CN110234662A - 组织特异性wnt信号增强分子和其用途 - Google Patents

组织特异性wnt信号增强分子和其用途 Download PDF

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Publication number
CN110234662A
CN110234662A CN201880008831.XA CN201880008831A CN110234662A CN 110234662 A CN110234662 A CN 110234662A CN 201880008831 A CN201880008831 A CN 201880008831A CN 110234662 A CN110234662 A CN 110234662A
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Prior art keywords
tissue
polypeptide
molecule
wnt
wnt signaling
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Chinese (zh)
Inventor
张正健
詹妮弗·吉恩·布雷迪
亚伦·肯·佐藤
叶文琛
李阳
山口铁平
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Throzern Co
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Throzern Co
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CN201880008831.XA 2017-01-26 2018-01-26 组织特异性wnt信号增强分子和其用途 Pending CN110234662A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762450804P 2017-01-26 2017-01-26
US62/450,804 2017-01-26
US201762487135P 2017-04-19 2017-04-19
US62/487,135 2017-04-19
PCT/US2018/015595 WO2018140821A1 (en) 2017-01-26 2018-01-26 Tissue-specific wnt signal enhancing molecules and uses thereof

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CN110234662A true CN110234662A (zh) 2019-09-13

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US (2) US11958891B2 (https=)
EP (1) EP3574019A4 (https=)
JP (3) JP7305543B2 (https=)
CN (1) CN110234662A (https=)
AU (1) AU2018211985B2 (https=)
CA (1) CA3050133A1 (https=)
WO (1) WO2018140821A1 (https=)

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CN112386687A (zh) * 2020-12-09 2021-02-23 北京欣颂生物科技有限公司 一种干细胞外泌体及其在药品和化妆品中的应用
CN113293214A (zh) * 2021-06-17 2021-08-24 深圳华因康基因科技有限公司 一种检测神经母细胞瘤复发转移基因wnt2扩增的引物探针及其应用
CN113677690A (zh) * 2019-10-18 2021-11-19 因科斯医药公司 缓解脱发及促进毛发生长的肽、包含其的化妆品组合物及药学组合物
CN116789843A (zh) * 2022-03-16 2023-09-22 伯桢生物科技(杭州)有限公司 Wnt重组蛋白及其应用
CN116836274A (zh) * 2022-03-23 2023-10-03 东莞市朋志生物科技有限公司 抗血清淀粉样蛋白a抗体、检测血清淀粉样蛋白a的试剂和试剂盒
WO2025146152A1 (zh) * 2024-01-04 2025-07-10 上海宝济药业股份有限公司 一种药物组合物及其应用
CN120647751A (zh) * 2025-08-18 2025-09-16 成都迈科康生物科技有限公司 抗人乳头瘤病毒e1蛋白的抗体或其试剂盒和相关应用

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US11993645B2 (en) 2017-01-11 2024-05-28 The Board Of Trustees Of The Leland Stanford Junior University Compositions comprising R-Spondin (RSPO) surrogate molecules
WO2018140821A1 (en) 2017-01-26 2018-08-02 Surrozen, Inc. Tissue-specific wnt signal enhancing molecules and uses thereof
US11773171B2 (en) 2017-12-19 2023-10-03 Surrozen Operating, Inc. WNT surrogate molecules and uses thereof
CN111699003B (zh) 2017-12-19 2024-05-03 瑟罗泽恩奥普瑞汀公司 抗lrp5/6抗体和使用方法
CN117946267A (zh) 2017-12-19 2024-04-30 瑟罗泽恩奥普瑞汀公司 抗卷曲蛋白抗体和使用方法
CA3104868A1 (en) * 2018-07-09 2020-01-16 Surrozen, Inc. Tissue-specific wnt signal enhancing molecules and uses thereof
AU2019416324A1 (en) * 2018-12-27 2021-07-22 H. Lee Moffitt Cancer Center And Research Institute Inc. Bispecific antibody for membrane clearance of target receptors
EP3924381A4 (en) * 2019-02-11 2023-07-26 Surrozen Operating, Inc. MODULATION OF WNT SIGNALING IN EYE DISEASES
US20220175884A1 (en) * 2019-04-02 2022-06-09 Surrozen Operating, Inc. Modulation of wnt signaling in auditory disorders
JP7377288B2 (ja) * 2019-06-11 2023-11-09 アントレラ セラピューティクス インコーポレイテッド 多価ｆｚｄおよびｗｎｔ結合分子とその使用
CA3141632A1 (en) 2019-06-21 2020-12-24 Regeneron Pharmaceuticals, Inc. Treatment of decreased bone mineral density with zinc and ring finger 3 (znrf3) inhibitors
CA3166963A1 (en) * 2020-01-09 2021-07-15 Kimberly Drenser Neural regeneration with synthetic protein administration
CA3170340A1 (en) * 2020-02-24 2021-09-02 Surrozen Operating, Inc. Wnt super agonists
MX2023005032A (es) * 2020-11-10 2023-05-16 Scripps Research Inst Anticuerpos para tratamientos con opioides.
JP2023549854A (ja) * 2020-11-16 2023-11-29 スロゼン オペレーティング， インコーポレイテッド 肝臓特異的Ｗｎｔシグナル増強分子およびその使用
CN113307882B (zh) * 2021-05-12 2022-12-20 东北大学 靶向治疗Rspo过度激活导致的结直肠癌的融合蛋白SZ1及其偶联纳米药物
IL310154A (en) * 2021-07-15 2024-03-01 Diogenx Recombinant variants of r-spondin proteins and their use
EP4428238A1 (en) * 2021-11-02 2024-09-11 Rena Therapeutics Inc. Ligand-bound nucleic acid complex
JP2025525362A (ja) * 2022-06-21 2025-08-05 スロゼン オペレーティング， インコーポレイテッド 角膜障害におけるｗｎｔシグナル伝達の調節
CA3265221A1 (en) * 2022-09-09 2024-03-14 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts TARGETED PD-L1 DEGRADATION

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