ATE554186T1 - Eph-b4 spezifische sirna zur reduktion von epo- induziertem tumorzellwachstum während anämiebehandlung in krebspatienten, gewebeschutz- erythropoietin-rezeptor (nepor) und verfahren zu seiner verwendung - Google Patents
Eph-b4 spezifische sirna zur reduktion von epo- induziertem tumorzellwachstum während anämiebehandlung in krebspatienten, gewebeschutz- erythropoietin-rezeptor (nepor) und verfahren zu seiner verwendungInfo
- Publication number
- ATE554186T1 ATE554186T1 AT08854346T AT08854346T ATE554186T1 AT E554186 T1 ATE554186 T1 AT E554186T1 AT 08854346 T AT08854346 T AT 08854346T AT 08854346 T AT08854346 T AT 08854346T AT E554186 T1 ATE554186 T1 AT E554186T1
- Authority
- AT
- Austria
- Prior art keywords
- nepor
- epo
- erythropoietin
- disclosed
- eph
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G01N33/5758—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/746—Erythropoetin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99104207P | 2007-11-29 | 2007-11-29 | |
| PCT/EP2008/066480 WO2009068677A1 (en) | 2007-11-29 | 2008-11-28 | Novel tissue protective erythropoietin receptor (nepor) and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE554186T1 true ATE554186T1 (de) | 2012-05-15 |
Family
ID=40370571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08854346T ATE554186T1 (de) | 2007-11-29 | 2008-11-28 | Eph-b4 spezifische sirna zur reduktion von epo- induziertem tumorzellwachstum während anämiebehandlung in krebspatienten, gewebeschutz- erythropoietin-rezeptor (nepor) und verfahren zu seiner verwendung |
Country Status (12)
| Country | Link |
|---|---|
| EP (3) | EP2960341B1 (de) |
| AT (1) | ATE554186T1 (de) |
| AU (1) | AU2008328754B2 (de) |
| CA (2) | CA2706994C (de) |
| DK (1) | DK2492355T3 (de) |
| ES (2) | ES2542033T3 (de) |
| HR (1) | HRP20150733T1 (de) |
| HU (1) | HUE026591T2 (de) |
| PL (1) | PL2492355T3 (de) |
| PT (1) | PT2492355E (de) |
| SI (1) | SI2492355T1 (de) |
| WO (1) | WO2009068677A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2540309T3 (pl) | 2005-08-05 | 2018-03-30 | Araim Pharmaceuticals, Inc. | Peptydy chroniące tkanki i ich zastosowanie |
| HUE037173T2 (hu) | 2006-08-08 | 2018-08-28 | Univ Bonn Rheinische Friedrich Wilhelms | 5'-Foszfát-oligonukleotidok szerkezete és alkalmazása |
| US8357501B2 (en) * | 2007-11-29 | 2013-01-22 | Molecular Health Gmbh | Tissue protective erythropoietin receptor (NEPOR) and methods of use |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| US20130210030A1 (en) * | 2010-07-19 | 2013-08-15 | Cellzome Ag | In vivo method for the evaluation of a compound-target interaction |
| EP2508530A1 (de) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags |
| EP2721067B1 (de) * | 2011-06-15 | 2019-07-31 | F.Hoffmann-La Roche Ag | Anti-human-epo-rezeptor-antikörper und verfahren zu deren verwendung |
| EP2712870A1 (de) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Neuartige RIG-I-Liganden und Herstellungsverfahren dafür |
| EP3021863A4 (de) * | 2013-07-17 | 2017-01-04 | Araim Pharmaceuticals, Inc. | Gewebeschützende peptide und peptidanaloga zur prävention und behandlung von erkrankungen und störungen im zusammenhang mit gewebeschäden |
| US11702477B2 (en) | 2015-11-06 | 2023-07-18 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
| JP6991979B2 (ja) | 2016-02-05 | 2022-03-04 | オリオニス バイオサイエンシズ ビーブイ | Ｃｄ８結合物質 |
| CA3023883A1 (en) | 2016-05-13 | 2017-11-16 | Orionis Biosciences Nv | Targeted mutant interferon-beta and uses thereof |
| EP3455245A2 (de) | 2016-05-13 | 2019-03-20 | Orionis Biosciences NV | Therapeutisches targeting von nichtzellulären strukturen |
| CN110114368B (zh) | 2016-10-24 | 2024-08-02 | 奥睿尼斯生物科学私人有限公司 | 靶向突变干扰素-γ及其用途 |
| WO2018141964A1 (en) | 2017-02-06 | 2018-08-09 | Orionis Biosciences Nv | Targeted chimeric proteins and uses thereof |
| EP3576765B1 (de) | 2017-02-06 | 2025-07-16 | Orionis Biosciences, Inc. | Zielgerichtetes manipuliertes interferon und verwendungen davon |
| CA3090406A1 (en) | 2018-02-05 | 2019-08-08 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
| CN111175519B (zh) * | 2020-01-09 | 2020-11-27 | 浙江大学 | Epo在制备肝细胞癌tace疗效评估试剂中的应用 |
| WO2022054748A1 (ja) * | 2020-09-10 | 2022-03-17 | 扶桑薬品工業株式会社 | エリスロポエチンシグナル伝達阻害タンパク質 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002951409A0 (en) * | 2002-09-16 | 2002-09-26 | North Western Adelaide Health Services | Methods for regulating cancer |
| US7381410B2 (en) * | 2003-03-12 | 2008-06-03 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| CA2518912A1 (en) * | 2003-03-12 | 2004-09-23 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| US7718363B2 (en) * | 2003-04-25 | 2010-05-18 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
| AU2005286663A1 (en) * | 2004-09-23 | 2006-03-30 | Vasgene Therapeutics, Inc. | Compositions and methods for detecting and treating tumors |
-
2008
- 2008-11-28 EP EP15000987.6A patent/EP2960341B1/de not_active Not-in-force
- 2008-11-28 AU AU2008328754A patent/AU2008328754B2/en not_active Ceased
- 2008-11-28 SI SI200831453T patent/SI2492355T1/sl unknown
- 2008-11-28 AT AT08854346T patent/ATE554186T1/de active
- 2008-11-28 EP EP11004689.3A patent/EP2492355B1/de not_active Not-in-force
- 2008-11-28 CA CA2706994A patent/CA2706994C/en not_active Expired - Fee Related
- 2008-11-28 CA CA2802984A patent/CA2802984C/en not_active Expired - Fee Related
- 2008-11-28 HU HUE11004689A patent/HUE026591T2/hu unknown
- 2008-11-28 ES ES11004689.3T patent/ES2542033T3/es active Active
- 2008-11-28 WO PCT/EP2008/066480 patent/WO2009068677A1/en not_active Ceased
- 2008-11-28 EP EP08854346A patent/EP2109690B9/de not_active Not-in-force
- 2008-11-28 PT PT110046893T patent/PT2492355E/pt unknown
- 2008-11-28 DK DK11004689.3T patent/DK2492355T3/da active
- 2008-11-28 PL PL11004689T patent/PL2492355T3/pl unknown
- 2008-11-28 ES ES08854346T patent/ES2386495T3/es active Active
-
2015
- 2015-07-06 HR HRP20150733TT patent/HRP20150733T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2960341B1 (de) | 2018-06-27 |
| PT2492355E (pt) | 2015-09-10 |
| EP2109690B9 (de) | 2012-10-24 |
| AU2008328754A1 (en) | 2009-06-04 |
| CA2706994C (en) | 2013-03-12 |
| EP2109690A1 (de) | 2009-10-21 |
| PL2492355T3 (pl) | 2015-09-30 |
| AU2008328754B2 (en) | 2015-04-16 |
| ES2386495T3 (es) | 2012-08-21 |
| DK2492355T3 (da) | 2015-07-13 |
| EP2492355A1 (de) | 2012-08-29 |
| CA2802984A1 (en) | 2009-06-04 |
| WO2009068677A1 (en) | 2009-06-04 |
| EP2960341A1 (de) | 2015-12-30 |
| HRP20150733T1 (hr) | 2015-08-14 |
| EP2492355B1 (de) | 2015-04-08 |
| ES2542033T3 (es) | 2015-07-29 |
| HUE026591T2 (hu) | 2016-06-28 |
| EP2109690B1 (de) | 2012-04-18 |
| CA2706994A1 (en) | 2009-06-04 |
| SI2492355T1 (sl) | 2015-08-31 |
| CA2802984C (en) | 2016-04-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE554186T1 (de) | Eph-b4 spezifische sirna zur reduktion von epo- induziertem tumorzellwachstum während anämiebehandlung in krebspatienten, gewebeschutz- erythropoietin-rezeptor (nepor) und verfahren zu seiner verwendung | |
| Pascual et al. | Dietary palmitic acid promotes a prometastatic memory via Schwann cells | |
| EP2531598A4 (de) | Whsc1 und whsc1l1 für zielgene zur krebstherapie und -diagnose | |
| Marcuzzo et al. | Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells | |
| Kimura et al. | Tumor-homing effect of human mesenchymal stem cells in a TH-MYCN mouse model of neuroblastoma | |
| Abdullah et al. | Proliferation rate of stem cells derived from human dental pulp and identification of differentially expressed genes | |
| Kim et al. | MicroRNA-34a regulates migration of chondroblast and IL-1β-induced degeneration of chondrocytes by targeting EphA5 | |
| MXPA05014220A (es) | Genes regulados en cancer ovarico como objetivos de pronostico y terapeuticos. | |
| Griner et al. | Aggressive myeloid leukemia formation is directed by the Musashi 2/Numb pathway | |
| Chen et al. | Hypoxia stimulates proliferation of rat neural stem/progenitor cells by regulating mir-21: an in vitro study | |
| CN107326071A (zh) | Plpp4作为非小细胞肺癌诊断、治疗、预后靶点的应用 | |
| Kim et al. | Derivation of neural stem cells from human teratomas | |
| Luo et al. | TM4SF19-AS1 facilitates the proliferation of lung squamous cell carcinoma by recruiting WDR5 to mediate TM4SF19 | |
| WO2005083086A3 (en) | Epha4 as therapeutic target of prc and pdaca | |
| Wu et al. | Protein phosphatase 2A regulatory subunit B56β modulates erythroid differentiation | |
| Liu et al. | Interaction between stromal cells and tumor cells promotes GCB-DLBCL cell survival via the CD40/RANK-KDM6B-NF-κB axis | |
| Assadollahi et al. | Comparison of Oct4, Sox2 and Nanog expression in pancreatic cancer cell lines and human pancreatic tumor | |
| Schachter et al. | Expression of kinase genes in primary hyperparathyroidism: adenoma versus hyperplastic parathyroid tissue | |
| Hang et al. | TET3 Protein Represses Proliferation of the MG-63 Human Osteosarcoma Cell Line by Regulating DNA Demethylation: an Epigenetic Study | |
| Yalim-Camci et al. | Dual high expression of epithelial-mesenchymal transcription factors ZEB1 and ELF3 was inversely correlated with survival of liver cancer patients | |
| Moolsuwan et al. | Dopachrome tautomerase is a retinoblastoma-specific gene, and its proximal promoter is preferentially active in human retinoblastoma cells | |
| Mondal et al. | 18P Trastuzumab in HER2-amplified or overexpressed gallbladder cancer: Experience from an Indian cancer center | |
| Triplett et al. | MiR-27 and MiR-145 mediate neural differentiation signaling pathways in dental pulp stem cells | |
| Paltuev et al. | Automated analysis of cell density in breast cancer as an additional method of increasing objectivity and accuracy of breast cancer prognosis | |
| Verma | RNA-seq based transcriptome profiling provides important insights into progression of gastric cancer |