CN110337305A - 治疗性rna - Google Patents

治疗性rna Download PDF

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Publication number
CN110337305A
CN110337305A CN201880013857.3A CN201880013857A CN110337305A CN 110337305 A CN110337305 A CN 110337305A CN 201880013857 A CN201880013857 A CN 201880013857A CN 110337305 A CN110337305 A CN 110337305A
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Prior art keywords
rna
seq
protein
composition
tumor
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CN201880013857.3A
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Chinese (zh)
Inventor
F·吉塞克
U·萨欣
D·G·威德沙因
T·R·瓦格纳尔
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Debiotech SA
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Sanofi SA
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • C07K14/52Cytokines; Lymphokines; Interferons
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/335Modified T or U

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CN201880013857.3A 2017-02-28 2018-02-27 治疗性rna Pending CN110337305A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762464981P 2017-02-28 2017-02-28
US62/464,981 2017-02-28
EP17306089.8 2017-08-23
EP17306089 2017-08-23
US201762597527P 2017-12-12 2017-12-12
US62/597,527 2017-12-12
PCT/US2018/019878 WO2018160540A1 (en) 2017-02-28 2018-02-27 Therapeutic rna

Publications (1)

Publication Number Publication Date
CN110337305A true CN110337305A (zh) 2019-10-15

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CN201880013857.3A Pending CN110337305A (zh) 2017-02-28 2018-02-27 治疗性rna

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US (3) US20200147176A1 (enExample)
EP (1) EP3589308A1 (enExample)
JP (4) JP6949131B2 (enExample)
KR (2) KR20240144261A (enExample)
CN (1) CN110337305A (enExample)
AU (1) AU2018229278A1 (enExample)
BR (1) BR112019017743A2 (enExample)
CA (1) CA3054733A1 (enExample)
CL (1) CL2019002461A1 (enExample)
CO (1) CO2019010355A2 (enExample)
CR (1) CR20190444A (enExample)
EC (1) ECSP19070336A (enExample)
IL (1) IL268894A (enExample)
MA (1) MA47680A (enExample)
MX (1) MX2019010269A (enExample)
PE (1) PE20200735A1 (enExample)
PH (1) PH12019501959A1 (enExample)
SG (1) SG11201907846VA (enExample)
TW (2) TW202428301A (enExample)
UY (1) UY37621A (enExample)
WO (1) WO2018160540A1 (enExample)

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CN113557060A (zh) * 2019-01-21 2021-10-26 赛诺菲 用于晚期实体瘤癌症的治疗性rna
WO2023056915A1 (en) * 2021-10-08 2023-04-13 Suzhou Abogen Biosciences Co., Ltd. Polynucleotides encoding interleukin-12 (il-12) and related composition and methods thereof
CN115960906A (zh) * 2022-05-07 2023-04-14 苏州科锐迈德生物医药科技有限公司 用于抗肿瘤免疫治疗的rna组合物、rna制剂及用途
CN116438306A (zh) * 2020-10-20 2023-07-14 St制药株式会社 用于5'-加帽的rna合成的寡核苷酸
CN116585464A (zh) * 2020-04-22 2023-08-15 生物技术欧洲股份公司 Rna构建体及其用途
WO2023246938A1 (zh) * 2022-06-24 2023-12-28 深圳瑞吉生物科技有限公司 用于实体肿瘤的治疗性mRNA及其应用

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TW202026423A (zh) * 2018-08-24 2020-07-16 法商賽諾菲公司 用於實體瘤癌症的治療性rna
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JP7650873B2 (ja) 2019-10-09 2025-03-25 トランスレイト バイオ, インコーポレイテッド メッセンジャーrnaの組成物、方法および使用
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CN116710079A (zh) * 2020-07-24 2023-09-05 斯特兰德生物科技公司 包含经修饰的核苷酸的脂质纳米颗粒
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US20240166707A1 (en) 2021-01-08 2024-05-23 Strand Therapeutics Inc. Expression constructs and uses thereof
WO2022162027A2 (en) * 2021-01-27 2022-08-04 Curevac Ag Method of reducing the immunostimulatory properties of in vitro transcribed rna
US12186387B2 (en) 2021-11-29 2025-01-07 BioNTech SE Coronavirus vaccine
CN116179549A (zh) 2021-12-08 2023-05-30 南京吉迈生物技术有限公司 通过5’utr序列变体修饰基因转录和翻译效率
JP2025516226A (ja) 2022-04-26 2025-05-27 ストランド セラピューティクス インコーポレイテッド ベネズエラウマ脳炎(vee)レプリコンを含む脂質ナノ粒子及びその使用
EP4524250A4 (en) 2022-05-13 2025-11-26 Shanghai Regenelead Therapies Co Ltd CONSTRUCTION OF NUCLEIC ACIDS INCLUDING A UTR AND ITS USE
US11878055B1 (en) 2022-06-26 2024-01-23 BioNTech SE Coronavirus vaccine
EP4561602A1 (en) 2022-07-28 2025-06-04 Stemcell Technologies Canada Inc. Polynucleotides encoding linked antigens and uses thereof
WO2024074211A1 (en) * 2022-10-06 2024-04-11 BioNTech SE Rna compositions targeting claudin-18.2
JP2025534447A (ja) * 2022-10-06 2025-10-15 バイオエヌテック エスエー クローディン18.2を標的とするrna組成物
CN120958133A (zh) 2023-04-12 2025-11-14 斯特兰德生物科技公司 合成回路及其用途
WO2025024559A1 (en) 2023-07-24 2025-01-30 Strand Therapeutics Inc. Rna-based synthetic circuit for producing engineered immune cells for an extracorporeal cell therapy
WO2025024704A1 (en) 2023-07-25 2025-01-30 Strand Therapeutics Inc. Polynucleotides comprising a micro rna detargeting sensor and uses thereof
KR20250034228A (ko) * 2023-09-01 2025-03-11 한양대학교 산학협력단 증강된 유전자 발현을 위한 5‘ 비번역 영역을 포함하는 뉴클레오타이드를 포함하는 조성물 및 방법
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