CN1103593C - 协同组合物 - Google Patents

协同组合物 Download PDF

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Publication number
CN1103593C
CN1103593C CN96194050A CN96194050A CN1103593C CN 1103593 C CN1103593 C CN 1103593C CN 96194050 A CN96194050 A CN 96194050A CN 96194050 A CN96194050 A CN 96194050A CN 1103593 C CN1103593 C CN 1103593C
Authority
CN
China
Prior art keywords
amino
cis
oxathiolane
pyrimid
methylol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96194050A
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English (en)
Chinese (zh)
Other versions
CN1185110A (zh
Inventor
D·W·巴里
M·H·St·克莱尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ViiV Healthcare UK Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26306774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1103593(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9506490.3A external-priority patent/GB9506490D0/en
Priority claimed from GBGB9506489.5A external-priority patent/GB9506489D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of CN1185110A publication Critical patent/CN1185110A/zh
Application granted granted Critical
Publication of CN1103593C publication Critical patent/CN1103593C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicinal Preparation (AREA)
CN96194050A 1995-03-30 1996-03-28 协同组合物 Expired - Lifetime CN1103593C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9506490.3A GB9506490D0 (en) 1995-03-30 1995-03-30 Antiviral combinations
GBGB9506489.5A GB9506489D0 (en) 1995-03-30 1995-03-30 Antiviral combinations
GB9506490.3 1995-03-30
GB9506489.5 1995-03-30

Publications (2)

Publication Number Publication Date
CN1185110A CN1185110A (zh) 1998-06-17
CN1103593C true CN1103593C (zh) 2003-03-26

Family

ID=26306774

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96194050A Expired - Lifetime CN1103593C (zh) 1995-03-30 1996-03-28 协同组合物

Country Status (35)

Country Link
US (1) US6417191B1 (OSRAM)
EP (1) EP0817637B1 (OSRAM)
JP (1) JP2954357B2 (OSRAM)
KR (1) KR100542536B1 (OSRAM)
CN (1) CN1103593C (OSRAM)
AP (1) AP652A (OSRAM)
AT (1) ATE220551T1 (OSRAM)
AU (1) AU715213B2 (OSRAM)
BR (3) BRPI9612992B1 (OSRAM)
CA (1) CA2216634C (OSRAM)
CZ (1) CZ295940B6 (OSRAM)
DE (3) DE122005000029I2 (OSRAM)
DK (1) DK0817637T3 (OSRAM)
EA (1) EA000626B3 (OSRAM)
EE (1) EE04047B1 (OSRAM)
ES (1) ES2179193T3 (OSRAM)
FR (1) FR05C0022I2 (OSRAM)
GE (1) GEP20022647B (OSRAM)
HU (1) HU224010B1 (OSRAM)
IL (1) IL117727A (OSRAM)
LU (1) LU91171I2 (OSRAM)
MX (1) MX9707316A (OSRAM)
MY (1) MY115461A (OSRAM)
NL (1) NL300195I2 (OSRAM)
NO (2) NO313787B1 (OSRAM)
NZ (1) NZ306419A (OSRAM)
OA (1) OA10616A (OSRAM)
PL (1) PL187085B1 (OSRAM)
PT (1) PT817637E (OSRAM)
RO (1) RO117995B1 (OSRAM)
SI (1) SI0817637T1 (OSRAM)
SK (1) SK283825B6 (OSRAM)
TR (1) TR199701074T1 (OSRAM)
UA (1) UA60293C2 (OSRAM)
WO (1) WO1996030025A1 (OSRAM)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000515852A (ja) * 1996-06-25 2000-11-28 グラクソ、グループ、リミテッド Ｈｉｖの治療に使用するためのｖｘ４７８、ジドブジン、ｆｔｃおよび／または３ｔｃを含んでなる組合わせ
US6113920A (en) * 1996-10-31 2000-09-05 Glaxo Wellcome Inc. Pharmaceutical compositions
TW536403B (en) * 1997-03-24 2003-06-11 Glaxo Group Ltd An ethanol and ethylenediaminetetraacetic acid free pharmaceutical composition comprising lamivudine and exhibiting antimicrobial preservative efficacy
AU769660B2 (en) * 1997-05-17 2004-01-29 Glaxo Group Limited Carbocyclic nucleoside hemisulfate and its use in treating viral infections
GB9709945D0 (en) * 1997-05-17 1997-07-09 Glaxo Group Ltd A novel salt
AU7912398A (en) * 1997-05-17 1998-12-11 Glaxo Group Limited Antiviral combinations containing the carbocyclic nucleoside 1592u89
GB9809213D0 (en) * 1998-04-29 1998-07-01 Glaxo Group Ltd Pharmaceutical compositions
AU4219799A (en) * 1998-05-29 1999-12-13 University Of Florida Combination therapy for treatment of fiv infection
US6875773B1 (en) 1998-05-29 2005-04-05 Ben M. Dunn Combination therapy for treatment of FIV infection
GB9820417D0 (en) * 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
US6432966B2 (en) 1999-10-29 2002-08-13 Smithkline Beecham Corporation Antiviral combinations
US7074417B2 (en) * 2000-10-13 2006-07-11 Advancis Pharmaceutical Corporation Multiple-delayed release anti-viral product, use and formulation thereof
AP2220A (en) * 2001-05-11 2011-03-24 Cipla Medpro Pty Ltd Pharmaceutical composition.
AR040242A1 (es) * 2002-06-04 2005-03-23 Glaxo Group Ltd Composiciones farmaceuticas
JP4996241B2 (ja) 2003-01-14 2012-08-08 ギリアード サイエンシーズ， インコーポレイテッド 組み合わせ抗ウイルス治療のための組成物および方法
CA2518823A1 (en) 2003-03-24 2004-10-07 F.Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
WO2005040816A1 (en) 2003-10-24 2005-05-06 Immunaid Pty Ltd Method of therapy
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
KR20080056220A (ko) 2005-10-19 2008-06-20 에프. 호프만-라 로슈 아게 페닐-아세트아마이드 ｎｎｒｔ 저해제
RU2469032C2 (ru) 2006-12-13 2012-12-10 Ф.Хоффманн-Ля Рош Аг Производные 2-(пиперидин-4-ил)-4-фенокси- или фениламинопиримидина в качестве ненуклеозидных ингибиторов обратной транскриптазы
DK2120878T3 (da) * 2007-02-09 2014-11-03 Alphapharm Pty Ltd Doseringsform indeholdende to aktive farmaceutiske ingredienser i forskellige fysiske former
US9122778B2 (en) 2009-05-27 2015-09-01 Biotempus Limited Methods of treating diseases
EA032868B1 (ru) 2010-01-27 2019-07-31 Вайв Хелткер Компани Комбинация для лечения вич-инфекции
WO2015028875A2 (en) 2013-08-29 2015-03-05 Teva Pharmaceuticals Industries Ltd. Unit dosage form comprising emtricitabine, tenofovir, darunavir and ritonavir and a monolithic tablet comprising darunavir and ritonavir
TW201622731A (zh) 2014-04-08 2016-07-01 泰瓦藥品工業有限公司 包含恩曲他濱（Ｅｍｔｒｉｃｉｔａｂｉｎｅ）、替諾福韋（Ｔｅｎｏｆｏｖｉｒ）、地瑞那韋（Ｄａｒｕｎａｖｉｒ）及利托那韋（Ｒｉｔｏｎａｖｉｒ）之單位劑型以及包含地瑞那韋及利托那韋之單層錠劑
CN117164657A (zh) 2014-08-12 2023-12-05 莫纳什大学 定向淋巴的前药
JP7118888B2 (ja) 2015-09-08 2022-08-16 モナッシュ ユニバーシティ リンパ指向性プロドラッグ
US11883497B2 (en) 2017-08-29 2024-01-30 Puretech Lyt, Inc. Lymphatic system-directing lipid prodrugs
EP3675838A4 (en) 2017-08-29 2021-04-21 PureTech LYT, Inc. LIPID PRODRUGS DIRECTED TO THE LYMPHATIC SYSTEM
US11304954B2 (en) 2017-12-19 2022-04-19 Puretech Lyt, Inc. Lipid prodrugs of mycophenolic acid and uses thereof
US11608345B1 (en) 2017-12-19 2023-03-21 Puretech Lyt, Inc. Lipid prodrugs of rapamycin and its analogs and uses thereof
CN115348864A (zh) 2020-02-05 2022-11-15 纯技术Lyt股份有限公司 神经甾体的脂质前药

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992015309A1 (en) * 1991-03-06 1992-09-17 The Wellcome Foundation Limited Antiviral nucleoside combination
CN1068570A (zh) * 1991-05-16 1993-02-03 格拉克索公司 抗病毒组合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US5047407A (en) 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5122517A (en) 1988-06-10 1992-06-16 Regents Of The University Of Minnesota Antiviral combination comprising nucleoside analogs
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US5204466A (en) 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
WO1993023021A2 (en) * 1992-05-13 1993-11-25 The Wellcome Foundation Limited Therapeutic combinations
US5723490A (en) 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
GB9417249D0 (en) 1994-08-26 1994-10-19 Wellcome Found A novel salt
US5869461A (en) 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
JP2000515852A (ja) 1996-06-25 2000-11-28 グラクソ、グループ、リミテッド Ｈｉｖの治療に使用するためのｖｘ４７８、ジドブジン、ｆｔｃおよび／または３ｔｃを含んでなる組合わせ
ATE230267T1 (de) 1996-06-25 2003-01-15 Glaxo Group Ltd Zusammensetzungen enthaltend vx478, zidovudine und 159u89 für die verwendung in der behandlung von hiv
DE10226522A1 (de) * 2002-06-14 2003-12-24 Degussa Verwendung von Übergangsmetallkomplexen mit stickstoffhaltigen mehrzähnigen Liganden als Bleichkatalysator und Bleichmittelzusammensetzung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992015309A1 (en) * 1991-03-06 1992-09-17 The Wellcome Foundation Limited Antiviral nucleoside combination
CN1068570A (zh) * 1991-05-16 1993-02-03 格拉克索公司 抗病毒组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCRIP WORLD PHARMACEU 1994-10-25 TISDALEM, 等人RAPID IN - *

Also Published As

Publication number Publication date
HU224010B1 (hu) 2005-04-28
DE69622386T2 (de) 2003-02-13
NZ306419A (en) 2000-01-28
PT817637E (pt) 2002-11-29
IL117727A0 (en) 1996-07-23
AP652A (en) 1998-06-19
DE69622386D1 (de) 2002-08-22
HK1009401A1 (en) 1999-09-10
KR100542536B1 (ko) 2006-03-23
NO313787B1 (no) 2002-12-02
IL117727A (en) 1999-11-30
SK283825B6 (sk) 2004-02-03
WO1996030025A1 (en) 1996-10-03
MX9707316A (es) 1997-11-29
LU91171I2 (fr) 2005-07-04
MY115461A (en) 2003-06-30
ATE220551T1 (de) 2002-08-15
NO2005014I2 (no) 2008-02-11
CN1185110A (zh) 1998-06-17
EA199700203A1 (ru) 1998-02-26
KR19980703420A (ko) 1998-11-05
AU715213B2 (en) 2000-01-20
JP2954357B2 (ja) 1999-09-27
US6417191B1 (en) 2002-07-09
PL187085B1 (pl) 2004-05-31
NL300195I1 (nl) 2005-08-01
TR199701074T1 (xx) 1998-02-21
LU91171I9 (OSRAM) 2018-12-28
BRPI9612992B1 (pt) 2020-08-04
AU5497296A (en) 1996-10-16
DK0817637T3 (da) 2002-11-11
CZ309097A3 (cs) 1998-05-13
BRPI9607851B8 (pt) 2019-11-05
AP9701089A0 (en) 1997-10-31
GEP20022647B (en) 2002-03-25
EP0817637A1 (en) 1998-01-14
EA000626B1 (ru) 1999-12-29
EP0817637B1 (en) 2002-07-17
CA2216634C (en) 2004-07-20
PL322532A1 (en) 1998-02-02
EA000626B3 (ru) 2016-04-29
NO974510L (no) 1997-09-29
FR05C0022I2 (OSRAM) 2005-10-21
DE122005000029I2 (de) 2006-04-27
NL300195I2 (nl) 2005-11-01
UA60293C2 (uk) 2003-10-15
NO974510D0 (no) 1997-09-29
OA10616A (en) 2001-03-15
HUP9801571A2 (hu) 1999-01-28
CZ295940B6 (cs) 2005-12-14
DE122005000029I1 (de) 2005-10-06
ES2179193T3 (es) 2003-01-16
BR9607851B1 (pt) 2009-01-13
SI0817637T1 (en) 2002-10-31
FR05C0022I1 (OSRAM) 2005-06-10
CA2216634A1 (en) 1996-10-03
NO2005014I1 (no) 2005-06-06
BR9607851A (pt) 1998-07-21
SK129597A3 (en) 1998-07-08
JPH10511682A (ja) 1998-11-10
HUP9801571A3 (en) 2001-04-28
EE04047B1 (et) 2003-06-16
RO117995B1 (ro) 2002-12-30
EE9700240A (et) 1998-04-15

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SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: VIIV HEALTHCARE UK LTD.

Free format text: FORMER OWNER: THE WELLCOME FOUNDATION LTD. (GB) 183-193 EUSTON ROAD. LONDON. N.W.1. ENGLAND

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Address after: The Middlesex County

Patentee after: Viiv Healthcare Uk Ltd

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Granted publication date: 20030326

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