MX387359B - Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos. - Google Patents

Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos.

Info

Publication number
MX387359B
MX387359B MX2019010642A MX2019010642A MX387359B MX 387359 B MX387359 B MX 387359B MX 2019010642 A MX2019010642 A MX 2019010642A MX 2019010642 A MX2019010642 A MX 2019010642A MX 387359 B MX387359 B MX 387359B
Authority
MX
Mexico
Prior art keywords
intermediaries
mitogen
inhibitors
synthesis
activated kinase
Prior art date
Application number
MX2019010642A
Other languages
English (en)
Other versions
MX2019010642A (es
Inventor
Alexander L Ruchelman
Chengmin Zhang
Gregg Brian Feigelson
Hon- Wah Man
John F Traverse
Kelvin Hin- Yeong Yong
Maryll E Geherty
Mohit Kothare
Jr Richard Martin Heid
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2019010642A publication Critical patent/MX2019010642A/es
Publication of MX387359B publication Critical patent/MX387359B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a métodos para preparar un inhibidor de MK2, e intermediarios relacionados a los mismos.
MX2019010642A 2017-03-16 2018-03-15 Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos. MX387359B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762472024P 2017-03-16 2017-03-16
PCT/US2018/022547 WO2018170203A1 (en) 2017-03-16 2018-03-15 Mk2 inhibitors, synthesis thereof, and intermediates thereto

Publications (2)

Publication Number Publication Date
MX2019010642A MX2019010642A (es) 2019-10-17
MX387359B true MX387359B (es) 2025-03-18

Family

ID=63523971

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019010642A MX387359B (es) 2017-03-16 2018-03-15 Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos.

Country Status (8)

Country Link
US (2) US10894796B2 (es)
EP (1) EP3596086A4 (es)
JP (1) JP7282039B2 (es)
CN (1) CN110678471B (es)
AU (1) AU2018236290B2 (es)
CA (1) CA3054826A1 (es)
MX (1) MX387359B (es)
WO (1) WO2018170203A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037299B1 (ru) 2014-09-17 2021-03-05 Селджен Кар Ллс Ингибиторы mk2 и их применения
WO2018170201A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Deuterated analogs of mk2 inhibitors and uses thereof
US11098057B2 (en) 2017-03-16 2021-08-24 Celgene Car Llc 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof
MX387359B (es) 2017-03-16 2025-03-18 Bristol Myers Squibb Co Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos.
CN110678178B (zh) 2017-03-16 2023-10-03 百时美施贵宝公司 Mk2抑制剂的形式和组合物
US11124525B2 (en) 2017-03-16 2021-09-21 Celgene Car Llc Heteroaryl compounds useful as MK2 inhibitors
KR20220041042A (ko) * 2019-05-17 2022-03-31 셀젠 카르 엘엘씨 Mk2-매개 장애를 치료하는 방법
AR124726A1 (es) * 2021-02-01 2023-04-26 Celgene Corp Inhibidores de nk2, su síntesis y sus intermedios
TW202328141A (zh) * 2021-08-27 2023-07-16 大陸商瑞石生物醫藥有限公司 喹啉并呋喃衍生物及其用途
KR20240134978A (ko) 2022-01-14 2024-09-10 상하이 한서 바이오메디컬 컴퍼니 리미티드 피리딘 함유 폴리시클릭 유도체, 이의 제조 방법 및 용도
CN116643046B (zh) * 2023-05-30 2025-09-12 南昌市高新区人民医院(南昌大学第一附属医院高新医院) Mk2在癌症恶病质肌肉萎缩中的应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058176A2 (en) 2002-12-20 2004-07-15 Pharmacia Corporation Acyclic pyrazole compounds
WO2005105814A1 (en) 2004-04-28 2005-11-10 Incyte Corporation Tetracyclic inhibitors of janus kinases
EP2223925A1 (en) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2178874A1 (en) 2007-07-16 2010-04-28 Novartis Ag Heterocyclic compounds useful as mk2 inhibitors
CA2722035C (en) 2008-04-22 2016-10-11 Janssen Pharmaceutica Nv Quinoline or isoquinoline substituted p2x7 antagonists
CN102753179A (zh) 2009-11-17 2012-10-24 密执安大学评议会 具有治疗性能的1,4-苯并二氮杂*-2,5-二酮和相关化合物
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
SG186821A1 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds
PT2632925E (pt) 2010-10-29 2015-09-01 Pfizer Inibidores de n1/n2-lactama da acetil-coa carboxilase
NZ710636A (en) * 2010-11-01 2017-02-24 Celgene Avilomics Res Inc Heterocyclic compounds and uses thereof
WO2012078684A1 (en) * 2010-12-06 2012-06-14 Confluence Life Sciences, Inc. Substituted pyridinone-pyridinyl compounds
CN104662014B (zh) 2012-07-10 2017-02-22 阿雷斯贸易股份有限公司 嘧啶吡唑基衍生物
EP2872144A4 (en) * 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
CA2908098A1 (en) 2013-03-15 2014-09-25 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
CN104177340A (zh) * 2013-05-22 2014-12-03 中国中化股份有限公司 一种新型的喹唑啉（硫）酮类化合物及其用途
WO2015128884A1 (en) 2014-02-27 2015-09-03 Council Of Scientific & Industrial Research Poly-benzimidazole with pyrene and anthracene flourophore
US10005760B2 (en) * 2014-08-13 2018-06-26 Celgene Car Llc Forms and compositions of an ERK inhibitor
EA037299B1 (ru) 2014-09-17 2021-03-05 Селджен Кар Ллс Ингибиторы mk2 и их применения
WO2017040449A1 (en) 2015-09-03 2017-03-09 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase
MX387359B (es) 2017-03-16 2025-03-18 Bristol Myers Squibb Co Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos.
CN110678178B (zh) 2017-03-16 2023-10-03 百时美施贵宝公司 Mk2抑制剂的形式和组合物
WO2018170201A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Deuterated analogs of mk2 inhibitors and uses thereof
US11098057B2 (en) 2017-03-16 2021-08-24 Celgene Car Llc 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof
US11124525B2 (en) 2017-03-16 2021-09-21 Celgene Car Llc Heteroaryl compounds useful as MK2 inhibitors
KR20220041042A (ko) 2019-05-17 2022-03-31 셀젠 카르 엘엘씨 Mk2-매개 장애를 치료하는 방법
JP2023536427A (ja) 2020-07-24 2023-08-25 ブリストル－マイヤーズ スクイブ カンパニー 急性呼吸器障害の治療方法
AR124726A1 (es) 2021-02-01 2023-04-26 Celgene Corp Inhibidores de nk2, su síntesis y sus intermedios

Also Published As

Publication number Publication date
CA3054826A1 (en) 2018-09-20
US20210139501A1 (en) 2021-05-13
EP3596086A4 (en) 2020-12-16
WO2018170203A1 (en) 2018-09-20
MX2019010642A (es) 2019-10-17
CN110678471A (zh) 2020-01-10
US11655257B2 (en) 2023-05-23
AU2018236290B2 (en) 2022-06-02
US20200102326A1 (en) 2020-04-02
JP2020510063A (ja) 2020-04-02
CN110678471B (zh) 2022-09-13
JP7282039B2 (ja) 2023-05-26
AU2018236290A1 (en) 2019-09-19
US10894796B2 (en) 2021-01-19
EP3596086A1 (en) 2020-01-22

Similar Documents

Publication Publication Date Title
MX387359B (es) Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos.
CY1120988T1 (el) Παρεμποδιστες διαρυλ κινασης
CL2022000448A1 (es) Autoinyector (divisional solicitud no. 201903061)
IL282468A (en) 2- amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors
PH12018501151A1 (en) Tank-binding kinase inhibitor compounds
CY1124097T1 (el) Κρυσταλλικο πολυμορφο της ελευθερης βασης της 2-υδροξυ-6-((2-(1-ισοπροπυλο-1η-πυραζολ-5-υλο)πυριδιν-3-υλο)μεθοξυ)βενζαλδεϋδης
MX373341B (es) INHIBIDORES DE PROTEíNA CINASA 2 ACTIVADA POR PROTEíNA CINASA ACTIVADA POR MITóGENO (MK2) Y SUS USOS.
MA51616A (fr) Inhibiteurs d'adn-pk
MX2016015862A (es) Compuestos inhibidores de la cinasa de union a tank.
GEP20217234B (en) Pyridopyrimdinone cdk2/4/6 inhibitors
EA201891626A1 (ru) Ингибиторы тирозинкиназы брутона
AR111304A1 (es) Métodos para sintetizar un inhibidor de mcl-1
ECSP16067303A (es) Heteroarilos y usos de estos
AR095039A1 (es) Inhibidores quinazolínicos de formas mutadas activantes del receptor del factor de crecimiento epidérmico
MX2017003930A (es) Derivados de aminotriazina utiles como compuestos inhibidores de la cinasa de union a tank.
EP3613737A4 (en) NEW CYCLINE-DEPENDENT KINASE CDK9 INHIBITOR
MX2022006768A (es) Formulaciones/composiciones que comprenden un inhibidor de btk.
MX393600B (es) Formas y composiciones de un inhibidor de proteina cinasa 2 activada por la proteina cinasa activada por mitogeno (mk2).
EA201992147A1 (ru) Ингибиторы тирозинкиназы брутона
MX2020013630A (es) Analogos de rapamicina y usos de los mismos.
ZA202002951B (en) Albumin-binding prodrugs of auristatin e derivatives
MY188420A (en) Crystalline forms of (s)-afoxolaner
CY1123406T1 (el) Παραγωγο τριαζολοπυραζινονης χρησιμο ως ενας ανθρωπινος pde1 αναστολεας
JOP20210036A1 (ar) مثبطات او- جليكوبروتين-2-أسيتاميدو-2-ديوكسي-3-دي-جلوكوبيرانوسيداز
HUE062726T2 (hu) 1-(1,2-dimetilpropil)-N-etil-5-metil-N-piridazin-4-il-pirazol-4-karboxamid kristályos formái