CN110678471B - Mk2抑制剂及其合成和中间体 - Google Patents

Mk2抑制剂及其合成和中间体 Download PDF

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Publication number
CN110678471B
CN110678471B CN201880032092.8A CN201880032092A CN110678471B CN 110678471 B CN110678471 B CN 110678471B CN 201880032092 A CN201880032092 A CN 201880032092A CN 110678471 B CN110678471 B CN 110678471B
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China
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formula
compound
salt
base
compound represented
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Chinese (zh)
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CN110678471A (zh
Inventor
G·B·费格尔森
M·E·盖尔蒂
Jr·R·M·内斯
M·柯塔尔
H-W·曼
A·L·卢切尔曼
J·F·特拉弗斯
K·H-Y·勇
C·张
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Bristol Myers Squibb Co
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Celgene Avilomics Research Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201880032092.8A 2017-03-16 2018-03-15 Mk2抑制剂及其合成和中间体 Expired - Fee Related CN110678471B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762472024P 2017-03-16 2017-03-16
US62/472,024 2017-03-16
PCT/US2018/022547 WO2018170203A1 (en) 2017-03-16 2018-03-15 Mk2 inhibitors, synthesis thereof, and intermediates thereto

Publications (2)

Publication Number Publication Date
CN110678471A CN110678471A (zh) 2020-01-10
CN110678471B true CN110678471B (zh) 2022-09-13

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CN201880032092.8A Expired - Fee Related CN110678471B (zh) 2017-03-16 2018-03-15 Mk2抑制剂及其合成和中间体

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US (2) US10894796B2 (https=)
EP (1) EP3596086A4 (https=)
JP (1) JP7282039B2 (https=)
CN (1) CN110678471B (https=)
AU (1) AU2018236290B2 (https=)
CA (1) CA3054826A1 (https=)
MX (1) MX387359B (https=)
WO (1) WO2018170203A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS62017B1 (sr) 2014-09-17 2021-07-30 Celgene Car Llc Mk2 inhibitori i njihova upotreba
US11098057B2 (en) * 2017-03-16 2021-08-24 Celgene Car Llc 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof
EP3596085A4 (en) 2017-03-16 2020-11-25 Celgene CAR LLC DEUTERATED ANALOGUES OF MK2 INHIBITORS AND THEIR USES
WO2018170200A1 (en) * 2017-03-16 2018-09-20 Celgene Car Llc Heteroaryl compounds useful as mk2 inhibitors
WO2018170203A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Mk2 inhibitors, synthesis thereof, and intermediates thereto
US10882867B2 (en) 2017-03-16 2021-01-05 Celgene Car Llc Forms and compositions of a MK2 inhibitor
WO2020236636A1 (en) * 2019-05-17 2020-11-26 Celgene Car Llc Methods of treating a mk2-mediated disorder
CN116670142A (zh) * 2021-02-01 2023-08-29 细胞基因公司 Mk2抑制剂、其合成和其中间体
WO2023025298A1 (zh) * 2021-08-27 2023-03-02 瑞石生物医药有限公司 喹啉并呋喃衍生物及其用途
EP4464694A4 (en) 2022-01-14 2026-04-01 Shanghai Hansoh Biomedical Co Ltd POLYCYCLIC DERIVATIVE CONTAINING PYRIDINE, ITS PREPARATION PROCESS AND ITS USE
CN116643046B (zh) * 2023-05-30 2025-09-12 南昌市高新区人民医院(南昌大学第一附属医院高新医院) Mk2在癌症恶病质肌肉萎缩中的应用

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CN103269704A (zh) * 2010-11-01 2013-08-28 西建阿维拉米斯研究公司 杂环化合物和其用途
CN103391718A (zh) * 2010-12-06 2013-11-13 汇合生命科学股份有限公司 取代的吡啶酮-吡啶基化合物
CN104177340A (zh) * 2013-05-22 2014-12-03 中国中化股份有限公司 一种新型的喹唑啉（硫）酮类化合物及其用途
WO2016025561A1 (en) * 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Forms and compositions of an erk inhibitor
WO2016044463A2 (en) * 2014-09-17 2016-03-24 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof

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MX2009014247A (es) 2007-07-16 2010-01-28 Novartis Ag Compuestos heterociclicos utiles como inhibidores de mk2.
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WO2011062765A2 (en) 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
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WO2014011902A1 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
CA2908098A1 (en) 2013-03-15 2014-09-25 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
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US10407422B2 (en) 2015-09-03 2019-09-10 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase
WO2018170203A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Mk2 inhibitors, synthesis thereof, and intermediates thereto
WO2018170200A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Heteroaryl compounds useful as mk2 inhibitors
US10882867B2 (en) 2017-03-16 2021-01-05 Celgene Car Llc Forms and compositions of a MK2 inhibitor
US11098057B2 (en) 2017-03-16 2021-08-24 Celgene Car Llc 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof
EP3596085A4 (en) 2017-03-16 2020-11-25 Celgene CAR LLC DEUTERATED ANALOGUES OF MK2 INHIBITORS AND THEIR USES
WO2020236636A1 (en) 2019-05-17 2020-11-26 Celgene Car Llc Methods of treating a mk2-mediated disorder
KR20230044446A (ko) 2020-07-24 2023-04-04 브리스톨-마이어스 스큅 컴퍼니 급성 호흡기 장애의 치료 방법
CN116670142A (zh) 2021-02-01 2023-08-29 细胞基因公司 Mk2抑制剂、其合成和其中间体

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CN103189377A (zh) * 2010-10-29 2013-07-03 辉瑞大药厂 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂
CN103269704A (zh) * 2010-11-01 2013-08-28 西建阿维拉米斯研究公司 杂环化合物和其用途
CN103391718A (zh) * 2010-12-06 2013-11-13 汇合生命科学股份有限公司 取代的吡啶酮-吡啶基化合物
CN104177340A (zh) * 2013-05-22 2014-12-03 中国中化股份有限公司 一种新型的喹唑啉（硫）酮类化合物及其用途
WO2016025561A1 (en) * 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Forms and compositions of an erk inhibitor
WO2016044463A2 (en) * 2014-09-17 2016-03-24 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
US11655257B2 (en) 2023-05-23
US20200102326A1 (en) 2020-04-02
WO2018170203A1 (en) 2018-09-20
MX387359B (es) 2025-03-18
EP3596086A1 (en) 2020-01-22
CN110678471A (zh) 2020-01-10
JP7282039B2 (ja) 2023-05-26
CA3054826A1 (en) 2018-09-20
US20210139501A1 (en) 2021-05-13
EP3596086A4 (en) 2020-12-16
AU2018236290B2 (en) 2022-06-02
JP2020510063A (ja) 2020-04-02
MX2019010642A (es) 2019-10-17
AU2018236290A1 (en) 2019-09-19
US10894796B2 (en) 2021-01-19

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Effective date of registration: 20230619

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Patentee before: CELGENE AVILOMICS RESEARCH, Inc.

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Granted publication date: 20220913