡的组合物的各种用途。
背景技术
近来，随着医疗技术和公共卫生利益的提高，超龄社会正迅速形成。因此，人们追求生活质量的改善，而对维持青春的需求也在增加。在各个领域进行了许多研究，以延迟和防止身体外观的老化，特别是首先发生在皮肤上的老化。
在另一方面，皱纹是由皮肤老化引起，而老化的皮肤是老化过程相关的自然变化的总和。皮肤老化主要分为两类：生理性老化，其在整个皮肤表面显示皮肤功能、结构或形状中年龄相关的改变；以及紫外线引起的光老化。
随着皮肤老化的进行，真皮中会出现显著变化，而70岁或以上的人出现的皮肤萎缩是典型的老化现象。真皮中的变化是由于成纤维细胞数量及其合成能力降低导致胞外基质中高分子量物质变化所致。这种改变的具体例子可以包括胶原束的分离、粘多糖合成减少、胶原和弹性蛋白的数量和直径减少、胶原和弹性蛋白的分解、血管扩张等。通常，在包括皮肤的水分含量、胶原蛋白含量以及对外部环境施加免疫作用的能力等多种因素中，对皱纹形成影响最大的通常是胶原酶的表达水平和活性，这是一种降低胶原产生和胶原含量的胶原降解酶。
人皮肤的颜色取决于皮肤中黑色素的浓度和分布。人皮肤的黑素细胞产生的黑色素是具有黑色色素和蛋白的复合物形式的酚醛聚合物，并且在阻止由紫外线引起的皮肤损伤中起重要作用。据报道，在黑色素的生物合成中，存在于黑素细胞中的酪氨酸酶的作用最重要，酪氨酸酶通过将酪氨酸(一类氨基酸)转化为DOPA和多巴醌(黑色素聚合物产生中的中间产物)而在皮肤变黑过程中起关键作用。
在另一方面，环境污染、汽车废气等使得激素失衡变得更加普遍。因此，脱发的发生率升高，开始脱发的年龄也降低，并且发生皮肤免疫系统的不和谐，从而引起各种皮肤疾病，例如特应性皮炎或银屑病。此外，尽管年轻，但是随着饮食转向快餐和肉类，患有肥胖症的人口正在迅速增长。
因此，已经进行了深入的研究以开发能够有效解决各种现象的物质，这些现象不仅在美学水平上成问题，而且正成为严重的社会问题，例如固有的老化和紫外线引起的皱纹形成、黄褐斑或雀斑、肥胖、免疫失衡和脱发。
技术问题
本发明的目的是提供包含植物来源的胞外囊泡的组合物，该组合物具有各种作用，例如改善皮肤、治疗脱发和治疗伤口。
技术问题的解决方案
皮肤由表皮、真皮和皮下组织组成。表皮是皮肤的最外层，其由分层的鳞状上皮组成，并作为身体抵御外部环境的保护屏障。从外部开始，表皮分为角质层、透明层、颗粒层、棘层和基底层。真皮是表皮和皮下组织之间的一层，分为乳头状真皮和网状真皮，并包含血管、胶原、弹性蛋白纤维、毛孔、毛细血管肌肉、皮脂腺、汗腺、各种感觉神经、成纤维细胞、巨噬细胞以及表皮中不存在的类似物质。真皮占据皮肤的最大部分。
真皮主要由胶原和弹力蛋白纤维组成，用于支撑皮肤。因此，在真皮中发生问题的情况下，皱纹形成并且皮肤弹性丧失，这导致皮肤老化发展。已知胶原在皮肤再生、皮肤水分含量、伤口愈合、皱纹改善等中起最重要的作用，胶原是成纤维细胞产生的。胶原具有包含大量水分的能力，因此可以为真皮提供水分。随着皮肤老化，胶原包含水分的能力降低，因此皱纹增加。此外，当发生伤口时，胶原还通过成纤维细胞的连续产生来填充伤口区域而起到治愈伤口的作用。
此外，在现代社会中，人体因大量的压力而逐渐受到损害，由此引起的脱发成为主要的社会问题。脱发是由多种因素引起的，包括毛发生长不良和缺乏促进毛发根细胞生长的生长因子。
由于精神压力，这种脱发会降低生活质量，并给人际关系或社会生活带来诸多不便。在社交生活中，来自身体外观的个人形象留下了非常深刻的记忆，而身体外观为自尊或社交生活提供了无形的能量。从这一观点出发，对脱发的原因及治疗方法的兴趣日益增长。
据报道，当某物质对脱发有效时，该物质对伤口愈合也有效(参见韩国专利公开号10-2013-0075981)。这是因为其信号转导系统彼此共享或相互影响。实际上，根据本发明的实施方式，可以说在某物质具有毛发生长作用的情况下，该物质还具有伤口愈合作用。
本发明人已发现，源自植物的胞外囊泡，特别是青龙(Green dragon)、油菜籽、何首乌(包括多花何首乌(Pleuropterus multiflorus)和隔山消(Cynanchum wilfordii))或野人参不定根具有优异的皮肤通透性；被吸收入皮肤后，具有例如伤口愈合、皮肤保湿、皮肤美白、改善皱纹、抗衰老等优异的效果；并且还具有优异的毛发生长和促进毛发生长的作用；从而完成了本发明。
本发明的一个实施方式提供了用于皮肤改善的化妆品组合物，其包含植物来源的胞外囊泡作为活性成分。更优选地，所述胞外囊泡的包含浓度可以为5至10μg/ml。
本发明的另一实施方式提供了用于皮肤改善的食品组合物，其包含植物来源的胞外囊泡作为活性成分。更优选地，所述胞外囊泡的包含浓度可以为5至10μg/ml。
本发明的还有另一实施方式提供了用于伤口愈合的药物组合物，其包含植物来源的胞外囊泡作为活性成分。更优选地，所述胞外囊泡的包含浓度可以为5至10μg/ml。
本发明的还有另一实施方式提供了用于预防或治疗脱发的药物组合物，其包含植物来源的胞外囊泡作为活性成分。更优选地，所述胞外囊泡的包含浓度可以为5至10μg/ml。
本发明的还有另一实施方式提供了用于改善脱发的化妆品组合物，其包含植物来源的胞外囊泡作为活性成分。更优选地，所述胞外囊泡的包含浓度可以为5至10μg/ml。
本发明的还有另一实施方式提供了用于改善脱发的食品组合物，其包含植物来源的胞外囊泡作为活性成分。更优选地，所述胞外囊泡的包含浓度可以为5至10μg/ml。
本文所用的术语“胞外囊泡”是指各种细胞分泌的膜性小囊，并且也被定义为纳米囊泡。胞外囊泡的直径为约30至1,000nm，优选平均直径为100至300nm。胞外囊泡是指通过多囊泡体和质膜之间的融合而释放到胞外环境中的小囊。
本文所用的术语“植物”应理解为不仅包括成熟的植物，还包括可以发育为成熟植物的植物细胞、植物组织、植物的种子等。
可以用于本发明的植物的类型没有特别限制。例如，可以使用选自青龙、油菜籽、何首乌和组织培养的野山参根的植物。然而，可用于本发明的植物的类型不限于上述类型，并且可以使用任何材料而没有限制，只要该材料属于植物即可。
本文所用的“野山参”是含有大量功能成分的植物的实例，并且是天然生长在山中的人参，其属于高丽人参(Panax ginseng C.A.Meyer，五加科)。野山参是一种半荫植物，其也属于显花植物(phanerogam)，其中当出芽时，带有花的梗具有叶和茎，还属于被子植物。野山参在韩国传统医学百科全书，东医实录(Donguibogam)中记录为“神草”，其是一种稀有植物，自古以来就被视为神秘的长生不老药。野山参已被用作各种疾病的治疗剂，并被用作帮助提高生命力的药物。野山参分为四种：天种(Cheonjong)、地种(Jijong)、人种(Injong)和栽培的野山参。具体而言，所述天种(天然野山参)是从山上天然生长的野山参上掉下来的种子的产物；所述地种是野生动物或鸟类摄取并排泄到山上的野山参种子的产物；所述人种是人类播种的野山参种子的产物；所述栽培的野山参是通过收获野山参的种子，将其深播到山中，并在野外进行人工栽培而获得的产品。通常，野山参即使播种也不能很好地发芽，即使野山参生长起来，也常常在几年内腐烂，从这样的观点看，野山参是难以栽培的非常稀有的植物。
在本发明中，作为野山参，可以使用野山参不定根。在此，野山参不定根可以通过本领域技术人员已知的植物组织培养方法获得，例如，韩国专利号0353636和0392513中描述的方法等。其生产方法没有特别限制。
本文所用术语“青龙”具有科学名称“三叉叶半夏(Pinellia tripartita)”，其是指属于天南星科(Araceae)的植物。青龙是多年生植物，在地上有一圆形的球茎。青龙的果实是一椭圆形的多汁浆果，里面有种子，成熟后呈绿色。
本文所用的术语“油菜籽”具有科学名称“甘蓝型油菜(Brassica napus)”，其是指属于十字花科(cruciferous family)和罂粟目(Papaverales order)的两年生双子叶植物。其花在四月左右以总状花序(racemose form)的形式开花，并位于枝的末端。其果实为末端具长喙状的圆柱状，中间有成熟时裂开的接缝，露出20个暗褐色种子。油菜籽通过种子进行繁殖。油菜籽分布在日本、中国和韩国。在韩国，它遍布全国，主要在南部种植。
如本文所用的术语“何首乌”是指两类何首乌，即白色一种(隔山消)和红色一种(多花何首乌)中的白色一种。白色何首乌属于隔山消(Cynanchum wilfordii,Hemsley，萝藦科)，已知可用于疾病后的虚弱、贫血、早期白发、神经衰弱、慢性风痹等，因为它具有补气和补血的功效。
此外，在本发明中，根据常规方法，药物组合物还可包含适当的运载体、赋形剂或稀释剂。作为本发明药物组合物中可包含的运载体、赋形剂和稀释剂，可以利用乳糖、右旋糖、蔗糖、山梨糖醇、甘露糖醇、木糖醇、赤藓糖醇、麦芽糖醇、淀粉、阿拉伯胶、藻酸盐、明胶、磷酸钙、硅酸钙、纤维素、甲基纤维素、微晶纤维素、聚乙烯吡咯烷酮、羟基苯甲酸甲酯、羟基苯甲酸丙酯、滑石粉、硬脂酸镁、矿物油等。然而，所述运载体、赋形剂和稀释剂不限于此。
此外，可以根据常规方法将本发明的药物组合物分别配制成口服制剂的形式，例如粉剂、颗粒剂、片剂、胶囊剂、混悬剂、乳剂、糖浆、气雾剂等，外用制剂、栓剂和无菌可注射溶液，并使用。具体地，在制成制剂的情况下，可以通过使用常用的稀释剂或赋形剂，例如填充剂、增量剂、粘合剂、湿润剂、崩解剂和表面活性剂来制备制剂。用于口服给药的固体制剂包括片剂、丸剂、粉末剂、颗粒剂、胶囊剂等。此类固体制剂可以通过将本发明的上述药物组合物与至少一种赋形剂，例如淀粉、碳酸钙、蔗糖、乳糖、明胶等混合来制备。此外，除简单的赋形剂外，还可使用硬脂酸镁和滑石粉等润滑剂。用于口服给药的液体制剂包括混悬剂、溶液剂、乳剂、糖浆剂等。除了通常使用的简单稀释剂，水和液体石蜡之外，液体制剂还可以包含各种赋形剂，例如润湿剂、甜味剂、香料和防腐剂。肠胃外给药的制剂包括无菌水溶液、非水溶液、悬浮液、乳剂、冻干制剂和栓剂。对于非水溶液和悬浮液，可以使用丙二醇、聚乙二醇、植物油，例如橄榄油，可注射酯，例如油酸乙酯等。作为栓剂的基质，可以使用维特索尔、聚乙二醇、吐温61、可可脂、月桂脂、甘油明胶等。
本发明的药物组合物的给药途径包括但不限于，口服、静脉内、肌内、动脉内、髓内、硬膜内、心内、透皮、皮下、腹膜内、鼻内、经肠、局部、舌下或直肠途径。优选口服或肠胃外给药。如本文所用的术语“肠胃外”包括皮下、皮内、静脉内、肌内、关节内、法氏囊内、胸骨内、硬膜内、病变内和颅内注射或输注技术。本发明的药物组合物也可以采用直肠给药的栓剂形式给予。
本发明的药物组合物可根据多种因素而有所不同，包括所用某种化合物的活性、患者的年龄、体重、总体健康状况、性别、饮食、给药时间、给药途径、排泄率、药物联用以及要预防或治疗的某些疾病的严重性。药物组合物的剂量可以根据患者的状况、体重、疾病的严重程度、药物形式、给药途径和持续时间而有所不同，并且可以由本领域技术人员适当地选择。药物组合物可以每天0.0001至50mg/kg或0.001至50mg/kg的量施用。可以一天一次或一天几次进行给药。该剂量无意以任何方式限制本发明的范围。本发明的药物组合物可以配制成丸剂、糖衣片剂、胶囊剂、液体剂、凝胶剂、糖浆剂、浆剂或混悬剂的形式。
在本发明中，食品组合物可以制备成各种食物的形式，例如饮料、咀嚼胶、茶、维生素复合物、粉末、颗粒、片剂、胶囊、糖果、年糕、面包等。本发明的食品组合物由毒性和副作用小的植物提取物构成，因此，在为了预防目的而长时间摄取的情况下，可以放心使用。
在食品组合物中含有植物来源的胞外囊泡或含有其的滤液(在本发明中各自作为有效成分而包含)的情况下，其添加量可以为食品组合物总重量的0.1％至50％。
在此，在将食品组合物制成饮料形式的情况下，除了饮料含有指定比例的所述食品组合物之外没有特定限制，并且与传统饮料一样，所述饮料可以包含各种调味剂或天然碳水化合物等作为其它成分。即，天然碳水化合物的实例可以包括单糖，例如葡萄糖，二糖，例如果糖，多糖，例如蔗糖，常规糖，例如糊精和环糊精以及糖醇，例如木糖醇、山梨糖醇和赤藓糖醇。调味剂的实例可包括天然调味剂(甜蛋白、甜叶菊提取物(如甜菊糖双甙A)、甘草甜素等)和合成调味剂(糖精、阿斯巴甜等)。
此外，本发明的食品组合物可包含各种营养素、维生素、矿物质(电解质)、调味剂，例如合成调味剂和天然调味剂，着色剂、果胶酸及其盐、藻酸及其盐、有机酸、保护性胶体增稠剂、pH调节剂、稳定剂、防腐剂、甘油、酒精、碳酸饮料中使用的碳化剂等。
这些成分可以单独使用或组合使用。此类添加剂的比例不是很重要，并且以本发明食品组合物的重量计，通常选自每100重量份0.1至约50重量份的范围。
此外，在本发明中，可以将化妆品组合物制备成以下形式：皮肤柔软剂、营养乳液、营养精华、按摩霜、化妆品沐浴水添加剂、身体乳液、身体乳、沐浴油、婴儿油、婴儿爽身粉、沐浴露、沐浴乳、防晒液、防晒乳、防晒霜、护肤液、护肤乳、防紫外线化妆品、卸妆乳、脱毛剂(美容目的)、脸部和身体洗液、脸部和身体霜、皮肤美白霜、护手霜、头发乳液、美容霜、茉莉油、沐浴皂、液体皂、美容皂、洗发水、洗手液、药用肥皂(用于非医疗目的用途)、乳霜肥皂、洗面奶、身体清洁剂、头皮清洁剂、洗发水、香皂、牙齿增白凝胶、牙膏等。为此，本发明的组合物还可包含常规用于制备化妆品组合物的溶剂，或合适的运载体、赋形剂或稀释剂。
对可以进一步添加到本发明的化妆品组合物中的溶剂的类型没有特别限制，溶剂的实例可以包括：水、盐水、DMSO或其组合。此外，运载体、赋形剂或稀释剂的实例包括但不限于：纯净水、油、蜡、脂肪酸、脂肪酸醇、脂肪酸酯、表面活性剂、保湿剂、增稠剂、抗氧化剂、粘度稳定剂、螯合剂、缓冲剂、低级醇等。此外，如果需要，本发明的化妆品组合物可以包含增白剂、保湿剂、维生素、紫外线阻断剂、香料、染料、抗生素、抗菌剂和抗真菌剂。
油的实例可以包括：氢化植物油、蓖麻油、棉籽油、橄榄油、棕榈仁油、霍霍巴油和鳄梨油；蜡的实例可以包括：蜂蜡、鲸蜡、巴西棕榈蜡、小烛树蜡、褐煤蜡、地蜡、液体石蜡和羊毛脂。
脂肪酸的实例可以包括：硬脂酸、亚油酸、亚麻酸和油酸；脂肪酸醇的实例可以包括：鲸蜡醇、辛基十二烷醇、油醇、泛醇、羊毛脂醇、硬脂醇和十六烷醇；脂肪酸酯的实例可以包括：肉豆蔻酸异丙酯、棕榈酸异丙酯和硬脂酸丁酯。表面活性剂的实例可包括本领域已知的阳离子表面活性剂、阴离子表面活性剂和非离子表面活性剂。其中，如果可能，优选天然产物衍生的表面活性剂。
此外，本发明的化妆品组合物可以包含化妆品领域熟知的保湿剂、增稠剂、抗氧化剂等，其类型和用量是本领域已知的。
本发明一实施方式提供了用于防止脱发或用于毛发生长的化妆品组合物，其包含植物来源的胞外囊泡作为活性成分。在该实施方式的化妆品组合物中，所述植物是选自青龙、油菜籽、何首乌和野山参不定根的至少一种。此外，本发明的一实施方式提供了用于预防脱发或用于毛发生长的食品组合物，其包含植物来源的胞外囊泡作为活性成分。在该实施方式的食品组合物中，植物是选自青龙、油菜籽、何首乌和野山参不定根中的至少一种。此外，本发明的一实施方式提供了用于预防脱发或用于毛发生长的药物组合物，其包含植物来源的胞外囊泡作为活性成分。在该实施方式的药物组合物中，植物是选自青龙、油菜籽、何首乌和野山参不定根的至少一种。
本发明的一实施方式提供了用于伤口愈合或改善的化妆品组合物，其包含植物来源的胞外囊泡作为活性成分。在该实施方式的化妆品组合物中，植物是选自青龙、油菜籽、何首乌和野山参不定根的至少一种。此外，本发明的一实施方式提供了用于伤口愈合或改善的食品组合物，其包含植物来源的胞外囊泡作为活性成分。在该实施方式的食品组合物中，植物是选自青龙、油菜籽、何首乌和野山参不定根中的至少一种。另外，本发明的一实施方式提供了用于伤口愈合的药物组合物，其包含植物来源的胞外囊泡作为活性成分。在该实施方式的药物组合物中，植物是选自青龙、油菜籽、何首乌和野山参不定根的至少一种。
本发明的一实施方式提供了用于毛发生长或防止脱发的方法，包括向有此需要的对象施用有效量的植物来源的胞外囊泡作为活性成分的步骤。在该实施方式的方法中，植物是选自青龙、油菜籽、何首乌和野山参不定根的至少一种。
本发明的一实施方式提供了用于预防脱发或用于毛发生长的组合物，其包含植物来源的胞外囊泡作为活性成分。在该实施方式的组合物中，植物是选自青龙、油菜籽、何首乌和野山参不定根的至少一种。
本发明的有利效果
本发明提供的植物来源的胞外囊泡具有优异的皮肤通透性；当吸收到皮肤中，具有优异的皮肤改善作用，例如皮肤保湿、皮肤美白、改善皱纹和抗衰老；使用安全，而不会对皮肤造成刺激或副作用。
此外，本发明提供的植物来源的胞外囊泡促进伤口区域的细胞增殖，并导致具有优异伤口愈合作用的生长因子等的表达水平提高，从而表现出优异的伤口愈合活性或促进伤口愈合活性。
此外，本发明提供的植物来源的胞外囊泡具有优异的毛发生长和促进毛发生长的作用，因此表现出预防和治疗脱发的优异作用；并且从摄入或涂在皮肤上没有副作用的观点来看是安全的。
附图简述
图1示出了根据本发明一实施方式，通过蛋白质印迹分析的毛发生长相关PCNA的量的结果。
图2示出了根据本发明一实施方式，毛发生长相关PCNA的密度值水平的结果。
图3示出了根据本发明一实施方式，相对于毛发生长相关基因的表达水平，相对mRNA水平的结果。
图4示出了根据本发明一实施方式，通过测量人头皮组织分离的毛囊的长度获得的结果。
发明详述
下文将通过以下实施例详细描述本发明。然而，给出以下实施例仅为说明本发明，本发明的范围不限于以下实施例。
实施例1.微囊泡的分离
4℃下，将青龙、油菜籽、隔山消和野山参不定根的组织培养液或提取汁离心10分钟。取出上清液并在4℃下以1200g离心20分钟。然后，取上清液并在4℃下以10,000g离心30分钟。取上清液，并在4℃使用超速离心机以110,000g离心1小时10分钟。然后，弃去上清液，并将沉淀物悬浮在PBS中以分离微囊泡。
实施例2.所分离微囊泡的性能鉴定
鉴定毛发生长相关蛋白的表达
为了鉴定实施例1的微囊泡对毛发生长相关基因的蛋白水平的影响，进行了微囊泡样品的处理，然后通过蛋白质印迹法比较并鉴定了PCNA的量(见图1和2)。结果，发现源自青龙、大豆、油菜籽、隔山消和培养的野山参根的所有微囊泡均导致蛋白表达水平等于或高于阳性对照，米诺地尔。尤其是，源自隔山消的微囊泡导致蛋白表达水平提高了约20％。
鉴定毛发生长相关基因的表达
为进一步验证微囊泡的促进毛发生长的作用，检查了与毛发生长相关的基因的表达(见图3)。结果，尽管各个基因的表达趋势有所不同，但鉴定到源自青龙、大豆、油菜籽、隔山消和培养的野山参根的微囊泡导致基因表达增加。具体地，对于检查的4种基因类型，源自隔山消的微囊泡导致基因表达显著高于阳性对照，米诺地尔。
使用人毛囊组织作有效性评估
作为可以代替动物试验的有效性评估方法，使用人毛囊组织进行有效性评估。从因意外和医院手术而有待丢弃的人头皮组织中分离出毛囊，并用阳性对照，米诺地尔和样品微囊泡处理5天。然后，测量其长度，从而根据长度评估微囊泡对毛囊生长的有效性(参见图4)。就长度而言，发现源自隔山消的微囊泡相比于阳性对照导致毛囊显著生长。
本发明的范围不限于上述实施例，并且由所附权利要求书限定。对于本领域技术人员将显而易见的是，在不脱离本发明的技术构思的情况下可以做出各种改进和改变。
工业适用性
本发明提供的植物来源的胞外囊泡具有优异的皮肤通透性；当吸收入皮肤时，具有优异的皮肤改善作用，例如皮肤保湿、皮肤美白、改善皱纹和抗衰老；促进伤口区域的细胞增殖并导致具有优异伤口愈合作用的生长因子等的表达水平提高，从而表现出优异的伤口愈合活性或伤口愈合促进活性。因此，可以采用药物组合物、化妆品组合物和食品组合物的形式使用该活性成分。
Claims (16)
1.一种用于防止脱发或用于毛发生长的化妆品组合物，其特征在于，包含植物来源的胞外囊泡作为活性成分。
2.如权利要求1所述的化妆品组合物，其特征在于，所述植物是选自青龙、油菜籽、隔山消和野山参不定根的至少一种。
3.一种用于防止脱发或用于毛发生长的食品组合物，其特征在于，包含植物来源的胞外囊泡作为活性成分。
4.如权利要求3所述的食品组合物，其特征在于，所述植物是选自青龙、油菜籽、隔山消和野山参不定根的至少一种。
5.一种用于防止脱发或用于毛发生长的药物组合物，其特征在于，包含植物来源的胞外囊泡作为活性成分。
6.如权利要求5所述的药物组合物，其特征在于，所述植物是选自青龙、油菜籽、隔山消和野山参不定根的至少一种。
7.一种用于伤口愈合或改善的化妆品组合物，其特征在于，包含植物来源的胞外囊泡作为活性成分。
8.如权利要求7所述的化妆品组合物，其特征在于，所述植物是选自青龙、油菜籽、隔山消和野山参不定根的至少一种。
9.一种用于伤口愈合或改善的食品组合物，其特征在于，包含植物来源的胞外囊泡作为活性成分。
10.如权利要求9所述的食品组合物，其特征在于，所述植物是选自青龙、油菜籽、隔山消和野山参不定根的至少一种。
11.一种用于伤口愈合的药物组合物，其特征在于，包含植物来源的胞外囊泡作为活性成分。
12.如权利要求11所述的药物组合物，其特征在于，所述植物是选自青龙、油菜籽、隔山消和野山参不定根的至少一种。
13.一种用于毛发生长或防止脱发的方法，其特征在于，包括向有此需要的对象施用有效量的植物来源的胞外囊泡作为活性成分的步骤。
14.如权利要求13所述的方法，其特征在于，所述植物是选自青龙、油菜籽、隔山消和野山参不定根的至少一种。
15.一种用于预防脱发或用于毛发生长的组合物，其特征在于，包含植物来源的胞外囊泡作为活性成分。
16.如权利要求15所述的组合物，其特征在于，所述植物是选自青龙、油菜籽、隔山消和野山参不定根的至少一种。
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| CN111297790B (zh) * | 2020-02-25 | 2023-02-17 | 暨南大学 | 茶叶外囊泡的应用 |
| KR102248258B1 (ko) * | 2020-05-04 | 2021-05-04 | 주식회사 바이오에프디엔씨 | 녹차 식물세포 유래 엑소좀을 유효성분으로 포함하는 피부개선용 조성물 |
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| KR102391645B1 (ko) | 2021-11-11 | 2022-04-28 | 주식회사 에이바이오머티리얼즈 | 무화과 유래 엑소좀을 유효성분으로 함유하는 모발 화장료 조성물 |
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2017
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2018
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- 2018-09-28 JP JP2020517929A patent/JP2020535189A/ja not_active Withdrawn
- 2018-09-28 CN CN201880063858.9A patent/CN111163755A/zh active Pending
- 2018-09-28 US US16/651,876 patent/US20200254044A1/en not_active Abandoned
- 2018-09-28 WO PCT/KR2018/011508 patent/WO2019066538A1/ko unknown
- 2018-09-28 EP EP18861914.2A patent/EP3689329A1/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1988883A (zh) * | 2004-05-21 | 2007-06-27 | 株式会社故里村开发中心 | 头皮头发用组合物 |
| KR20170037381A (ko) * | 2015-09-25 | 2017-04-04 | (주)프로스테믹스 | 탈모의 예방 또는 치료용 조성물 |
| KR20170037380A (ko) * | 2015-09-25 | 2017-04-04 | (주)프로스테믹스 | 식물 착즙물 유래 세포 외 소포체를 포함하는 피부 개선 및 탈모 방지용 조성물 |
| KR20170038383A (ko) * | 2015-09-30 | 2017-04-07 | (주)아모레퍼시픽 | 인삼 유래의 엑소좀 유사 베지클을 포함하는 탈모 방지 또는 육모 촉진용 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102207364B1 (ko) | 2021-01-27 |
| KR20190037162A (ko) | 2019-04-05 |
| US20200254044A1 (en) | 2020-08-13 |
| WO2019066538A1 (ko) | 2019-04-04 |
| WO2019066121A1 (ko) | 2019-04-04 |
| JP2020535189A (ja) | 2020-12-03 |
| EP3689329A1 (en) | 2020-08-05 |
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