CN110869011B - 用于治疗神经退行性疾病的组合物 - Google Patents
用于治疗神经退行性疾病的组合物 Download PDFInfo
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- CN110869011B CN110869011B CN201880046006.9A CN201880046006A CN110869011B CN 110869011 B CN110869011 B CN 110869011B CN 201880046006 A CN201880046006 A CN 201880046006A CN 110869011 B CN110869011 B CN 110869011B
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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| DK3099296T3 (en) | 2014-01-31 | 2019-04-15 | Cognition Therapeutics Inc | ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE |
| AU2018269964B2 (en) * | 2017-05-15 | 2022-07-07 | Cognition Therapeutics, Inc. | Compositions for treating neurodegenerative diseases |
| CN116867488A (zh) * | 2020-12-11 | 2023-10-10 | 考格尼申治疗股份有限公司 | 用于治疗干性老年性黄斑变性(amd)的组合物 |
| EP4308565A4 (en) * | 2021-03-19 | 2025-01-01 | Cognition Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL DISEASES |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002222A1 (de) * | 1977-11-30 | 1979-06-13 | BASF Aktiengesellschaft | Aralkylpiperidinone und deren Anwendung als Fungizide |
| JPH01305085A (ja) * | 1988-05-31 | 1989-12-08 | Yamanouchi Pharmaceut Co Ltd | ピリジルチアゾリジンカルボン酸アミド誘導体 |
| JPH02215789A (ja) * | 1989-02-15 | 1990-08-28 | Yamanouchi Pharmaceut Co Ltd | チアゾロ[3,4―a]ピラジン誘導体 |
| CN104053435A (zh) * | 2011-08-25 | 2014-09-17 | 考格尼申治疗股份有限公司 | 用于治疗神经退行性疾病的组合物和方法 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA732136B (en) | 1972-04-12 | 1974-03-27 | Lilly Co Eli | Dopamine derivatives |
| US4321386A (en) | 1981-01-28 | 1982-03-23 | Mead Johnson & Company | Quaternary piperidinium halides |
| DE3222152A1 (de) | 1982-06-12 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Substituierte maleinsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
| EP0117647B1 (en) | 1983-01-31 | 1988-08-17 | Eli Lilly And Company | Improvements in or relating to phenethanolamines |
| JPS62283922A (ja) | 1986-05-30 | 1987-12-09 | Tsumura Juntendo Inc | 血小板凝集抑制剤 |
| US4697024A (en) | 1986-11-24 | 1987-09-29 | Merrell Dow Pharmaceuticals Inc. | Medroxalol intermediates |
| US4958029A (en) | 1987-01-13 | 1990-09-18 | Banyu Pharmaceutical Co., Ltd. | Process for the production of isoindoline derivatives, novel intermediates and process for their production |
| JPH01180822A (ja) | 1988-01-12 | 1989-07-18 | Dainippon Pharmaceut Co Ltd | 抗遅延型アレルギー剤 |
| CA2071897A1 (en) | 1989-12-28 | 1991-06-29 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
| DE4000610A1 (de) | 1990-01-11 | 1991-07-18 | Knoll Ag | Verfahren zur herstellung von optisch aktiven 3-amino-1-arylbutanen und 3-benzylamino-1-arylbutanen |
| JP2818958B2 (ja) | 1990-02-23 | 1998-10-30 | 塩野義製薬株式会社 | 4―(4―アルコキシフェニル)―2―ブチルアミン誘導体およびその製造法 |
| JPH045266A (ja) | 1990-04-24 | 1992-01-09 | Toyo Pharma- Kk | ドパミン誘導体の製造方法 |
| DE4142366A1 (de) | 1991-07-15 | 1993-06-24 | Thomae Gmbh Dr K | Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US6011068A (en) | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| AU702629B2 (en) | 1991-08-23 | 1999-02-25 | Nps Pharmaceuticals, Inc. | Calcium receptor-active arylalkyl amines |
| US6610493B1 (en) | 1993-06-17 | 2003-08-26 | Brigham And Women's Hospital | Screening compounds for the ability to alter the production of amyloid-β peptide |
| CA2115900A1 (en) | 1993-02-22 | 1994-08-23 | Gerald W. Becker | Pharmaceutical screens and antibodies |
| JPH06321781A (ja) | 1993-05-13 | 1994-11-22 | Yamanouchi Pharmaceut Co Ltd | 血小板活性化因子拮抗剤 |
| JPH0714147A (ja) | 1993-06-25 | 1995-01-17 | Dainippon Printing Co Ltd | 磁気記録媒体および磁気記録媒体の記録方法 |
| JPH07145147A (ja) * | 1993-11-26 | 1995-06-06 | Yamanouchi Pharmaceut Co Ltd | 安息香酸誘導体又はその塩 |
| CZ290670B6 (cs) | 1994-10-21 | 2002-09-11 | Nps Pharmaceuticals, Inc. | Sloučeniny modulující receptory anorganických iontů a farmaceutický prostředek, který je obsahuje |
| DE19529411A1 (de) * | 1995-08-10 | 1997-02-13 | Bayer Ag | Substituierte Tetrahydro-5-nitro-pyrimidine |
| JP3522930B2 (ja) | 1995-12-06 | 2004-04-26 | 花王株式会社 | 抗菌剤及びこれを含有する口腔用組成物 |
| WO1997030038A1 (en) | 1996-02-15 | 1997-08-21 | Mitsubishi Chemical Corporation | Diarylsultam derivatives |
| US6235731B1 (en) | 1996-04-24 | 2001-05-22 | Takeda Chemical Industries, Ltd. | Fused imidazopyridine derivatives as antihyperlipidemic agents |
| US6218506B1 (en) | 1997-02-05 | 2001-04-17 | Northwestern University | Amyloid β protein (globular assembly and uses thereof) |
| US6518315B1 (en) | 1997-10-21 | 2003-02-11 | The University Of Sydney | Medicinal uses of phenylaikanols and derivatives |
| CO4980891A1 (es) | 1997-11-14 | 2000-11-27 | Sanofi Sa | Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer |
| CO5011072A1 (es) | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
| TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| IL138686A0 (en) | 1999-10-01 | 2001-10-31 | Pfizer Prod Inc | α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS |
| AU2300001A (en) | 1999-10-22 | 2001-05-08 | Board Of Trustees Of The University Of Illinois, The | Pharmaceutical compositions useful in the prevention and treatment of beta-amyloid protein-induced disease |
| DE10027151A1 (de) | 2000-05-31 | 2001-12-06 | Bayer Ag | Herbizide Mittel auf Basis von substituierten Carbonsäureamiden |
| ES2225624T3 (es) | 2000-06-28 | 2005-03-16 | Smithkline Beecham Plc | Procedimiento de molienda por via humeda. |
| JP4329290B2 (ja) * | 2000-10-06 | 2009-09-09 | 田辺三菱製薬株式会社 | 脂肪族含窒素五員環化合物 |
| CA2440358C (en) | 2001-03-05 | 2013-08-20 | Wangxia Wang | Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their uses |
| JP4312402B2 (ja) | 2001-07-31 | 2009-08-12 | 有限会社大長企画 | 抗うつ剤、抗更年期障害剤、抗老人性痴呆症剤、抗アルツハイマー剤 |
| US20030073681A1 (en) | 2001-08-21 | 2003-04-17 | Hauske James R. | 2-substituted piperidines that are ligands for monoamine receptors and transporters |
| US6991814B2 (en) | 2001-12-13 | 2006-01-31 | Council Of Scientific And Industrial Research | Herbal medicaments for the treatment of neurocerebrovascular disorders |
| EA007067B1 (ru) | 2001-12-14 | 2006-06-30 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | Композиция для лечения нейроцереброваскулярных нарушений |
| JP4329381B2 (ja) | 2002-04-04 | 2009-09-09 | 田辺三菱製薬株式会社 | 医薬組成物 |
| JP2004002517A (ja) | 2002-05-31 | 2004-01-08 | Dae Sil Kim | 生姜成分を含む石鹸の組成物及びその製造方法 |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| DE10320560A1 (de) | 2003-05-07 | 2004-01-29 | Brosig, Stefan, Dr. | Mittel zur Bekämpfung der Alzheimer Erkrankung und/oder der Parkinson Krankheit |
| US7829562B2 (en) | 2003-06-12 | 2010-11-09 | M's Science Corporation | Sigma ligands for neuronal regeneration and functional recovery |
| US7863272B2 (en) | 2003-06-12 | 2011-01-04 | M's Science Corporation | Sigma ligands for neuronal regeneration and functional recovery |
| WO2005020991A1 (en) * | 2003-08-21 | 2005-03-10 | Pfizer Products, Inc. | Compounds for the treatment of neurodegenerative disorders |
| AU2004317129A1 (en) | 2004-03-12 | 2005-09-22 | Egis Gyogyszergyar Nyrt. | Combined pharmaceutical composition for the inhibition of the decline of cognitive functions |
| JPWO2005115366A1 (ja) | 2004-05-31 | 2008-03-27 | 株式会社カネカ | ウコン精油成分を含有する生活習慣病予防・改善剤 |
| ES2415665T3 (es) | 2004-06-21 | 2013-07-26 | Proteome Sciences Plc | Procedimientos de cribado usando c-abl, fyn y sky en combinación con la proteína tau |
| TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| JP2008512417A (ja) | 2004-09-10 | 2008-04-24 | ユセベ ファルマ ソシエテ アノニム | シグマ受容体リガンド |
| WO2006047254A1 (en) | 2004-10-22 | 2006-05-04 | Regents Of The University Of Minnesota | Assemblies of oligomeric amyloid beta protein and uses thereof |
| US20060153772A1 (en) | 2004-12-15 | 2006-07-13 | Wyeth | Contextual fear conditioning for predicting immunotherapeutic efficacy |
| US20090035295A1 (en) | 2005-03-05 | 2009-02-05 | Abbott Gmgh & Co. Kg | Screening Method, Process for Purifying of Non-Diffusible A-Beta Oligomers, Selective Antibodies Against Said Non-Diffusible a-Beta Oligomers and a Process for Manufacturing of Said Antibodies |
| KR20080041624A (ko) | 2005-06-15 | 2008-05-13 | 대릭 에스. 에치. 엘. 김 | 베타-아밀로이드 단백질-유발 안질환의 치료 방법 |
| TW200726774A (en) | 2005-06-30 | 2007-07-16 | Merck & Co Inc | Composition and method for producing stable amyloid beta oligomers |
| EP1745778A3 (en) | 2005-07-20 | 2007-03-07 | Speedel Experimenta AG | Diaminoalcohols as therapeutic compounds |
| ITRM20060007A1 (it) | 2006-01-05 | 2007-07-06 | Univ Bari | Recettore sigma-2 metodo di screening di ligandi specifici e uso degli stessi in metodi diagnostici o terapeutici |
| US20070218491A1 (en) | 2006-02-08 | 2007-09-20 | Oligomerix, Inc. | Oligomerization of amyloid proteins |
| KR20090007564A (ko) | 2006-03-17 | 2009-01-19 | 허발사이언스 싱가포르 피티이 리미티드 | 쿠르쿠마 종을 포함한 추출물 및 이를 수득하는 방법 |
| WO2007112288A2 (en) | 2006-03-23 | 2007-10-04 | Mount Sinai School Of Medicine | Cardiovascular composition and use the same for the treatment of alzheimers disease |
| WO2007126473A2 (en) | 2006-04-10 | 2007-11-08 | Oligomerix, Inc. | Oligomerization of amyloid proteins |
| CA2653628C (en) | 2006-06-01 | 2015-07-14 | Elan Pharmaceuticals, Inc. | Neuroactive fragments of app |
| US7561775B2 (en) | 2006-08-22 | 2009-07-14 | Senko Advanced Components, Inc. | Fiber optic protective shutter |
| EP2066692B1 (en) | 2006-09-08 | 2012-01-11 | VIB, vzw | Means and methods for the production of amyloid oligomers |
| WO2008042755A2 (en) | 2006-09-29 | 2008-04-10 | Cognition Therapeutics, Inc. | Inhibitors of cognitive decline |
| US20080131233A1 (en) | 2006-10-17 | 2008-06-05 | Yao Chun I | Plate-shaped fastener device |
| US20100028333A1 (en) | 2006-12-15 | 2010-02-04 | Getty Krista L | Receptor for amyloid beta and uses thereof |
| WO2008134034A1 (en) | 2007-04-26 | 2008-11-06 | Yale University | Prion protein as a receptor for amyloid-beta oligomers |
| US7968524B2 (en) | 2007-05-15 | 2011-06-28 | Helicon Therapeutics, Inc. | Methods of enhancing long term memory formation by inhibition of Gpr12 |
| CN101121670A (zh) | 2007-09-11 | 2008-02-13 | 上海紫源制药有限公司 | 一种3,4-二甲氧基-N-[3-(4-甲氧基苯基)-1-甲基-正丙基]-β-苯乙胺盐酸盐的制备方法 |
| US20090246191A1 (en) | 2007-10-11 | 2009-10-01 | University Of Tennessee Research Foundation | Preparation of Purified Covalently Cross-linked Abeta Oligomers and Uses Thereof |
| ES2498065T3 (es) | 2007-10-24 | 2014-09-24 | Astellas Pharma Inc. | Compuesto de azolcarboxamida o sal del mismo |
| WO2009059214A1 (en) | 2007-11-02 | 2009-05-07 | The Regents Of The University Of California | Abeta-binding small molecules |
| WO2009067493A2 (en) | 2007-11-19 | 2009-05-28 | Envivo Pharmaceuticals, Inc. | 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders |
| EP2303920A4 (en) | 2008-07-25 | 2011-11-09 | Abbott Lab | SS-AMYLOID PEPTIDE ANALOGUES, OLIGOMERS THEREOF, PREPARATION METHODS AND COMPOSITIONS COMPRISING THE SAME OR OLIGOMERIC ANALOGUES, AND USES THEREOF |
| KR101515822B1 (ko) | 2008-11-29 | 2015-04-29 | 더 타일랜드 리서치 펀드 | 바이러스와 타겟 세포의 상호작용 저해 |
| WO2010088450A2 (en) | 2009-01-30 | 2010-08-05 | Celladon Corporation | Methods for treating diseases associated with the modulation of serca |
| WO2010093704A1 (en) | 2009-02-10 | 2010-08-19 | Abbott Laboratories | Agonists and antagonists of the s1p5 receptor, and methods of uses thereof |
| DK3255146T3 (da) | 2009-03-16 | 2019-08-19 | Pangu Biopharma Ltd | Præparater og fremgangsmåder omfattende histidyl-tRNA-synthetasesplejsningsvarianter med ikke-kanoniske biologiske aktiviteter |
| ES2545795T3 (es) | 2009-04-09 | 2015-09-15 | Cognition Therapeutics, Inc. | Inhibidores del deterioro cognitivo |
| EP2459742B1 (en) | 2009-07-29 | 2016-04-06 | Pharnext | New diagnostic tools for alzheimer disease |
| EP2458983B1 (en) | 2009-07-31 | 2015-07-08 | Cognition Therapeutics, Inc. | Inhibitors of cognitive decline |
| US20150160228A1 (en) | 2010-02-05 | 2015-06-11 | Susan Catalano | Compositions and method for determining the efficacy of amyloidosis treatments |
| US20130071330A1 (en) | 2010-02-26 | 2013-03-21 | Susan Catalano | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| WO2012027548A1 (en) | 2010-08-25 | 2012-03-01 | The Feinstein Institute For Medical Research | Compounds and methods for prevention and treatment of alzheimer's and other diseases |
| EP2670402B1 (en) | 2011-02-02 | 2017-09-20 | Cognition Therapeutics, Inc. | Isolated compounds from turmeric oil and methods of use |
| HK1202246A1 (en) | 2011-08-25 | 2015-09-25 | 考格尼申治疗股份有限公司 | Compositions and methods for treating neurodegenerative disease |
| WO2015020523A1 (en) | 2013-08-07 | 2015-02-12 | Stichting Vu-Vumc | Biomarkers for early diagnosis of alzheimer's disease |
| DK3099296T3 (en) * | 2014-01-31 | 2019-04-15 | Cognition Therapeutics Inc | ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE |
| AU2018269964B2 (en) * | 2017-05-15 | 2022-07-07 | Cognition Therapeutics, Inc. | Compositions for treating neurodegenerative diseases |
| EP3704092A4 (en) | 2017-11-01 | 2021-08-25 | Cognition Therapeutics, Inc. | ISOINDOLINE COMPOSITIONS AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISEASE |
| CN110283082A (zh) | 2019-07-15 | 2019-09-27 | 泰州职业技术学院 | 一种3-苯基丙胺的制备方法 |
| CN116867488A (zh) | 2020-12-11 | 2023-10-10 | 考格尼申治疗股份有限公司 | 用于治疗干性老年性黄斑变性(amd)的组合物 |
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- 2018-05-15 MX MX2019013524A patent/MX388366B/es unknown
- 2018-05-15 KR KR1020197037075A patent/KR102614814B1/ko active Active
- 2018-05-15 EP EP18802363.4A patent/EP3634394B1/en active Active
- 2018-05-15 JP JP2019563101A patent/JP7218306B2/ja active Active
- 2018-05-15 IL IL270251A patent/IL270251B2/en unknown
- 2018-05-15 CA CA3061787A patent/CA3061787A1/en active Pending
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2019
- 2019-10-30 ZA ZA201907238A patent/ZA201907238B/en unknown
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2021
- 2021-11-29 US US17/537,110 patent/US11981636B2/en active Active
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2024
- 2024-01-16 US US18/413,817 patent/US20240409509A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002222A1 (de) * | 1977-11-30 | 1979-06-13 | BASF Aktiengesellschaft | Aralkylpiperidinone und deren Anwendung als Fungizide |
| JPH01305085A (ja) * | 1988-05-31 | 1989-12-08 | Yamanouchi Pharmaceut Co Ltd | ピリジルチアゾリジンカルボン酸アミド誘導体 |
| JPH02215789A (ja) * | 1989-02-15 | 1990-08-28 | Yamanouchi Pharmaceut Co Ltd | チアゾロ[3,4―a]ピラジン誘導体 |
| CN104053435A (zh) * | 2011-08-25 | 2014-09-17 | 考格尼申治疗股份有限公司 | 用于治疗神经退行性疾病的组合物和方法 |
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| AU2018269964A1 (en) | 2019-11-28 |
| KR102614814B1 (ko) | 2023-12-20 |
| IL270251B1 (en) | 2024-09-01 |
| US11981636B2 (en) | 2024-05-14 |
| CN110869011A (zh) | 2020-03-06 |
| BR112019023851A2 (pt) | 2020-08-18 |
| KR20200005749A (ko) | 2020-01-16 |
| US20220356153A1 (en) | 2022-11-10 |
| ZA201907238B (en) | 2020-11-25 |
| MX2019013524A (es) | 2020-02-10 |
| WO2018213281A1 (en) | 2018-11-22 |
| US20240409509A1 (en) | 2024-12-12 |
| IL270251B2 (en) | 2025-01-01 |
| CA3061787A1 (en) | 2018-11-22 |
| JP2020519659A (ja) | 2020-07-02 |
| RU2019141272A3 (enExample) | 2021-12-24 |
| MX388366B (es) | 2025-03-19 |
| US20200299234A1 (en) | 2020-09-24 |
| EP3634394A1 (en) | 2020-04-15 |
| EP3634394A4 (en) | 2021-04-07 |
| AU2018269964B2 (en) | 2022-07-07 |
| US11214540B2 (en) | 2022-01-04 |
| RU2019141272A (ru) | 2021-06-16 |
| JP7218306B2 (ja) | 2023-02-06 |
| IL270251A (en) | 2019-12-31 |
| EP3634394B1 (en) | 2025-12-24 |
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