JP7282039B2 - Mk2阻害剤、その合成、およびそれに至るまでの中間体 - Google Patents

Mk2阻害剤、その合成、およびそれに至るまでの中間体 Download PDF

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JP7282039B2
JP7282039B2 JP2019550605A JP2019550605A JP7282039B2 JP 7282039 B2 JP7282039 B2 JP 7282039B2 JP 2019550605 A JP2019550605 A JP 2019550605A JP 2019550605 A JP2019550605 A JP 2019550605A JP 7282039 B2 JP7282039 B2 JP 7282039B2
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JP2020510063A (ja
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グレッグ・ブライアン・フェイゲルソン
マリル・イー・ジェハーティ
リチャード・マーティン・ハイド・ジュニア
モヒト・コータレ
ホン-ワー・マン
アレクサンダー・エル・ルチェルマン
ジョン・エフ・トラバース
ケルビン・ヒンヨン・ヨン
チェンミン・ジャン
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セルジーン シーエーアール エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2019550605A 2017-03-16 2018-03-15 Mk2阻害剤、その合成、およびそれに至るまでの中間体 Active JP7282039B2 (ja)

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Application Number Priority Date Filing Date Title
US201762472024P 2017-03-16 2017-03-16
US62/472,024 2017-03-16
PCT/US2018/022547 WO2018170203A1 (en) 2017-03-16 2018-03-15 Mk2 inhibitors, synthesis thereof, and intermediates thereto

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JP2020510063A JP2020510063A (ja) 2020-04-02
JP2020510063A5 JP2020510063A5 (https=) 2021-04-30
JP7282039B2 true JP7282039B2 (ja) 2023-05-26

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US (2) US10894796B2 (https=)
EP (1) EP3596086A4 (https=)
JP (1) JP7282039B2 (https=)
CN (1) CN110678471B (https=)
AU (1) AU2018236290B2 (https=)
CA (1) CA3054826A1 (https=)
MX (1) MX387359B (https=)
WO (1) WO2018170203A1 (https=)

Cited By (1)

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JP2023051962A (ja) * 2017-03-16 2023-04-11 セルジーン シーエーアール エルエルシー 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用

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RS62017B1 (sr) 2014-09-17 2021-07-30 Celgene Car Llc Mk2 inhibitori i njihova upotreba
EP3596085A4 (en) 2017-03-16 2020-11-25 Celgene CAR LLC DEUTERATED ANALOGUES OF MK2 INHIBITORS AND THEIR USES
WO2018170200A1 (en) * 2017-03-16 2018-09-20 Celgene Car Llc Heteroaryl compounds useful as mk2 inhibitors
WO2018170203A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Mk2 inhibitors, synthesis thereof, and intermediates thereto
US10882867B2 (en) 2017-03-16 2021-01-05 Celgene Car Llc Forms and compositions of a MK2 inhibitor
WO2020236636A1 (en) * 2019-05-17 2020-11-26 Celgene Car Llc Methods of treating a mk2-mediated disorder
CN116670142A (zh) * 2021-02-01 2023-08-29 细胞基因公司 Mk2抑制剂、其合成和其中间体
WO2023025298A1 (zh) * 2021-08-27 2023-03-02 瑞石生物医药有限公司 喹啉并呋喃衍生物及其用途
EP4464694A4 (en) 2022-01-14 2026-04-01 Shanghai Hansoh Biomedical Co Ltd POLYCYCLIC DERIVATIVE CONTAINING PYRIDINE, ITS PREPARATION PROCESS AND ITS USE
CN116643046B (zh) * 2023-05-30 2025-09-12 南昌市高新区人民医院(南昌大学第一附属医院高新医院) Mk2在癌症恶病质肌肉萎缩中的应用

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WO2016044463A2 (en) 2014-09-17 2016-03-24 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
JP2016518316A (ja) 2013-03-15 2016-06-23 セルジーン アビロミクス リサーチ, インコーポレイテッド Mk2阻害剤およびそれらの使用
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WO2020236636A1 (en) 2019-05-17 2020-11-26 Celgene Car Llc Methods of treating a mk2-mediated disorder
KR20230044446A (ko) 2020-07-24 2023-04-04 브리스톨-마이어스 스큅 컴퍼니 급성 호흡기 장애의 치료 방법
CN116670142A (zh) 2021-02-01 2023-08-29 细胞基因公司 Mk2抑制剂、其合成和其中间体

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JP2013533885A (ja) 2010-07-02 2013-08-29 ギリアード サイエンシーズ, インコーポレイテッド Hiv抗ウイルス化合物としての2−キノリニル−酢酸誘導体
JP2016518316A (ja) 2013-03-15 2016-06-23 セルジーン アビロミクス リサーチ, インコーポレイテッド Mk2阻害剤およびそれらの使用
WO2016044463A2 (en) 2014-09-17 2016-03-24 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
WO2017040449A1 (en) 2015-09-03 2017-03-09 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023051962A (ja) * 2017-03-16 2023-04-11 セルジーン シーエーアール エルエルシー 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用

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US11655257B2 (en) 2023-05-23
US20200102326A1 (en) 2020-04-02
WO2018170203A1 (en) 2018-09-20
MX387359B (es) 2025-03-18
EP3596086A1 (en) 2020-01-22
CN110678471A (zh) 2020-01-10
CA3054826A1 (en) 2018-09-20
US20210139501A1 (en) 2021-05-13
CN110678471B (zh) 2022-09-13
EP3596086A4 (en) 2020-12-16
AU2018236290B2 (en) 2022-06-02
JP2020510063A (ja) 2020-04-02
MX2019010642A (es) 2019-10-17
AU2018236290A1 (en) 2019-09-19
US10894796B2 (en) 2021-01-19

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