JP2020510063A5 - - Google Patents
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- JP2020510063A5 JP2020510063A5 JP2019550605A JP2019550605A JP2020510063A5 JP 2020510063 A5 JP2020510063 A5 JP 2020510063A5 JP 2019550605 A JP2019550605 A JP 2019550605A JP 2019550605 A JP2019550605 A JP 2019550605A JP 2020510063 A5 JP2020510063 A5 JP 2020510063A5
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- 0 CC(C1)C*2C1CC=CC2 Chemical compound CC(C1)C*2C1CC=CC2 0.000 description 4
- JVJPAINKNFQARD-UHFFFAOYSA-N CC(C)(C)OC(NCCNc(c1c2cc3)c(C(OC)=O)[s]c1ccc2nc3OCc1ccccc1)=O Chemical compound CC(C)(C)OC(NCCNc(c1c2cc3)c(C(OC)=O)[s]c1ccc2nc3OCc1ccccc1)=O JVJPAINKNFQARD-UHFFFAOYSA-N 0.000 description 1
- PYOQIOLRFIRRSO-LLVKDONJSA-N CCOCc(c(Oc(cc1)nc(cc2)c1c1c2[s]c2c1NC[C@@H](C)NC2=O)n1)cnc1Cl Chemical compound CCOCc(c(Oc(cc1)nc(cc2)c1c1c2[s]c2c1NC[C@@H](C)NC2=O)n1)cnc1Cl PYOQIOLRFIRRSO-LLVKDONJSA-N 0.000 description 1
- ICWMRCDLQYPYEV-QMMMGPOBSA-N C[C@@H](CNc(c1c2cc3)c(C(OC)=O)[s]c1ccc2nc3O)N Chemical compound C[C@@H](CNc(c1c2cc3)c(C(OC)=O)[s]c1ccc2nc3O)N ICWMRCDLQYPYEV-QMMMGPOBSA-N 0.000 description 1
- ICWMRCDLQYPYEV-MRVPVSSYSA-N C[C@H](CNc(c1c2cc3)c(C(OC)=O)[s]c1ccc2nc3O)N Chemical compound C[C@H](CNc(c1c2cc3)c(C(OC)=O)[s]c1ccc2nc3O)N ICWMRCDLQYPYEV-MRVPVSSYSA-N 0.000 description 1
- MUHAUXCKZWLACN-SSDOTTSWSA-N C[C@H](CNc1c2[s]c(cc3)c1c(cc1)c3nc1O)NC2=O Chemical compound C[C@H](CNc1c2[s]c(cc3)c1c(cc1)c3nc1O)NC2=O MUHAUXCKZWLACN-SSDOTTSWSA-N 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N OS(c1ccccc1)(=O)=O Chemical compound OS(c1ccccc1)(=O)=O SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762472024P | 2017-03-16 | 2017-03-16 | |
| US62/472,024 | 2017-03-16 | ||
| PCT/US2018/022547 WO2018170203A1 (en) | 2017-03-16 | 2018-03-15 | Mk2 inhibitors, synthesis thereof, and intermediates thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510063A JP2020510063A (ja) | 2020-04-02 |
| JP2020510063A5 true JP2020510063A5 (https=) | 2021-04-30 |
| JP7282039B2 JP7282039B2 (ja) | 2023-05-26 |
Family
ID=63523971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550605A Active JP7282039B2 (ja) | 2017-03-16 | 2018-03-15 | Ｍｋ２阻害剤、その合成、およびそれに至るまでの中間体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10894796B2 (https=) |
| EP (1) | EP3596086A4 (https=) |
| JP (1) | JP7282039B2 (https=) |
| CN (1) | CN110678471B (https=) |
| AU (1) | AU2018236290B2 (https=) |
| CA (1) | CA3054826A1 (https=) |
| MX (1) | MX387359B (https=) |
| WO (1) | WO2018170203A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62017B1 (sr) | 2014-09-17 | 2021-07-30 | Celgene Car Llc | Mk2 inhibitori i njihova upotreba |
| US11098057B2 (en) * | 2017-03-16 | 2021-08-24 | Celgene Car Llc | 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof |
| EP3596085A4 (en) | 2017-03-16 | 2020-11-25 | Celgene CAR LLC | DEUTERATED ANALOGUES OF MK2 INHIBITORS AND THEIR USES |
| WO2018170200A1 (en) * | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Heteroaryl compounds useful as mk2 inhibitors |
| WO2018170203A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Mk2 inhibitors, synthesis thereof, and intermediates thereto |
| US10882867B2 (en) | 2017-03-16 | 2021-01-05 | Celgene Car Llc | Forms and compositions of a MK2 inhibitor |
| WO2020236636A1 (en) * | 2019-05-17 | 2020-11-26 | Celgene Car Llc | Methods of treating a mk2-mediated disorder |
| CN116670142A (zh) * | 2021-02-01 | 2023-08-29 | 细胞基因公司 | Mk2抑制剂、其合成和其中间体 |
| WO2023025298A1 (zh) * | 2021-08-27 | 2023-03-02 | 瑞石生物医药有限公司 | 喹啉并呋喃衍生物及其用途 |
| EP4464694A4 (en) | 2022-01-14 | 2026-04-01 | Shanghai Hansoh Biomedical Co Ltd | POLYCYCLIC DERIVATIVE CONTAINING PYRIDINE, ITS PREPARATION PROCESS AND ITS USE |
| CN116643046B (zh) * | 2023-05-30 | 2025-09-12 | 南昌市高新区人民医院(南昌大学第一附属医院高新医院) | Mk2在癌症恶病质肌肉萎缩中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200504898B (en) | 2002-12-20 | 2006-11-29 | Pharmacia Corp | Acyclic pyrazole compounds |
| US20060106020A1 (en) | 2004-04-28 | 2006-05-18 | Rodgers James D | Tetracyclic inhibitors of Janus kinases |
| EP2223925A1 (en) | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| MX2009014247A (es) | 2007-07-16 | 2010-01-28 | Novartis Ag | Compuestos heterociclicos utiles como inhibidores de mk2. |
| KR101598397B1 (ko) | 2008-04-22 | 2016-02-29 | 얀센 파마슈티카 엔.브이. | 퀴놀린 또는 이소퀴놀린 치환된 피2엑스7 안타고니스트 |
| WO2011062765A2 (en) | 2009-11-17 | 2011-05-26 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| EP2588455B1 (en) | 2010-07-02 | 2018-04-04 | Gilead Sciences, Inc. | 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds |
| ES2546465T3 (es) | 2010-10-29 | 2015-09-23 | Pfizer Inc | Inhibidores de N1/N2-lactama acetil-CoA carboxilasa |
| EP2635284B1 (en) * | 2010-11-01 | 2019-12-18 | Celgene CAR LLC | Heterocyclic compounds and uses thereof |
| SI2648516T1 (sl) * | 2010-12-06 | 2019-01-31 | Aclaris Therapeutics, Inc. | Substituirane spojine piridinon-piridinila |
| JP6189434B2 (ja) | 2012-07-10 | 2017-08-30 | アレス トレーディング ソシエテ アノニム | ピリミジンピラゾリル誘導体 |
| WO2014011902A1 (en) | 2012-07-11 | 2014-01-16 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CA2908098A1 (en) | 2013-03-15 | 2014-09-25 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| CN104177340A (zh) * | 2013-05-22 | 2014-12-03 | 中国中化股份有限公司 | 一种新型的喹唑啉（硫）酮类化合物及其用途 |
| WO2015128884A1 (en) | 2014-02-27 | 2015-09-03 | Council Of Scientific & Industrial Research | Poly-benzimidazole with pyrene and anthracene flourophore |
| EP3179858B1 (en) * | 2014-08-13 | 2019-05-15 | Celgene Car Llc | Forms and compositions of an erk inhibitor |
| RS62017B1 (sr) | 2014-09-17 | 2021-07-30 | Celgene Car Llc | Mk2 inhibitori i njihova upotreba |
| US10407422B2 (en) | 2015-09-03 | 2019-09-10 | Bristol-Myers Squibb Company | Triazolopyridine inhibitors of myeloperoxidase |
| WO2018170203A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Mk2 inhibitors, synthesis thereof, and intermediates thereto |
| WO2018170200A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Heteroaryl compounds useful as mk2 inhibitors |
| US10882867B2 (en) | 2017-03-16 | 2021-01-05 | Celgene Car Llc | Forms and compositions of a MK2 inhibitor |
| US11098057B2 (en) | 2017-03-16 | 2021-08-24 | Celgene Car Llc | 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof |
| EP3596085A4 (en) | 2017-03-16 | 2020-11-25 | Celgene CAR LLC | DEUTERATED ANALOGUES OF MK2 INHIBITORS AND THEIR USES |
| WO2020236636A1 (en) | 2019-05-17 | 2020-11-26 | Celgene Car Llc | Methods of treating a mk2-mediated disorder |
| KR20230044446A (ko) | 2020-07-24 | 2023-04-04 | 브리스톨-마이어스 스큅 컴퍼니 | 급성 호흡기 장애의 치료 방법 |
| CN116670142A (zh) | 2021-02-01 | 2023-08-29 | 细胞基因公司 | Mk2抑制剂、其合成和其中间体 |
-
2018
- 2018-03-15 WO PCT/US2018/022547 patent/WO2018170203A1/en not_active Ceased
- 2018-03-15 EP EP18768733.0A patent/EP3596086A4/en not_active Withdrawn
- 2018-03-15 CA CA3054826A patent/CA3054826A1/en active Pending
- 2018-03-15 AU AU2018236290A patent/AU2018236290B2/en not_active Ceased
- 2018-03-15 MX MX2019010642A patent/MX387359B/es unknown
- 2018-03-15 CN CN201880032092.8A patent/CN110678471B/zh not_active Expired - Fee Related
- 2018-03-15 JP JP2019550605A patent/JP7282039B2/ja active Active
- 2018-03-15 US US16/494,701 patent/US10894796B2/en active Active
-
2021
- 2021-01-14 US US17/148,903 patent/US11655257B2/en active Active
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