ATE554186T1 - Eph-b4 spezifische sirna zur reduktion von epo- induziertem tumorzellwachstum während anämiebehandlung in krebspatienten, gewebeschutz- erythropoietin-rezeptor (nepor) und verfahren zu seiner verwendung - Google Patents
Eph-b4 spezifische sirna zur reduktion von epo- induziertem tumorzellwachstum während anämiebehandlung in krebspatienten, gewebeschutz- erythropoietin-rezeptor (nepor) und verfahren zu seiner verwendungInfo
- Publication number
- ATE554186T1 ATE554186T1 AT08854346T AT08854346T ATE554186T1 AT E554186 T1 ATE554186 T1 AT E554186T1 AT 08854346 T AT08854346 T AT 08854346T AT 08854346 T AT08854346 T AT 08854346T AT E554186 T1 ATE554186 T1 AT E554186T1
- Authority
- AT
- Austria
- Prior art keywords
- nepor
- epo
- erythropoietin
- disclosed
- eph
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 2
- 108010075944 Erythropoietin Receptors Proteins 0.000 title 1
- 102100036509 Erythropoietin receptor Human genes 0.000 title 1
- 208000007502 anemia Diseases 0.000 title 1
- 230000004565 tumor cell growth Effects 0.000 title 1
- 102000003951 Erythropoietin Human genes 0.000 abstract 6
- 108090000394 Erythropoietin Proteins 0.000 abstract 6
- 229940105423 erythropoietin Drugs 0.000 abstract 6
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 230000014509 gene expression Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 230000004083 survival effect Effects 0.000 abstract 2
- 206010061309 Neoplasm progression Diseases 0.000 abstract 1
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- 230000003828 downregulation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 230000002669 organ and tissue protective effect Effects 0.000 abstract 1
- 230000006461 physiological response Effects 0.000 abstract 1
- 239000000092 prognostic biomarker Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/746—Erythropoetin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99104207P | 2007-11-29 | 2007-11-29 | |
| PCT/EP2008/066480 WO2009068677A1 (en) | 2007-11-29 | 2008-11-28 | Novel tissue protective erythropoietin receptor (nepor) and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE554186T1 true ATE554186T1 (de) | 2012-05-15 |
Family
ID=40370571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08854346T ATE554186T1 (de) | 2007-11-29 | 2008-11-28 | Eph-b4 spezifische sirna zur reduktion von epo- induziertem tumorzellwachstum während anämiebehandlung in krebspatienten, gewebeschutz- erythropoietin-rezeptor (nepor) und verfahren zu seiner verwendung |
Country Status (12)
| Country | Link |
|---|---|
| EP (3) | EP2109690B9 (de) |
| AT (1) | ATE554186T1 (de) |
| AU (1) | AU2008328754B2 (de) |
| CA (2) | CA2802984C (de) |
| DK (1) | DK2492355T3 (de) |
| ES (2) | ES2386495T3 (de) |
| HR (1) | HRP20150733T1 (de) |
| HU (1) | HUE026591T2 (de) |
| PL (1) | PL2492355T3 (de) |
| PT (1) | PT2492355E (de) |
| SI (1) | SI2492355T1 (de) |
| WO (1) | WO2009068677A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2371855T1 (sl) | 2005-08-05 | 2015-11-30 | Araim Pharmaceuticals, Inc. | Peptidi, ki ščitijo tkiva, in načini njihove uporabe |
| WO2008017473A2 (en) | 2006-08-08 | 2008-02-14 | Gunther Hartmann | Structure and use of 5' phosphate oligonucleotides |
| US8357501B2 (en) * | 2007-11-29 | 2013-01-22 | Molecular Health Gmbh | Tissue protective erythropoietin receptor (NEPOR) and methods of use |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| EP2596125A1 (de) * | 2010-07-19 | 2013-05-29 | Cellzome Ag | In-vivo-verfahren zur beurteilung einer verbindung-target-interaktion |
| EP2508530A1 (de) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags |
| RU2013158627A (ru) * | 2011-06-15 | 2015-07-20 | Ф. Хоффманн-Ля Рош Аг | Антитела к рецептору человеческого эритропоэтина и способы их применения |
| EP2712870A1 (de) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Neuartige RIG-I-Liganden und Herstellungsverfahren dafür |
| KR20160052537A (ko) * | 2013-07-17 | 2016-05-12 | 아라임 파마슈티칼즈, 인크. | 조직 손상과 연관된 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 |
| WO2017077382A1 (en) | 2015-11-06 | 2017-05-11 | Orionis Biosciences Nv | Bi-functional chimeric proteins and uses thereof |
| EP3998281A1 (de) | 2016-02-05 | 2022-05-18 | Orionis Biosciences BV | Cd8-bindemittel |
| JP7105200B2 (ja) | 2016-05-13 | 2022-07-22 | オリオニス バイオサイエンシズ ビーブイ | 標的突然変異体インターフェロン－ベータおよびその使用 |
| CA3023881A1 (en) | 2016-05-13 | 2017-11-16 | Orionis Biosciences Nv | Therapeutic targeting of non-cellular structures |
| US11084859B2 (en) | 2016-10-24 | 2021-08-10 | Orionis Biosciences BV | Targeted mutant interferon-gamma and uses thereof |
| EP3576765B1 (de) | 2017-02-06 | 2025-07-16 | Orionis Biosciences, Inc. | Zielgerichtetes manipuliertes interferon und verwendungen davon |
| IL268346B2 (en) | 2017-02-06 | 2024-08-01 | Orionis Biosciences BV | Targeted chimeric proteins and uses thereof |
| CN112074267B (zh) | 2018-02-05 | 2024-06-28 | 奥里尼斯生物科学公司股份有限公司 | 成纤维细胞结合剂及其用途 |
| CN111175519B (zh) * | 2020-01-09 | 2020-11-27 | 浙江大学 | Epo在制备肝细胞癌tace疗效评估试剂中的应用 |
| WO2022054748A1 (ja) * | 2020-09-10 | 2022-03-17 | 扶桑薬品工業株式会社 | エリスロポエチンシグナル伝達阻害タンパク質 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002951409A0 (en) * | 2002-09-16 | 2002-09-26 | North Western Adelaide Health Services | Methods for regulating cancer |
| JP4762889B2 (ja) * | 2003-03-12 | 2011-08-31 | バスジーン セラピューティクス，インコーポレイテッド | 血管形成及び腫瘍成長を阻止するための核酸化合物 |
| US7381410B2 (en) * | 2003-03-12 | 2008-06-03 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| US7718363B2 (en) * | 2003-04-25 | 2010-05-18 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
| EP1799867A2 (de) * | 2004-09-23 | 2007-06-27 | Vasgene Therapeutics, Inc. | Zusammensetzungen und verfahren zur erkennung und behandlung von tumoren |
-
2008
- 2008-11-28 EP EP08854346A patent/EP2109690B9/de not_active Not-in-force
- 2008-11-28 AU AU2008328754A patent/AU2008328754B2/en not_active Ceased
- 2008-11-28 PT PT110046893T patent/PT2492355E/pt unknown
- 2008-11-28 CA CA2802984A patent/CA2802984C/en not_active Expired - Fee Related
- 2008-11-28 AT AT08854346T patent/ATE554186T1/de active
- 2008-11-28 PL PL11004689T patent/PL2492355T3/pl unknown
- 2008-11-28 ES ES08854346T patent/ES2386495T3/es active Active
- 2008-11-28 WO PCT/EP2008/066480 patent/WO2009068677A1/en not_active Ceased
- 2008-11-28 CA CA2706994A patent/CA2706994C/en not_active Expired - Fee Related
- 2008-11-28 ES ES11004689.3T patent/ES2542033T3/es active Active
- 2008-11-28 HU HUE11004689A patent/HUE026591T2/hu unknown
- 2008-11-28 DK DK11004689.3T patent/DK2492355T3/da active
- 2008-11-28 SI SI200831453T patent/SI2492355T1/sl unknown
- 2008-11-28 EP EP15000987.6A patent/EP2960341B1/de not_active Not-in-force
- 2008-11-28 EP EP11004689.3A patent/EP2492355B1/de not_active Not-in-force
-
2015
- 2015-07-06 HR HRP20150733TT patent/HRP20150733T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE026591T2 (hu) | 2016-06-28 |
| EP2109690A1 (de) | 2009-10-21 |
| SI2492355T1 (sl) | 2015-08-31 |
| WO2009068677A1 (en) | 2009-06-04 |
| CA2706994C (en) | 2013-03-12 |
| CA2706994A1 (en) | 2009-06-04 |
| EP2109690B9 (de) | 2012-10-24 |
| ES2386495T3 (es) | 2012-08-21 |
| CA2802984A1 (en) | 2009-06-04 |
| EP2109690B1 (de) | 2012-04-18 |
| EP2960341A1 (de) | 2015-12-30 |
| PT2492355E (pt) | 2015-09-10 |
| ES2542033T3 (es) | 2015-07-29 |
| EP2492355A1 (de) | 2012-08-29 |
| AU2008328754B2 (en) | 2015-04-16 |
| DK2492355T3 (da) | 2015-07-13 |
| AU2008328754A1 (en) | 2009-06-04 |
| EP2960341B1 (de) | 2018-06-27 |
| HRP20150733T1 (hr) | 2015-08-14 |
| EP2492355B1 (de) | 2015-04-08 |
| PL2492355T3 (pl) | 2015-09-30 |
| CA2802984C (en) | 2016-04-12 |
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