AU2018211985B2 - Tissue-specific Wnt signal enhancing molecules and uses thereof - Google Patents

Tissue-specific Wnt signal enhancing molecules and uses thereof Download PDF

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Publication number
AU2018211985B2
AU2018211985B2 AU2018211985A AU2018211985A AU2018211985B2 AU 2018211985 B2 AU2018211985 B2 AU 2018211985B2 AU 2018211985 A AU2018211985 A AU 2018211985A AU 2018211985 A AU2018211985 A AU 2018211985A AU 2018211985 B2 AU2018211985 B2 AU 2018211985B2
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tissue
domain
molecule
wnt
cell
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AU2018211985A1 (en
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Jennifer Jean BRADY
Yang Li
Aaron Ken Sato
Teppei YAMAGUCHI
Wen-Chen Yeh
Zhengjian ZHANG
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Surrozen Operating Inc
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Surrozen Operating Inc
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AU2018211985A 2017-01-26 2018-01-26 Tissue-specific Wnt signal enhancing molecules and uses thereof Active AU2018211985B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762450804P 2017-01-26 2017-01-26
US62/450,804 2017-01-26
US201762487135P 2017-04-19 2017-04-19
US62/487,135 2017-04-19
PCT/US2018/015595 WO2018140821A1 (en) 2017-01-26 2018-01-26 Tissue-specific wnt signal enhancing molecules and uses thereof

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AU2018211985A1 AU2018211985A1 (en) 2019-07-18
AU2018211985B2 true AU2018211985B2 (en) 2025-02-13

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US (2) US11958891B2 (https=)
EP (1) EP3574019A4 (https=)
JP (3) JP7305543B2 (https=)
CN (1) CN110234662A (https=)
AU (1) AU2018211985B2 (https=)
CA (1) CA3050133A1 (https=)
WO (1) WO2018140821A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7617603B2 (ja) 2017-01-11 2025-01-20 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Ｒ－スポンジン（ｒｓｐｏ）サロゲート分子
JP7305543B2 (ja) 2017-01-26 2023-07-10 スロゼン オペレーティング， インコーポレイテッド 組織特異的Ｗｎｔシグナル増強分子およびその使用
EP3732201A4 (en) 2017-12-19 2022-04-20 Surrozen Operating, Inc. WNT SURROGATES AND THEIR USES
CN111699003B (zh) 2017-12-19 2024-05-03 瑟罗泽恩奥普瑞汀公司 抗lrp5/6抗体和使用方法
CN111655729B (zh) 2017-12-19 2023-10-20 瑟罗泽恩奥普瑞汀公司 抗卷曲蛋白抗体和使用方法
JP2021530223A (ja) * 2018-07-09 2021-11-11 スロゼン， インコーポレイテッド 組織特異性Ｗｎｔシグナル増強分子及びその使用
US20220041753A1 (en) * 2018-12-27 2022-02-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bispecific antibody for membrane clearance of target receptors
JP7663501B2 (ja) * 2019-02-11 2025-04-16 スロゼン オペレーティング， インコーポレイテッド 眼障害におけるｗｎｔシグナル伝達の調節
US20220175884A1 (en) * 2019-04-02 2022-06-09 Surrozen Operating, Inc. Modulation of wnt signaling in auditory disorders
CN120025448A (zh) * 2019-06-11 2025-05-23 安托拉诊疗公司 多价fzd和wnt结合分子及其用途
US11713461B2 (en) 2019-06-21 2023-08-01 Regeneran Pharmaceuticals, Inc. Treatment of decreased bone mineral density with zinc and ring finger 3 (ZNRF3) inhibitors
KR102192471B1 (ko) * 2019-10-18 2020-12-17 주식회사 인코스팜 탈모 완화 및 모발 성장을 촉진시키는 펩타이드 및 이를 포함하는 화장료 조성물
US20240000890A1 (en) * 2020-01-09 2024-01-04 Retinal Solutions, LLC Neural regeneration with synthetic protein administration
CN115427446A (zh) * 2020-02-24 2022-12-02 瑟罗泽恩奥普瑞汀公司 Wnt超级激动剂
CN116745318A (zh) * 2020-11-10 2023-09-12 斯克里普斯研究学院 用于阿片样物质治疗的抗体
TW202233656A (zh) * 2020-11-16 2022-09-01 美商蘇羅森營運公司 肝特異性wnt訊號增強分子及其用途
CN112386687B (zh) * 2020-12-09 2021-05-04 爱龄医美国际健康咨询服务(北京)有限公司 一种干细胞外泌体及其在药品和化妆品中的应用
CN113307882B (zh) * 2021-05-12 2022-12-20 东北大学 靶向治疗Rspo过度激活导致的结直肠癌的融合蛋白SZ1及其偶联纳米药物
CN113293214A (zh) * 2021-06-17 2021-08-24 深圳华因康基因科技有限公司 一种检测神经母细胞瘤复发转移基因wnt2扩增的引物探针及其应用
AU2022311529A1 (en) * 2021-07-15 2024-01-25 Centre National De La Recherche Scientifique (Cnrs) Recombinant variants of r-spondin proteins and their use
JPWO2023080159A1 (https=) * 2021-11-02 2023-05-11
CN116789843B (zh) * 2022-03-16 2024-09-17 伯桢生物科技(杭州)有限公司 Wnt重组蛋白及其应用
CN116836274B (zh) * 2022-03-23 2024-11-22 东莞市朋志生物科技有限公司 抗血清淀粉样蛋白a抗体、检测血清淀粉样蛋白a的试剂和试剂盒
CN119403570A (zh) * 2022-06-21 2025-02-07 瑟罗泽恩奥普瑞汀公司 Wnt信号传导在角膜病中的调节作用
CN119744268A (zh) * 2022-09-09 2025-04-01 德国癌症研究中心公共法律基金会 靶向pd-l1降解
WO2025146152A1 (zh) * 2024-01-04 2025-07-10 上海宝济药业股份有限公司 一种药物组合物及其应用
CN120647751B (zh) * 2025-08-18 2025-12-02 成都迈科康生物科技有限公司 抗人乳头瘤病毒e1蛋白的抗体或其试剂盒和相关应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070244061A1 (en) * 2003-10-10 2007-10-18 Deutsches Krebsforschungszentrum Compositions for Diagnosis and Therapy of Diseases Associated with Aberrant Expression of Futrins (R-Spondisn) and/or Wnt
EP2305274A1 (en) * 2009-09-21 2011-04-06 Centre National de la Recherche Scientifique (CNRS) Use of WNT stimulators for treating demyelinating diseases
WO2013054307A2 (en) * 2011-10-14 2013-04-18 Novartis Ag Antibodies and methods for wnt pathway-related diseases
US20140044713A1 (en) * 2011-04-14 2014-02-13 Koninklijke Nederlandse Akademie Van Wetenschappen Compounds
WO2017069628A2 (en) * 2015-10-23 2017-04-27 Merus N.V. Binding molecules that inhibit cancer growth
WO2018132572A1 (en) * 2017-01-11 2018-07-19 The Board Of Trustees Of The Leland Stanford Junior University R-spondin (rspo) surrogate molecules

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044409A1 (en) 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
DE102004050620A1 (de) 2004-10-13 2006-04-20 Eberhard-Karls-Universität Tübingen Monoklonaler Antikörper gegen Frizzled-Rezeptoren
DE102005035568A1 (de) 2005-07-25 2007-02-01 M-Phasys Gmbh Frizzled 9 als Biomarker für Substrukturen des humanen Gehirns
EP3611266B1 (en) 2005-08-23 2022-11-09 The Trustees of the University of Pennsylvania Rna containing modified nucleosides and methods of use thereof
CN101573383B (zh) 2006-06-21 2015-05-13 肿瘤疗法科学股份有限公司 靶向肿瘤的针对卷曲同源物10的单克隆抗体及其用途
AU2007285217B2 (en) 2006-08-14 2013-02-07 Forerunner Pharma Research Co., Ltd Diagnosis and treatment of cancer using anti-desmoglein-3 antibodies
WO2008093646A1 (ja) 2007-02-01 2008-08-07 National University Corporation NARA Institute of Science and Technology Wntシグナル伝達系活性化ペプチド
CN103002911B (zh) 2008-09-26 2015-08-26 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
ES2579909T3 (es) 2009-02-03 2016-08-17 Koninklijke Nederlandse Akademie Van Wetenschappen Medio de cultivo para células madre epiteliales y organoides que comprenden dichas células madre
WO2010092457A1 (en) 2009-02-10 2010-08-19 Nokia Corporation Method, apparatus and computer program product for transfer of capability support information in a multi-rat environment
PT2510012T (pt) 2009-12-09 2017-07-13 Bayer Pharma AG Anticorpos anti-c4.4a e utilizações dos mesmos
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
CA2796464C (en) 2010-04-16 2021-08-03 Immune Disease Institute, Inc. Sustained polypeptide expression from synthetic, modified rnas and uses thereof
RU2013120302A (ru) 2010-10-01 2014-11-20 Модерна Терапьютикс, Инк. Сконструированные нуклеиновые кислоты и способы их применения
SG10201602394QA (en) 2011-03-29 2016-05-30 Roche Glycart Ag Antibody FC Variants
EP2694660B1 (en) 2011-04-03 2018-08-08 The General Hospital Corporation Efficient protein expression in vivo using modified rna (mod-rna)
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
WO2013071047A1 (en) 2011-11-11 2013-05-16 Children's Medical Center Corporation Compositions and methods for in vitro transcription of rna
WO2013078199A2 (en) 2011-11-23 2013-05-30 Children's Medical Center Corporation Methods for enhanced in vivo delivery of synthetic, modified rnas
EP2820151B1 (en) 2012-02-28 2020-03-25 Novartis AG Cancer patient selection for administration of wnt signaling inhibitors using rnf43 mutation status
CA2868391A1 (en) 2012-04-02 2013-10-10 Stephane Bancel Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
EP2882775B1 (en) 2012-08-09 2018-02-14 Roche Glycart AG Asgpr antibodies and uses thereof
WO2014093924A1 (en) 2012-12-13 2014-06-19 Moderna Therapeutics, Inc. Modified nucleic acid molecules and uses thereof
WO2014081507A1 (en) 2012-11-26 2014-05-30 Moderna Therapeutics, Inc. Terminally modified rna
US20160022840A1 (en) 2013-03-09 2016-01-28 Moderna Therapeutics, Inc. Heterologous untranslated regions for mrna
MA39896A (fr) 2014-04-21 2017-03-01 Abbvie Stemcentrx Llc Nouveaux anticorps antii-rnf43 et méthodes d'utilisation
US11142577B2 (en) 2014-09-12 2021-10-12 The Board Of Trustees Of The Leland Stanford Junior University WNT signaling agonist molecules
US10259874B2 (en) 2014-10-27 2019-04-16 Agency For Science, Technology And Research Anti-TIM-3 antibodies
WO2016073879A2 (en) 2014-11-06 2016-05-12 Scholar Rock, Inc. Transforming growth factor-related antibodies and uses thereof
EP3221361B1 (en) 2014-11-19 2021-04-21 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
CA2983008A1 (en) 2015-04-17 2016-10-20 Merrimack Pharmaceuticals, Inc. Combination treatments with seribantumab
AU2016365834B2 (en) 2015-12-08 2023-09-28 Regeneron Pharmaceuticals, Inc. Compositions and methods for internalizing enzymes
US20170349659A1 (en) 2016-06-03 2017-12-07 The Board Of Trustees Of The Leland Stanford Junior University Wnt signaling agonist molecules
WO2018107116A1 (en) 2016-12-09 2018-06-14 Abbvie Stemcentrx Llc Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby
JP7305543B2 (ja) 2017-01-26 2023-07-10 スロゼン オペレーティング， インコーポレイテッド 組織特異的Ｗｎｔシグナル増強分子およびその使用
EP3619238A4 (en) 2017-05-02 2021-02-24 Chugai Seiyaku Kabushiki Kaisha CYTOTOXICITY INDUCING THERAPEUTIC
GB201708330D0 (en) 2017-05-24 2017-07-05 Koninklijke Nederlandse Akademie Van Wetenschappen Fusion protein for enhancing intestinal regeneration
EP3732201A4 (en) 2017-12-19 2022-04-20 Surrozen Operating, Inc. WNT SURROGATES AND THEIR USES
CN111655729B (zh) 2017-12-19 2023-10-20 瑟罗泽恩奥普瑞汀公司 抗卷曲蛋白抗体和使用方法
CN111699003B (zh) 2017-12-19 2024-05-03 瑟罗泽恩奥普瑞汀公司 抗lrp5/6抗体和使用方法
CA3104526A1 (en) 2018-07-05 2020-01-09 Surrozen, Inc. Multi-specific wnt surrogate molecules and uses thereof
JP2021530223A (ja) 2018-07-09 2021-11-11 スロゼン， インコーポレイテッド 組織特異性Ｗｎｔシグナル増強分子及びその使用
US20220064337A1 (en) 2018-12-19 2022-03-03 Surrozen, Inc. Antigen binding formats for receptor complexes
JP7663501B2 (ja) 2019-02-11 2025-04-16 スロゼン オペレーティング， インコーポレイテッド 眼障害におけるｗｎｔシグナル伝達の調節
US20220195053A1 (en) 2019-03-11 2022-06-23 Surrozen Operating Inc. Modulation of wnt signaling in gastrointestinal disorders
US20220175884A1 (en) 2019-04-02 2022-06-09 Surrozen Operating, Inc. Modulation of wnt signaling in auditory disorders
CN120025448A (zh) 2019-06-11 2025-05-23 安托拉诊疗公司 多价fzd和wnt结合分子及其用途
US11050604B2 (en) 2019-07-01 2021-06-29 Rampart Communications, Inc. Systems, methods and apparatuses for modulation-agnostic unitary braid division multiplexing signal transformation
CN115427446A (zh) 2020-02-24 2022-12-02 瑟罗泽恩奥普瑞汀公司 Wnt超级激动剂
TW202233656A (zh) 2020-11-16 2022-09-01 美商蘇羅森營運公司 肝特異性wnt訊號增強分子及其用途
JP2024509266A (ja) 2021-03-10 2024-02-29 スロゼン オペレーティング， インコーポレイテッド 胃腸障害におけるｗｎｔシグナル伝達のモジュレーション

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070244061A1 (en) * 2003-10-10 2007-10-18 Deutsches Krebsforschungszentrum Compositions for Diagnosis and Therapy of Diseases Associated with Aberrant Expression of Futrins (R-Spondisn) and/or Wnt
EP2305274A1 (en) * 2009-09-21 2011-04-06 Centre National de la Recherche Scientifique (CNRS) Use of WNT stimulators for treating demyelinating diseases
US20140044713A1 (en) * 2011-04-14 2014-02-13 Koninklijke Nederlandse Akademie Van Wetenschappen Compounds
WO2013054307A2 (en) * 2011-10-14 2013-04-18 Novartis Ag Antibodies and methods for wnt pathway-related diseases
WO2017069628A2 (en) * 2015-10-23 2017-04-27 Merus N.V. Binding molecules that inhibit cancer growth
WO2018132572A1 (en) * 2017-01-11 2018-07-19 The Board Of Trustees Of The Leland Stanford Junior University R-spondin (rspo) surrogate molecules

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