CN110546160A - 靶向嵌合蛋白及其用途 - Google Patents

靶向嵌合蛋白及其用途 Download PDF

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Publication number
CN110546160A
CN110546160A CN201880023712.1A CN201880023712A CN110546160A CN 110546160 A CN110546160 A CN 110546160A CN 201880023712 A CN201880023712 A CN 201880023712A CN 110546160 A CN110546160 A CN 110546160A
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seq
cancer
activity
modified
receptor
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Chinese (zh)
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N·克雷
J·塔威尼尔
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Universiteit Gent
Vlaams Instituut voor Biotechnologie VIB
Orionis Biosciences NV
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Universiteit Gent
Vlaams Instituut voor Biotechnologie VIB
Orionis Biosciences NV
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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CN201880023712.1A 2017-02-06 2018-02-05 靶向嵌合蛋白及其用途 Pending CN110546160A (zh)

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US201762454993P 2017-02-06 2017-02-06
US62/454,993 2017-02-06
PCT/EP2018/052814 WO2018141964A1 (en) 2017-02-06 2018-02-05 Targeted chimeric proteins and uses thereof

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US (2) US11384154B2 (enExample)
EP (1) EP3577133A1 (enExample)
JP (2) JP7476467B2 (enExample)
KR (1) KR102642385B1 (enExample)
CN (1) CN110546160A (enExample)
AU (1) AU2018216032B2 (enExample)
CA (1) CA3052523A1 (enExample)
IL (1) IL268346B2 (enExample)
MX (1) MX2019009255A (enExample)
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CN113354738A (zh) * 2020-03-05 2021-09-07 宁波德方华生物技术有限公司 融合毒素VEGF165b/mGEL及其编码基因与应用
WO2022002153A1 (zh) * 2020-06-30 2022-01-06 正大天晴药业集团股份有限公司 用于治疗肿瘤的药物
CN117430716A (zh) * 2023-10-16 2024-01-23 珠海臻谱基因科技有限公司 靶向保守的HIV gp41亚基近膜端外区的重组干扰素药物及其应用
WO2025026282A1 (en) * 2023-07-29 2025-02-06 Shanghai Kaijin Biotechnology, Ltd Modified type e multi-specific antibodies

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EP3577133A1 (en) * 2017-02-06 2019-12-11 Orionis Biosciences NV Targeted chimeric proteins and uses thereof
CN117924493A (zh) 2017-08-09 2024-04-26 奥里尼斯生物科学有限公司 Clec9a结合剂及其用途
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CN119285770A (zh) 2017-08-09 2025-01-10 奥里尼斯生物科学有限公司 Pd-1和pd-l1结合剂
MX2020008208A (es) 2018-02-05 2020-11-09 Orionis Biosciences Inc Agentes de unión a fibroblastos y uso de estos.
US12084497B2 (en) 2018-08-08 2024-09-10 Orionis Biosciences, Inc. SIRP1α targeted chimeric proteins and uses thereof
BR112021005465A2 (pt) * 2018-10-02 2021-06-15 Mitsubishi Tanabe Pharma Corporation agentes de ligação biespecíficos direcionados ao sindecano-1 e receptor do fator de crescimento de fibroblasto
AU2019370031A1 (en) * 2018-10-29 2021-05-27 Umc Utrecht Holding B.V. IgA mediated killing of aberrant cells by CD47- SIRPα checkpoint inhibition of neutrophils
US12410225B2 (en) 2018-11-08 2025-09-09 Orionis Biosciences, Inc Modulation of dendritic cell lineages
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JP7689079B2 (ja) 2019-03-28 2025-06-05 オリオニス バイオサイエンシズ，インコーポレイテッド 治療用インターフェロンアルファ１タンパク質
US12351614B2 (en) 2019-03-28 2025-07-08 Orionis Biosciences, Inc. CLEC9A-based chimeric protein complexes
EP4023679A4 (en) * 2019-08-30 2023-10-04 Nanjing Shunxin Pharmaceuticals Co., Ltd. of Chiatai Tianqing Pharmaceutical Group FUSION PROTEIN TARGETING PD-L1 AND TGF-BETA AND USE THEREOF
EP4034146A4 (en) * 2019-09-26 2024-03-06 Orionis Biosciences, Inc. CONJUGATED CHIMERIC PROTEINS
EP4061951A4 (en) * 2019-11-18 2024-03-13 The Brigham & Women's Hospital, Inc. NEXT GENERATION CODON-OPTIMIZED ONCOLYTIC ONCOLYTIC HERPES SIMPLEX VIRUS TYPE 1 AND METHODS OF USE
AU2020398327A1 (en) 2019-12-03 2022-07-14 Evotec International Gmbh Interferon-associated antigen binding proteins and uses thereof
US20230279108A1 (en) * 2020-04-30 2023-09-07 Arch Oncology, Inc. Therapeutic sirp-alpha antibodies
AU2021331474A1 (en) * 2020-08-27 2023-03-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Oncolytic viruses encoding recombinant transforming growth factor (tgf)-beta monomers and uses thereof
WO2022053651A2 (en) 2020-09-10 2022-03-17 Precirix N.V. Antibody fragment against fap
US20220196651A1 (en) * 2020-12-06 2022-06-23 ALX Oncology Inc. Multimers for reducing the interference of drugs that bind cd47 in serological assays
CN114349850A (zh) * 2020-12-18 2022-04-15 蒋庆华 抗体及其制备方法和编码核酸以及工程细胞
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
IL318992A (en) 2022-05-02 2025-04-01 Precirix N V Cancer treatment through advance directives
JP2025537826A (ja) 2022-11-16 2025-11-20 ベーリンガー・インゲルハイム・インターナショナル・ゲーエムベーハー 抗ｓｉｒｐａ抗体についての効力予測バイオマーカー
EP4480501A1 (en) * 2023-06-21 2024-12-25 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen Sirp nanobodies

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WO2015138600A2 (en) * 2014-03-11 2015-09-17 The Board Of Trustees Of The Leland Stanford Junior University Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies
CN106574272A (zh) * 2014-08-29 2017-04-19 哥莫阿波单克隆有限责任公司 靶向多样的多种抗原的通用嵌合抗原受体表达性免疫细胞及其制造方法及其在癌症、感染和自身免疫病的治疗中的应用

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